KEGG   PATHWAY: map04391
Entry
map04391                    Pathway                                

Name
Hippo signaling pathway - fly
Description
Hippo signaling is an evolutionarily conserved signaling pathway that controls organ size during development from flies to humans. The core of the drosophila pathway is a kinase cascade consisting of four proteins including Hippo, Salvador, Warts and Mats. Upon activation by stimuli such as high cell density in cell culture, the Hippo pathway kinase cascade phosphorylates and inhibits the transcriptional co-activator Yorkie, thereby promoting cell apoptosis and restricting organ size overgrowth. When the Hippo pathway is inactivated, Yorkie translocates into the nucleus to bind to transcriptional factors to promote cell growth and proliferation.
Class
Environmental Information Processing; Signal transduction
Pathway map
map04391  Hippo signaling pathway - fly
map04391

Other DBs
GO: 0035329
Reference
  Authors
Halder G, Johnson RL
  Title
Hippo signaling: growth control and beyond.
  Journal
Development 138:9-22 (2011)
DOI:10.1242/dev.045500
Reference
  Authors
Zhao B, Li L, Lei Q, Guan KL
  Title
The Hippo-YAP pathway in organ size control and tumorigenesis: an updated version.
  Journal
Genes Dev 24:862-74 (2010)
DOI:10.1101/gad.1909210
Reference
  Authors
Pan D
  Title
The hippo signaling pathway in development and cancer.
  Journal
Dev Cell 19:491-505 (2010)
DOI:10.1016/j.devcel.2010.09.011
Reference
  Authors
Schroeder MC, Halder G
  Title
Regulation of the Hippo pathway by cell architecture and mechanical signals.
  Journal
Semin Cell Dev Biol 23:803-11 (2012)
DOI:10.1016/j.semcdb.2012.06.001
Reference
  Authors
Zhao B, Tumaneng K, Guan KL
  Title
The Hippo pathway in organ size control, tissue regeneration and stem cell self-renewal.
  Journal
Nat Cell Biol 13:877-83 (2011)
DOI:10.1038/ncb2303
Reference
  Authors
Yin M, Zhang L
  Title
Hippo signaling: a hub of growth control, tumor suppression and pluripotency maintenance.
  Journal
J Genet Genomics 38:471-81 (2011)
DOI:10.1016/j.jgg.2011.09.009
Reference
  Authors
Chan SW, Lim CJ, Chen L, Chong YF, Huang C, Song H, Hong W
  Title
The Hippo pathway in biological control and cancer development.
  Journal
J Cell Physiol 226:928-39 (2011)
DOI:10.1002/jcp.22435
Reference
  Authors
Hilman D, Gat U
  Title
The evolutionary history of YAP and the hippo/YAP pathway.
  Journal
Mol Biol Evol 28:2403-17 (2011)
DOI:10.1093/molbev/msr065
Reference
  Authors
Zhao B, Lei QY, Guan KL
  Title
The Hippo-YAP pathway: new connections between regulation of organ size and cancer.
  Journal
Curr Opin Cell Biol 20:638-46 (2008)
DOI:10.1016/j.ceb.2008.10.001
Reference
  Authors
Badouel C, Garg A, McNeill H
  Title
Herding Hippos: regulating growth in flies and man.
  Journal
Curr Opin Cell Biol 21:837-43 (2009)
DOI:10.1016/j.ceb.2009.09.010
Reference
  Authors
Zhang L, Yue T, Jiang J
  Title
Hippo signaling pathway and organ size control.
  Journal
Fly (Austin) 3:68-73 (2009)
DOI:10.4161/fly.3.1.7788
Reference
  Authors
Harvey K, Tapon N
  Title
The Salvador-Warts-Hippo pathway - an emerging tumour-suppressor network.
  Journal
Nat Rev Cancer 7:182-91 (2007)
DOI:10.1038/nrc2070
Reference
  Authors
Kango-Singh M, Singh A
  Title
Regulation of organ size: insights from the Drosophila Hippo signaling pathway.
  Journal
Dev Dyn 238:1627-37 (2009)
DOI:10.1002/dvdy.21996
Reference
  Authors
Sun G, Irvine KD
  Title
Regulation of Hippo signaling by Jun kinase signaling during compensatory cell proliferation and regeneration, and in neoplastic tumors.
  Journal
Dev Biol 350:139-51 (2011)
DOI:10.1016/j.ydbio.2010.11.036
Reference
  Authors
Fausti F, Di Agostino S, Sacconi A, Strano S, Blandino G
  Title
Hippo and rassf1a Pathways: A Growing Affair.
  Journal
Mol Biol Int 2012:307628 (2012)
DOI:10.1155/2012/307628
Reference
  Authors
Oh H, Irvine KD
  Title
Yorkie: the final destination of Hippo signaling.
  Journal
Trends Cell Biol 20:410-7 (2010)
DOI:10.1016/j.tcb.2010.04.005
Reference
  Authors
Buttitta LA, Edgar BA
  Title
How size is controlled: from Hippos to Yorkies.
  Journal
Nat Cell Biol 9:1225-7 (2007)
DOI:10.1038/ncb1107-1225
Reference
  Authors
Chen L, Loh PG, Song H
  Title
Structural and functional insights into the TEAD-YAP complex in the Hippo signaling pathway.
  Journal
Protein Cell 1:1073-83 (2010)
DOI:10.1007/s13238-010-0138-3
Reference
  Authors
Oh H, Reddy BV, Irvine KD
  Title
Phosphorylation-independent repression of Yorkie in Fat-Hippo signaling.
  Journal
Dev Biol 335:188-97 (2009)
DOI:10.1016/j.ydbio.2009.08.026
Reference
  Authors
Badouel C, McNeill H
  Title
Apical junctions and growth control in Drosophila.
  Journal
Biochim Biophys Acta 1788:755-60 (2009)
DOI:10.1016/j.bbamem.2008.08.026
Related
pathway
map04350  TGF-beta signaling pathway
map04630  JAK-STAT signaling pathway
KO pathway
ko04391   

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