KEGG   Manis javanica (Malayan pangolin): 108397877
Entry
108397877         CDS       T06054                                 
Symbol
TNF
Name
(RefSeq) tumor necrosis factor
  KO
K03156  tumor necrosis factor superfamily, member 2
Organism
mjv  Manis javanica (Malayan pangolin)
Pathway
mjv01523  Antifolate resistance
mjv04010  MAPK signaling pathway
mjv04060  Cytokine-cytokine receptor interaction
mjv04061  Viral protein interaction with cytokine and cytokine receptor
mjv04064  NF-kappa B signaling pathway
mjv04071  Sphingolipid signaling pathway
mjv04150  mTOR signaling pathway
mjv04210  Apoptosis
mjv04217  Necroptosis
mjv04350  TGF-beta signaling pathway
mjv04380  Osteoclast differentiation
mjv04612  Antigen processing and presentation
mjv04620  Toll-like receptor signaling pathway
mjv04621  NOD-like receptor signaling pathway
mjv04622  RIG-I-like receptor signaling pathway
mjv04625  C-type lectin receptor signaling pathway
mjv04640  Hematopoietic cell lineage
mjv04650  Natural killer cell mediated cytotoxicity
mjv04657  IL-17 signaling pathway
mjv04660  T cell receptor signaling pathway
mjv04664  Fc epsilon RI signaling pathway
mjv04668  TNF signaling pathway
mjv04920  Adipocytokine signaling pathway
mjv04930  Type II diabetes mellitus
mjv04931  Insulin resistance
mjv04932  Non-alcoholic fatty liver disease
mjv04933  AGE-RAGE signaling pathway in diabetic complications
mjv04936  Alcoholic liver disease
mjv04940  Type I diabetes mellitus
mjv05010  Alzheimer disease
mjv05014  Amyotrophic lateral sclerosis
mjv05020  Prion disease
mjv05022  Pathways of neurodegeneration - multiple diseases
mjv05132  Salmonella infection
mjv05133  Pertussis
mjv05134  Legionellosis
mjv05135  Yersinia infection
mjv05140  Leishmaniasis
mjv05142  Chagas disease
mjv05143  African trypanosomiasis
mjv05144  Malaria
mjv05145  Toxoplasmosis
mjv05146  Amoebiasis
mjv05152  Tuberculosis
mjv05160  Hepatitis C
mjv05161  Hepatitis B
mjv05163  Human cytomegalovirus infection
mjv05164  Influenza A
mjv05165  Human papillomavirus infection
mjv05166  Human T-cell leukemia virus 1 infection
mjv05168  Herpes simplex virus 1 infection
mjv05169  Epstein-Barr virus infection
mjv05170  Human immunodeficiency virus 1 infection
mjv05171  Coronavirus disease - COVID-19
mjv05205  Proteoglycans in cancer
mjv05310  Asthma
mjv05321  Inflammatory bowel disease
mjv05322  Systemic lupus erythematosus
mjv05323  Rheumatoid arthritis
mjv05330  Allograft rejection
mjv05332  Graft-versus-host disease
mjv05410  Hypertrophic cardiomyopathy
mjv05414  Dilated cardiomyopathy
mjv05417  Lipid and atherosclerosis
mjv05418  Fluid shear stress and atherosclerosis
Brite
KEGG Orthology (KO) [BR:mjv00001]
 09130 Environmental Information Processing
  09132 Signal transduction
   04010 MAPK signaling pathway
    108397877 (TNF)
   04350 TGF-beta signaling pathway
    108397877 (TNF)
   04064 NF-kappa B signaling pathway
    108397877 (TNF)
   04668 TNF signaling pathway
    108397877 (TNF)
   04071 Sphingolipid signaling pathway
    108397877 (TNF)
   04150 mTOR signaling pathway
    108397877 (TNF)
  09133 Signaling molecules and interaction
   04060 Cytokine-cytokine receptor interaction
    108397877 (TNF)
   04061 Viral protein interaction with cytokine and cytokine receptor
    108397877 (TNF)
 09140 Cellular Processes
  09143 Cell growth and death
   04210 Apoptosis
    108397877 (TNF)
   04217 Necroptosis
    108397877 (TNF)
 09150 Organismal Systems
  09151 Immune system
   04640 Hematopoietic cell lineage
    108397877 (TNF)
   04620 Toll-like receptor signaling pathway
    108397877 (TNF)
   04621 NOD-like receptor signaling pathway
    108397877 (TNF)
   04622 RIG-I-like receptor signaling pathway
    108397877 (TNF)
   04625 C-type lectin receptor signaling pathway
    108397877 (TNF)
   04650 Natural killer cell mediated cytotoxicity
    108397877 (TNF)
   04612 Antigen processing and presentation
    108397877 (TNF)
   04660 T cell receptor signaling pathway
    108397877 (TNF)
   04657 IL-17 signaling pathway
    108397877 (TNF)
   04664 Fc epsilon RI signaling pathway
    108397877 (TNF)
  09152 Endocrine system
   04920 Adipocytokine signaling pathway
    108397877 (TNF)
  09158 Development and regeneration
   04380 Osteoclast differentiation
    108397877 (TNF)
 09160 Human Diseases
  09161 Cancer: overview
   05205 Proteoglycans in cancer
    108397877 (TNF)
  09172 Infectious disease: viral
