KEGG   PATHWAY: map00730
Entry
map00730                    Pathway                                
Name
Thiamine metabolism
Class
Metabolism; Metabolism of cofactors and vitamins
Pathway map
map00730  Thiamine metabolism
map00730

Module
M00127  Thiamine biosynthesis, prokaryotes, AIR (+ DXP/tyrosine) => TMP/TPP [PATH:map00730]
M00895  Thiamine biosynthesis, prokaryotes, AIR (+ DXP/glycine) => TMP/TPP [PATH:map00730]
M00896  Thiamine biosynthesis, archaea, AIR (+ NAD+) => TMP/TPP [PATH:map00730]
M00897  Thiamine biosynthesis, plants, AIR (+ NAD+) => TMP/thiamine/TPP [PATH:map00730]
M00898  Thiamine biosynthesis, pyridoxal-5P => TMP/thiamine/TPP [PATH:map00730]
M00899  Thiamine salvage pathway, HMP/HET => TMP [PATH:map00730]
Other DBs
GO: 0006772
Reference
PMID:15614489
  Authors
Kawasaki Y, Onozuka M, Mizote T, Nosaka K.
  Title
Biosynthesis of hydroxymethylpyrimidine pyrophosphate in Saccharomyces cerevisiae.
  Journal
Curr Genet 47:156-62 (2005)
DOI:10.1007/s00294-004-0557-x
Reference
PMID:14567704
  Authors
Park JH, Dorrestein PC, Zhai H, Kinsland C, McLafferty FW, Begley TP.
  Title
Biosynthesis of the thiazole moiety of thiamin pyrophosphate (vitamin B1).
  Journal
Biochemistry 42:12430-8 (2003)
DOI:10.1021/bi034902z
Reference
PMID:22616866
  Authors
Begley TP, Ealick SE, McLafferty FW
  Title
Thiamin biosynthesis: still yielding fascinating biological chemistry.
  Journal
Biochem Soc Trans 40:555-60 (2012)
DOI:10.1042/BST20120084
Reference
PMID:12777485
  Authors
Wightman R, Meacock PA
  Title
The THI5 gene family of Saccharomyces cerevisiae: distribution of homologues among the hemiascomycetes and functional redundancy in the aerobic biosynthesis of thiamin from pyridoxine.
  Journal
Microbiology 149:1447-60 (2003)
DOI:10.1099/mic.0.26194-0
Reference
PMID:22031445
  Authors
Chatterjee A, Abeydeera ND, Bale S, Pai PJ, Dorrestein PC, Russell DH, Ealick SE, Begley TP
  Title
Saccharomyces cerevisiae THI4p is a suicide thiamine thiazole synthase.
  Journal
Nature 478:542-6 (2011)
DOI:10.1038/nature10503
Reference
PMID:19348578
  Authors
Jurgenson CT, Begley TP, Ealick SE
  Title
The structural and biochemical foundations of thiamin biosynthesis.
  Journal
Annu Rev Biochem 78:569-603 (2009)
DOI:10.1146/annurev.biochem.78.072407.102340
Related
pathway
map00010  Glycolysis / Gluconeogenesis
map00230  Purine metabolism
map00260  Glycine, serine and threonine metabolism
map00270  Cysteine and methionine metabolism
map00400  Phenylalanine, tyrosine and tryptophan biosynthesis
map00750  Vitamin B6 metabolism
KO pathway
ko00730   

  All links  
Pathway (6)   
   KEGG MODULE (6)   
Chemical substance (31)   
   KEGG COMPOUND (31)   
Chemical reaction (61)   
   KEGG ENZYME (28)   
   KEGG REACTION (33)   
Gene (177777)   
   KEGG ORTHOLOGY (36)   
   RefGene (177741)   
Literature (6)   
   PubMed (6)   
All databases (177881)   

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