KEGG   Macaca mulatta (rhesus monkey): 708706
Entry
708706            CDS       T01028                                 
Symbol
CACNA1S
Name
(RefSeq) voltage-dependent L-type calcium channel subunit alpha-1S
  KO
K04857  voltage-dependent calcium channel L type alpha-1S
Organism
mcc  Macaca mulatta (rhesus monkey)
Pathway
mcc04010  MAPK signaling pathway
mcc04020  Calcium signaling pathway
mcc04022  cGMP-PKG signaling pathway
mcc04024  cAMP signaling pathway
mcc04260  Cardiac muscle contraction
mcc04261  Adrenergic signaling in cardiomyocytes
mcc04270  Vascular smooth muscle contraction
mcc04723  Retrograde endocannabinoid signaling
mcc04725  Cholinergic synapse
mcc04726  Serotonergic synapse
mcc04727  GABAergic synapse
mcc04911  Insulin secretion
mcc04912  GnRH signaling pathway
mcc04921  Oxytocin signaling pathway
mcc04924  Renin secretion
mcc04925  Aldosterone synthesis and secretion
mcc04927  Cortisol synthesis and secretion
mcc04929  GnRH secretion
mcc04934  Cushing syndrome
mcc04935  Growth hormone synthesis, secretion and action
mcc05010  Alzheimer disease
mcc05020  Prion disease
mcc05022  Pathways of neurodegeneration - multiple diseases
mcc05207  Chemical carcinogenesis - receptor activation
mcc05410  Hypertrophic cardiomyopathy
mcc05412  Arrhythmogenic right ventricular cardiomyopathy
mcc05414  Dilated cardiomyopathy
Brite
KEGG Orthology (KO) [BR:mcc00001]
 09130 Environmental Information Processing
  09132 Signal transduction
   04010 MAPK signaling pathway
    708706 (CACNA1S)
   04020 Calcium signaling pathway
    708706 (CACNA1S)
   04024 cAMP signaling pathway
    708706 (CACNA1S)
   04022 cGMP-PKG signaling pathway
    708706 (CACNA1S)
 09150 Organismal Systems
  09152 Endocrine system
   04911 Insulin secretion
    708706 (CACNA1S)
   04929 GnRH secretion
    708706 (CACNA1S)
   04912 GnRH signaling pathway
    708706 (CACNA1S)
   04921 Oxytocin signaling pathway
    708706 (CACNA1S)
   04935 Growth hormone synthesis, secretion and action
    708706 (CACNA1S)
   04924 Renin secretion
    708706 (CACNA1S)
   04925 Aldosterone synthesis and secretion
    708706 (CACNA1S)
   04927 Cortisol synthesis and secretion
    708706 (CACNA1S)
  09153 Circulatory system
   04260 Cardiac muscle contraction
    708706 (CACNA1S)
   04261 Adrenergic signaling in cardiomyocytes
    708706 (CACNA1S)
   04270 Vascular smooth muscle contraction
    708706 (CACNA1S)
  09156 Nervous system
   04727 GABAergic synapse
    708706 (CACNA1S)
   04725 Cholinergic synapse
    708706 (CACNA1S)
   04726 Serotonergic synapse
    708706 (CACNA1S)
   04723 Retrograde endocannabinoid signaling
    708706 (CACNA1S)
 09160 Human Diseases
  09161 Cancer: overview
   05207 Chemical carcinogenesis - receptor activation
    708706 (CACNA1S)
  09164 Neurodegenerative disease
   05010 Alzheimer disease
    708706 (CACNA1S)
   05020 Prion disease
    708706 (CACNA1S)
   05022 Pathways of neurodegeneration - multiple diseases
    708706 (CACNA1S)
