KEGG   Macaca mulatta (rhesus monkey): 717764Help
Entry
717764            CDS       T01028                                 

Gene name
PLCB3
Definition
(RefSeq) phospholipase C beta 3
  KO
K05858  phosphatidylinositol phospholipase C, beta [EC:3.1.4.11]
Organism
mcc  Macaca mulatta (rhesus monkey)
Pathway
mcc00562  Inositol phosphate metabolism
mcc01100  Metabolic pathways
mcc04015  Rap1 signaling pathway
mcc04020  Calcium signaling pathway
mcc04022  cGMP-PKG signaling pathway
mcc04062  Chemokine signaling pathway
mcc04070  Phosphatidylinositol signaling system
mcc04071  Sphingolipid signaling pathway
mcc04072  Phospholipase D signaling pathway
mcc04261  Adrenergic signaling in cardiomyocytes
mcc04270  Vascular smooth muscle contraction
mcc04310  Wnt signaling pathway
mcc04371  Apelin signaling pathway
mcc04540  Gap junction
mcc04611  Platelet activation
mcc04621  NOD-like receptor signaling pathway
mcc04713  Circadian entrainment
mcc04720  Long-term potentiation
mcc04723  Retrograde endocannabinoid signaling
mcc04724  Glutamatergic synapse
mcc04725  Cholinergic synapse
mcc04726  Serotonergic synapse
mcc04728  Dopaminergic synapse
mcc04730  Long-term depression
mcc04750  Inflammatory mediator regulation of TRP channels
mcc04911  Insulin secretion
mcc04912  GnRH signaling pathway
mcc04915  Estrogen signaling pathway
mcc04916  Melanogenesis
mcc04918  Thyroid hormone synthesis
mcc04919  Thyroid hormone signaling pathway
mcc04921  Oxytocin signaling pathway
mcc04922  Glucagon signaling pathway
mcc04924  Renin secretion
mcc04925  Aldosterone synthesis and secretion
mcc04926  Relaxin signaling pathway
mcc04927  Cortisol synthesis and secretion
mcc04928  Parathyroid hormone synthesis, secretion and action
mcc04933  AGE-RAGE signaling pathway in diabetic complications
mcc04934  Cushing's syndrome
mcc04961  Endocrine and other factor-regulated calcium reabsorption
mcc04970  Salivary secretion
mcc04971  Gastric acid secretion
mcc04972  Pancreatic secretion
mcc05010  Alzheimer's disease
mcc05016  Huntington's disease
mcc05142  Chagas disease (American trypanosomiasis)
mcc05143  African trypanosomiasis
mcc05146  Amoebiasis
mcc05163  Human cytomegalovirus infection
mcc05200  Pathways in cancer
Module
mcc_M00130  Inositol phosphate metabolism, PI=> PIP2 => Ins(1,4,5)P3 => Ins(1,3,4,5)P4
Brite
KEGG Orthology (KO) [BR:mcc00001]
 Metabolism
  Carbohydrate metabolism
   00562 Inositol phosphate metabolism
    717764 (PLCB3)
 Environmental Information Processing
  Signal transduction
   04015 Rap1 signaling pathway
    717764 (PLCB3)
   04310 Wnt signaling pathway
    717764 (PLCB3)
   04371 Apelin signaling pathway
    717764 (PLCB3)
   04020 Calcium signaling pathway
    717764 (PLCB3)
   04070 Phosphatidylinositol signaling system
    717764 (PLCB3)
   04072 Phospholipase D signaling pathway
