KEGG   PATHWAY: map04976
Entry
map04976                    Pathway                                

Name
Bile secretion
Description
Bile is a vital secretion, essential for digestion and absorption of fats and fat-soluble vitamins in the small intestine. Moreover, bile is an important route of elimination for excess cholesterol and many waste product, bilirubin, drugs and toxic compounds. Bile secretion depends on the function of membrane transport systems in hepatocytes and cholangiocytes and on the structural and functional integrity of the biliary tree. The hepatocytes generate the so-called primary bile in their canaliculi. Cholangiocytes modify the canalicular bile by secretory and reabsorptive processes as bile passes through the bile ducts. The main solutes in bile are bile acids, which stimulate bile secretion osmotically, as well as facilitate the intestinal absorption of dietary lipids by their detergent properties. Bile acids are also important signalling molecules. Through the activation of nuclear receptors, they regulate their own synthesis and transport rates.
Class
Organismal Systems; Digestive system
Pathway map
map04976  Bile secretion
map04976

Other DBs
GO: 0032782
Reference
  Authors
Meier PJ, Stieger B
  Title
Bile salt transporters.
  Journal
Annu Rev Physiol 64:635-61 (2002)
DOI:10.1146/annurev.physiol.64.082201.100300
Reference
  Authors
Kullak-Ublick GA, Beuers U, Paumgartner G
  Title
Hepatobiliary transport.
  Journal
J Hepatol 32:3-18 (2000)
DOI:10.1016/S0168-8278(00)80411-0
Reference
  Authors
Kosters A, Karpen SJ
  Title
Bile acid transporters in health and disease.
  Journal
Xenobiotica 38:1043-71 (2008)
DOI:10.1080/00498250802040584
Reference
  Authors
Anwer MS
  Title
Cellular regulation of hepatic bile acid transport in health and cholestasis.
  Journal
Hepatology 39:581-90 (2004)
DOI:10.1002/hep.20090
Reference
  Authors
Alrefai WA, Gill RK
  Title
Bile acid transporters: structure, function, regulation and pathophysiological implications.
  Journal
Pharm Res 24:1803-23 (2007)
DOI:10.1007/s11095-007-9289-1
Reference
  Authors
Trauner M, Boyer JL
  Title
Bile salt transporters: molecular characterization, function, and regulation.
  Journal
Physiol Rev 83:633-71 (2003)
DOI:10.1152/physrev.00027.2002
Reference
  Authors
Klaassen CD, Aleksunes LM
  Title
Xenobiotic, bile acid, and cholesterol transporters: function and regulation.
  Journal
Pharmacol Rev 62:1-96 (2010)
DOI:10.1124/pr.109.002014
Reference
  Authors
Trauner M, Wagner M, Fickert P, Zollner G
  Title
Molecular regulation of hepatobiliary transport systems: clinical implications for understanding and treating cholestasis.
  Journal
J Clin Gastroenterol 39:S111-24 (2005)
DOI:10.1097/01.mcg.0000155551.37266.26
Reference
  Authors
Arrese M, Trauner M
  Title
Molecular aspects of bile formation and cholestasis.
  Journal
Trends Mol Med 9:558-64 (2003)
DOI:10.1016/j.molmed.2003.10.002
Reference
  Authors
Esteller A
  Title
Physiology of bile secretion.
  Journal
World J Gastroenterol 14:5641-9 (2008)
DOI:10.3748/wjg.14.5641
Reference
  Authors
Takikawa H
  Title
Hepatobiliary transport of bile acids and organic anions.
  Journal
J Hepatobiliary Pancreat Surg 9:443-7 (2002)
DOI:10.1007/s005340200055
Reference
  Authors
St-Pierre MV, Kullak-Ublick GA, Hagenbuch B, Meier PJ
  Title
Transport of bile acids in hepatic and non-hepatic tissues.
  Journal
J Exp Biol 204:1673-86 (2001)
Reference
  Authors
Thomas C, Pellicciari R, Pruzanski M, Auwerx J, Schoonjans K
  Title
Targeting bile-acid signalling for metabolic diseases.
  Journal
Nat Rev Drug Discov 7:678-93 (2008)
DOI:10.1038/nrd2619
Reference
  Authors
Pauli-Magnus C, Stieger B, Meier Y, Kullak-Ublick GA, Meier PJ
  Title
Enterohepatic transport of bile salts and genetics of cholestasis.
  Journal
J Hepatol 43:342-57 (2005)
DOI:10.1016/j.jhep.2005.03.017
Reference
  Authors
Pellicoro A, Faber KN
  Title
Review article: The function and regulation of proteins involved in bile salt biosynthesis and transport.
  Journal
Aliment Pharmacol Ther 26 Suppl 2:149-60 (2007)
DOI:10.1111/j.1365-2036.2007.03522.x
Reference
  Authors
Jonker JW, Stedman CA, Liddle C, Downes M
  Title
Hepatobiliary ABC transporters: physiology, regulation and implications for disease.
  Journal
Front Biosci 14:4904-20 (2009)
DOI:10.2741/3576
Reference
  Authors
Modica S, Bellafante E, Moschetta A
  Title
Master regulation of bile acid and xenobiotic metabolism via the FXR, PXR and CAR trio.
  Journal
Front Biosci 14:4719-45 (2009)
DOI:10.2741/3563
Reference
  Authors
Cai SY, Boyer JL
  Title
FXR: a target for cholestatic syndromes?
  Journal
Expert Opin Ther Targets 10:409-21 (2006)
DOI:10.1517/14728222.10.3.409
Reference
  Authors
Ballatori N, Li N, Fang F, Boyer JL, Christian WV, Hammond CL
  Title
OST alpha-OST beta: a key membrane transporter of bile acids and conjugated steroids.
  Journal
Front Biosci 14:2829-44 (2009)
DOI:10.2741/3416
Reference
  Authors
Roma MG, Crocenzi FA, Sanchez Pozzi EA
  Title
Hepatocellular transport in acquired cholestasis: new insights into functional, regulatory and therapeutic aspects.
  Journal
Clin Sci (Lond) 114:567-88 (2008)
DOI:10.1042/CS20070227
Reference
  Authors
Arrese M, Macias RI, Briz O, Perez MJ, Marin JJ
  Title
Molecular pathogenesis of intrahepatic cholestasis of pregnancy.
  Journal
Expert Rev Mol Med 10:e9 (2008)
DOI:10.1017/S1462399408000628
Related
pathway
map00120  Primary bile acid biosynthesis
map04144  Endocytosis
map04530  Tight junction
map04975  Fat digestion and absorption
KO pathway
ko04976   

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