KEGG   PATHWAY: map00010Help
Entry
map00010                    Pathway                                

Name
Glycolysis / Gluconeogenesis
Description
Glycolysis is the process of converting glucose into pyruvate and generating small amounts of ATP (energy) and NADH (reducing power). It is a central pathway that produces important precursor metabolites: six-carbon compounds of glucose-6P and fructose-6P and three-carbon compounds of glycerone-P, glyceraldehyde-3P, glycerate-3P, phosphoenolpyruvate, and pyruvate [MD:M00001]. Acetyl-CoA, another important precursor metabolite, is produced by oxidative decarboxylation of pyruvate [MD:M00307]. When the enzyme genes of this pathway are examined in completely sequenced genomes, the reaction steps of three-carbon compounds from glycerone-P to pyruvate form a conserved core module [MD:M00002], which is found in almost all organisms and which sometimes contains operon structures in bacterial genomes. Gluconeogenesis is a synthesis pathway of glucose from noncarbohydrate precursors. It is essentially a reversal of glycolysis with minor variations of alternative paths [MD:M00003].
Class
Metabolism; Carbohydrate metabolism
BRITE hierarchy
Pathway map
map00010  Glycolysis / Gluconeogenesis
map00010

Ortholog table
Module
M00001  Glycolysis (Embden-Meyerhof pathway), glucose => pyruvate [PATH:map00010]
M00002  Glycolysis, core module involving three-carbon compounds [PATH:map00010]
M00003  Gluconeogenesis, oxaloacetate => fructose-6P [PATH:map00010]
M00114  Ascorbate biosynthesis, plants, glucose-6P => ascorbate [PATH:map00010]
M00265  PTS system, glucose-specific II component [PATH:map00010]
M00266  PTS system, maltose/glucose-specific II component [PATH:map00010]
M00272  PTS system, beta-glucoside (arbutin/salicin/cellobiose)-specific II component [PATH:map00010]
M00307  Pyruvate oxidation, pyruvate => acetyl-CoA [PATH:map00010]
M00809  PTS system, glucose-specific II component [PATH:map00010]
Disease
H00069  Glycogen storage diseases (GSD)
H00071  Hereditary fructose intolerance
H00072  Pyruvate dehydrogenase complex deficiency
H00114  Fructose-1,6-bisphosphatase deficiency
H00664  Anemia due to disorders of glycolytic enzymes
H01071  Acute alcohol sensitivity
H01096  Pyruvate kinase (PK) deficiency
H01267  Familial hyperinsulinemic hypoglycemia (HHF)
H01760  Hepatic glycogen storage disease
H01762  Muscle glycogen storage disease
H01939  Glycogen storage disease type I
H01945  Glycogen storage disease type VII
H01946  Glycogen storage disease type XI
H01951  Glycogen storage disease type X
H01952  Glycogen storage disease type XII
H01953  Glycogen storage disease type XIII
H01954  Glycogen storage disease type XIV
H01997  Pyruvate dehydrogenase E1-alpha deficiency
H01998  Pyruvate dehydrogenase E1-beta deficiency
H01999  Pyruvate dehydrogenase E2 deficiency
H02000  Dihydrolipoamide dehydrogenase deficiency
Other DBs
GO: 0006096 0006094
Reference
(map 1)
  Authors
Nishizuka Y (ed).
  Title
[Metabolic Maps] (In Japanese)
  Journal
Tokyo Kagaku Dojin (1980)
Reference
(map 1)
  Authors
Nishizuka Y, Seyama Y, Ikai A, Ishimura Y, Kawaguchi A (eds).
  Title
[Cellular Functions and Metabolic Maps] (In Japanese)
  Journal
Tokyo Kagaku Dojin (1997)
Reference
  Authors
Michal G.
  Title
Biochemical Pathways
  Journal
Wiley (1999)
KO pathway
ko00010   

DBGET integrated database retrieval system