Kang Q, Shen Y, Bai L

Biosynthesis of 3,5-AHBA-derived natural products.

Nat Prod Rep 29:243-63 (2012)
DOI:10.1039/c2np00019a

Floss HG, Yu TW, Arakawa K

The biosynthesis of 3-amino-5-hydroxybenzoic acid (AHBA), the precursor of mC7N units in ansamycin and mitomycin antibiotics: a review.

J Antibiot (Tokyo) 64:35-44 (2011)
DOI:10.1038/ja.2010.139

Guo J, Frost JW

Kanosamine biosynthesis: a likely source of the aminoshikimate pathway's nitrogen atom.

J Am Chem Soc 124:10642-3 (2002)
DOI:10.1021/ja026628m

Wenzel SC, Williamson RM, Grunanger C, Xu J, Gerth K, Martinez RA, Moss SJ, Carroll BJ, Grond S, Unkefer CJ, Muller R, Floss HG

On the biosynthetic origin of methoxymalonyl-acyl carrier protein, the substrate for incorporation of "glycolate" units into ansamitocin and soraphen A.

J Am Chem Soc 128:14325-36 (2006)
DOI:10.1021/ja064408t

Kato Y, Bai L, Xue Q, Revill WP, Yu TW, Floss HG

Functional expression of genes involved in the biosynthesis of the novel polyketide chain extension unit, methoxymalonyl-acyl carrier protein, and engineered biosynthesis of 2-desmethyl-2-methoxy-6-deoxyerythronolide B.

J Am Chem Soc 124:5268-9 (2002)
DOI:10.1021/ja0127483

Yu TW, Bai L, Clade D, Hoffmann D, Toelzer S, Trinh KQ, Xu J, Moss SJ, Leistner E, Floss HG

The biosynthetic gene cluster of the maytansinoid antitumor agent ansamitocin from Actinosynnema pretiosum.

Proc Natl Acad Sci U S A 99:7968-73 (2002)
DOI:10.1073/pnas.092697199

Spiteller P, Bai L, Shang G, Carroll BJ, Yu TW, Floss HG

The post-polyketide synthase modification steps in the biosynthesis of the antitumor agent ansamitocin by Actinosynnema pretiosum.

J Am Chem Soc 125:14236-7 (2003)
DOI:10.1021/ja038166y

Taft F, Brunjes M, Knobloch T, Floss HG, Kirschning A

Timing of the Delta(10,12)-Delta(11,13) double bond migration during ansamitocin biosynthesis in Actinosynnema pretiosum.

J Am Chem Soc 131:3812-3 (2009)
DOI:10.1021/ja8088923

Li Y, Zhao P, Kang Q, Ma J, Bai L, Deng Z

Dual carbamoylations on the polyketide and glycosyl moiety by asm21 result in extended ansamitocin biosynthesis.

Chem Biol 18:1571-80 (2011)
DOI:10.1016/j.chembiol.2011.11.007

Wu Y, Kang Q, Shang G, Spiteller P, Carroll B, Yu TW, Su W, Bai L, Floss HG

N-methylation of the amide bond by methyltransferase asm10 in ansamitocin biosynthesis.

Chembiochem 12:1759-66 (2011)
DOI:10.1002/cbic.201100062

Zhao P, Bai L, Ma J, Zeng Y, Li L, Zhang Y, Lu C, Dai H, Wu Z, Li Y, Wu X, Chen G, Hao X, Shen Y, Deng Z, Floss HG

Amide N-glycosylation by Asm25, an N-glycosyltransferase of ansamitocins.

Chem Biol 15:863-74 (2008)
DOI:10.1016/j.chembiol.2008.06.007

Arakawa K, Muller R, Mahmud T, Yu TW, Floss HG

Characterization of the early stage aminoshikimate pathway in the formation of 3-amino-5-hydroxybenzoic acid: the RifN protein specifically converts kanosamine into kanosamine 6-phosphate.

J Am Chem Soc 124:10644-5 (2002)
DOI:10.1021/ja0206339

Watanabe K, Rude MA, Walsh CT, Khosla C

Engineered biosynthesis of an ansamycin polyketide precursor in Escherichia coli.

Proc Natl Acad Sci U S A 100:9774-8 (2003)
DOI:10.1073/pnas.1632167100

Floss HG, Yu TW.

Rifamycin-mode of action, resistance, and biosynthesis.

Chem Rev 105:621-32 (2005)
DOI:10.1021/cr030112j

Xu J, Mahmud T, Floss HG

Isolation and characterization of 27-O-demethylrifamycin SV methyltransferase provides new insights into the post-PKS modification steps during the biosynthesis of the antitubercular drug rifamycin B by Amycolatopsis mediterranei S699.

Arch Biochem Biophys 411:277-88 (2003)
DOI:10.1016/S0003-9861(03)00004-3

Xiong Y, Wu X, Mahmud T

A homologue of the Mycobacterium tuberculosis PapA5 protein, rif-orf20, is an acetyltransferase involved in the biosynthesis of antitubercular drug rifamycin B by Amycolatopsis mediterranei S699.

Chembiochem 6:834-7 (2005)
DOI:10.1002/cbic.200400387

Xu J, Wan E, Kim CJ, Floss HG, Mahmud T

Identification of tailoring genes involved in the modification of the polyketide backbone of rifamycin B by Amycolatopsis mediterranei S699.

Microbiology 151:2515-28 (2005)
DOI:10.1099/mic.0.28138-0