  09166 Cardiovascular disease
   05410 Hypertrophic cardiomyopathy
    708706 (CACNA1S)
   05412 Arrhythmogenic right ventricular cardiomyopathy
    708706 (CACNA1S)
   05414 Dilated cardiomyopathy
    708706 (CACNA1S)
  09167 Endocrine and metabolic disease
   04934 Cushing syndrome
    708706 (CACNA1S)
 09180 Brite Hierarchies
  09183 Protein families: signaling and cellular processes
   04040 Ion channels [BR:mcc04040]
    708706 (CACNA1S)
Ion channels [BR:mcc04040]
 Voltage-gated cation channels
  Calcium channel, voltage-gated (Cav)
   708706 (CACNA1S)
SSDB
Motif
Pfam: Ion_trans Ca_chan_IQ GPHH PKD_channel CAC1F_C
Other DBs
NCBI-GeneID: 708706
NCBI-ProteinID: XP_014975975
Ensembl: ENSMMUG00000017414
Position
1:complement(58468289..58543090)
AA seq 1873 aa
MEPSSPQDEGLRKKQPKKPVPEILPRPPRALFCLTLENPLRKACISIVEWKPFETIILLT
IFANCVALAVYLPMPEDDNNSLNLGLEKLEYFFLIVFSIEAAMKIIAYGFLFHQDAYLRS
GWNVLDFTIVFLGVFTVILEQVNVIQSNTAPMSSKGAGLDVKALRAFRVLRPLRLVSGVP
SLQVVLNSIFKAMLPLFHIALLVLFMVIIYAIIGLELFKGKMHKTCYFTGTDIVATVENE
EPSPCARTGSGRRCTINGSECRGGWPGPNHGITHFDNFGFSMLTVYQCITMEGWTDVLYW
VNDAIGNEWPWIYFVTLILLGSFFILNLVLGVLSGEFTKEREKAKSRGTFQKLREKQQLD
EDLRGYMSWITQGEVMDVEDFREGKLSLDEGGSDTESLYEIAGLNKIIQFIRHWRQWNRI
FRWKCHDIVKSKVFYWLVILIVALNTLSIASEHHNQPLWLTRLQDIANRVLLSLFTVEML
MKMYGLGLRQYFMSIFNRFDCFVVCSGILEILLVESGAMTPLGISVLRCIRLLRIFKITK
YWTSLSNLVASLLNSIRSIASLLLLLFLFIVIFALLGMQLFGGRYDFEDTEVRRSNFDNF
PQALISVFQVLTGEDWTSMMYNGIMAYGGPSYPGMLVCIYFIILFVCGNYILLNVFLAIA
VDNLAEAESLTSAQKAKAEERKRRKMSKGLPDKSEEEKSTMAKKLEQKPKGEGIPTTAKL
KIDEFESNVNEVKDPYPSADFPGDDEEDEPEIPLSPRPRPLAELQLKEKAVPIPEASSFF
IFSPTNKIRVLCHRIVNATWFTNFILLFILLSSAALAAEDPIRADSMRNQILKHFDIGFT
SVFTVEIVLKMTTYGAFLHKGSFCRNYFNMLDLLVVAVSLISMGLESSAISVVKILRVLR
VLRPLRAINRAKGLKHVVQCMFVAISTIGNIVLVTTLLQFMFACIGVQLFKGKFFRCTDL
SKMTEEECRGYYYVYKDGDPMQIELRHREWVHSDFHFDNVLSAMMSLFTVSTFEGWPQLL
YKAIDSNEEDVGPIYNNRVEMAIFFIIYIILIAFFMMNIFVGFVIVTFQEQGETEYKNCE
LDKNQRQCVQYALKARPLRCYIPKNPYQYQVWYVVTSSYFEYLMFALIMLNTICLGMQHY
NQSEQMNHISDILNVAFTIIFTLEMILKLMAFKARGYFGDPWNVFDFLIVIGSIIDVILS
EIDTFLASSGGLYCLGGGCGNVDPDESARISSAFFRLFRVMRLIKLLSRAEGVRTLLWTF
IKSFQALPYVALLIVMLFFIYAVIGMQMFGKIALVDGTQINRNNNFQTFPQAVLLLFRCA
TGEAWQEILLACSYGKLCDPESDYAPGEEYTCGTNFAYYYFISFYMLCAFLVINLFVAVI
MDNFDYLTRDWSILGPHHLDEFKAIWAEYDPEAKGRIKHLDVVTLLRRIQPPLGFGKFCP
HRVACKRLVGMNMPLNSDGTVTFNATLFALVRTALKIKTEGNFEQANEELRAIIKKIWKR
TSMKLLDQVIPPIGDDEVTVGKFYATFLIQEHFRKFMKRQEEYYGYRPKKDIVQIQAGLR
TIEEEAAPEIRRTVSGDLAAEEELERAMVEAAMEEGIFRRTGGLFGQVDNFLERTNSLPP
VMASQRPLQFTEIEMEELESPVFLEDFHQDPRTNPLARANTNNANANVAYGNSNHSNSHV
FSSVHYEREFPEETETSAIRGGALGQPCRALGPHSKPCVEKLKGLMTQRAMPRGQAPPAP
CQCPRVESPMPEDRRSSTPGSLHEETPHSRSTGENTSRCSAPATTLLIQEALVRGGLGTL
AADANFIMATGQALADACQMEPEEVEVMATELLKGREAPEGMASSLGCLNLGSSLGSLDQ
HQGSQETLIPPRL
NT seq 5622 nt   +upstreamnt  +downstreamnt
atggagccgtcctcaccccaggatgaaggcctgaggaagaaacagcccaagaagccggtt
cctgagattctgccaaggccaccccgggccttgttctgcctgaccctggagaaccccctg
aggaaggcctgcatcagcatcgtagaatggaagcccttcgagacgatcatcttgcttacc
atctttgccaactgtgtggccttggccgtgtacctgcccatgccagaagatgacaacaac
