KEGG   Mus caroli (Ryukyu mouse): 110300614
Entry
110300614         CDS       T05910                                 
Symbol
Irs2
Name
(RefSeq) insulin receptor substrate 2
  KO
K07187  insulin receptor substrate 2
Organism
mcal  Mus caroli (Ryukyu mouse)
Pathway
mcal04022  cGMP-PKG signaling pathway
mcal04068  FoxO signaling pathway
mcal04140  Autophagy - animal
mcal04152  AMPK signaling pathway
mcal04211  Longevity regulating pathway
mcal04213  Longevity regulating pathway - multiple species
mcal04910  Insulin signaling pathway
mcal04920  Adipocytokine signaling pathway
mcal04923  Regulation of lipolysis in adipocytes
mcal04930  Type II diabetes mellitus
mcal04931  Insulin resistance
mcal04932  Non-alcoholic fatty liver disease
mcal04935  Growth hormone synthesis, secretion and action
mcal05010  Alzheimer disease
mcal05206  MicroRNAs in cancer
Brite
KEGG Orthology (KO) [BR:mcal00001]
 09130 Environmental Information Processing
  09132 Signal transduction
   04068 FoxO signaling pathway
    110300614 (Irs2)
   04022 cGMP-PKG signaling pathway
    110300614 (Irs2)
   04152 AMPK signaling pathway
    110300614 (Irs2)
 09140 Cellular Processes
  09141 Transport and catabolism
   04140 Autophagy - animal
    110300614 (Irs2)
 09150 Organismal Systems
  09152 Endocrine system
   04910 Insulin signaling pathway
    110300614 (Irs2)
   04923 Regulation of lipolysis in adipocytes
    110300614 (Irs2)
   04920 Adipocytokine signaling pathway
    110300614 (Irs2)
   04935 Growth hormone synthesis, secretion and action
    110300614 (Irs2)
  09149 Aging
   04211 Longevity regulating pathway
    110300614 (Irs2)
   04213 Longevity regulating pathway - multiple species
    110300614 (Irs2)
 09160 Human Diseases
  09161 Cancer: overview
   05206 MicroRNAs in cancer
    110300614 (Irs2)
  09164 Neurodegenerative disease
   05010 Alzheimer disease
    110300614 (Irs2)
  09167 Endocrine and metabolic disease
   04930 Type II diabetes mellitus
    110300614 (Irs2)
   04932 Non-alcoholic fatty liver disease
    110300614 (Irs2)
   04931 Insulin resistance
    110300614 (Irs2)
SSDB
Motif
Pfam: IRS PH PH_11 MEKK4_N
Other DBs
NCBI-GeneID: 110300614
NCBI-ProteinID: XP_021026522
Ensembl: MGP_CAROLIEiJ_G0030813
UniProt: A0A6P5Q9L7
Position
8:complement(7418280..7441266)
AA seq 1324 aa
MASAPLPGPPASAGGDGPNLNNNNNNNNHSVRKCGYLRKQKHGHKRFFVLRGPGTGGDEA
SAAGGSPPQPPRLEYYESEKKWRSKAGAPKRVIALDCCLNINKRADAKHKYLIALYTKDE
YFAVAAENEQEQEGWYRALTDLVSEGRSGEGGSGTTGGSCSASLPGVLGGSAGAAGCDDN
YGLVTPATAVYREVWQVNLKPKGLGQSKNLTGVYRLCLSARTIGFVKLNCEQPSVTLQLM
NIRRCGHSDSFFFIEVGRSAVTGPGELWMQADDSVVAQNIHETILEAMKALKELFEFRPR
SKSQSSGSSATHPISVPGARRHHHLVNLPPSQTGLVRRSRTDSLAATPPAAKCTSCRVRT
ASEGDGGAAGGAGTAGGRPMSVAGSPLSPGPVRAPLSRSHTLSAGCGGRPSKVTLAPAGG
