KEGG   MODULE: M00705
Entry
M00705            Signature Module                                 
Name
Multidrug resistance, efflux pump MepA
Definition
K18909 K18908
Diagram
M00705

Orthology
K18909  
mepR; MarR family transcriptional regulator, repressor for mepA [COG:COG1846]
K18908  
mepA; multidrug efflux pump [COG:COG0534] [TC:2.A.66.1.13]
Class
Signature modules; Gene set; Drug resistance
Comment
Resistance mechanism: limitation of drug accumulation as a result of active drug efflux
Reference
PMID:15855508
  Authors
McAleese F, Petersen P, Ruzin A, Dunman PM, Murphy E, Projan SJ, Bradford PA
  Title
A novel MATE family efflux pump contributes to the reduced susceptibility of laboratory-derived Staphylococcus aureus mutants to tigecycline.
  Journal
Antimicrob Agents Chemother 49:1865-71 (2005)
DOI:10.1128/AAC.49.5.1865-1871.2005
Reference
PMID:23749979
  Authors
Schindler BD, Seo SM, Jacinto PL, Kumaraswami M, Birukou I, Brennan RG, Kaatz GW
  Title
Functional consequences of substitution mutations in MepR, a repressor of the Staphylococcus aureus MepA multidrug efflux pump gene.
  Journal
J Bacteriol 195:3651-62 (2013)
DOI:10.1128/JB.00565-13
Reference
PMID:23034325
  Authors
Fernandez L, Hancock RE
  Title
Adaptive and mutational resistance: role of porins and efflux pumps in drug resistance.
  Journal
Clin Microbiol Rev 25:661-81 (2012)
DOI:10.1128/CMR.00043-12

  All links  
Gene (2)   
   KEGG ORTHOLOGY (2)   
Literature (3)   
   PubMed (3)   
All databases (5)   

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