KEGG   Mus caroli (Ryukyu mouse): 110290813
Entry
110290813         CDS       T05910                                 
Name
(RefSeq) 3 beta-hydroxysteroid dehydrogenase/Delta 5-->4-isomerase type 3-like isoform X1
  KO
K00070  3beta-hydroxy-Delta5-steroid dehydrogenase / steroid Delta-isomerase [EC:1.1.1.145 5.3.3.1]
Organism
mcal  Mus caroli (Ryukyu mouse)
Pathway
mcal00140  Steroid hormone biosynthesis
mcal01100  Metabolic pathways
mcal04913  Ovarian steroidogenesis
mcal04925  Aldosterone synthesis and secretion
mcal04927  Cortisol synthesis and secretion
mcal04934  Cushing syndrome
Module
mcal_M00107  Steroid hormone biosynthesis, cholesterol => pregnenolone => progesterone
mcal_M00110  C19/C18-Steroid hormone biosynthesis, pregnenolone => androstenedione => estrone
mcal_M00976  C19-Steroid hormone biosynthesis, pregnenolone => testosterone => dihydrotestosterone
mcal_M00977  C19-Steroid hormone biosynthesis (androgen backdoor pathway), pregnenolone => androsterone => dihydrotestosterone
Brite
KEGG Orthology (KO) [BR:mcal00001]
 09100 Metabolism
  09103 Lipid metabolism
   00140 Steroid hormone biosynthesis
    110290813
 09150 Organismal Systems
  09152 Endocrine system
   04913 Ovarian steroidogenesis
    110290813
   04925 Aldosterone synthesis and secretion
    110290813
   04927 Cortisol synthesis and secretion
    110290813
 09160 Human Diseases
  09167 Endocrine and metabolic disease
   04934 Cushing syndrome
    110290813
Enzymes [BR:mcal01000]
 1. Oxidoreductases
  1.1  Acting on the CH-OH group of donors
   1.1.1  With NAD+ or NADP+ as acceptor
    1.1.1.145  3beta-hydroxy-Delta5-steroid dehydrogenase
     110290813
 5. Isomerases
  5.3  Intramolecular oxidoreductases
   5.3.3  Transposing C=C bonds
    5.3.3.1  steroid Delta-isomerase
     110290813
SSDB
Motif
Pfam: 3Beta_HSD Epimerase NAD_binding_4 NAD_binding_10 Polysacc_synt_2 GDP_Man_Dehyd NmrA Ldh_1_N
Other DBs
NCBI-GeneID: 110290813
NCBI-ProteinID: XP_021013258
UniProt: A0A6P5PEY8
Position
3:complement(92784298..92847855)
AA seq 347 aa
MPGWSCLVTGAGGFWGQRIIQLLVQEKDLEENRVLDKFFRPEAQEQFFNLGKIIKVTVLE
GDILDTQYLRRACQGISVVIRTADVIDVTGVIPRQTILDVNLKGTQNLLEACIQASVPNF
IFSSSVDVAGPNLYKDIILNGHEDEHRESTCSDPYPYSKKMAEKAVLAANGSILKNGGML
HTCALRPMYIYGERSRFISNTIITALKNKCVLRIGDKFSTTNPVYVGNVAWADILAARGL
RDPKKSPDIQGEFYYISDDTPHQSYSDLSYTLSKEWGFFLDSSWSLPVPLLYWLAFLLET
VSFLLSPIYRYIPPFNRHLVTLSGCTFTFPYKKPQQDLGYEPLVSWE
NT seq 1044 nt   +upstreamnt  +downstreamnt
atgcctgggtggagctgcctggtgactggagcaggagggttttgggggcagaggatcatc
cagttgttggtgcaggagaaagatcttgaggagaacagggtcctggacaagttcttcaga
ccagaagctcaggagcaattcttcaacctagggaaaatcatcaaggtgacagtgttggaa
ggagacattcttgacacccagtacctgaggagagcttgccagggcatctctgttgtcatc
cgcactgctgatgtcattgatgtcacaggtgtcattcccaggcagaccatcctagatgtc
aatctgaaaggtacccagaacttattggaggcctgtatccaagccagtgtgccaaacttc
atcttctccagctcagttgatgttgcagggcccaacttgtacaaggacatcatcctgaat
ggccacgaggacgaacatcgtgaaagcacatgttctgacccatacccatacagcaaaaag
atggctgagaaggcagtgctggcagccaatgggagcatcctgaaaaatggtggtatgctg
catacttgtgcattaaggcccatgtacatttatggggagagaagtcgattcatttctaac
acaataattacagccctcaaaaataagtgtgttctgagaattggggacaaattctccaca
accaacccagtatatgtaggtaatgtggcctgggcagacattctggctgccaggggcctt
cgagaccccaaaaagtcaccagatattcaaggagagttctactacatctcagatgacacc
cctcaccaaagctatagtgatttaagttacaccctgagcaaggagtggggcttcttcctt
gattccagctggagccttcctgtgcccttactgtactggcttgccttcctgctggaaact
gtgagcttcctgctgagtccaatctacagatatatacctccctttaaccgccacttggtc
acactatcaggttgcacattcactttcccctacaagaaacctcagcaagatctgggctat
gaaccacttgtcagctgggagtaa

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Ontology (2)   
   KEGG BRITE (2)   
Pathway (10)   
   KEGG PATHWAY (6)   
   KEGG MODULE (4)   
Chemical substance (19)   
   KEGG COMPOUND (19)   
Chemical reaction (10)   
   KEGG ENZYME (2)   
   KEGG REACTION (8)   
Genome (1)   
   KEGG GENOME (1)   
Gene (3)   
   KEGG ORTHOLOGY (1)   
   NCBI-PROTEINID (1)   
   NCBI-Gene (1)   
Protein sequence (5)   
   UniProt (1)   
   RefSeq(pep) (4)   
DNA sequence (4)   
   RefSeq(nuc) (4)   
Protein domain (8)   
   Pfam (8)   
All databases (62)   

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