ALQHSRSMSMPVAHSPPAATSPGSLSSSSGHGSGSYPLPPGSHPHLPHPLHHPQGQRPSS
GSASASGSPSDPGFMSLDEYGSSPGDLRAFSSHRSNTPESIAETPPARDGSGGELYGYMS
MDRPLSHCGRPYRRVSGDGAQDLDRGLRKRTYSLTTPARQRQVPQPSSASLDEYTLMRAT
FSGSSGRLCPSFPASSPKVAYNPYPEDYGDIEIGSHKSSSSNLGADDGYMPMTPGAALRS
GGPNSCKSDDYMPMSPTSVSAPKQILQPRLAAALPPSGAAVPAPPSGVGRTFPVNGGGYK
ASSPAESSPEDSGYMRMWCGSKLSMENPDPKLLPNGDYLNMSPSEAGTAGTPPDFSAALR
GGSEGLKGIPGHCYSSLPRSYKAPCSCSGDNDQYVLMSSPVGRILEEERLEPQATPGAGT
FGAAGGSHTQPHHSAVPSSMRPSAIGGRPEGFLGQRCRAVRPTRLSLEGLQTLPSMQEYP
LPTEPKSPGEYINIDFGEAGTRLSPPAPPLLASAASSSSLLSASSPASSLGSGTPGTSSD
SRQRSPLSDYMNLDFSSPKSPKPSTRSGDTVGSMDGLLSPEASSPYPPLPPRPSTSPSSL
QQPLPPAPGELYRLPPASPATSQGPTVGSSMSSEPGDNGDYTEMAFGVAATPPQPIVAPP
KPEGARVASPTSGLKRLSLMDQVSGVEAFLQVSQPPDPHRGAKVIRADPQGGRRRHSSET
FSSTTTVTPVSPSFAHNSKRHNSASVENVSLRKSSEGSSTLGGGDEPPTSPGQAQPLVAV
PPVPQARPWNPGQPGALIGCPGGSSSPMRRETSVGFQNGLNYIAIDVRGEQGSLAQSQPQ
HPQPGDKNSWSRTRSLGGLLGTVGGSGASGVCGGPGTGALPSASTYASIDFLSHHLKEAT
VVKE
NT seq 3975 nt   +upstreamnt  +downstreamnt
atggctagcgcgcccctgcctgggccccccgcatcggcgggcggggacggcccgaacctc
aataacaacaacaacaacaacaaccacagcgtgcgcaagtgcggctacctgcgcaagcag
aagcacggccacaagcgctttttcgtgctgcgcggccccggcacgggcggcgacgaggca
tccgcggctggggggtcgccgccgcagcctccgcggctggagtactacgagagcgagaag
aagtggaggagcaaggcgggcgcgccgaagcgagtgatcgcgctcgactgctgtctgaac
atcaacaagcgtgcggacgccaagcacaagtacctgatcgccctctacaccaaggacgag
tacttcgctgtagcggcggagaacgagcaggagcaggagggctggtaccgcgcactcacc
gacttggtcagcgaaggccgctctggcgaggggggctcgggcaccaccggcggctcttgc
agcgcctctctcccgggagtcctgggcggctcagcgggcgccgctggctgcgatgacaac
tacgggctcgtgacacccgccacggccgtctaccgcgaggtgtggcaggtgaacctgaaa
cctaagggactgggccagagcaagaacctgactggtgtataccgcctatgcctgtctgcg
cgcaccatcggcttcgtgaagctcaattgcgaacagccgtcggtgacgctgcagcttatg
aacattcgccgctgcggccactcggacagcttcttcttcatcgaggtgggccgttcggcc
gtcaccggtcccggggagttgtggatgcaagccgacgactcggtggtggcgcagaacatc
catgagaccatcctggaggctatgaaggcactcaaagagctcttcgagttccggcctcgc
agcaagagtcagtcgtccgggtcgtcagccacgcatcccatcagcgtgccgggcgcgcgc
cgccaccaccacctagtcaacctaccccctagccagaccggcctggtgcgtcgctcgcgc
actgacagcctggctgccacccccccagcagccaagtgcacttcgtgccgggttcgtacg
gccagcgagggcgacggcggcgcggcaggcggggccgggacggcaggaggcaggccgatg
tcggtggcagggagccccctgagtcccgggccggtgcgcgcgccccttagccgctcgcac
accctgagcgccggctgcggaggccgcccgagcaaagtgactctggcgccggcaggggga
gccctgcaacacagccgctccatgtccatgcccgtggcgcactcgccgcctgcagccacc
agccctggcagcctgtcctccagcagtgggcacggctcgggctcctacccgctgcctcct
ggctcccacccgcacctgcctcatccactgcatcacccccaaggccagcgtccgtccagc
ggtagtgcctccgcctcgggctcccccagcgacccgggtttcatgtcccttgacgagtat
ggctccagccctggcgacctgagagccttcagtagccacaggagcaacacacccgagtca
atcgcggagaccccgccagccagagatggcagtgggggcgaactctatgggtacatgagc
atggatagacccctgagccactgtggccgcccttaccgtagggtctcaggggatggggcc
caggacctggatagaggactgaggaagaggacttactccctaaccacgcctgccaggcag