tctctgaacctcggcctggagaagctggagtatttcttcctcatcgtcttctcgattgaa
gccgccatgaagatcattgcctacggcttcttattccaccaggatgcttacctgcgcagc
ggctggaatgtgctggacttcaccattgtcttcctgggggtcttcaccgtgattctggaa
caggttaacgtcatccaaagcaacacagccccaatgagcagcaaaggagccggcttggat
gtcaaggccctcagagccttccgagtgctcagacccctccggctggtgtcgggggtgcct
agcctgcaggtggtcctgaactccatcttcaaggccatgctccccctcttccacatcgcc
ctgctggtcctctttatggtcatcatctatgccatcatcgggctggagctcttcaagggc
aagatgcacaagacctgctacttcactggcacagatatcgtggccacagtggagaatgag
gagccatcgccctgtgccaggacaggctcagggcgccggtgcaccatcaatggcagtgag
tgccggggtggctggccagggcccaaccatggcatcacccactttgacaacttcggcttc
tccatgctcaccgtgtaccagtgcatcaccatggagggatggactgacgtcctttactgg
gtcaatgatgccatcgggaatgagtggccctggatctattttgtcaccctcattctgctg
ggatccttcttcatcctcaacctggtgctgggtgtcctgagcggggaattcaccaaggag
cgggagaaggccaagtccaggggaaccttccagaagctccgggagaagcagcagctagat
gaggaccttcggggctacatgagctggatcacgcagggcgaggtcatggacgttgaggac
ttcagagaaggaaaactgtctttggatgaaggtggctctgacacagagagcctgtatgaa
attgcaggcttgaacaaaatcatccagttcatccggcactggaggcagtggaaccgcatc
tttcgctggaagtgccacgacatcgtgaagtccaaggtcttctattggctagtgattctc
atcgttgccctcaacaccctgtctatcgcctcagagcaccacaaccagcctctctggctg
acccgtttacaagacattgccaaccgggtgctactgtccctcttcactgtcgagatgctg
atgaagatgtatgggctgggcctgcgccagtacttcatgtccatcttcaaccgcttcgac
tgcttcgtggtgtgcagcggcatcctggagatcctgctggtggagtcgggcgccatgacg
cccctgggcatctccgtgctccgctgcatccgcctcctgaggatcttcaagatcaccaaa
tactggacgtcgctgagcaacctggtggcatccctgctcaactccatccgctccatcgcc
tccctgctgctgctgctcttcctcttcatcgtcatcttcgccctcctgggcatgcagctc
tttggggggaggtatgactttgaggacacagaagtacggcgcagcaacttcgacaacttt
ccccaagccctcatcagcgtcttccaggtcctgacgggtgaagactggacttcaatgatg
tacaatgggatcatggcctacggtgggccgtcctaccccggcatgcttgtgtgcatttac
ttcatcatcctttttgtctgtggcaactacatcctgctcaatgtcttcctggccattgcc
gtggacaacctggccgaggcggagagcctgacttctgcccagaaagccaaggctgaggaa
agaaaacgcaggaagatgtccaagggtctcccagacaagtcagaggaggagaagtccacg
atggccaagaagctggagcagaaacccaagggtgaaggcatccccaccactgccaagctg
aaaattgatgagtttgaatctaatgtcaatgaggtgaaggatccctatccctcagctgac
ttcccaggggatgacgaggaagatgagcccgagatcccactgagcccccgtccacgcccc
ctggctgagctgcagctgaaagagaaggccgtgcccattccagaagccagttccttcttc
attttcagccccaccaataagatccgtgtcctgtgtcaccgcatcgtcaatgccacctgg
ttcaccaacttcatcctgctctttatcctgctcagcagcgctgcactggctgcggaagac
cccatccgggctgattccatgaggaatcagatccttaaacactttgacatcgggttcacc
tctgtcttcactgtggagattgtcctcaagatgacgacctatggagccttcctgcacaaa
ggttccttctgccgcaattacttcaacatgctggacctgctggtggtggccgtgtccctc
atctccatgggacttgagtccagcgccatctccgtggtgaagatcctgagggttctgagg
gtgctccgaccactcagagccatcaacagagccaaggggttgaagcacgtggtgcagtgc
atgttcgtggccatcagcaccatcgggaacatcgtgctggtcactaccctcctacagttc
atgtttgcctgcatcggcgtccagctcttcaaggggaagttcttcaggtgcaccgacttg
tccaagatgacagaggaggagtgcaggggctactactacgtgtacaaggacggggacccc
atgcagatagagctgcgtcaccgtgagtgggtacacagcgacttccacttcgacaatgtg
ctctcagccatgatgtccctcttcacggtctccaccttcgagggatggcctcaactgctg
tacaaggccatagactccaatgaggaggatgtgggtcccatctacaacaaccgtgtggag
atggccatcttcttcatcatctacatcatcctcattgctttcttcatgatgaacatcttc
