KEGG   Macaca mulatta (rhesus monkey): 708938Help
Entry
708938            CDS       T01028                                 

Gene name
MAPK3
Definition
(RefSeq) mitogen-activated protein kinase 3
  KO
K04371  mitogen-activated protein kinase 1/3 [EC:2.7.11.24]
Organism
mcc  Macaca mulatta (rhesus monkey)
Pathway
mcc01521  EGFR tyrosine kinase inhibitor resistance
mcc01522  Endocrine resistance
mcc01524  Platinum drug resistance
mcc04010  MAPK signaling pathway
mcc04012  ErbB signaling pathway
mcc04014  Ras signaling pathway
mcc04015  Rap1 signaling pathway
mcc04022  cGMP-PKG signaling pathway
mcc04024  cAMP signaling pathway
mcc04062  Chemokine signaling pathway
mcc04066  HIF-1 signaling pathway
mcc04068  FoxO signaling pathway
mcc04071  Sphingolipid signaling pathway
mcc04072  Phospholipase D signaling pathway
mcc04114  Oocyte meiosis
mcc04140  Autophagy - animal
mcc04150  mTOR signaling pathway
mcc04151  PI3K-Akt signaling pathway
mcc04210  Apoptosis
mcc04218  Cellular senescence
mcc04261  Adrenergic signaling in cardiomyocytes
mcc04270  Vascular smooth muscle contraction
mcc04350  TGF-beta signaling pathway
mcc04360  Axon guidance
mcc04370  VEGF signaling pathway
mcc04371  Apelin signaling pathway
mcc04380  Osteoclast differentiation
mcc04510  Focal adhesion
mcc04520  Adherens junction
mcc04540  Gap junction
mcc04550  Signaling pathways regulating pluripotency of stem cells
mcc04611  Platelet activation
mcc04620  Toll-like receptor signaling pathway
mcc04621  NOD-like receptor signaling pathway
mcc04625  C-type lectin receptor signaling pathway
mcc04650  Natural killer cell mediated cytotoxicity
mcc04657  IL-17 signaling pathway
mcc04658  Th1 and Th2 cell differentiation
mcc04659  Th17 cell differentiation
mcc04660  T cell receptor signaling pathway
mcc04662  B cell receptor signaling pathway
mcc04664  Fc epsilon RI signaling pathway
mcc04666  Fc gamma R-mediated phagocytosis
mcc04668  TNF signaling pathway
mcc04713  Circadian entrainment
mcc04720  Long-term potentiation
mcc04722  Neurotrophin signaling pathway
mcc04723  Retrograde endocannabinoid signaling
mcc04724  Glutamatergic synapse
mcc04725  Cholinergic synapse
mcc04726  Serotonergic synapse
mcc04730  Long-term depression
mcc04810  Regulation of actin cytoskeleton
mcc04910  Insulin signaling pathway
mcc04912  GnRH signaling pathway
mcc04914  Progesterone-mediated oocyte maturation
mcc04915  Estrogen signaling pathway
mcc04916  Melanogenesis
mcc04917  Prolactin signaling pathway
mcc04919  Thyroid hormone signaling pathway
mcc04921  Oxytocin signaling pathway
mcc04926  Relaxin signaling pathway
mcc04928  Parathyroid hormone synthesis, secretion and action
mcc04930  Type II diabetes mellitus
mcc04933  AGE-RAGE signaling pathway in diabetic complications
mcc04934  Cushing's syndrome
mcc04960  Aldosterone-regulated sodium reabsorption
mcc05010  Alzheimer's disease
mcc05020  Prion diseases
mcc05034  Alcoholism
mcc05132  Salmonella infection
mcc05133  Pertussis
mcc05140  Leishmaniasis
mcc05142  Chagas disease (American trypanosomiasis)
mcc05145  Toxoplasmosis
mcc05152  Tuberculosis
mcc05160  Hepatitis C
mcc05161  Hepatitis B
mcc05164  Influenza A
mcc05165  Human papillomavirus infection
mcc05167  Kaposi's sarcoma-associated herpesvirus infection
mcc05200  Pathways in cancer
mcc05203  Viral carcinogenesis
mcc05205  Proteoglycans in cancer
mcc05210  Colorectal cancer
mcc05211  Renal cell carcinoma