cggcaggtacctcagccttcctctgcctctctagatgaatacactctcatgagggccacc
ttctctggcagttcaggtcgcctctgcccatccttccctgcgtcctctcccaaagtggcc
tacaacccttacccagaggactatggagacattgagattggttctcacaagagttccagc
agtaacctgggagcagatgatggctacatgcccatgacccctggggcagcccttaggagt
ggtggtcccaatagctgcaagagcgatgactacatgcccatgagccccaccagcgtgtct
gctcccaaacagattctgcagccacgcttggcagcggccttgcccccttccggagcagcc
gtgccagcacccccttcaggggtgggcaggaccttcccagtaaacggaggtggctacaaa
gccagctccccagcggagagctccccagaagatagtgggtacatgcgaatgtggtgtggc
tccaagctgtctatggagaacccagaccctaagctactccccaacggggactacctcaac
atgtcccccagcgaggcaggcactgcagggaccccacctgacttctcagcagctttgcgt
ggaggcagtgaaggcctcaaaggcatccccggccactgctacagctctttgccccgctct
tataaggctccctgttcctgcagcggagacaatgaccagtatgtgctcatgagctcccct
gtgggccggatcttggaagaggagagactggagccccaggccaccccaggggctggcacc
tttggggcagctggtggtagtcatacccagcctcatcactcagcagtgccttcctccatg
aggccgagtgccatcggtggccgccctgagggcttcctgggccagcgctgtcgggcagtg
cggcccacacgcctatcactagagggactgcagacccttcccagcatgcaagagtaccct
ctacccacagagcccaagagccctggcgagtatatcaacattgactttggtgaggcaggt
acccgtctgtctccgcctgcccccccactactggcatccgcagcctcatcttcttcactg
ctctcagccagtagtcctgcttcatccctgggttcaggtaccccaggcaccagcagcgac
agccggcagcgctctccactctctgactatatgaacctggacttcagttctcccaagtcc
cctaagcctagcacccgcagtggggacacagtaggctccatggatggccttctctctcca
gaggcttcatccccatacccaccactgcctccacgtccttccacttccccttcctcctta
cagcagcctctgccacctgccccgggagaactataccgcctgcctccagcatcacctgcc
acttcccagggtcccactgttggctcctcaatgtcctctgagcctggggataatggtgac
tataccgagatggcctttggtgtggctgcaaccccgcctcaacctatcgtggcaccccca
aagccagaaggtgcccgagtggccagtcccacttcgggcttgaagcggctaagtctcatg
gatcaggtatccggggtggaggccttccttcaagtcagccagccccctgacccccaccgg
ggtgctaaggtcatccgtgcagacccacaggggggacgtcgtcgccacagttcagagacc
ttttcctctaccaccaccgtcaccccagtgtccccatcctttgcccacaattccaagcgc
cacaattcggcctctgtggaaaatgtctcactcaggaaaagcagtgaaggcagcagcacc
ctgggaggaggtgatgagccacccacatccccaggacaggcacagcccttggtggctgtg
cccccagtgccacaggctaggccgtggaatccaggtcagcccggagctttgattggctgt
cctggaggcagcagttctcccatgcgcagagagacctccgtgggtttccagaacggcctc
aactatatcgccatcgatgtgagaggtgagcaggggtccttggcgcagtctcagccgcag
catccgcagccaggagacaagaactcctggagccggacccgtagccttggggggctcctc
ggcaccgtcggaggctctggcgccagcggagtgtgtgggggtccaggcactggagctttg
ccctctgccagcacctatgcaagcatcgacttcctgtcccatcacttgaaggaagccaca
gtcgtgaaagagtga

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Ontology (1)   
   KEGG BRITE (1)   
Pathway (15)   
   KEGG PATHWAY (15)   
Genome (1)   
   KEGG GENOME (1)   
Gene (4)   
   KEGG ORTHOLOGY (1)   
   NCBI-PROTEINID (1)   
   NCBI-Gene (1)   
   Ensembl (1)   
Protein sequence (2)   
   UniProt (1)   
   RefSeq(pep) (1)   
DNA sequence (1)   
   RefSeq(nuc) (1)   
Protein domain (4)   
   Pfam (4)   
All databases (28)   

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