KEGG   Manis javanica (Malayan pangolin): 108405993
Entry
108405993         CDS       T06054                                 
Symbol
JAK1
Name
(RefSeq) tyrosine-protein kinase JAK1
  KO
K11217  Janus kinase 1 [EC:2.7.10.2]
Organism
mjv  Manis javanica (Malayan pangolin)
Pathway
mjv01521  EGFR tyrosine kinase inhibitor resistance
mjv04151  PI3K-Akt signaling pathway
mjv04217  Necroptosis
mjv04380  Osteoclast differentiation
mjv04550  Signaling pathways regulating pluripotency of stem cells
mjv04620  Toll-like receptor signaling pathway
mjv04621  NOD-like receptor signaling pathway
mjv04630  JAK-STAT signaling pathway
mjv04658  Th1 and Th2 cell differentiation
mjv04659  Th17 cell differentiation
mjv05140  Leishmaniasis
mjv05145  Toxoplasmosis
mjv05152  Tuberculosis
mjv05160  Hepatitis C
mjv05161  Hepatitis B
mjv05162  Measles
mjv05163  Human cytomegalovirus infection
mjv05164  Influenza A
mjv05165  Human papillomavirus infection
mjv05166  Human T-cell leukemia virus 1 infection
mjv05167  Kaposi sarcoma-associated herpesvirus infection
mjv05168  Herpes simplex virus 1 infection
mjv05169  Epstein-Barr virus infection
mjv05171  Coronavirus disease - COVID-19
mjv05200  Pathways in cancer
mjv05203  Viral carcinogenesis
mjv05212  Pancreatic cancer
mjv05235  PD-L1 expression and PD-1 checkpoint pathway in cancer
Brite
KEGG Orthology (KO) [BR:mjv00001]
 09130 Environmental Information Processing
  09132 Signal transduction
   04630 JAK-STAT signaling pathway
    108405993 (JAK1)
   04151 PI3K-Akt signaling pathway
    108405993 (JAK1)
 09140 Cellular Processes
  09143 Cell growth and death
   04217 Necroptosis
    108405993 (JAK1)
  09144 Cellular community - eukaryotes
   04550 Signaling pathways regulating pluripotency of stem cells
    108405993 (JAK1)
 09150 Organismal Systems
  09151 Immune system
   04620 Toll-like receptor signaling pathway
    108405993 (JAK1)
   04621 NOD-like receptor signaling pathway
    108405993 (JAK1)
   04658 Th1 and Th2 cell differentiation
    108405993 (JAK1)
   04659 Th17 cell differentiation
    108405993 (JAK1)
  09158 Development and regeneration
   04380 Osteoclast differentiation
    108405993 (JAK1)
 09160 Human Diseases
  09161 Cancer: overview
   05200 Pathways in cancer
    108405993 (JAK1)
   05203 Viral carcinogenesis
    108405993 (JAK1)
   05235 PD-L1 expression and PD-1 checkpoint pathway in cancer
    108405993 (JAK1)
  09162 Cancer: specific types
   05212 Pancreatic cancer
    108405993 (JAK1)
  09172 Infectious disease: viral
   05166 Human T-cell leukemia virus 1 infection
    108405993 (JAK1)
   05161 Hepatitis B
    108405993 (JAK1)
   05160 Hepatitis C
    108405993 (JAK1)
   05171 Coronavirus disease - COVID-19
    108405993 (JAK1)
   05164 Influenza A
    108405993 (JAK1)
   05162 Measles
    108405993 (JAK1)
   05168 Herpes simplex virus 1 infection
    108405993 (JAK1)
   05163 Human cytomegalovirus infection
    108405993 (JAK1)
   05167 Kaposi sarcoma-associated herpesvirus infection
    108405993 (JAK1)
   05169 Epstein-Barr virus infection
    108405993 (JAK1)