mcc05212  Pancreatic cancer
mcc05213  Endometrial cancer
mcc05214  Glioma
mcc05215  Prostate cancer
mcc05216  Thyroid cancer
mcc05218  Melanoma
mcc05219  Bladder cancer
mcc05220  Chronic myeloid leukemia
mcc05221  Acute myeloid leukemia
mcc05223  Non-small cell lung cancer
mcc05224  Breast cancer
mcc05225  Hepatocellular carcinoma
mcc05226  Gastric cancer
mcc05230  Central carbon metabolism in cancer
mcc05231  Choline metabolism in cancer
Module
mcc_M00687  MAPK (ERK1/2) signaling
Brite
KEGG Orthology (KO) [BR:mcc00001]
 Environmental Information Processing
  Signal transduction
   04014 Ras signaling pathway
    708938 (MAPK3)
   04015 Rap1 signaling pathway
    708938 (MAPK3)
   04010 MAPK signaling pathway
    708938 (MAPK3)
   04012 ErbB signaling pathway
    708938 (MAPK3)
   04350 TGF-beta signaling pathway
    708938 (MAPK3)
   04370 VEGF signaling pathway
    708938 (MAPK3)
   04371 Apelin signaling pathway
    708938 (MAPK3)
   04668 TNF signaling pathway
    708938 (MAPK3)
   04066 HIF-1 signaling pathway
    708938 (MAPK3)
   04068 FoxO signaling pathway
    708938 (MAPK3)
   04072 Phospholipase D signaling pathway
    708938 (MAPK3)
   04071 Sphingolipid signaling pathway
    708938 (MAPK3)
   04024 cAMP signaling pathway
    708938 (MAPK3)
   04022 cGMP - PKG signaling pathway
    708938 (MAPK3)
   04151 PI3K-Akt signaling pathway
    708938 (MAPK3)
   04150 mTOR signaling pathway
    708938 (MAPK3)
 Cellular Processes
  Transport and catabolism
   04140 Autophagy - animal
    708938 (MAPK3)
  Cell growth and death
   04114 Oocyte meiosis
    708938 (MAPK3)
   04210 Apoptosis
    708938 (MAPK3)
   04218 Cellular senescence
    708938 (MAPK3)
  Cellular community - eukaryotes
   04510 Focal adhesion
    708938 (MAPK3)
   04520 Adherens junction
    708938 (MAPK3)
   04540 Gap junction
    708938 (MAPK3)
   04550 Signaling pathways regulating pluripotency of stem cells
    708938 (MAPK3)
  Cell motility
   04810 Regulation of actin cytoskeleton
    708938 (MAPK3)
 Organismal Systems
  Immune system
   04611 Platelet activation
    708938 (MAPK3)
   04620 Toll-like receptor signaling pathway
    708938 (MAPK3)
   04621 NOD-like receptor signaling pathway
    708938 (MAPK3)
   04625 C-type lectin receptor signaling pathway
    708938 (MAPK3)
   04650 Natural killer cell mediated cytotoxicity
    708938 (MAPK3)
   04660 T cell receptor signaling pathway
    708938 (MAPK3)
   04658 Th1 and Th2 cell differentiation
    708938 (MAPK3)
   04659 Th17 cell differentiation
    708938 (MAPK3)
   04657 IL-17 signaling pathway
    708938 (MAPK3)
   04662 B cell receptor signaling pathway
    708938 (MAPK3)
   04664 Fc epsilon RI signaling pathway
    708938 (MAPK3)
   04666 Fc gamma R-mediated phagocytosis
    708938 (MAPK3)
   04062 Chemokine signaling pathway
    708938 (MAPK3)
  Endocrine system
   04910 Insulin signaling pathway
    708938 (MAPK3)
   04912 GnRH signaling pathway
    708938 (MAPK3)
   04915 Estrogen signaling pathway
    708938 (MAPK3)
   04914 Progesterone-mediated oocyte maturation
    708938 (MAPK3)
   04917 Prolactin signaling pathway
    708938 (MAPK3)
   04921 Oxytocin signaling pathway
    708938 (MAPK3)
   04926 Relaxin signaling pathway
    708938 (MAPK3)
   04919 Thyroid hormone signaling pathway
    708938 (MAPK3)
   04928 Parathyroid hormone synthesis, secretion and action
    708938 (MAPK3)
   04916 Melanogenesis