gtgggcttcgtcattgtcaccttccaggagcagggagagactgagtacaagaactgtgag
ctggacaagaaccagcgccaatgtgtacagtacgccctgaaggcccgcccactgaggtgc
tacattcccaaaaacccataccagtaccaggtgtggtacgttgtcacctcctcctacttt
gaatacctgatgtttgcccttatcatgctcaacaccatctgccttggcatgcagcactac
aaccagtcagagcagatgaaccacatttcagacatcctcaatgtggccttcactatcatc
ttcaccctggagatgatccttaagctcatggccttcaaggccaggggttactttggagac
ccctggaatgtgtttgacttcctgattgtcattggcagcatcattgatgtcatcctcagc
gagatcgacactttcctggcctccagcgggggactgtattgcctgggtggaggctgcggg
aacgttgacccagatgagagtgcccgcatctccagtgccttcttccgcctgttccgtgtc
atgaggctgatcaagctgctgagccgggcagagggagtgcgcaccctcctgtggacgttc
atcaagtccttccaggccctaccctacgtggctctgctcatcgtcatgctcttcttcatc
tacgctgtcatcggcatgcagatgtttgggaagatcgccttggtggatgggacccaaata
aaccggaacaacaacttccagaccttcccacaagctgtgctgctgctcttcaggtgtgca
acaggtgaggcctggcaggaaatcctactggcctgcagctatgggaagctgtgtgaccca
gagtcggactacgccccaggggaggagtacacatgtggcaccaactttgcatactactac
ttcatcagcttctacatgctctgcgccttcctggtcatcaacctctttgtggctgtcatc
atggacaattttgactacctcacccgggactggtccatcctgggccctcatcacctggat
gagttcaaggccatctgggcagagtatgacccggaggctaaggggaggatcaaacacctg
gacgtggtgaccctgctgagaaggattcagccccctctgggctttgggaagttctgccca
catcgcgtagcttgtaagcggctggtgggcatgaacatgcccctgaacagtgacggcaca
gtcaccttcaatgccacactcttcgccctggtccgcacagcacttaagatcaagacagaa
ggtaactttgagcaggccaatgaggagctgagggccatcatcaagaagatctggaagaga
accagcatgaagctcttggaccaggtcatccctccaataggagatgatgaggtgacagtg
gggaagttctacgccacattcctcatccaggagcacttccggaagttcatgaagcgccag
gaggagtattatggctatcggcccaagaaggacattgtacagatccaggcaggactgcgg
accattgaggaagaggcagcccccgagatccgtcgcacggtctcaggagacctggctgct
gaggaggagctggagagagccatggtggaggctgcaatggaggagggaatattccggagg
actggaggcctgtttggccaggtggacaacttcctggaaaggaccaactccctgcccccg
gtcatggccagtcagaggcccctccagtttactgagatagagatggaagagctggagtca
ccggtcttcttggaggacttccatcaagatccacgcaccaaccccctggctcgtgccaat
accaacaatgccaatgccaatgttgcctatggcaacagcaaccatagcaacagtcatgtg
ttttccagtgtccactatgaaagggagttcccagaagagacagagacatctgctatcaga
ggaggagcccttggccaaccctgcagggccctgggaccccacagcaaaccttgtgtggag
aagctaaagggactgatgacccagagggcaatgcccagaggccaggcacctcctgccccc
tgccagtgccccagggtggagtcccccatgcctgaggacagaaggagctccacaccaggg
tctctgcacgaggagacaccccacagcaggagcaccggggagaatacttccaggtgctca
gcgccagctacaaccctgctgatccaagaggctctggttcgagggggcctgggcaccttg
gcagctgatgcaaacttcatcatggcaacaggccaggccctggcagatgcctgccaaatg
gaaccagaggaagtggaggtcatggcaacagagctactgaaaggacgagaggccccagag
ggcatggctagctccctgggatgcctgaacctcggttcctccctgggcagccttgaccag
caccagggctcccaggagacccttattcctcccaggctgtga

  All links  
Ontology (2)   
   KEGG BRITE (2)   
Pathway (27)   
   KEGG PATHWAY (27)   
Genome (1)   
   KEGG GENOME (1)   
Gene (24)   
   KEGG ORTHOLOGY (1)   
   RefGene (19)   
   NCBI-PROTEINID (1)   
   NCBI-Gene (1)   
   Ensembl (1)   
   OC (1)   
Protein sequence (1)   
   RefSeq(pep) (1)   
DNA sequence (1)   
   RefSeq(nuc) (1)   
Protein domain (5)   
   Pfam (5)   
All databases (61)   

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