KEGG   Macaca fascicularis (crab-eating macaque): 102139081Help
Entry
102139081         CDS       T02918                                 

Gene name
INSR
Definition
(RefSeq) insulin receptor
  KO
K04527  insulin receptor [EC:2.7.10.1]
Organism
mcf  Macaca fascicularis (crab-eating macaque)
Pathway
mcf04010  MAPK signaling pathway
mcf04014  Ras signaling pathway
mcf04015  Rap1 signaling pathway
mcf04022  cGMP-PKG signaling pathway
mcf04066  HIF-1 signaling pathway
mcf04068  FoxO signaling pathway
mcf04072  Phospholipase D signaling pathway
mcf04150  mTOR signaling pathway
mcf04151  PI3K-Akt signaling pathway
mcf04152  AMPK signaling pathway
mcf04211  Longevity regulating pathway
mcf04213  Longevity regulating pathway - multiple species
mcf04520  Adherens junction
mcf04910  Insulin signaling pathway
mcf04913  Ovarian steroidogenesis
mcf04923  Regulation of lipolysis in adipocytes
mcf04930  Type II diabetes mellitus
mcf04931  Insulin resistance
mcf04932  Non-alcoholic fatty liver disease (NAFLD)
mcf04960  Aldosterone-regulated sodium reabsorption
Module
mcf_M00676  PI3K-Akt signaling
Brite
KEGG Orthology (KO) [BR:mcf00001]
 09130 Environmental Information Processing
  09132 Signal transduction
   04014 Ras signaling pathway
    102139081 (INSR)
   04015 Rap1 signaling pathway
    102139081 (INSR)
   04010 MAPK signaling pathway
    102139081 (INSR)
   04066 HIF-1 signaling pathway
    102139081 (INSR)
   04068 FoxO signaling pathway
    102139081 (INSR)
   04072 Phospholipase D signaling pathway
    102139081 (INSR)
   04022 cGMP - PKG signaling pathway
    102139081 (INSR)
   04151 PI3K-Akt signaling pathway
    102139081 (INSR)
   04152 AMPK signaling pathway
    102139081 (INSR)
   04150 mTOR signaling pathway
    102139081 (INSR)
 09140 Cellular Processes
  09144 Cellular community - eukaryotes
   04520 Adherens junction
    102139081 (INSR)
 09150 Organismal Systems
  09152 Endocrine system
   04910 Insulin signaling pathway
    102139081 (INSR)
   04923 Regulation of lipolysis in adipocyte
    102139081 (INSR)
   04913 Ovarian Steroidogenesis
    102139081 (INSR)
  09155 Excretory system
   04960 Aldosterone-regulated sodium reabsorption
    102139081 (INSR)
  09149 Aging
   04211 Longevity regulating pathway - mammal
    102139081 (INSR)
   04213 Longevity regulating pathway - multiple species
    102139081 (INSR)
 09160 Human Diseases
  09166 Endocrine and metabolic diseases
   04930 Type II diabetes mellitus
    102139081 (INSR)
   04932 Non-alcoholic fatty liver disease (NAFLD)
    102139081 (INSR)
   04931 Insulin resistance
    102139081 (INSR)
 09180 Brite Hierarchies
  09181 Protein families: metabolism
   01001 Protein kinases [BR:mcf01001]
    102139081 (INSR)
  09183 Protein families: signaling and cellular processes
   04090 CD Molecules [BR:mcf04090]
    102139081 (INSR)
Enzymes [BR:mcf01000]
 2. Transferases
  2.7  Transferring phosphorus-containing groups
   2.7.10  Protein-tyrosine kinases
    2.7.10.1  receptor protein-tyrosine kinase
     102139081 (INSR)
Protein kinases [BR:mcf01001]
