KEGG   Manis javanica (Malayan pangolin): 108410207
Entry
108410207         CDS       T06054                                 

Gene name
ADCY4
Definition
(RefSeq) adenylate cyclase type 4
  KO
K08044  adenylate cyclase 4 [EC:4.6.1.1]
Organism
mjv  Manis javanica (Malayan pangolin)
Pathway
mjv00230  Purine metabolism
mjv01100  Metabolic pathways
mjv01522  Endocrine resistance
mjv04015  Rap1 signaling pathway
mjv04020  Calcium signaling pathway
mjv04022  cGMP-PKG signaling pathway
mjv04024  cAMP signaling pathway
mjv04062  Chemokine signaling pathway
mjv04072  Phospholipase D signaling pathway
mjv04114  Oocyte meiosis
mjv04211  Longevity regulating pathway
mjv04213  Longevity regulating pathway - multiple species
mjv04261  Adrenergic signaling in cardiomyocytes
mjv04270  Vascular smooth muscle contraction
mjv04371  Apelin signaling pathway
mjv04540  Gap junction
mjv04611  Platelet activation
mjv04713  Circadian entrainment
mjv04714  Thermogenesis
mjv04723  Retrograde endocannabinoid signaling
mjv04724  Glutamatergic synapse
mjv04725  Cholinergic synapse
mjv04727  GABAergic synapse
mjv04742  Taste transduction
mjv04750  Inflammatory mediator regulation of TRP channels
mjv04911  Insulin secretion
mjv04912  GnRH signaling pathway
mjv04913  Ovarian steroidogenesis
mjv04914  Progesterone-mediated oocyte maturation
mjv04915  Estrogen signaling pathway
mjv04916  Melanogenesis
mjv04918  Thyroid hormone synthesis
mjv04921  Oxytocin signaling pathway
mjv04923  Regulation of lipolysis in adipocytes
mjv04925  Aldosterone synthesis and secretion
mjv04926  Relaxin signaling pathway
mjv04927  Cortisol synthesis and secretion
mjv04928  Parathyroid hormone synthesis, secretion and action
mjv04934  Cushing syndrome
mjv04935  Growth hormone synthesis, secretion and action
mjv04970  Salivary secretion
mjv04971  Gastric acid secretion
mjv04972  Pancreatic secretion
mjv04976  Bile secretion
mjv05032  Morphine addiction
mjv05163  Human cytomegalovirus infection
mjv05166  Human T-cell leukemia virus 1 infection
mjv05200  Pathways in cancer
mjv05414  Dilated cardiomyopathy (DCM)
Brite
KEGG Orthology (KO) [BR:mjv00001]
 09100 Metabolism
  09104 Nucleotide metabolism
   00230 Purine metabolism
    108410207 (ADCY4)
 09130 Environmental Information Processing
  09132 Signal transduction
   04015 Rap1 signaling pathway
    108410207 (ADCY4)
   04371 Apelin signaling pathway
    108410207 (ADCY4)
   04020 Calcium signaling pathway
    108410207 (ADCY4)
   04072 Phospholipase D signaling pathway
    108410207 (ADCY4)
   04024 cAMP signaling pathway
    108410207 (ADCY4)
   04022 cGMP-PKG signaling pathway
    108410207 (ADCY4)
 09140 Cellular Processes
  09143 Cell growth and death
   04114 Oocyte meiosis
    108410207 (ADCY4)
  09144 Cellular community - eukaryotes
   04540 Gap junction
    108410207 (ADCY4)
 09150 Organismal Systems
  09151 Immune system
   04611 Platelet activation
    108410207 (ADCY4)
   04062 Chemokine signaling pathway
    108410207 (ADCY4)
  09152 Endocrine system
   04911 Insulin secretion
    108410207 (ADCY4)
   04923 Regulation of lipolysis in adipocytes
    108410207 (ADCY4)
   04912 GnRH signaling pathway
    108410207 (ADCY4)
   04913 Ovarian steroidogenesis
    108410207 (ADCY4)
   04915 Estrogen signaling pathway
    108410207 (ADCY4)
   04914 Progesterone-mediated oocyte maturation
    108410207 (ADCY4)
   04921 Oxytocin signaling pathway
    108410207 (ADCY4)
   04926 Relaxin signaling pathway