    708938 (MAPK3)
  Circulatory system
   04261 Adrenergic signaling in cardiomyocytes
    708938 (MAPK3)
   04270 Vascular smooth muscle contraction
    708938 (MAPK3)
  Excretory system
   04960 Aldosterone-regulated sodium reabsorption
    708938 (MAPK3)
  Nervous system
   04724 Glutamatergic synapse
    708938 (MAPK3)
   04725 Cholinergic synapse
    708938 (MAPK3)
   04726 Serotonergic synapse
    708938 (MAPK3)
   04720 Long-term potentiation
    708938 (MAPK3)
   04730 Long-term depression
    708938 (MAPK3)
   04723 Retrograde endocannabinoid signaling
    708938 (MAPK3)
   04722 Neurotrophin signaling pathway
    708938 (MAPK3)
  Development
   04360 Axon guidance
    708938 (MAPK3)
   04380 Osteoclast differentiation
    708938 (MAPK3)
  Environmental adaptation
   04713 Circadian entrainment
    708938 (MAPK3)
 Human Diseases
  Cancers
   05200 Pathways in cancer
    708938 (MAPK3)
   05230 Central carbon metabolism in cancer
    708938 (MAPK3)
   05231 Choline metabolism in cancer
    708938 (MAPK3)
   05205 Proteoglycans in cancer
    708938 (MAPK3)
   05203 Viral carcinogenesis
    708938 (MAPK3)
   05210 Colorectal cancer
    708938 (MAPK3)
   05212 Pancreatic cancer
    708938 (MAPK3)
   05225 Hepatocellular carcinoma
    708938 (MAPK3)
   05226 Gastric cancer
    708938 (MAPK3)
   05214 Glioma
    708938 (MAPK3)
   05216 Thyroid cancer
    708938 (MAPK3)
   05221 Acute myeloid leukemia
    708938 (MAPK3)
   05220 Chronic myeloid leukemia
    708938 (MAPK3)
   05218 Melanoma
    708938 (MAPK3)
   05211 Renal cell carcinoma
    708938 (MAPK3)
   05219 Bladder cancer
    708938 (MAPK3)
   05215 Prostate cancer
    708938 (MAPK3)
   05213 Endometrial cancer
    708938 (MAPK3)
   05224 Breast cancer
    708938 (MAPK3)
   05223 Non-small cell lung cancer
    708938 (MAPK3)
  Neurodegenerative diseases
   05010 Alzheimer's disease
    708938 (MAPK3)
   05020 Prion diseases
    708938 (MAPK3)
  Substance dependence
   05034 Alcoholism
    708938 (MAPK3)
  Endocrine and metabolic diseases
   04930 Type II diabetes mellitus
    708938 (MAPK3)
   04933 AGE-RAGE signaling pathway in diabetic complications
    708938 (MAPK3)
   04934 Cushing's syndrome
    708938 (MAPK3)
  Infectious diseases
   05132 Salmonella infection
    708938 (MAPK3)
   05133 Pertussis
    708938 (MAPK3)
   05152 Tuberculosis
    708938 (MAPK3)
   05164 Influenza A
    708938 (MAPK3)
   05161 Hepatitis B
    708938 (MAPK3)
   05160 Hepatitis C
    708938 (MAPK3)
   05163 Human cytomegalovirus infection
    708938 (MAPK3)
   05167 Kaposi's sarcoma-associated herpesvirus infection
    708938 (MAPK3)
   05165 Human papillomavirus infection
    708938 (MAPK3)
   05145 Toxoplasmosis
    708938 (MAPK3)
   05140 Leishmaniasis
    708938 (MAPK3)
   05142 Chagas disease (American trypanosomiasis)
    708938 (MAPK3)
  Drug resistance
   01521 EGFR tyrosine kinase inhibitor resistance
    708938 (MAPK3)
   01524 Platinum drug resistance
    708938 (MAPK3)
   01522 Endocrine resistance
    708938 (MAPK3)
Enzymes [BR:mcc01000]
 2. Transferases
  2.7  Transferring phosphorus-containing groups
   2.7.11  Protein-serine/threonine kinases
    2.7.11.24  mitogen-activated protein kinase
     708938 (MAPK3)
Protein kinases [BR:mcc01001]
 Serine/threonine kinases: CMGC group
  MAPK family [OT]
   708938 (MAPK3)
Chromosome and associated proteins [BR:mcc03036]
 Eukaryotic Type
  Centromeric chromatin formation proteins