 Receptor tyrosine kinases (RTK)
  INSR family [OT]
   102139081 (INSR)
CD molecules [BR:mcf04090]
 Proteins
  102139081 (INSR)
BRITE hierarchy
SSDB OrthologParalogGFIT
Motif
Pfam: Pkinase_Tyr Recep_L_domain Pkinase Furin-like fn3 Kinase-like B2 DUF4476
Motif
Other DBs
NCBI-GeneID: 102139081
NCBI-ProteinID: XP_005587797
Position
19
AA seq 1382 aa AA seqDB search
MGTGGRRGTAAAPLLVAVAALLLGAAGHLYPGEVCPGMDIRNNLTRLHELENCSVIEGHL
QILLMFKTRPEDFRDLSFPKLIMITDYLLLFRVYGLESLKDLFPNLTVIRGSRLFFNYAL
VIFEMVHLKELGLYNLMNITRGSVRIEKNNELCYLATIDWSRILDSVEDNYIVLNKDDNE
ECGDICPGTAKGKTNCPATVINGQFVERCWTHSHCQKVCPTICKSHGCTAEGLCCHSECL
GNCSEPDDPTKCVACRNFYLDGRCVETCPPPYYHFQDWRCVNFSFCQDLHHKCKNSRRQG
CHQYVIHNNKCIPECPSGYTMNSSNLLCTPCLGPCPKVCHLLEGEKTIDSVTSAQELRGC
TVINGSLIINIRGGNNLAAELEANLGLIEEISGYLKIRRSYALVSLSFFRKLRLIRGETL
EIGNYSFYALDNQNLRQLWDWSKHNLTITQGKLFFHYNPKLCLSEIHKMEEVSGTKGRQE
RNDIALKTNGDQASCENELLKFSYIRTSFDKILLRWEPYWPPDFRDLLGFMLFYKEAPYQ
NVTEFDGQDACGSNSWTVVDIDPPLRSNDPKSQNHPGWLMRGLKPWTQYAIFVKTLVTFS
DERRTYGAKSDIIYVQTDATNPSVPLDPISVSNSSSQIILKWKPPSDPNGNITHYLVFGE
RQAEDSELFELDYCLKGLKLPSRTWSPPFESEDSQKHNQSEYEDSAGECCSCPKTDSQIL
KELEESSFRKTFEDYLHNVVFVPRKTSSGTGAEDPRPSRKRRSLGDVGNVTVAVPTVAAF
PNTSSTSTPTSPEEHRPFEKVVNKESLVISGLRHFTGYRIELQACNQDTPEERCSVAAYV
SARTMPEAKADDIVGPVTHEIFENNIVHLMWQEPKEPNGLIVLYEVSYRRYGDEELHLCV
SRKHFALERGCRLRGLSPGNYSVRVRATSLAGNGSWTEPTYFYVTDYLDVPSNIAKIIIG
PLIFVFLFSIVIGSIYLFLRKRQPDGPLGPLYASSNPEYLSASDVFPCSVYVPDEWEVPR
EKITLLRELGQGSFGMVYEGNARDIIKGEAETRVAVKTVNESASLRERIEFLNEASVMKG
FTCHHVVRLLGVVSKGQPTLVVMELMAHGDLKSYLRSLRPEAENNPGRPPPTLQEMIQMA
AEIADGMAYLNAKKFVHRDLAARNCMVAHDFTVKIGDFGMTRDIYETDYYRKGGKGLLPV
RWMAPESLKDGVFTTSSDMWSFGVVLWEITSLAEQPYQGLSNEQVLKFVMDGGYLDQPDN
CPERVTDLMRMCWQFNPKMRPTFLEIVNLLKDDLHPSFPEVSFFHSEENKAPENEELEME
FEDMENVPLDRSSHCQREEAGGRDGGSSLGFKRSYEEHIPYTHMNGGKKNGRILTLPRSN
PS
NT seq 4149 nt NT seq  +upstreamnt  +downstreamnt
atgggcaccgggggccggcgggggacagctgccgcgccgctgctggtggcggtggccgcg
ctgctactgggcgccgcgggccacctgtaccccggagaggtgtgtcccggcatggacatc
cggaacaacctcaccaggttacacgagctggagaattgctctgtcatcgaaggacacttg
cagatactcttgatgttcaaaacgaggcccgaagatttccgggacctcagtttccccaaa
ctcataatgatcactgattacttgctgctcttccgggtctatgggctcgagagcctgaag
gacctgttccccaacctcacggtcatccggggatcacgactgttctttaactacgcgctg
gtcatcttcgagatggttcacctcaaggaacttggcctctacaatctaatgaacatcacc
cggggttctgtccgcatcgagaagaacaacgagctctgttacttggccactatcgactgg
tcccgcatcctggattccgtggaggataattacatcgtgttgaacaaagatgacaacgag
gagtgtggagacatctgtccgggtacagcgaagggcaagaccaactgccccgccactgtc
atcaatgggcagtttgtcgaacggtgttggactcatagtcactgccagaaagtttgccca
accatctgtaagtcacacggctgcactgccgaaggcctctgttgccacagcgagtgcctg
ggcaactgttctgagcccgacgaccccaccaagtgcgtggcctgccgcaacttctacctg
gacggcaggtgtgtggagacctgcccgcccccgtactaccacttccaggactggcgctgt
gtgaacttcagcttctgccaggacctgcaccacaaatgcaagaactcgcggaggcagggc
tgccaccagtacgtcattcataacaacaagtgcatccctgagtgtccctccgggtacacg
atgaattccagcaacttgctgtgcaccccgtgcctgggtccctgtcccaaggtatgccac
ctcctagaaggcgagaagaccatcgactcggtgacgtctgcccaggagctccgaggatgc
accgtcatcaacgggagtctgatcatcaacattcgaggaggcaataatctggcagctgag
ctagaagccaacctcggcctcattgaagaaatttcaggttatctaaaaatccgccgatcc
