KEGG   Lipotes vexillifer (Yangtze River dolphin): 103090018
Entry
103090018         CDS       T03090                                 
Symbol
ARAF
Name
(RefSeq) serine/threonine-protein kinase A-Raf isoform X1
  KO
K08845  A-Raf proto-oncogene serine/threonine-protein kinase [EC:2.7.11.1]
Organism
lve  Lipotes vexillifer (Yangtze River dolphin)
Pathway
lve01521  EGFR tyrosine kinase inhibitor resistance
lve01522  Endocrine resistance
lve04010  MAPK signaling pathway
lve04012  ErbB signaling pathway
lve04068  FoxO signaling pathway
lve04270  Vascular smooth muscle contraction
lve04650  Natural killer cell mediated cytotoxicity
lve04720  Long-term potentiation
lve04726  Serotonergic synapse
lve04730  Long-term depression
lve04810  Regulation of actin cytoskeleton
lve04910  Insulin signaling pathway
lve04914  Progesterone-mediated oocyte maturation
lve04928  Parathyroid hormone synthesis, secretion and action
lve05010  Alzheimer disease
lve05022  Pathways of neurodegeneration - multiple diseases
lve05034  Alcoholism
lve05160  Hepatitis C
lve05161  Hepatitis B
lve05200  Pathways in cancer
lve05205  Proteoglycans in cancer
lve05208  Chemical carcinogenesis - reactive oxygen species
lve05210  Colorectal cancer
lve05211  Renal cell carcinoma
lve05212  Pancreatic cancer
lve05213  Endometrial cancer
lve05214  Glioma
lve05215  Prostate cancer
lve05218  Melanoma
lve05219  Bladder cancer
lve05220  Chronic myeloid leukemia
lve05221  Acute myeloid leukemia
lve05223  Non-small cell lung cancer
lve05224  Breast cancer
lve05225  Hepatocellular carcinoma
lve05226  Gastric cancer
Brite
KEGG Orthology (KO) [BR:lve00001]
 09130 Environmental Information Processing
  09132 Signal transduction
   04010 MAPK signaling pathway
    103090018 (ARAF)
   04012 ErbB signaling pathway
    103090018 (ARAF)
   04068 FoxO signaling pathway
    103090018 (ARAF)
 09140 Cellular Processes
  09142 Cell motility
   04810 Regulation of actin cytoskeleton
    103090018 (ARAF)
 09150 Organismal Systems
  09151 Immune system
   04650 Natural killer cell mediated cytotoxicity
    103090018 (ARAF)
  09152 Endocrine system
   04910 Insulin signaling pathway
    103090018 (ARAF)
   04914 Progesterone-mediated oocyte maturation
    103090018 (ARAF)
   04928 Parathyroid hormone synthesis, secretion and action
    103090018 (ARAF)
  09153 Circulatory system
   04270 Vascular smooth muscle contraction
    103090018 (ARAF)
  09156 Nervous system
   04726 Serotonergic synapse
    103090018 (ARAF)
   04720 Long-term potentiation
    103090018 (ARAF)
   04730 Long-term depression
    103090018 (ARAF)
 09160 Human Diseases
  09161 Cancer: overview
   05200 Pathways in cancer
    103090018 (ARAF)
   05205 Proteoglycans in cancer
    103090018 (ARAF)
   05208 Chemical carcinogenesis - reactive oxygen species
    103090018 (ARAF)
  09162 Cancer: specific types
   05210 Colorectal cancer
    103090018 (ARAF)
   05212 Pancreatic cancer
    103090018 (ARAF)
   05225 Hepatocellular carcinoma
    103090018 (ARAF)
   05226 Gastric cancer
    103090018 (ARAF)
   05214 Glioma
    103090018 (ARAF)
   05221 Acute myeloid leukemia
    103090018 (ARAF)
   05220 Chronic myeloid leukemia
    103090018 (ARAF)
   05218 Melanoma
    103090018 (ARAF)
   05211 Renal cell carcinoma
    103090018 (ARAF)
   05219 Bladder cancer
    103090018 (ARAF)
   05215 Prostate cancer
    103090018 (ARAF)
   05213 Endometrial cancer
    103090018 (ARAF)
   05224 Breast cancer
    103090018 (ARAF)
   05223 Non-small cell lung cancer
    103090018 (ARAF)
  09172 Infectious disease: viral
   05161 Hepatitis B
    103090018 (ARAF)
   05160 Hepatitis C
    103090018 (ARAF)
  09164 Neurodegenerative disease
   05010 Alzheimer disease
    103090018 (ARAF)
   05022 Pathways of neurodegeneration - multiple diseases
    103090018 (ARAF)
  09165 Substance dependence
   05034 Alcoholism