    717764 (PLCB3)
   04071 Sphingolipid signaling pathway
    717764 (PLCB3)
   04022 cGMP - PKG signaling pathway
    717764 (PLCB3)
 Cellular Processes
  Cellular community - eukaryotes
   04540 Gap junction
    717764 (PLCB3)
 Organismal Systems
  Immune system
   04611 Platelet activation
    717764 (PLCB3)
   04621 NOD-like receptor signaling pathway
    717764 (PLCB3)
   04062 Chemokine signaling pathway
    717764 (PLCB3)
  Endocrine system
   04911 Insulin secretion
    717764 (PLCB3)
   04922 Glucagon signaling pathway
    717764 (PLCB3)
   04912 GnRH signaling pathway
    717764 (PLCB3)
   04915 Estrogen signaling pathway
    717764 (PLCB3)
   04921 Oxytocin signaling pathway
    717764 (PLCB3)
   04926 Relaxin signaling pathway
    717764 (PLCB3)
   04918 Thyroid hormone synthesis
    717764 (PLCB3)
   04919 Thyroid hormone signaling pathway
    717764 (PLCB3)
   04928 Parathyroid hormone synthesis, secretion and action
    717764 (PLCB3)
   04916 Melanogenesis
    717764 (PLCB3)
   04924 Renin secretion
    717764 (PLCB3)
   04925 Aldosterone synthesis and secretion
    717764 (PLCB3)
   04927 Cortisol synthesis and secretion
    717764 (PLCB3)
  Circulatory system
   04261 Adrenergic signaling in cardiomyocytes
    717764 (PLCB3)
   04270 Vascular smooth muscle contraction
    717764 (PLCB3)
  Digestive system
   04970 Salivary secretion
    717764 (PLCB3)
   04971 Gastric acid secretion
    717764 (PLCB3)
   04972 Pancreatic secretion
    717764 (PLCB3)
  Excretory system
   04961 Endocrine and other factor-regulated calcium reabsorption
    717764 (PLCB3)
  Nervous system
   04724 Glutamatergic synapse
    717764 (PLCB3)
   04725 Cholinergic synapse
    717764 (PLCB3)
   04728 Dopaminergic synapse
    717764 (PLCB3)
   04726 Serotonergic synapse
    717764 (PLCB3)
   04720 Long-term potentiation
    717764 (PLCB3)
   04730 Long-term depression
    717764 (PLCB3)
   04723 Retrograde endocannabinoid signaling
    717764 (PLCB3)
  Sensory system
   04750 Inflammatory mediator regulation of TRP channels
    717764 (PLCB3)
  Environmental adaptation
   04713 Circadian entrainment
    717764 (PLCB3)
 Human Diseases
  Cancers
   05200 Pathways in cancer
    717764 (PLCB3)
  Neurodegenerative diseases
   05010 Alzheimer's disease
    717764 (PLCB3)
   05016 Huntington's disease
    717764 (PLCB3)
  Endocrine and metabolic diseases
   04933 AGE-RAGE signaling pathway in diabetic complications
    717764 (PLCB3)
   04934 Cushing's syndrome
    717764 (PLCB3)
  Infectious diseases
   05163 Human cytomegalovirus infection
    717764 (PLCB3)
   05146 Amoebiasis
    717764 (PLCB3)
   05142 Chagas disease (American trypanosomiasis)
    717764 (PLCB3)
   05143 African trypanosomiasis
    717764 (PLCB3)
Enzymes [BR:mcc01000]
 3. Hydrolases
  3.1  Acting on ester bonds
   3.1.4  Phosphoric-diester hydrolases
