KEGG   MODULE: M00725Help
Entry
M00725            Signature Module                                 

Name
Cationic antimicrobial peptide (CAMP) resistance, dltABCD operon
Definition
K19077 K19078 K03367+K03739+K14188+K03740
Module map
M00725

Orthology
K19077  
graS; two-component system, OmpR family, sensor histidine kinase GraS [EC:2.7.13.3] [COG:COG0642] [GO:0000155]
K19078  
graR; two-component system, OmpR family, response regulator protein GraR [COG:COG0745] [GO:0000156]
K03367  
dltA; D-alanine--poly(phosphoribitol) ligase subunit 1 [EC:6.1.1.13] [COG:COG1020] [GO:0047473]
K03739  
dltB; membrane protein involved in D-alanine export [COG:COG1696]
K14188  
dltC; D-alanine--poly(phosphoribitol) ligase subunit 2 [EC:6.1.1.13] [COG:COG0236] [GO:0047473]
K03740  
dltD; D-alanine transfer protein [COG:COG3966]
Ortholog tableTaxonomy
Class
Signature modules; Gene set; Drug resistance
BRITE hierarchy
Pathway
map01503  Cationic antimicrobial peptide (CAMP) resistance
Comment
Resistance mechanism: addition of alanine to teichoic acids
Reference
  Authors
Falord M, Karimova G, Hiron A, Msadek T
  Title
GraXSR proteins interact with the VraFG ABC transporter to form a five-component system required for cationic antimicrobial peptide sensing and resistance in Staphylococcus aureus.
  Journal
Antimicrob Agents Chemother 56:1047-58 (2012)
DOI:10.1128/AAC.05054-11
Reference
  Authors
Yang SJ, Bayer AS, Mishra NN, Meehl M, Ledala N, Yeaman MR, Xiong YQ, Cheung AL
  Title
The Staphylococcus aureus two-component regulatory system, GraRS, senses and confers resistance to selected cationic antimicrobial peptides.
  Journal
Infect Immun 80:74-81 (2012)
DOI:10.1128/IAI.05669-11
Reference
  Authors
Otto M
  Title
Staphylococcus epidermidis--the 'accidental' pathogen.
  Journal
Nat Rev Microbiol 7:555-67 (2009)
DOI:10.1038/nrmicro2182
Reference
  Authors
Falord M, Mader U, Hiron A, Debarbouille M, Msadek T
  Title
Investigation of the Staphylococcus aureus GraSR regulon reveals novel links to virulence, stress response and cell wall signal transduction pathways.
  Journal
PLoS One 6:e21323 (2011)
DOI:10.1371/journal.pone.0021323

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