Autophagy (or macroautophagy) is a cellular catabolic pathway involving in protein degradation, organelle turnover, and non-selective breakdown of cytoplasmic components, which is evolutionarily conserved among eukaryotes and exquisitely regulated. This progress initiates with production of the autophagosome, a double-membrane intracellular structure of reticular origin that engulfs cytoplasmic contents and ultimately fuses with lysosomes for cargo degradation. Autophagy is regulated in response to extra- or intracellular stress and signals such as starvation, growth factor deprivation and ER stress. Constitutive level of autophagy plays an important role in cellular homeostasis and maintains quality control of essential cellular components.

Cellular Processes; Transport and catabolism
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PMID:15325584

Meijer AJ, Codogno P.

Regulation and role of autophagy in mammalian cells.

Int J Biochem Cell Biol 36:2445-62 (2004)
DOI:10.1016/j.biocel.2004.02.002

PMID:16099218

Deretic V.

Autophagy in innate and adaptive immunity.

Trends Immunol 26:523-8 (2005)
DOI:10.1016/j.it.2005.08.003

PMID:16200202

Levine B, Yuan J.

Autophagy in cell death: an innocent convict?

J Clin Invest 115:2679-88 (2005)
DOI:10.1172/JCI26390

PMID:15325588

Tanida I, Ueno T, Kominami E.

LC3 conjugation system in mammalian autophagy.

Int J Biochem Cell Biol 36:2503-18 (2004)
DOI:10.1016/j.biocel.2004.05.009

PMID:15928708

Lum JJ, DeBerardinis RJ, Thompson CB.

Autophagy in metazoans: cell survival in the land of plenty.

Nat Rev Mol Cell Biol 6:439-48 (2005)
DOI:10.1038/nrm1660

PMID:15978794

Reggiori F, Klionsky DJ.

Autophagosomes: biogenesis from scratch?

Curr Opin Cell Biol 17:415-22 (2005)
DOI:10.1016/j.ceb.2005.06.007

PMID:11099404

Klionsky DJ, Emr SD.

Autophagy as a regulated pathway of cellular degradation.

Science 290:1717-21 (2000)
DOI:10.1126/science.290.5497.1717

PMID:16125113

Bechet D, Tassa A, Taillandier D, Combaret L, Attaix D.

Lysosomal proteolysis in skeletal muscle.

Int J Biochem Cell Biol 37:2098-114 (2005)
DOI:10.1016/j.biocel.2005.02.029

PMID:19653858

He C, Klionsky DJ

Regulation mechanisms and signaling pathways of autophagy.

Annu Rev Genet 43:67-93 (2009)
DOI:10.1146/annurev-genet-102808-114910

PMID:19802558

Yang Z, Klionsky DJ

An overview of the molecular mechanism of autophagy.

Curr Top Microbiol Immunol 335:1-32 (2009)
DOI:10.1007/978-3-642-00302-8_1

PMID:20034776

Yang Z, Klionsky DJ

Mammalian autophagy: core molecular machinery and signaling regulation.

Curr Opin Cell Biol 22:124-31 (2010)
DOI:10.1016/j.ceb.2009.11.014

PMID:21187343

Chen Y, Klionsky DJ

The regulation of autophagy - unanswered questions.

J Cell Sci 124:161-70 (2011)
DOI:10.1242/jcs.064576

PMID:21801009

Mizushima N, Yoshimori T, Ohsumi Y

The role of Atg proteins in autophagosome formation.

Annu Rev Cell Dev Biol 27:107-32 (2011)
DOI:10.1146/annurev-cellbio-092910-154005

PMID:24343578

Russell RC, Yuan HX, Guan KL

Autophagy regulation by nutrient signaling.

Cell Res 24:42-57 (2014)
DOI:10.1038/cr.2013.166

PMID:25948417

Noda NN, Fujioka Y

Atg1 family kinases in autophagy initiation.

Cell Mol Life Sci 72:3083-96 (2015)
DOI:10.1007/s00018-015-1917-z