KEGG   MODULE: M00730
Entry
M00730            Signature Module                                 
Name
Cationic antimicrobial peptide (CAMP) resistance, VraFG transporter
Definition
K19077 K19078 K19079+K19080
Diagram
M00730

Orthology
K19077  
graS; two-component system, OmpR family, sensor histidine kinase GraS [EC:2.7.13.3] [COG:COG0642] [GO:0000155]
K19078  
graR; two-component system, OmpR family, response regulator protein GraR [COG:COG0745] [GO:0000156]
K19079  
vraF; cationic antimicrobial peptide transport system ATP-binding protein [COG:COG1136] [TC:3.A.1.134.7]
K19080  
vraG; cationic antimicrobial peptide transport system permease protein [COG:COG0577] [TC:3.A.1.134.7]
Class
Signature modules; Gene set; Drug resistance
Pathway
map01503  Cationic antimicrobial peptide (CAMP) resistance
Comment
Resistance mechanism: putative antimicrobial peptide (AMP) export
Reference
PMID:22123691
  Authors
Falord M, Karimova G, Hiron A, Msadek T
  Title
GraXSR proteins interact with the VraFG ABC transporter to form a five-component system required for cationic antimicrobial peptide sensing and resistance in Staphylococcus aureus.
  Journal
Antimicrob Agents Chemother 56:1047-58 (2012)
DOI:10.1128/AAC.05054-11
Reference
PMID:21986630
  Authors
Yang SJ, Bayer AS, Mishra NN, Meehl M, Ledala N, Yeaman MR, Xiong YQ, Cheung AL
  Title
The Staphylococcus aureus two-component regulatory system, GraRS, senses and confers resistance to selected cationic antimicrobial peptides.
  Journal
Infect Immun 80:74-81 (2012)
DOI:10.1128/IAI.05669-11
Reference
PMID:19609257
  Authors
Otto M
  Title
Staphylococcus epidermidis--the 'accidental' pathogen.
  Journal
Nat Rev Microbiol 7:555-67 (2009)
DOI:10.1038/nrmicro2182

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Pathway (1)   
   KEGG PATHWAY (1)   
Chemical reaction (1)   
   KEGG ENZYME (1)   
Gene (4)   
   KEGG ORTHOLOGY (4)   
Literature (3)   
   PubMed (3)   
All databases (9)   

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