KEGG   Mycobacterium sp. KMS: Mkms_4753
Entry
Mkms_4753         CDS       T00442                                 
Name
(GenBank) Mur ligase, middle domain protein
  KO
K01929  UDP-N-acetylmuramoyl-tripeptide--D-alanyl-D-alanine ligase [EC:6.3.2.10]
Organism
mkm  Mycobacterium sp. KMS
Pathway
mkm00300  Lysine biosynthesis
mkm00550  Peptidoglycan biosynthesis
mkm01100  Metabolic pathways
mkm01502  Vancomycin resistance
Brite
KEGG Orthology (KO) [BR:mkm00001]
 09100 Metabolism
  09105 Amino acid metabolism
   00300 Lysine biosynthesis
    Mkms_4753
  09107 Glycan biosynthesis and metabolism
   00550 Peptidoglycan biosynthesis
    Mkms_4753
 09160 Human Diseases
  09175 Drug resistance: antimicrobial
   01502 Vancomycin resistance
    Mkms_4753
Enzymes [BR:mkm01000]
 6. Ligases
  6.3  Forming carbon-nitrogen bonds
   6.3.2  Acid-D-amino-acid ligases (peptide synthases)
    6.3.2.10  UDP-N-acetylmuramoyl-tripeptide---D-alanyl-D-alanine ligase
     Mkms_4753
SSDB
Motif
Pfam: PGA_cap Mur_ligase_M Mur_ligase_C VWA_3_C
Other DBs
NCBI-ProteinID: ABL93944
UniProt: A1UM86
Position
complement(4981457..4985356)
AA seq 1299 aa
MENSADRSHDCEDRPDIGRFLARANPGESVATAQPCDIRLTRADVDAAIALGGRYLVSAQ
REDGSFVYEVDWMTGEESADDNVVRQAGATWGVALLHRETREPDHRAAVDRSLRKWDTAV
REIDGRRWLADGEFRSGKLGAVALIGLSLLERLAVPEGLDDPARMRASLDALCRFVEDAR
SPSGGFQKAFDTRTGNHSGAADPYSSGEALLLLARSGIELGEPDRLERALAWAEEDYHEF
VVRPLADEPDPDVTKGYYQWGSMTWFAFATAGHAPETWGRRLIEQALWMVDVHRTLSRKR
NTGYAYEGIVPAWEWARRTGNEDTARKLACVVHQGLRKLCAWQLGHPLASSALRSAPEQF
HGAVQNHARQSALRIDVTQHQLHALMYARRFSVDAAEHLCATDISAAPAVSVQTGNRNHK
APSSDLNAHELAEITQGVWEVMPPDGWTMKAVAFVKKRLEPQALVLPHCRTYRYGVDRDT
VRGLNGNGYALLADATPLAFPHGVPRLKVASVRNALTNLALATRASYPGRIVAVTGSAGK
TSTCNMIEDLLQVFGVPKRPTKNFNTFDGVNGEVANLTNEAIAVIEVAASFLSQRGGPRP
NVLRPEVAMITSIGEAHLEYFGSPQGVAEVKSNVFDLMSRGTAVIPRDADTYDYMVQRAR
AAGATTVSFGAHPSADAHLLSYSAADGVVEAEIFGERITYELGALGRHFARNSVGALGVV
AALGLDWRRAAGALASSREVTGRGMTFDVGSASGRFTLIDDAYNANPSSVRAAIEMLSER
ATPPRGRRIAVLADMLELGPRSEEFHRALAEPLLGAAIDRVYLVGDQMRALWDDLPSEIR
GQYYPTVDGLQAALDREFADGDVVLFKGSNGTELHKVVAHFKRATKRRSDAPKDLARSED
TGFVQPAGRRRLEVRARHPKSSQSGSRRTSLVFVGDLSMGDCYLKRPHLSVARHRLEENP
WSFVELLAPLVQDKSLLVANLETVLAERPADPFRGMKKYQGWDDPVRTLAVMQRLGVDAV
SLANNHTMDFGVAPLRRTIAHLESTNIVPFGAGENEVQAARPLSVSAPFGNVHIFAGYEF
RTGYARKWNFYASGDAAGVNPLTGRATGSLIADIARTRTDDPASVIVVYPHWSGARNYQW
ATDEMIGMNSEFLDAGADFVIGHGAHRMQEIVSGREGTTVFSLGNFVFNSPGRYAKFGSP
