KEGG   PATHWAY: map00984
Entry
map00984                    Pathway                                

Name
Steroid degradation
Class
Metabolism; Xenobiotics biodegradation and metabolism
Pathway map
map00984  Steroid degradation
map00984

Other DBs
GO: 0006707
Reference
  Authors
Ouellet H, Johnston JB, de Montellano PR
  Title
Cholesterol catabolism as a therapeutic target in Mycobacterium tuberculosis.
  Journal
Trends Microbiol 19:530-9 (2011)
DOI:10.1016/j.tim.2011.07.009
Reference
  Authors
Van der Geize R, Yam K, Heuser T, Wilbrink MH, Hara H, Anderton MC, Sim E, Dijkhuizen L, Davies JE, Mohn WW, Eltis LD
  Title
A gene cluster encoding cholesterol catabolism in a soil actinomycete provides insight into Mycobacterium tuberculosis survival in macrophages.
  Journal
Proc Natl Acad Sci U S A 104:1947-52 (2007)
DOI:10.1073/pnas.0605728104
Reference
  Authors
Thomas ST, VanderVen BC, Sherman DR, Russell DG, Sampson NS
  Title
Pathway profiling in Mycobacterium tuberculosis: elucidation of cholesterol-derived catabolite and enzymes that catalyze its metabolism.
  Journal
J Biol Chem 286:43668-78 (2011)
DOI:10.1074/jbc.M111.313643
Reference
  Authors
Driscoll MD, McLean KJ, Levy C, Mast N, Pikuleva IA, Lafite P, Rigby SE, Leys D, Munro AW
  Title
Structural and biochemical characterization of Mycobacterium tuberculosis CYP142: evidence for multiple cholesterol 27-hydroxylase activities in a human pathogen.
  Journal
J Biol Chem 285:38270-82 (2010)
DOI:10.1074/jbc.M110.164293
Reference
  Authors
Johnston JB, Ouellet H, Ortiz de Montellano PR
  Title
Functional redundancy of steroid C26-monooxygenase activity in Mycobacterium tuberculosis revealed by biochemical and genetic analyses.
  Journal
J Biol Chem 285:36352-60 (2010)
DOI:10.1074/jbc.M110.161117
Reference
  Authors
Yang X, Dubnau E, Smith I, Sampson NS
  Title
Rv1106c from Mycobacterium tuberculosis is a 3beta-hydroxysteroid dehydrogenase.
  Journal
Biochemistry 46:9058-67 (2007)
DOI:10.1021/bi700688x
Reference
  Authors
Lack NA, Yam KC, Lowe ED, Horsman GP, Owen RL, Sim E, Eltis LD
  Title
Characterization of a carbon-carbon hydrolase from Mycobacterium tuberculosis involved in cholesterol metabolism.
  Journal
J Biol Chem 285:434-43 (2010)
DOI:10.1074/jbc.M109.058081
Reference
  Authors
Kreit J, Sampson NS
  Title
Cholesterol oxidase: physiological functions.
  Journal
FEBS J 276:6844-56 (2009)
DOI:10.1111/j.1742-4658.2009.07378.x
Reference
  Authors
Horinouchi M, Hayashi T, Kudo T
  Title
Steroid degradation in Comamonas testosteroni.
  Journal
J Steroid Biochem Mol Biol 129:4-14 (2012)
DOI:10.1016/j.jsbmb.2010.10.008
Reference
  Authors
Horinouchi M, Kurita T, Hayashi T, Kudo T
  Title
Steroid degradation genes in Comamonas testosteroni TA441: Isolation of genes encoding a Delta4(5)-isomerase and 3alpha- and 3beta-dehydrogenases and evidence for a 100 kb steroid degradation gene hot spot.
  Journal
J Steroid Biochem Mol Biol 122:253-63 (2010)
DOI:10.1016/j.jsbmb.2010.06.002
Related
pathway
map00100  Steroid biosynthesis
map00140  Steroid hormone biosynthesis
map00622  Xylene degradation
KO pathway
ko00984   

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