    108410207 (ADCY4)
   04935 Growth hormone synthesis, secretion and action
    108410207 (ADCY4)
   04918 Thyroid hormone synthesis
    108410207 (ADCY4)
   04928 Parathyroid hormone synthesis, secretion and action
    108410207 (ADCY4)
   04916 Melanogenesis
    108410207 (ADCY4)
   04925 Aldosterone synthesis and secretion
    108410207 (ADCY4)
   04927 Cortisol synthesis and secretion
    108410207 (ADCY4)
  09153 Circulatory system
   04261 Adrenergic signaling in cardiomyocytes
    108410207 (ADCY4)
   04270 Vascular smooth muscle contraction
    108410207 (ADCY4)
  09154 Digestive system
   04970 Salivary secretion
    108410207 (ADCY4)
   04971 Gastric acid secretion
    108410207 (ADCY4)
   04972 Pancreatic secretion
    108410207 (ADCY4)
   04976 Bile secretion
    108410207 (ADCY4)
  09156 Nervous system
   04724 Glutamatergic synapse
    108410207 (ADCY4)
   04727 GABAergic synapse
    108410207 (ADCY4)
   04725 Cholinergic synapse
    108410207 (ADCY4)
   04723 Retrograde endocannabinoid signaling
    108410207 (ADCY4)
  09157 Sensory system
   04742 Taste transduction
    108410207 (ADCY4)
   04750 Inflammatory mediator regulation of TRP channels
    108410207 (ADCY4)
  09149 Aging
   04211 Longevity regulating pathway
    108410207 (ADCY4)
   04213 Longevity regulating pathway - multiple species
    108410207 (ADCY4)
  09159 Environmental adaptation
   04713 Circadian entrainment
    108410207 (ADCY4)
   04714 Thermogenesis
    108410207 (ADCY4)
 09160 Human Diseases
  09161 Cancer: overview
   05200 Pathways in cancer
    108410207 (ADCY4)
  09165 Substance dependence
   05032 Morphine addiction
    108410207 (ADCY4)
  09166 Cardiovascular disease
   05414 Dilated cardiomyopathy (DCM)
    108410207 (ADCY4)
  09167 Endocrine and metabolic disease
   04934 Cushing syndrome
    108410207 (ADCY4)
  09172 Infectious disease: viral
   05166 Human T-cell leukemia virus 1 infection
    108410207 (ADCY4)
   05163 Human cytomegalovirus infection
    108410207 (ADCY4)
  09176 Drug resistance: antineoplastic
   01522 Endocrine resistance
    108410207 (ADCY4)
Enzymes [BR:mjv01000]
 4. Lyases
  4.6  Phosphorus-oxygen lyases
   4.6.1  Phosphorus-oxygen lyases (only sub-subclass identified to date)
    4.6.1.1  adenylate cyclase
     108410207 (ADCY4)
SSDB
Motif
Pfam: Guanylate_cyc DUF1053 AC_N CD52
Other DBs
NCBI-GeneID: 108410207
NCBI-ProteinID: XP_017536654
Position
Unknown
AA seq 1075 aa
MARLCSPRQPPSEDLFYETYYSLSQQYPLLLLLLVIVLCTLLALLAVAWASGRELASDPG
FLTTVLCALGGFSLLLGLASREQRLQLWTRPLSGLVWAALLALGHGFLFTGGLVSAWDQV
SFFLFVIFTVYAMLPLGMRDAAAAGLASSLSHLLVLGLYLGPQPDSRPALLPQLAANAVL
FLCGNVAGAYHKALMERALRATFREALSSLHSRRRLDTEKKHQEHLLLSILPAYLAREMK
AEIMARLQAGQGSRPESTNNFHSLYVKRHQGVSVLYADIVGFTRLASECSPKELVLMLNE
LFGKFDQIAKEHECMRIKILGDCYYCVSGLPLSLPDHAINCVRMGLDMCRAIRKLRAATG
VDVNMRVGVHSGSVLCGVIGLQKWQYDVWSHDVTLANHMEAGGVPGRVHITGATLALLAG
AYAVEDAAVEHRDPYLRELGEPTYLVIDPRAEEEDEMGAAGGLLSSLEGPKMRPSLLMTR
YLESWGAAKPFAHLSHIESPVSTSTPLPEKALASFSPQWSLDRSRTRLDDDLDTGDAKFF
QVIEQLNSQKQWKQSKDFNPLTLYFREKEMEKEYRLSALPAFKYYTACTFLVFLSNFVIQ
MLVTNRPPALAITYSITFLLFLLLLLVCFSEHLMRCVLKGPKMLHWLSALSGLVATRPGL
RVALGTATILLVFAMAITSLFFSPAASNCPFQAPNVSSIACNLSWELPGSLPLVSIPYSM
HCCVLGFLSCSLFLHMSFELKLTLLLLWLAASCSLFLHSHAWLSDCLVARLYLSPLDSRP
GVLKEPKLMGAISFFIFFFTLLVLARQVSHPAQSSRASLLRGKHSXXXXXXXENLTRLLL
ENVLPAHVAPQFIGQNRRNEDLYHQSYECVCVLFASVPDFKEFYSESDINHEGLECLRLL
NEIIADFDELLSKPKFSGVEKIKTIGSTYMAATGLNATSGQDTQQDAERSCSHLGTMVEF
AVALGSKLDVINKHSFNNFRLRVGLNHGPVVAGVIGAQKPQYDIWGNTVNVASRMESTGV