TFSLVARLEIEDGDPVTGIGADLHIYPIMSDNRETGFRPRPVRKSEAVQVYNILAGQSGA
RFREDFDLEHGDRGWYIGRTIPLSMAGGQRRRDAVTSPA
NT seq 3900 nt   +upstreamnt  +downstreamnt
atggaaaatagcgctgatcgttctcacgattgcgaggaccggcccgacatcggccgattc
ttggcgcgtgcgaatccgggtgaatccgtcgctaccgcacagccatgcgatattcgcctc
acacgcgcagatgtcgacgcggcgatcgctctgggcgggcgatacctcgtctcggcccag
cgggaggacggcagcttcgtctacgaggtcgactggatgacgggggaggagtcggcggat
gacaacgtcgtccgccaagccggcgcaacctggggtgtcgcattgctgcaccgagagacg
cgcgaacccgatcatcgggccgccgtggaccgatcgcttagaaagtgggataccgcggta
cgggagatcgatggtcggcgctggctggccgatggggagttcaggtcagggaagctcggc
gccgtcgctctgatcggcctctccctgctcgagcgccttgctgtcccagagggtctcgat
gaccctgcgcggatgcgcgcctcgctcgacgcgctctgccgattcgtcgaggatgcccgg
tcgcccagtggaggatttcagaaggcgttcgacaccagaactggaaaccactccggcgcc
gcggatccgtactcttctggtgaagcgcttctgctactcgcgcgcagcggtatcgaactc
ggtgagcccgatcgactggaacgggcactcgcttgggctgaggaggactatcacgagttc
gtcgtgcgtccgctcgccgacgaaccggacccagatgtcactaaaggctattaccagtgg
gggtcgatgacttggttcgctttcgcgactgccgggcacgctccggagacttggggtcgc
cgccttatcgagcaagcgttgtggatggtcgacgtgcaccgcacgttgtcccgcaaacgg
aacaccgggtacgcctacgaagggatcgtgccagcatgggagtgggctcgtcgcacaggc
aacgaagacaccgcccgtaagctcgcatgcgtcgtgcaccaggggctccgcaagctctgt
gcgtggcaactcgggcacccactcgcgtcatctgcgttacggtctgcgccggaacagttt
catggggcggtccaaaaccacgcgcgccagtccgcgctacgtatcgacgtcacccagcac
caactccacgcgctgatgtatgcgcggcgattcagcgtcgatgcagccgagcatttgtgc
gcgacggacatctcggcggcgccggcggtatctgtccagacagggaaccggaatcacaaa
gcgccctcgtcggacttgaatgcgcatgagttggctgagatcacgcaaggagtgtgggaa
gtcatgccacccgacgggtggaccatgaaggcggtcgcgttcgtcaagaaacggctggag
ccccaagcgctggtgctaccgcattgtcgaacgtacagatatggggtagatcgagacacg
gtgcggggattgaacgggaatggttacgccctgctcgctgacgccacgccgctggccttc
ccgcacggtgttcctcgcctgaaggttgcgtcggtgcggaacgccttgaccaacctcgca
ttggccaccagagccagctatcccgggcggattgtggccgtcacgggcagtgctggaaaa
accagcacctgcaacatgatcgaagatctgctccaggtctttggagtaccgaaacggccg
acgaagaacttcaacacctttgacggggtcaacggcgaggtggccaatctgaccaacgag
gcgatcgccgtcatcgaagtggcggccagcttcctgtctcagcgcggcgggccccgtccg
aacgtacttcgtcccgaagtggcgatgattaccagtatcggcgaggcgcatctggagtac
ttcggatcgccgcaaggggtcgctgaggtgaagagcaacgtgttcgatctgatgtcgcgg
ggcacagcggtcatcccccgtgacgccgacacgtacgactacatggtgcaacgcgcacgt
gcggcaggcgctacgaccgtctccttcggggcccatcccagtgccgacgcccaccttctc
tcatactcagcggcagacggagtggtcgaagcggagatcttcggcgagagaatcacttat
