Entry
Name
Acarbose and validamycin biosynthesis
Class
Metabolism; Biosynthesis of other secondary metabolites
BRITE hierarchy
Pathway map
map00525 Acarbose and validamycin biosynthesis
Ortholog table
Module
M00814 Acarbose biosynthesis, sedoheptulopyranose-7P => acarbose [PATH:map00525 ]
M00815 Validamycin A biosynthesis, sedoheptulopyranose-7P => validamycin A [PATH:map00525 ]
Reference
Authors
Flatt PM, Mahmud T
Title
Biosynthesis of aminocyclitol-aminoglycoside antibiotics and related compounds.
Journal
Reference
Authors
Mahmud T, Flatt PM, Wu X
Title
Biosynthesis of unusual aminocyclitol-containing natural products.
Journal
Reference
Authors
Wendler S, Hurtgen D, Kalinowski J, Klein A, Niehaus K, Schulte F, Schwientek P, Wehlmann H, Wehmeier UF, Puhler A
Title
The cytosolic and extracellular proteomes of Actinoplanes sp. SE50/110 led to the identification of gene products involved in acarbose metabolism.
Journal
Reference
Authors
Schwientek P, Szczepanowski R, Ruckert C, Kalinowski J, Klein A, Selber K, Wehmeier UF, Stoye J, Puhler A
Title
The complete genome sequence of the acarbose producer Actinoplanes sp. SE50/110.
Journal
Reference
Authors
Deng Z, Bai L
Title
Antibiotic biosynthetic pathways and pathway engineering--a growing research field in China.
Journal
Reference
Authors
Asamizu S, Yang J, Almabruk KH, Mahmud T
Title
Pseudoglycosyltransferase catalyzes nonglycosidic C-N coupling in validamycin a biosynthesis.
Journal
Reference
Authors
Choi WS, Wu X, Choeng YH, Mahmud T, Jeong BC, Lee SH, Chang YK, Kim CJ, Hong SK
Title
Genetic organization of the putative salbostatin biosynthetic gene cluster including the 2-epi-5-epi-valiolone synthase gene in Streptomyces albus ATCC 21838.
Journal
Reference
Authors
Wu X, Flatt PM, Xu H, Mahmud T
Title
Biosynthetic gene cluster of cetoniacytone A, an unusual aminocyclitol from the endosymbiotic Bacterium Actinomyces sp. Lu 9419.
Journal
Related pathway
map00520 Amino sugar and nucleotide sugar metabolism
KO pathway