LGKIQVTEETARALQSLGYTCYIRGVIKVKGKGQLCTYFLNTDLTRIGPPSATLG
NT seq 3228 nt   +upstreamnt  +downstreamnt
atggcccgcctctgcagcccccggcagccccccagcgaagacctcttctacgagacctac
tacagcctgagccagcagtacccgctattgctcctgctcctggtgattgtgctgtgcacg
ctcctggcactcctagctgtggcctgggcaagcggcagggagctggcctcagacccgggc
ttcctgaccactgtgctgtgcgcactgggcggcttctcgctccttctgggcctggcttcc
cgcgagcagcgactgcagctctggacgcgtcccctgtcgggccttgtgtgggcagcgctg
cttgcgctgggccacggcttcctattcaccgggggcctagtgagcgcctgggaccaggtg
tctttttttctatttgtcatcttcaccgtgtacgccatgttgcccttgggcatgcgggac
gctgccgccgcgggcctggcctcttcgctctcgcacctgctggtcctcgggctgtatctt
gggcctcagccggactcacggccggcgctgctgccacagctggcagcaaacgcggtgctg
ttcctgtgcgggaacgtggcgggcgcgtaccacaaggcgctgatggagcgcgcgttgcgc
gccacattccgtgaggcgctcagttccctgcactcgcgccggaggctggacacggagaag
aagcaccaggaacaccttctcttgtctatccttcctgcctacctggcccgagagatgaag
gcagaaatcatggcacggctgcaggctggacaaggttcacgaccagagagcaccaataac
ttccacagcctttatgtcaagagacaccagggagtcagcgtgctatatgctgacatcgtg
ggcttcacacggctggccagtgagtgttcccctaaggagttggtgctcatgctcaacgag
ctctttggcaagttcgaccagattgccaaggagcatgaatgcatgcggatcaagatcctg
ggcgactgttactactgtgtctctgggctgccgctctcgctgccagaccacgccatcaac
tgtgtgcgcatggggctggacatgtgccgggccatcaggaaacttcgggcagccactggc
gtggacgtcaacatgcgtgtgggcgtgcactcgggcagtgtgctctgcggagtcattggg
ctgcagaagtggcagtatgatgtctggtctcatgatgtcacactggccaaccacatggag
gcaggaggcgtaccaggacgagtacatattacaggggctaccctggccctgctggcaggg
gcttatgctgtggaggatgcagctgtggagcaccgggacccataccttcgggagctgggg
gagcctacctacctggtcattgatccccgggctgaggaggaggatgagatgggtgctgca
ggagggttgctgtcctctcttgagggccccaagatgcgtccatcactgctgatgacccgc
tacctggagtcctggggtgcagccaagccttttgcccacctgagccacatagagagccct
gtgtccacatccacccctcttccggagaaggccctggcttccttcagcccccagtggagc
ctggaccggagccgtactcgactagatgatgacctggacactggggatgccaagttcttc
caggtcattgaacagctcaactctcagaaacagtggaagcagtcgaaggatttcaaccca
ctgacactgtacttcagagagaaggagatggagaaagagtatcgactctctgcactccct
gccttcaaatactacacagcctgcaccttcctggtttttctctccaactttgtcatccag
atgctggtgacaaacaggcccccagctctggccatcacctatagcatcaccttcctcctc
ttcctcctcctcctcctcgtctgcttctcagagcacctgatgaggtgtgttttgaaaggc
cccaagatgttacactggctgtctgcactgtctggcttggtagccacacgacccggactg
cgagtcgccctgggcaccgccaccatcctcctcgttttcgccatggccattaccagcctg
ttcttctcaccagcagcatcgaactgccctttccaggcccccaatgtgtcctccatagcg
tgcaacctctcctgggagcttcctggatccctgcctctcgtcagcatcccatactccatg
cattgctgcgtgctgggcttcctctcctgctccctcttcctgcacatgagcttcgagctg
aaactgacgctgctcctgctgtggctggcggcctcctgctccctcttcctgcactcccat
gcctggctgtccgactgcctcgtcgcccgcctctatctgagccccctggactccaggcca
ggggtgctgaaggaacccaaactgatgggagctatctccttcttcatcttcttcttcacc
ctccttgtcctggctcggcaggtaagtcacccagctcagtcctccagggcctccctattg
aggggtaaacactcgnnnnnnnnnnnnnnnnnnntggagaacctgactcggctgctcttg
gagaacgtgctccctgcccatgtggccccccagttcattggccagaaccggcgcaatgag
gacctctaccaccagtcctacgagtgtgtctgtgtcctgttcgcctcagtcccagacttt
aaggagttttactctgaatctgacatcaaccatgaggggctagagtgtttgaggctgctc
aatgagataattgctgattttgatgagctgctctccaagcccaagttcagtggggtggag
aagatcaaaaccattggcagcacctacatggcagctacaggcttaaatgccacctctgga
caggacacacagcaggatgctgaacgaagctgcagccaccttggtaccatggtggagttt
gcggtggcccttggatctaagctggatgtcatcaataagcactctttcaacaacttccgc
ttgcgtgtggggttgaaccatggacctgtagtagctggagtgatcggggctcagaagcca
cagtatgatatctggggcaacacagtgaacgtggccagccgcatggagagcacaggagtt
ctgggcaagatccaagtgactgaagagacagcccgggccctgcagtcattaggctacacc
tgctatatccggggagtcatcaaggtcaaaggcaaagggcagctctgcacctacttcctc
aacacagatttgacacgaattggacctccctcagccaccctgggctga

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