    103090018 (ARAF)
  09176 Drug resistance: antineoplastic
   01521 EGFR tyrosine kinase inhibitor resistance
    103090018 (ARAF)
   01522 Endocrine resistance
    103090018 (ARAF)
 09180 Brite Hierarchies
  09181 Protein families: metabolism
   01001 Protein kinases [BR:lve01001]
    103090018 (ARAF)
Enzymes [BR:lve01000]
 2. Transferases
  2.7  Transferring phosphorus-containing groups
   2.7.11  Protein-serine/threonine kinases
    2.7.11.1  non-specific serine/threonine protein kinase
     103090018 (ARAF)
Protein kinases [BR:lve01001]
 Serine/threonine kinases: TKL group
  RAF family [OT]
   103090018 (ARAF)
SSDB
Motif
Pfam: PK_Tyr_Ser-Thr Pkinase RBD C1_1 Kinase-like zf-RING-like TUG-UBL1
Other DBs
NCBI-GeneID: 103090018
NCBI-ProteinID: XP_007450911
UniProt: A0A340WQ35
Position
Unknown
AA seq 606 aa
MEPPRAPPANGAEPSRAVGTVKVYLPNKQRTVVTVRDGMSVYDSLDKALKVRGLNQDCCV
VYRLIKGRKTVTAWDTAIAPLDGEELIVEVLEDVPLTMHNFVRKTFFSLAFCDFCLKFLF
HGFRCQTCGYKFHQHCSSKVPTVCVDMSTNRRQFYHSVQDLSGGSRQHEAPSNRPLNEPL
TPQGPSSCTQHRDPKHFPFSAPANAPLQRIRSTSTPNVHMVSTTAPMDSGLIQLPAQSFN
TDAAGNRGGGDGTPRGSPSPASMSSGRKSPHSKSPSEQRERKSLADDKKKVKNLGYRDSG
YYWEVPPSEVQLLKRIGTGSFGTVFRGRWHGDVAVKVLKVAQPTAEQAQAFKNEMQVLRK
TRHVNILLFMGFMTRPGFAIITQWCEGSSLYHHLHVADTRFDMVQLIDVARQTAQGMDYL
HAKNIIHRDLKSNSIFLHEGLTVKIGDFGLATVKTRWSGAQPLEQPSGSVLWMAAEVIRM
QDPNPYSFQSDVYAYGVVLYELMTGSLPYSHIGSRDQIIFMVGRGYLSPDLSKISSNCPK
AMRRLLSDCLKFQREERPLFPQILATIELLQRSLPKIERSASEPSLHRTQADELPACLLS
AARLVP
NT seq 1821 nt   +upstreamnt  +downstreamnt
atggagccaccacgggccccccctgccaacggggccgagccatcccgggcagtgggcact
gtcaaagtgtacctgcccaacaagcaacgcacagtggtgactgtccgggatggcatgagt
gtctacgactctttagacaaggccctcaaggtgcggggactcaatcaggattgctgtgtg
gtctaccggctcatcaagggtcgaaagacagtcaccgcctgggacacagccattgcaccc
ctggatggcgaggagctcattgtggaggtccttgaagacgtccccctgaccatgcacaat
tttgtacggaagacattcttcagcctggccttttgtgacttctgccttaagtttctgttc
catggcttccgctgccaaacctgtggatacaagttccaccagcattgttcctccaaggtc
cccacagtctgtgttgacatgagtaccaaccgccgacagttctaccacagtgtccaagat
ttgtccggaggctccagacagcatgaggctccctcgaaccgccccctgaatgagccactc
acccctcagggtcccagctcctgcacccagcaccgcgaccccaagcacttccccttctct
gccccggccaacgcccccctccagcgcatccgctccacatctacccccaacgtccacatg
gtcagcaccacggcccccatggactccggcctcatccagctccctgcccagagtttcaac
actgacgctgctgggaatagaggtggtggcgatggaaccccccgggggagccccagccca
gccagcatgtcctcggggaggaagtccccacattccaagtccccgtcagagcagcgggag
cggaagtccttggccgatgacaagaagaaagtgaagaatctggggtaccgggactcgggc
tattactgggaggtgccacccagtgaggtgcagctgctgaagaggatcgggacgggctcg
tttgggaccgtgtttcgtgggcggtggcacggtgatgtggccgtgaaggtgctcaaggtg
gcccaacccacagctgagcaggcccaggccttcaagaacgagatgcaggtgctcaggaag
acacgtcacgtcaacatcttgctgttcatgggcttcatgacccggccgggatttgctatc
atcacacagtggtgcgagggctccagtctctaccaccacctgcacgtggccgacacacgc
ttcgacatggtccagctcattgatgtggcccggcagactgcccagggcatggactatctc
catgccaagaacatcatccaccgagatctcaagtctaacagtatcttcctacacgagggg
ctcacggtgaagatcggggacttcggcctggccacagtgaagacgcggtggagtggggcc
cagcctttggagcagccctcgggctctgtgctatggatggcagctgaggtgatccgtatg
caggacccgaacccctatagcttccagtcggatgtctacgcctatggggttgtgctctac
gaactcatgaccggctcgctgccttacagccacattggcagccgtgaccagattatcttt
atggtgggccgtggctatctgtccccggacctcagcaaaatctccagcaactgccccaag
gccatgaggcgcctgctgtctgactgcctcaagttccagcgggaggagcggcccctcttc
ccccagatcctggccacgattgagctgctgcagcggtcactccccaagattgagcggagt
gcctccgaaccctccttgcaccgtacccaggctgatgagttgcctgcctgcctactcagc
gcagcccgccttgtgccttag

  All links  
Ontology (3)   
   KEGG BRITE (3)   
Pathway (36)   
   KEGG PATHWAY (36)   
Chemical reaction (1)   
   KEGG ENZYME (1)   
Genome (1)   
   KEGG GENOME (1)   
Gene (10)   
   KEGG ORTHOLOGY (1)   
   RefGene (6)   
   NCBI-PROTEINID (1)   
   NCBI-Gene (1)   
   OC (1)   
Protein sequence (3)   
   UniProt (1)   
   RefSeq(pep) (2)   
DNA sequence (2)   
   RefSeq(nuc) (2)   
Protein domain (7)   
   Pfam (7)   
All databases (63)   

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