    3.1.4.11  phosphoinositide phospholipase C
     717764 (PLCB3)
Membrane trafficking [BR:mcc04131]
 Exocytosis
  Calcium ion-dependent exocytosis
   Phospholipases
    717764 (PLCB3)
 Endocytosis
  Macropinocytosis
   Phospholipase C
    717764 (PLCB3)
BRITE hierarchy
SSDB OrthologParalogGFIT
Motif
Pfam: PI-PLC-X PLC-beta_C PI-PLC-Y EF-hand_like C2 DUF1154 BPL_N
Motif
Other DBs
NCBI-GeneID: 717764
NCBI-ProteinID: XP_014969380
Ensembl: ENSMMUG00000012948
UniProt: A0A1D5Q4D0
Position
14
AA seq 1234 aa AA seqDB search
MAGAQPGVHALQLEPPTVVETLRRGSKFIKWDEETSSRNLVTLRVDPSGFFLYWTGPNME
VDTLDISSIRDTRTGRYARLPKDPKIREVLGFGGPDARLEEKLMTVVSGPDPVNTVFLNF
MAVQDDTAKVWSEELFKLAMNILAQNASRNTFLRKAYTKLKLQVNQDGRIPVKNILKMFS
ADKKRVETALESCGLNFNRSESIRPDEFSLEIFERFLNKLCLRPDIDKILLEIGAKGKPY
LTLEQLMDFINQKQRDPRLNEVLYPPLRPSQARLLIEKYEPNQQFLERDQMSMEGFSRYL
GGEENGILPLEALDLSADMTQPLSAYFINSSHNTYLTAGQLAGTSSVEMYRQVLLWGCRC
VELDVWKGRPPEEEPFITHGFTMTTEVPLRDVLEAIAETAFKTSPYPVILSFENHVDSAK
QQAKMAEYCRSIFGDALLIEPLDKYPLAPGVPLPSPQDLMGRILVKNKKRHRPSTGGPDS
AGRKRPLEQSNSALSESSAATEPSSPQLGSPSSDSCPGLSNGEEGALEKPSLEPRKSLGE
EGLNRGPYALGPADREDEEEDEEEEEQTDPKKPTTDEGTASSEVNATEEMSTLVNYIEPV
KFKSFEAARKRNKCFEMSSFVETKAMEQLTKSPMEFVEYNKQQLSRIYPKGTRVDSSNYM
PQLFWNVGCQLVALNFQTLDVAMQLNAGVFEYNGRSGYLLKPEFMRRPDKSFDPFTEVIV
DGIVANALRVKVISGQFLSDRKVGIYVEVDMFGLPVDTRRKYRTRTSQGNSFNPVWDEEP
FDFPKVVLPTLASLRIAAFEEGGKFVGHRILPVSAIRSGYHYVCLRNEANQPLCLPALLI
YTEASDYIPDDHQDYAEALINPIKHVSLMDQRARQLAALIGESEAQAGQEMCQDTQSQQL
GSQLSPNPTPSPLDASPRRPPGPTASPASTSLSSPGQRDDLIASILSEVAPTPLDELRGH
KALVKLQSRQERDLRELRKKHQRKAVTLTCRLLDGLAQAQAEGRCRLRPGALGGAADVED
TKEGEDEAKRYQEFQNRQVQSLLELREAQVDAEAQRRLEHLRQALQRLREVVLDANTTQF
KRLKEMNEREKKELQKILDRKRHNSISEAKTRDKHKKEAELTEINRRHITESVNSIRRLE
EAQKQRHDRLVAGQQQVLQQLAEEEPKLLAQLAQECQEQRARLPQEIRRSLLGEMPEGLG
DGLLVACASNGHAPGSSGHLSGADSESQEENTQL
NT seq 3705 nt NT seq  +upstreamnt  +downstreamnt
atggcgggcgcccagcccggcgtccacgcgctgcagctggagccgcctaccgtggtggag
accctgcggcgcgggagtaagttcatcaaatgggacgaggagacctccagtcggaacctg
gtgaccctgcgtgtggaccccagtggcttcttcttgtactggacaggccccaacatggag
gtggacacactggacatcagttccatcagggacacacggacaggccggtacgcccgtctg
cccaaggaccccaagatccgggaagttctgggctttgggggtcccgatgcccggctggag
gagaagctgatgacggtggtgtctgggccggacccagtgaacacagtgttcttgaacttc
atggccgtgcaggatgacacagccaaggtctggtccgaggagctgttcaagctggctatg
aacatcctggctcagaacgcctcccggaacaccttcctgcgcaaagcatacacaaagctg
aagctgcaggtgaaccaggatggtcggatccccgtcaagaacatcctgaagatgttctca
gcagacaagaagcgggtggagactgcactggaatcctgtggcctcaatttcaaccggagt
gagtccatccggcctgatgagttttccttggaaatctttgagcggttcctgaacaagctg
tgtctgcggccggacattgacaagatcctgctggagataggtgccaagggcaagccatac
ctgacactggagcagctcatggacttcatcaaccagaagcaacgcgacccgagactcaac
gaagtgctgtacccgccgctgcggccctcccaggcccgactgctcatcgaaaagtatgag
cccaaccagcagtttctggagcgagaccagatgtccatggagggctttagccgctacctg
ggaggcgaggagaacggcatcctgcccctggaagccctggatctgagcgccgacatgacc