   05165 Human papillomavirus infection
    108405993 (JAK1)
  09171 Infectious disease: bacterial
   05152 Tuberculosis
    108405993 (JAK1)
  09174 Infectious disease: parasitic
   05145 Toxoplasmosis
    108405993 (JAK1)
   05140 Leishmaniasis
    108405993 (JAK1)
  09176 Drug resistance: antineoplastic
   01521 EGFR tyrosine kinase inhibitor resistance
    108405993 (JAK1)
 09180 Brite Hierarchies
  09181 Protein families: metabolism
   01001 Protein kinases [BR:mjv01001]
    108405993 (JAK1)
Enzymes [BR:mjv01000]
 2. Transferases
  2.7  Transferring phosphorus-containing groups
   2.7.10  Protein-tyrosine kinases
    2.7.10.2  non-specific protein-tyrosine kinase
     108405993 (JAK1)
Protein kinases [BR:mjv01001]
 Non-receptor tyrosine kinases
  JAK family [OT]
   108405993 (JAK1)
SSDB
Motif
Pfam: PK_Tyr_Ser-Thr Pkinase Jak1_Phl FERM_F2 FERM_F1 ABC1 SH2
Other DBs
NCBI-GeneID: 108405993
NCBI-ProteinID: XP_036880273
Position
Unknown
AA seq 1153 aa
MQYLNIKEDCNAMAFCAKMRSSKKTEVNLEAPEPGVEVLFYLSDREPLLLGIGEYTAEEL
CIRAAQECCISPLCHNLFALYDENTKIWYAPNHTITVDDKTTLRLHYRMRFYFTNWHGTN
DNEQSVWRHSPKKQKNGYEKKKVPDATPLLDASSLEYLFAQGQYDLVKCLAPIRDPKTEQ
DGHDIENECLGMAVLAISHYAMMKKMQLPELPKDISYKRYIPETLNKSIRQRNLLTRMRI
NNVFKDFLKEFNNKTICDSSVSTHDLKVKYLATLETLTKHYGAEIFETSMLVISSENEMN
RFHPNDSGNILYYEVMVTGNLGIQWRQKPNVITVEKEKNKLKRKKLENKHKKDEEKNKIR
EEWNNFSYFPEITHIVIKECVVSINKQDNKKMELKLYSHEEALSFVSLVDGYFRLTADAH
HYLCTDVAPPLIVHNIQNGCHGPICTEYAINKLRQEGGEEGMYVLRWSCTDFDNILMTVT
CFEKSEMLGGQKQFKNFQIEVQKGRYSLHGSDRSFPSLGDLMSHLKKQILRTDNISFVLK
RCCQPKPREISNLLVATKKAQEWQPVYPMSQLSFDRILKKDIVQSEHLGRGTRTHIYSGT
LVDFKDDEGASEEKRIKVILKVLDPSHRDISLAFFEAASMMRQVSHKHIVYLYGVCVRDV
ENIMVEEFVEGGPLDLFMHRKSDVLTTPWKFKVAKQLASALSYLEDKDLVHGNVCTKNLL
LAREGIDSECGPFIKLSDPGIPITVLSRQECIERIPWIAPECVEDCKNLSVAADKWSFGT
TLWEICYNGEIPLKDKTLIEKERFYESRCRPVTPSCKELADLMTRCMNYDPNQRPFFRAI
MRDINKLEEQNPDIVSEKKPQTEVDPTHFEKRFLKRIRDLGEGHFGKVELCRYDPEGDNT
GEQVAVKSLKPESGGNHIADLKKEIEILRNLYHENIVKYKGICTEDGGNGIKLIMEFLPS
GSLKEYLPKNKNKINLKQQLKYAVQICKGMDYLGSRQYVHRDLAARNVLVESEHQVKIGD
FGLTKAIETDKEYYTVKDDRDSPVFWYAPECLIQCKFYIASDVWSFGVTLHELLTYCDSD
SSPMALFLKMIGPTHGQMTVTRLVNTLKEGKRLPCPPNCPDEVYQLMRKCWEFQPSNRTT
FQNLIEGFEALLK
NT seq 3462 nt   +upstreamnt  +downstreamnt
atgcagtatctaaatataaaagaggactgcaatgccatggctttctgtgctaaaatgagg
agctccaagaagactgaagtgaatctggaggcccctgaaccaggggtagaagtgctcttc
tatctgtctgatagggagccactcctgctgggcatcggagaatacacggcagaggagctg
tgcatcagggctgctcaggaatgctgtatctctcctctttgtcacaacctctttgccctg
tatgatgagaacaccaagatttggtatgctcctaatcacaccatcactgttgatgataag
acaacactccggctccactaccggatgaggttttatttcaccaattggcatgggaccaat
gataatgagcagtcagtatggcgacattctccaaaaaagcagaaaaatggctatgagaaa
aaaaaagttccagatgcaactcccctccttgatgccagctccctggagtatctgtttgct
caggggcagtatgatttggtcaaatgcctggctcccattcgagaccccaagactgagcag
gatgggcacgacatcgagaatgagtgtctgggaatggctgtcctggccatctcccactat
gccatgatgaagaagatgcagttgccagaactgcccaaggacatcagctacaagcgatat
attccagaaacattgaataagtccatcagacagaggaaccttcttaccaggatgcggata
aataatgttttcaaggatttcctaaaggaatttaacaacaagactatttgtgacagcagt
gtgtccacacatgacctgaaggtgaaatacctggctaccttggaaactttgacaaaacat
tatggtgctgaaatatttgagacttccatgttagtgatttcatcagaaaatgagatgaat
