Entry |
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Name |
Streptomycin biosynthesis
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Description |
Streptomycin is an aminocyclitol-aminoglycoside antibiotic produced by Streptomyces griseus. Streptomycin consists of aminocyclitol (streptidine), 6-deoxyhexose (streptose), and N-methyl-L-glucosamine moieties, which are formed by independent biosynthetic pathways. All of the moieties are derived from D-glucose. The streptidine moiety is synthesized via myo-inositol, which is then oxidized at C-1 and transaminated to give scyllo-inosamine. After phosphorylation, the compound is transamidinated by arginine. The same procedure is repeated at the C-3 position. The streptose moiety is made from D-glucose via a dTDP-glucose pathway. The exact biosynthetic route for the N-methyl-L-glucosamine moiety is unknown, though the biosynthetic gene cluster have been proposed.
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Class |
Metabolism; Biosynthesis of other secondary metabolites
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Pathway map |

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Module |
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Drug |
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Other DBs |
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Reference |
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Authors |
Wehmeier UF, Piepersberg W |
Title |
Enzymology of aminoglycoside biosynthesis-deduction from gene clusters. |
Journal |
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Reference |
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Authors |
Flatt PM, Mahmud T |
Title |
Biosynthesis of aminocyclitol-aminoglycoside antibiotics and related compounds. |
Journal |
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Reference |
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Authors |
Walker JB |
Title |
Possible evolutionary relationships between streptomycin and bluensomycin biosynthetic pathways: detection of novel inositol kinase and O-carbamoyltransferase activities. |
Journal |
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Reference |
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Authors |
Ohnuki T, Imanaka T, Aiba S |
Title |
Self-cloning in Streptomyces griseus of an str gene cluster for streptomycin biosynthesis and streptomycin resistance. |
Journal |
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Reference |
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Authors |
Ahlert J, Distler J, Mansouri K, Piepersberg W |
Title |
Identification of stsC, the gene encoding the L-glutamine:scyllo-inosose aminotransferase from streptomycin-producing Streptomycetes. |
Journal |
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Reference |
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Authors |
Distler J, Mansouri K, Mayer G, Stockmann M, Piepersberg W |
Title |
Streptomycin biosynthesis and its regulation in Streptomycetes. |
Journal |
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Reference |
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Authors |
Mansouri K, Piepersberg W. |
Title |
Genetics of streptomycin production in Streptomyces griseus: nucleotide sequence of five genes, strFGHIK, including a phosphatase gene. |
Journal |
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Reference |
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Authors |
Fritsche E, Bergner A, Humm A, Piepersberg W, Huber R |
Title |
Crystal structure of L-arginine:inosamine-phosphate amidinotransferase StrB1 from Streptomyces griseus: an enzyme involved in streptomycin biosynthesis. |
Journal |
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Related pathway |
map00523 | Polyketide sugar unit biosynthesis |
map00524 | Neomycin, kanamycin and gentamicin biosynthesis |
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KO pathway |
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