KEGG   PATHWAY: map00533
Entry
map00533                    Pathway                                

Name
Glycosaminoglycan biosynthesis - keratan sulfate
Description
Keratan sulfate (KS) is a glycosaminoglycan with the basic disaccharide unit of N-acetyllactosamine, Gal(b1-4)GlcNAc(b1-3), with sulfate esters at C-6 of GlcNAc and Gal residues. There are two types of KS distinguished by the protein linkage: type I for N-linked via the N-glycan core structure and type II for O-linked via the O-glycan core 2 structure.
Class
Metabolism; Glycan biosynthesis and metabolism
Pathway map
map00533  Glycosaminoglycan biosynthesis - keratan sulfate
map00533

Disease
H00954  Macular corneal dystrophy
Reference
  Authors
Funderburgh JL.
  Title
Keratan sulfate: structure, biosynthesis, and function.
  Journal
Glycobiology 10:951-958 (2000)
DOI:10.1093/glycob/10.10.951
Reference
  Authors
Seko A, Yamashita K.
  Title
beta1,3-N-Acetylglucosaminyltransferase-7 (beta3Gn-T7) acts efficiently on keratan sulfate-related glycans.
  Journal
FEBS Lett 556:216-20 (2004)
DOI:10.1016/S0014-5793(03)01440-6
Reference
  Authors
Seko A, Dohmae N, Takio K, Yamashita K.
  Title
Beta 1,4-galactosyltransferase (beta 4GalT)-IV is specific for GlcNAc 6-O-sulfate. Beta 4GalT-IV acts on keratan sulfate-related glycans and a precursor glycan of 6-sulfosialyl-Lewis X.
  Journal
J Biol Chem 278:9150-8 (2003)
DOI:10.1074/jbc.M211480200
Related
pathway
map00510  N-Glycan biosynthesis
map00512  Mucin type O-glycan biosynthesis
KO pathway
ko00533   

  All links  
Disease (1)   
   KEGG DISEASE (1)   
Chemical reaction (6)   
   KEGG ENZYME (6)   
Gene (7421)   
   KEGG ORTHOLOGY (14)   
   RefGene (7407)   
Literature (3)   
   PubMed (3)   
All databases (7431)   

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