tacgctctggtgtcactttccttcttccggaagttacgtctgattcgaggagagaccttg
gaaatcgggaactattccttctatgccttggacaaccagaacctaaggcagctctgggac
tggagcaaacacaacctcacgatcactcaggggaaactcttcttccactataaccccaaa
ctctgcttgtcagaaatccacaagatggaagaagtttcaggaaccaaggggcgccaggag
agaaatgacattgccctgaagacaaatggggaccaggcatcctgtgaaaatgagttactt
aaattttcttacattcggacgtctttcgataagatcttgctgagatgggagccgtactgg
ccccccgacttccgagacctcctggggttcatgctgttctacaaagaagccccttaccag
aatgtgacggagtttgatgggcaggatgcgtgtggttccaacagctggacggtggtagac
attgacccgcccctgaggtccaacgaccccaaatcacagaaccacccaggatggctaatg
cggggtctcaagccctggacccagtatgccatctttgtgaagaccctggtcaccttttcg
gatgaacgccggacctatggagccaagagtgacatcatttatgtccagacagatgccacc
aacccctccgtgcccctggatccaatctcagtgtctaactcatcatcccagattattctg
aagtggaaaccgccctccgaccccaatggcaacatcacccactacctggttttcggggag
aggcaggcggaagacagtgagctgttcgagctggattattgcctcaaagggctgaagctg
ccctcgaggacctggtctccaccattcgagtctgaagattctcagaagcacaaccagagt
gaatatgaggattcagccggtgaatgttgctcctgtccaaagacagactctcagatcctg
aaggagctggaggagtcctcgtttaggaagacgtttgaggattacctgcacaacgtggtt
ttcgtccccagaaaaacctcttcaggcactggtgccgaggaccctaggccatctcggaaa
cgcaggtcccttggcgatgttgggaatgtgacggtggccgtgcccacggtggcagctttc
cccaacacttcctcgaccagcacgcccacaagtccggaggagcacaggccctttgagaag
gtggtgaacaaggagtcgctggtcatctccggcttgcgacacttcacgggctatcgcatc
gagctgcaggcttgcaaccaagacacccctgaggaacggtgcagtgtggcagcctacgtc
agcgccaggaccatgcctgaagccaaggctgatgacattgttggccctgtgacgcatgaa
atctttgagaacaacatcgtccacttgatgtggcaggagccgaaggagcccaatggtctg
attgtgctgtatgaagtgagttatcggcgatatggcgatgaggagctgcatctctgtgtc
tcccgcaagcacttcgctctggaacggggctgcaggctgcgcgggctgtcgccggggaac
tacagcgtgcgagtccgggccacctccctcgcgggcaacggctcctggacggaacccacc
tatttctacgtgacggactatttagatgtcccgtcaaatattgcaaaaattatcatcggc
cccctcatctttgtctttctcttcagtattgtgattggaagtatttatctattcctgaga
aagaggcagccagatgggccgctgggaccgctttacgcttcttcaaaccctgagtatctc
agtgccagtgatgtgtttccatgctctgtgtacgtgccggacgagtgggaggtgcctcga
gagaagatcaccctccttcgagagctggggcagggctccttcggcatggtgtatgagggc
aacgccagggacatcatcaagggtgaggcagagacccgcgtggcagtgaagacggtcaac
gagtcagccagtctccgagagcggattgagttcctcaatgaggcctcggtcatgaagggc
ttcacctgccatcatgtggtgcgcctcctgggagtggtgtccaagggccagcccacgctg
gtggtgatggaactgatggctcacggagacctgaagagctacctccgttctctgcggcca
gaggctgagaataatcctggccgccctccccctaccctgcaagagatgattcagatggcg
gcggagattgctgacgggatggcctacctgaatgccaagaagttcgtgcatcgggacctg
gcagcgagaaactgcatggtcgcccatgattttactgtcaaaatcggagactttggaatg
accagagacatatatgaaacggattactaccggaaaggaggcaagggtctgctccctgta
cggtggatggcaccggagtccctgaaggatggggtctttaccacttcttctgacatgtgg
tcctttggcgtggtcctttgggaaatcaccagcttggcagaacagccttaccaaggcctg
tctaatgaacaggtgttgaaatttgtcatggacggagggtatctggatcaacccgacaac
tgtccagagagagtcactgacctcatgcgcatgtgctggcaattcaaccccaagatgagg
ccaaccttcctggagatcgtcaacctgctcaaggacgacctgcaccccagctttccggag
gtgtcgttctttcacagcgaggagaacaaggctcccgagaatgaggagctggagatggag
tttgaggacatggagaacgtgcccctggaccgttcctcgcactgtcagagggaggaggcg
gggggccgggatggagggtcctcgctgggtttcaagcggagctacgaggaacacatccct
tatacccacatgaacggaggcaagaaaaacgggcggattctgaccttgcctcggtccaat
ccttcctaa

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