cagccgctgagtgcctacttcatcaactcctcgcataacacctatctcactgctgggcag
ctggccgggacctcgtcggtggagatgtaccgccaggtgctgctgtggggctgccgctgt
gtggagctggatgtgtggaaaggacggccgcccgaggaggaacccttcatcacccatggc
ttcaccatgaccacggaggtgcctctgcgcgacgtgctggaggccattgccgagactgcc
ttcaagacctcgccctaccccgtcatcctctcctttgagaaccacgtggactcggcaaag
cagcaggcaaagatggctgagtactgccgctccatctttggagatgcgctactcatcgag
cctctggacaagtacccgctggccccaggtgttcccctgcccagcccccaggacctgatg
ggccgtatcctggtgaagaacaagaagcggcacagacccagcacaggtggcccagacagc
gccgggcgcaagcggccgctggagcagagcaattcggccctgagcgagagctccgctgcc
actgagccctcctccccgcagcttgggtcgcccagctctgacagctgcccaggcctgagc
aacggggaggagggggcccttgagaagcccagcctggagcctcggaagtctttgggtgag
gagggcctgaaccggggcccctatgctcttggacctgctgaccgtgaggatgaggaggaa
gatgaggaagaggaggagcagacagaccccaaaaagccgaccacagatgagggcacggcc
agcagcgaggtgaatgccactgaggagatgtccacgcttgtcaactacatcgagcctgtc
aagttcaagtcctttgaagctgctcgaaagaggaacaaatgcttcgagatgtcgtccttc
gtggagaccaaggccatggagcaactgaccaagagccccatggagtttgtggaatacaac
aagcagcagctcagccgcatctaccccaagggcacccgcgtggactcctccaactacatg
ccccagctcttctggaacgtagggtgccagcttgttgcgctcaacttccagaccctcgat
gtggcgatgcagctcaatgcgggcgtttttgagtacaacgggcgcagcgggtacctgctc
aagccggagttcatgcggcggcctgacaaatccttcgaccccttcactgaggtcatcgtg
gatggcatcgtggccaatgccttgcgggtcaaggtgatctcggggcagttcctatccgac
aggaaggtgggcatctacgtggaggtggacatgtttggcctccctgttgacacgcggcgc
aagtaccgcacccggacctctcaggggaactcgttcaaccccgtgtgggatgaggagccc
ttcgacttccccaaggtggtgctgcctacgttggcttcacttcgaatcgcagcctttgag
gaggggggtaaattcgtagggcaccggatcctgcctgtctctgccatccgctctgggtac
cactacgtctgcctgcggaacgaggccaaccagccgctgtgccttccggccctgctcatc
tacactgaagcctcggactacattcctgatgaccaccaggactacgcggaggccctgatc
aaccccattaagcacgtcagcctgatggaccagagggcccggcagctggccgccctcatt
ggggagagtgaggctcaggctggccaagagatgtgccaggacacccagtctcagcagctg
gggtctcagctgtccccaaaccccacccctagcccactggatgcctccccccgccggccc
cccggccccaccgcctcccctgccagcacctccctcagcagcccagggcagcgcgacgat
ctcatcgccagcatcctctcagaggtggcccccaccccgctggatgagctccgaggtcac
aaggctctggtcaagctccagagccggcaagagcgagacctgcgggagctgcgcaagaag
catcagcggaaggcagtcaccctcacctgccgcctgctggatggcctggctcaggcacag
gctgagggcaggtgccggctgcggccaggtgccctaggcggggccgctgatgtggaggac
acgaaggagggggaggacgaggcaaagcggtatcaggagttccagaacagacaggtgcag
agcctgctggagctgcgggaggcccaggtggacgcagaggcccagcggaggctggagcat
ctgagacaggctctgcagcggctcagggaggtcgtccttgatgcaaacacaactcagttc
aagaggctgaaagagatgaacgagagggaaaagaaggaactgcagaagatcctggacaga
aagcgccataacagcatctcggaggccaagacgagggacaagcataagaaggaggcggaa
ctgacggagattaaccgtcggcacatcactgagtcagtcaactccatccgtcggctggag
gaggcccagaagcagcggcatgaccgtcttgtggctgggcagcagcaggtcctgcaacag
ctggcagaagaggagcccaagctgctggcccagctggcccaggagtgtcaggagcagcgg
gcgaggctcccccaggagatccgcaggagcctgctgggcgagatgccggaggggctgggg
gatgggcttctggtggcctgtgccagcaacggtcacgcacctgggagcagcgggcacctg
tcgggcgctgactcggagagccaggaggagaacacgcagctctga

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