   SAC (spindle assembly checkpoint) factors
    Protein kinases
     708938 (MAPK3)
Exosome [BR:mcc04147]
 Exosomal proteins
  Exosomal proteins of haemopoietic cells  (B-cell, T-cell, DC-cell, reticulocyte, and mast cell)
   708938 (MAPK3)
BRITE hierarchy
SSDB OrthologParalogGFIT
Motif
Pfam: Pkinase Pkinase_Tyr APH Haspin_kinase Kdo FTA2 Choline_kinase
Motif
Other DBs
NCBI-GeneID: 708938
NCBI-ProteinID: XP_014981384
Position
20
AA seq 694 aa AA seqDB search
MALRSALGPRRPPLQAASPHGLLRPLPGPGAGWVAVTAARPRNPRLPHARRPTGGPRPGP
PAPPGPSLTCCRERTVTPQKPEVEEEEEEEEGAGGAGDSPAEDALVKTMNEKQPCARLQG
GRAPWGGALPGPPCAPGPLLRPPPSPAPARAPRTKALQARPPGLGVRPSPATPPPPPDPA
DASAGSAGGAGGTGEEKPRALPDPRDLALAWLRDLHMGGPGSRFSSLVSCLHREHPCPPA
EIIRHHGHLLRARGYRVERGRRARQAPAREEPSLGEGGGAHGRSKPGFGEGSRGGGVGPG
EPRGSARGPGGGGDGEGQPFDVGPRYTQLQYIGEGAYGMVSSAYDHVRKTRVAIKKISPF
EHQTYCQRTLREIQILLRFRHENVIGIRDILRASTLEAMRDVYIVQDLMETDLYKLLKSQ
QLSNDHICYFLYQILRGLKYIHSANVLHRDLKPSNLLINTTCDLKICDFGLARIADPEHD
HTGFLTEYVATRWYRAPEIMLNSKGYTKSIDIWSVGCILAEMLSNRPIFPGKHYLDQLNH
ILGILGSPSQEDLNCIINMKARNYLQSLPSKTKVAWAKLFPKSDSKALDLLDRMLTFNPN
KRITVEEALAHPYLEQYYDPTDEVGQSPAAVGPGAGGXVGIPHARPEPCCLCPQPVAEEP
FTFAMELDDLPKERLKELIFQETARFQPGALEAP
NT seq 2085 nt NT seq  +upstreamnt  +downstreamnt
atggctctgaggagcgctctggggccccggcggcccccactccaggcagcgtccccccac
gggctgctgcgcccgctccctggccccggcgctggctgggtcgcggtgacagccgcgcgc
ccccgcaacccgcggctcccacacgcgcgccgccccacaggtggccctcgccccggtcca
cccgcgcctcctgggcccagcctcacctgctgcagagagaggacagtgaccccccaaaag
ccggaggtggaggaggaggaggaagaggaggaaggagctggaggagccggggactcgccc
gctgaggatgctcttgtcaagacaatgaatgagaagcagccgtgtgcccgcctccagggt
ggccgcgccccttggggcggagctcttccaggcccgccctgcgctcccgggcccctgctg
cggccgcctccctcccctgccccagcccgcgccccacgcacgaaagcgctccaggcccgc
ccgccaggcctcggtgtccgccccagcccggcgacgccgccccctcctcccgaccccgca
gacgcgagcgcggggagcgcggggggcgcggggggcacgggcgaggagaagcccagagcg
ctcccggacccaagggacctggctcttgcttggctccgagatctacacatgggtggcccc
gggagtcgcttctcctccctggtctcctgtcttcatcgggaacacccctgccctcctgct
gaaataattcggcatcacgggcacctacttcgtgccaggggctacagggtcgagcgaggc
aggcgagccaggcaggctcccgcccgtgaagagcccagcctgggggaaggaggaggagcc
cacggccgctccaagcccggctttggcgaaggctcgaggggcgggggtgtggggcccgga
gagccgagggggtcggcccggggtcccgggggaggtggagatggtgaagggcagccgttc
gacgtgggcccgcgctacacgcagctgcaatacatcggcgagggcgcgtacggcatggtc
agctcggcctatgaccacgtgcgcaagactcgcgtggccatcaagaagatcagccccttc
gagcatcagacctactgccagcgcacgctccgggagatccagatcctgctgcgcttccgc
catgagaatgtcatcggcatccgagacattctgcgtgcgtccaccctggaagccatgagg
gatgtctacattgtgcaggacctgatggagactgacctgtacaagttgctgaaaagccag
caactgagcaatgaccacatctgctacttcctctaccagatcctgcggggcctcaagtac
atccactccgctaatgtgctccaccgggatctaaagccctccaacctgctcatcaacacc
acctgcgaccttaagatttgcgatttcggcctggcccggattgccgatcctgagcatgac
cacactggcttcctgacggagtatgtggctacacgctggtaccgggccccagagatcatg
ctgaactccaagggctataccaagtccatcgacatctggtctgtgggctgcattctggct
gagatgctctctaaccggcccatcttccctggcaagcactacctggatcagctcaaccac
attctgggcatcctgggctccccatcccaggaggacctgaattgtatcatcaacatgaag
gcccgaaactacctacagtctctgccctccaagaccaaggtggcttgggccaagcttttc
cccaagtcagactccaaagcccttgacctgctggaccggatgttaacctttaaccccaat
aaacggatcacagtggaggaagcgctggctcacccctacctggagcagtactatgacccg
acggatgaggtgggccagtccccagcagcagtagggccaggggcaggggggtaagtaggc
atcccccatgccaggcctgagccttgctgtctctgcccccagccagtggccgaggagccc
ttcaccttcgccatggagctggatgacctacctaaggagcggctgaaggagctcatcttc
caggagacagcacgcttccagcctggggcgctagaggccccctaa

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