gaactcggggcacttggtcggcattttgcgcgcaacagtgtcggagcgttgggcgtcgtc
gcggcccttgggctggactggcggcgggccgccggcgcactggcgtcgagtcgggaagtc
actggtcgcggcatgacgtttgacgtcggttcagcgagcggtcgtttcacgttgatcgac
gacgcatacaacgcgaatccgagttcggtacgggccgcgatcgagatgctctccgaacgg
gccactcctccgagggggcgccgaatcgccgttctcgcggacatgctggaactgggccct
cgaagcgaggagtttcaccgagccctggctgagcccttactcggcgcagcgattgatcgt
gtgtacctggtcggtgatcagatgcgcgcgttgtgggacgacctgccttccgaaatccgt
ggccagtactaccccactgtggacggtctccaggcagcgctcgatagagagttcgccgac
ggagatgttgtcttgttcaagggttcgaacggcaccgaactccacaaagtcgtggcgcac
ttcaagagagcaacaaagcgtaggtcagacgctccgaaggacctggctcgtagcgaggac
acgggctttgtgcaacccgcaggccgtcgacggctggaagtgcgcgctcggcatccgaag
tcatcacagtcaggctcacggcgcaccagtctcgtcttcgtcggcgacttgagcatgggt
gattgttacctcaaacgcccacacctctctgtcgctcgccatcgactcgaggagaatccg
tggagcttcgtcgaactcttggctcctctcgtgcaggacaagtcactccttgtcgccaat
cttgaaaccgtcctggccgaaaggccggctgatccgttccgggggatgaagaaataccag
ggatgggacgatccggttcggacgcttgcggtcatgcagcgtttgggcgtagacgcggtg
tcgctcgcgaacaatcacacgatggatttcggagtggcgcccttgaggcggacgatcgcc
cacctcgagtcgaccaacatcgtgccattcggtgctggcgagaatgaggtgcaggccgct
cgaccactgagtgtttcggctcctttcggcaatgttcacatattcgccggttacgagttc
cggactggttatgcacggaagtggaatttctacgcgtcgggtgatgcggccggcgtgaat
cctctcaccggccgcgcgacaggaagtctcatcgccgatattgcgcggaccaggactgac
gacccggcgtcggtcatcgtcgtctatccacactggagtggcgcacggaattatcaatgg
gccacggatgaaatgatcgggatgaacagcgagttcctcgatgccggcgccgacttcgtt
atcgggcacggggcgcatcgaatgcaggagatagtctcgggaagagaaggaacgacggtg
ttctcgctgggcaatttcgtgttcaactcgcccggccggtatgccaaattcggctcacct
actttcagtcttgttgcacgcctagagattgaggatggcgatccggtgacgggaatcggg
gcggatctacatatctatcccataatgtcggacaatcgtgagacgggttttcgcccgagg
ccggtccggaaatccgaggcggttcaggtgtacaacatcctcgccggacagagtggcgca
cgcttcagagaggacttcgacctcgaacacggtgaccgggggtggtacatcggtcggacg
attccactgagcatggccggcggccaacgacgacgtgatgcggtcacttcgcccgcgtga

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Ontology (2)   
   KEGG BRITE (2)   
Pathway (4)   
   KEGG PATHWAY (4)   
Chemical substance (8)   
   KEGG COMPOUND (8)   
Chemical reaction (3)   
   KEGG ENZYME (1)   
   KEGG REACTION (2)   
Genome (1)   
   KEGG GENOME (1)   
Gene (3)   
   KEGG ORTHOLOGY (1)   
   NCBI-PROTEINID (1)   
   OC (1)   
Protein sequence (1)   
   UniProt (1)   
Protein domain (4)   
   Pfam (4)   
All databases (26)   

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