cgatttcatccaaatgacagtggaaacattctctactatgaagtgatggtaactggaaat
cttggaattcagtggaggcagaaaccaaatgttataactgttgaaaaggaaaaaaataaa
ctgaaacggaaaaaactggaaaataaacacaagaaggatgaagagaaaaacaaaatccgg
gaagagtggaacaatttttcttacttccctgaaatcactcacattgtaataaaggagtgt
gtggtcagcattaataagcaggacaacaaaaaaatggaactgaagctctattcccatgag
gaggccttgtcctttgtgtccctggtagacggctacttccggcttacagcagacgcccat
cattacctctgcaccgatgtggctcccccgttgattgtccacaacatacagaatggttgt
catggtccaatctgcacagaatatgccatcaataaattgcggcaagaaggaggtgaagag
gggatgtacgtgctaaggtggagctgcactgacttcgacaacattctcatgaccgtcacc
tgctttgaaaagtctgagatgcttggtggccagaaacagttcaagaactttcagattgag
gtgcagaagggccgctacagcctgcatggctcagaccgcagcttccccagtctgggggac
ctcatgagccacctcaagaagcagattctgcgcacggacaacatcagctttgtgctgaag
cggtgttgccagcccaagccccgagaaatctccaatctgctggtggctactaagaaagct
caggagtggcagcctgtctatcccatgagccagctgagtttcgatcggatcctcaagaaa
gatattgtgcaaagtgagcaccttgggagaggcacacggacacacatctactctgggacc
ttggtggatttcaaggatgatgaaggagcttctgaagagaagagaatcaaagtgatcctc
aaagtcttagaccccagccacagggacatttctctggctttttttgaggcagccagcatg
atgagacaggtctcgcacaaacacatcgtatacctctatggcgtctgtgtccgagacgtg
gagaatatcatggtggaagagtttgtggagggggggcccctggatctcttcatgcaccgg
aaaagtgatgtcctcaccacaccatggaagttcaaagttgccaagcagctggctagtgcc
ctgagttacttggaggataaggacctggtccatggaaatgtgtgcactaaaaacctcctc
ctggcccgtgagggcattgacagcgagtgtggcccgttcatcaagctcagtgaccccggc
atccccattactgtactgtccaggcaagagtgcatagaacgaatcccgtggattgctcct
gagtgtgtggaagactgcaagaacctgagcgtggccgcagacaaatggagctttggaacc
accctctgggaaatctgctacaatggcgagatccccctgaaagacaagacactgatcgag
aaagagagattctatgaaagccgatgcaggccagtgacaccatcttgtaaggagctggct
gaccttatgacccgctgcatgaactatgaccccaatcagagacctttcttccgagccatc
atgagagacatcaataagctggaggagcagaatccagacattgtttcagagaaaaagcca
caaactgaagtggatcccacacattttgaaaagcggttcttaaagagaatccgtgacttg
ggagagggccactttgggaaggttgagctctgcaggtatgaccctgagggggacaatacg
ggggagcaggtagctgtcaaatccctgaagcctgagagtggtggtaaccacatagctgat
ctgaagaaggaaatagaaatcttaaggaacctctatcatgagaacattgtgaagtacaaa
ggcatctgtacggaagacggaggaaatggcattaagctcatcatggaatttctgccttcg
ggaagccttaaagagtatcttccaaagaataagaacaaaataaacctcaaacagcagttg
aaatatgctgttcagatttgtaaggggatggactacttgggttctcggcagtatgttcac
cgggacttagcagcgagaaatgtccttgttgagagtgaacaccaagtgaaaattggagac
tttggtttaaccaaagcaattgaaactgataaggagtactacacagtcaaggacgaccgg
gacagccctgtgttttggtatgctccagagtgtttgattcagtgtaaattttatatcgcc
tctgatgtctggtcttttggagtaactctgcacgagctgcttacttactgtgattcagat
tccagtcccatggcgttgttcctgaaaatgataggtccaactcatggccagatgacagta
acaagacttgtgaatacattaaaagaaggaaaacgtttgccttgcccacctaactgtcca
gatgaggtttatcaacttatgagaaaatgctgggaattccaaccatctaatcggacaacc
tttcagaaccttattgaaggatttgaagcacttttaaaataa

  All links  
Ontology (3)   
   KEGG BRITE (3)   
Pathway (28)   
   KEGG PATHWAY (28)   
Chemical reaction (1)   
   KEGG ENZYME (1)   
Genome (1)   
   KEGG GENOME (1)   
Gene (3)   
   KEGG ORTHOLOGY (1)   
   NCBI-PROTEINID (1)   
   NCBI-Gene (1)   
Protein sequence (1)   
   RefSeq(pep) (1)   
DNA sequence (1)   
   RefSeq(nuc) (1)   
Protein domain (7)   
   Pfam (7)   
All databases (45)   

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