KEGG   PATHWAY: map00010
Entry
map00010                    Pathway                                

Name
Glycolysis / Gluconeogenesis
Description
Glycolysis is the process of converting glucose into pyruvate and generating small amounts of ATP (energy) and NADH (reducing power). It is a central pathway that produces important precursor metabolites: six-carbon compounds of glucose-6P and fructose-6P and three-carbon compounds of glycerone-P, glyceraldehyde-3P, glycerate-3P, phosphoenolpyruvate, and pyruvate [MD:M00001]. Acetyl-CoA, another important precursor metabolite, is produced by oxidative decarboxylation of pyruvate [MD:M00307]. When the enzyme genes of this pathway are examined in completely sequenced genomes, the reaction steps of three-carbon compounds from glycerone-P to pyruvate form a conserved core module [MD:M00002], which is found in almost all organisms and which sometimes contains operon structures in bacterial genomes. Gluconeogenesis is a synthesis pathway of glucose from noncarbohydrate precursors. It is essentially a reversal of glycolysis with minor variations of alternative paths [MD:M00003].
Class
Metabolism; Carbohydrate metabolism
Pathway map
map00010  Glycolysis / Gluconeogenesis
map00010

Module
M00001  Glycolysis (Embden-Meyerhof pathway), glucose => pyruvate [PATH:map00010]
M00002  Glycolysis, core module involving three-carbon compounds [PATH:map00010]
M00003  Gluconeogenesis, oxaloacetate => fructose-6P [PATH:map00010]
M00307  Pyruvate oxidation, pyruvate => acetyl-CoA [PATH:map00010]
Other DBs
GO: 0006096 0006094
Reference
(map 1)
  Authors
Nishizuka Y (ed).
  Title
[Metabolic Maps] (In Japanese)
  Journal
Tokyo Kagaku Dojin (1980)
Reference
(map 1)
  Authors
Nishizuka Y, Seyama Y, Ikai A, Ishimura Y, Kawaguchi A (eds).
  Title
[Cellular Functions and Metabolic Maps] (In Japanese)
  Journal
Tokyo Kagaku Dojin (1997)
Reference
  Authors
Michal G.
  Title
Biochemical Pathways
  Journal
Wiley (1999)
Related
pathway
map00020  Citrate cycle (TCA cycle)
map00030  Pentose phosphate pathway
map00500  Starch and sucrose metabolism
map00620  Pyruvate metabolism
map00640  Propanoate metabolism
map00710  Carbon fixation in photosynthetic organisms
KO pathway
ko00010   

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