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Entry
map05130                    Pathway                                

Name
Pathogenic Escherichia coli infection
Description
Enteropathogenic E. coli (EPEC) and enterohemorrhagic E. coli (EHEC) are closely related pathogenic strains of Escherichia coli. The hallmark of EPEC/EHEC infections [DS:H00278 H00277] is induction of attaching and effacing (A/E) lesions that damage intestinal epithelial cells. The capacity to form A/E lesions is encoded mainly by the locus of enterocyte effacement (LEE) pathogenicity island. Tir, Map, EspF, EspG are known LEE-encoded effector proteins secreted via the type III secretion system, which is also LEE-encoded, into the host cell. EPEC and EHEC Tir's link the extracellular bacterium to the cell cytoskeleton. Map and EspF are involved in mitochondrion membrane permeabilization. EspG interacts with tubulins and stimulates microtubule destabilization. LEE-encoded adhesin or intimin (Eae) is exported via the general secretory pathway to the periplasm, where it is inserted into the outer membrane. In addition to Tir, two potential host cell-carried intimin receptors, beta1 integrin (ITGB1) and nucleolin (NCL), have so far been identified. The distinguishing feature of EHEC is the elaboration of Shiga-like toxin (Stx). Stx cleaves ribosomal RNA, thereby disrupting protein synthesis and killing the intoxicated epithelial or endothelial cells.
Class
Human Diseases; Infectious diseases
BRITE hierarchy
Pathway map
map05130  Pathogenic Escherichia coli infection
map05130

Ortholog table
Module
M00363  EHEC pathogenicity signature, Shiga toxin [PATH:map05130]
M00542  EHEC/EPEC pathogenicity signature, T3SS and effectors [PATH:map05130]
Disease
H00277  Enterohemorrhagic Escherichia coli (EHEC) infection
H00278  Enteropathogenic Escherichia coli (EPEC) infection
Reference
  Authors
Kaper JB, Nataro JP, Mobley HL.
  Title
Pathogenic Escherichia coli.
  Journal
Nat Rev Microbiol 2:123-40 (2004)
DOI:10.1038/nrmicro818
Reference
  Authors
Torres AG, Zhou X, Kaper JB.
  Title
Adherence of diarrheagenic Escherichia coli strains to epithelial cells.
  Journal
Infect Immun 73:18-29 (2005)
DOI:10.1128/IAI.73.1.18-29.2005
Reference
  Authors
Dean P, Maresca M, Kenny B.
  Title
EPEC's weapons of mass subversion.
  Journal
Curr Opin Microbiol 8:28-34 (2005)
DOI:10.1016/j.mib.2004.12.010
Reference
  Authors
Garmendia J, Frankel G, Crepin VF.
  Title
Enteropathogenic and enterohemorrhagic Escherichia coli infections: translocation, translocation, translocation.
  Journal
Infect Immun 73:2573-85 (2005)
DOI:10.1128/IAI.73.5.2573-2585.2005
Reference
  Authors
Spears KJ, Roe AJ, Gally DL.
  Title
A comparison of enteropathogenic and enterohaemorrhagic Escherichia coli pathogenesis.
  Journal
FEMS Microbiol Lett 255:187-202 (2006)
DOI:10.1111/j.1574-6968.2006.00119.x
Reference
  Authors
Kenny B.
  Title
Enteropathogenic Escherichia coli (EPEC)-- a crafty subversive little bug.
  Journal
Microbiology 148:1967-78 (2002)
DOI:10.1099/00221287-148-7-1967
Reference
  Authors
Hayward RD, Leong JM, Koronakis V, Campellone KG.
  Title
Exploiting pathogenic Escherichia coli to model transmembrane receptor signalling.
  Journal
Nat Rev Microbiol 4:358-70 (2006)
DOI:10.1038/nrmicro1391
Reference
  Authors
Matsuzawa T, Kuwae A, Yoshida S, Sasakawa C, Abe A.
  Title
Enteropathogenic Escherichia coli activates the RhoA signaling pathway via the stimulation of GEF-H1.
  Journal
EMBO J 23:3570-82 (2004)
DOI:10.1038/sj.emboj.7600359
Reference
  Authors
Dean P, Kenny B
  Title
The effector repertoire of enteropathogenic E. coli: ganging up on the host cell.
  Journal
Curr Opin Microbiol 12:101-9 (2009)
DOI:10.1016/j.mib.2008.11.006
KO pathway
ko05130   

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