KEGG PATHWAY: map04115

PATHWAY: map04115

Entry

map04115                    Pathway

Name

p53 signaling pathway

Description

p53 activation is induced by a number of stress signals, including DNA damage, oxidative stress and activated oncogenes. The p53 protein is employed as a transcriptional activator of p53-regulated genes. This results in three major outputs; cell cycle arrest, cellular senescence or apoptosis. Other p53-regulated gene functions communicate with adjacent cells, repair the damaged DNA or set up positive and negative feedback loops that enhance or attenuate the functions of the p53 protein and integrate these stress responses with other signal transduction pathways.

Class

Cellular Processes; Cell growth and death

Pathway map

map04115

p53 signaling pathway

Reference

PMID:16557269

Authors

Levine AJ, Hu W, Feng Z.

Title

The P53 pathway: what questions remain to be explored?

Journal

Cell Death Differ 13:1027-36 (2006)
DOI:10.1038/sj.cdd.4401910

Reference

PMID:15838523

Authors

Harris SL, Levine AJ.

Title

The p53 pathway: positive and negative feedback loops.

Journal

Oncogene 24:2899-908 (2005)
DOI:10.1038/sj.onc.1208615

Reference

PMID:11747320

Authors

Balint E E, Vousden KH.

Title

Activation and activities of the p53 tumour suppressor protein.

Journal

Br J Cancer 85:1813-23 (2001)
DOI:10.1054/bjoc.2001.2128

Reference

PMID:11313928

Authors

Taylor WR, Stark GR.

Title

Regulation of the G2/M transition by p53.

Journal

Oncogene 20:1803-15 (2001)
DOI:10.1038/sj.onc.1204252

Reference

PMID:15116721

Authors

Hofseth LJ, Hussain SP, Harris CC.

Title

p53: 25 years after its discovery.

Journal

Trends Pharmacol Sci 25:177-81 (2004)
DOI:10.1016/j.tips.2004.02.009

Reference

PMID:12505356

Authors

Pietenpol JA, Stewart ZA.

Title

Cell cycle checkpoint signaling: cell cycle arrest versus apoptosis.

Journal

Toxicology 181-182:475-81 (2002)
DOI:10.1016/S0300-483X(02)00460-2

Reference

PMID:10714958

Authors

Tokino T, Nakamura Y.

Title

The role of p53-target genes in human cancer.

Journal

Crit Rev Oncol Hematol 33:1-6 (2000)
DOI:10.1016/S1040-8428(99)00051-7

Reference

PMID:16697662

Authors

Hermeking H, Benzinger A.

Title

14-3-3 proteins in cell cycle regulation.

Journal

Semin Cancer Biol 16:183-92 (2006)
DOI:10.1016/j.semcancer.2006.03.002

Reference

PMID:16915296

Authors

Sherr CJ.

Title

Divorcing ARF and p53: an unsettled case.

Journal

Nat Rev Cancer 6:663-73 (2006)
DOI:10.1038/nrc1954

Reference

PMID:17409411

Authors

Feng Z, Hu W, de Stanchina E, Teresky AK, Jin S, Lowe S, Levine AJ.

Title

The regulation of AMPK beta1, TSC2, and PTEN expression by p53: stress, cell and tissue specificity, and the role of these gene products in modulating the IGF-1-AKT-mTOR pathways.

Journal

Cancer Res 67:3043-53 (2007)
DOI:10.1158/0008-5472.CAN-06-4149

Reference

PMID:26037915

Authors

Resnick-Silverman L, Manfredi JJ

Title

Two Faces of SIVA.

Journal

Cancer Discov 5:581-3 (2015)
DOI:10.1158/2159-8290.CD-15-0484

Reference

PMID:19584092

Authors

Resch U, Schichl YM, Winsauer G, Gudi R, Prasad K, de Martin R

Title

Siva1 is a XIAP-interacting protein that balances NFkappaB and JNK signalling to promote apoptosis.

Journal

J Cell Sci 122:2651-61 (2009)
DOI:10.1242/jcs.049940

Reference

PMID:19240372

Authors

Barkinge JL, Gudi R, Sarah H, Chu F, Borthakur A, Prabhakar BS, Prasad KV

Title

The p53-induced Siva-1 plays a significant role in cisplatin-mediated apoptosis.

Journal

J Carcinog 8:2 (2009)
DOI:10.4103/1477-3163.45389

Reference

PMID:12135761

Authors

Ohiro Y, Garkavtsev I, Kobayashi S, Sreekumar KR, Nantz R, Higashikubo BT, Duffy SL, Higashikubo R, Usheva A, Gius D, Kley N, Horikoshi N

Title

A novel p53-inducible apoptogenic gene, PRG3, encodes a homologue of the apoptosis-inducing factor (AIF).

Journal

FEBS Lett 524:163-71 (2002)
DOI:10.1016/S0014-5793(02)03049-1

Reference

PMID:26646590

Authors

Hu Y, Ge W, Wang X, Sutendra G, Zhao K, Dedeic Z, Slee EA, Baer C, Lu X

Title

Caspase cleavage of iASPP potentiates its ability to inhibit p53 and NF-kappaB.

Journal

Oncotarget 6:42478-90 (2015)
DOI:10.18632/oncotarget.6478

Related
pathway

map04110

Cell cycle

map04210

Apoptosis

map04218

Cellular senescence

KO pathway

ko04115

All links

Gene (140110)   
   KEGG ORTHOLOGY (69)   
   RefGene (140041)   
Literature (15)   
   PubMed (15)   
All databases (140125)   

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