   05166 Human T-cell leukemia virus 1 infection
    108397877 (TNF)
   05170 Human immunodeficiency virus 1 infection
    108397877 (TNF)
   05161 Hepatitis B
    108397877 (TNF)
   05160 Hepatitis C
    108397877 (TNF)
   05171 Coronavirus disease - COVID-19
    108397877 (TNF)
   05164 Influenza A
    108397877 (TNF)
   05168 Herpes simplex virus 1 infection
    108397877 (TNF)
   05163 Human cytomegalovirus infection
    108397877 (TNF)
   05169 Epstein-Barr virus infection
    108397877 (TNF)
   05165 Human papillomavirus infection
    108397877 (TNF)
  09171 Infectious disease: bacterial
   05132 Salmonella infection
    108397877 (TNF)
   05135 Yersinia infection
    108397877 (TNF)
   05133 Pertussis
    108397877 (TNF)
   05134 Legionellosis
    108397877 (TNF)
   05152 Tuberculosis
    108397877 (TNF)
  09174 Infectious disease: parasitic
   05146 Amoebiasis
    108397877 (TNF)
   05144 Malaria
    108397877 (TNF)
   05145 Toxoplasmosis
    108397877 (TNF)
   05140 Leishmaniasis
    108397877 (TNF)
   05142 Chagas disease
    108397877 (TNF)
   05143 African trypanosomiasis
    108397877 (TNF)
  09163 Immune disease
   05310 Asthma
    108397877 (TNF)
   05322 Systemic lupus erythematosus
    108397877 (TNF)
   05323 Rheumatoid arthritis
    108397877 (TNF)
   05321 Inflammatory bowel disease
    108397877 (TNF)
   05330 Allograft rejection
    108397877 (TNF)
   05332 Graft-versus-host disease
    108397877 (TNF)
  09164 Neurodegenerative disease
   05010 Alzheimer disease
    108397877 (TNF)
   05014 Amyotrophic lateral sclerosis
    108397877 (TNF)
   05020 Prion disease
    108397877 (TNF)
   05022 Pathways of neurodegeneration - multiple diseases
    108397877 (TNF)
  09166 Cardiovascular disease
   05417 Lipid and atherosclerosis
    108397877 (TNF)
   05418 Fluid shear stress and atherosclerosis
    108397877 (TNF)
   05410 Hypertrophic cardiomyopathy
    108397877 (TNF)
   05414 Dilated cardiomyopathy
    108397877 (TNF)
  09167 Endocrine and metabolic disease
   04930 Type II diabetes mellitus
    108397877 (TNF)
   04940 Type I diabetes mellitus
    108397877 (TNF)
   04936 Alcoholic liver disease
    108397877 (TNF)
   04932 Non-alcoholic fatty liver disease
    108397877 (TNF)
   04931 Insulin resistance
    108397877 (TNF)
   04933 AGE-RAGE signaling pathway in diabetic complications
    108397877 (TNF)
  09176 Drug resistance: antineoplastic
   01523 Antifolate resistance
    108397877 (TNF)
 09180 Brite Hierarchies
  09183 Protein families: signaling and cellular processes
   04052 Cytokines and neuropeptides [BR:mjv04052]
    108397877 (TNF)
   00536 Glycosaminoglycan binding proteins [BR:mjv00536]
    108397877 (TNF)
Cytokines and neuropeptides [BR:mjv04052]
 Cytokines
  Tumor necrosis fators
   108397877 (TNF)
Glycosaminoglycan binding proteins [BR:mjv00536]
 Heparan sulfate / Heparin
  Cytokines
   108397877 (TNF)
SSDB
Motif
Pfam: TNF
Other DBs
NCBI-GeneID: 108397877
NCBI-ProteinID: XP_017516999
Position
Unknown
AA seq 233 aa
MSTESMIRDVELAEEALPKKAGGSQGSRRCLCLSLFSFLLVAGATTLFCLLHFGVIGPQR
EELLNGPQIFNPLAQTLRSSSQTPSNKPVAHVVANPQAEGQLQWLSRRANALLANGVKLT
DNQLVVPSDGLYLVYSQVLFKGQGCPSTHVLLTHTISRLALSYQTKVNLLSAIKSPCQLE
TPEGTEGKPWYEPIYLGGVFQLEKDDRLSAEINLPDYLDFAESGQVYFGIIAL
NT seq 702 nt   +upstreamnt  +downstreamnt
atgagcactgaaagcatgatccgggatgtggaactggccgaggaggcactccccaagaag
gcagggggctcccagggctccagaaggtgcttgtgcctcagcctcttctccttcctcctt
gtcgcaggagccaccacactcttctgcctgctgcactttggggtgattggcccccagaga
gaagagttattgaatggcccccagatattcaatcctctggctcagactctcagatcatct
tctcaaacaccaagcaacaagccagtggcccatgttgtagcaaacccccaagctgagggg
cagctccagtggcttagccggcgcgccaatgccctcctggctaatggcgtgaagctaaca
gacaaccagctggtggtgccgtccgatggactgtacctcgtctactcccaggtcctcttc
aagggccaaggctgcccttccacccatgtgctcctcacccacaccattagccgcttggcc
ctctcctaccagaccaaggtcaacctcctctctgccatcaagagcccttgccagttggag
accccagaggggactgagggcaagccctggtatgagcctatctatctgggaggggtcttc
cagctggagaaggatgatcgactcagcgctgagatcaatctgcctgactatcttgacttt
gccgagtctggacaggtctactttgggatcattgccctgtga

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Ontology (3)   
   KEGG BRITE (3)   
Pathway (65)   
   KEGG PATHWAY (65)   
Genome (1)   
   KEGG GENOME (1)   
Gene (3)   
   KEGG ORTHOLOGY (1)   
   NCBI-PROTEINID (1)   
   NCBI-Gene (1)   
Protein sequence (1)   
   RefSeq(pep) (1)   
DNA sequence (1)   
   RefSeq(nuc) (1)   
Protein domain (1)   
   Pfam (1)   
All databases (75)   

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