KEGG   Mycobacterium leprae TN: ML0135
Entry
ML0135            CDS       T00047                                 
Name
(GenBank) putative polyketide synthase
  KO
K12430  4-hydroxyphenylalkanoate synthase [EC:2.3.1.261]
Organism
mle  Mycobacterium leprae TN
Brite
KEGG Orthology (KO) [BR:mle00001]
 09180 Brite Hierarchies
  09181 Protein families: metabolism
   01004 Lipid biosynthesis proteins [BR:mle01004]
    ML0135
Enzymes [BR:mle01000]
 2. Transferases
  2.3  Acyltransferases
   2.3.1  Transferring groups other than aminoacyl groups
    2.3.1.261  (4-hydroxyphenyl)alkanoate synthase
     ML0135
Lipid biosynthesis proteins [BR:mle01004]
 Polyketide synthase
  Modular PKS
   ML0135
SSDB
Motif
Pfam: ketoacyl-synt KR Acyl_transf_1 Ketoacyl-synt_C PKS_DH_N PS-DH ADH_zinc_N_2 KAsynt_C_assoc PP-binding adh_short ADH_zinc_N adh_short_C2 Epimerase ADH_N Thiolase_N Docking Polysacc_synt_2 GDP_Man_Dehyd
Other DBs
NCBI-ProteinID: CAC29643
Pasteur: ML0135
UniProt: Q9CD81
Position
182173..188484
AA seq 2103 aa
MTASVEGADQKSEKLISYLKKVVVELDETRARLREYEQRATEPVAVVGIGCRFPGGVDSP
DRLWDVVSECRDVVSEFPTDRGWDVDGLFDPDPDAEGKTYTRWGAFLDDAAGFDAGFFGI
APSEVLAMDPQQRLMLEVSWEALEYAGIDPLSLRGSATGVFTGIFAPSYGSRDTGGLQGY
GLTGTAVSVASGRVSYVLGLEGPAVSVDTACSSSLVAIHWAMSSLRSGECDLALAGGVTV
MGLPSIFVGFSRQRGLAADGRCKAFARAADGTGWGEGAGVVVLERLSDAQRLGHTVLAVV
RGSAVNQDGASNGLTAPNGLAQQRVIQAALTNAGLSSADVDVVEAHGTATTLGDPIEAQA
LLATYGQGRPADQPLWVGSIKSNMGHTQAAAGVAGVIKMVQAMRHHVMPATLHVDEPSPR
VDWTTGAVSVLTEARDWSVEGRPRRAGVSSFGISGTNAHVILEEAPTPVEASYSTADQQR
LSVVPWVVSGRSTAALMAQASRLAFYVQADPEVDPVDVGCALAARSVFEHRAVVVGESRE
QLIAGLAGLAVGESGAGVAIGQAAPLGKTVVVFPGQGAQRIGMGRELCSQLPVFAEEFDA
VTGELDRHMRLPLRDVVWGADAGLLDSTEFAQPALFAVEVALFAVLQHWGLQPDFVMGHS
IGELAAAYVAGVLAPADAAMLVVARGRLMQSMPAGGTMWAVAASEDEVVSLLGEGVGIAA
INAPESVVISGPQAAVSAIADKFAAQGRRVHQLAVSHAFHSPLMEPMLEEFVRVAAQVEV
RKPQIGLVSNVTGELAGPDFGSPQYWGEHVSRAVRFVDSARHLQTLGATHFIESGPSSGL
MGAIEQSLAPAEAVVVSMMGKDRPELASVLGAAGQLFATGMPVEWPAVFAGSSRRRVTLP
TYAFQRRRFWETPGTDGTASVSGLGLGSTEHALLGAVVERPDSGGVVLTGRLSLANQPWL
ADHVIGGVVLFPGAGFVELVIRAGDEVGCAGVEELVLAAPLVLHPGSGVQVQVVVAAADE
SSRRAVSVYSRGDQSHGGWLLNAEGLLEVDAAEATVDLSLWPPEGAESVDISDAYPQLAE
RGYAYGPAFQGLVAIWRRGSELFAEVVAPTGVVVDGMGMHPALLDAVLHALGLAIENTQA
TTEMRLPFCWRGVSLHAGGAGRVRARFTSAGADAIAVDIADSAGLPVLTVRSLVTRAMTA
EQLRTAVTAAGGALEQGPMDLVWSPIPLSSDGHGGGLPSVVSWADYCAGRGNDTGVVVWE
FGSASAGAQAPVDSVAAVYSATHAALQVLQFWFGQDRAGTLVVLTRGAVGLVGEGISDLA
AAAVWGMVRSAQSEHSGKIVLIDTDSAVDVAVLADLGESQLLVRCNTVHAARLSPAPQLL
ALPVGESMWRLAADGGGTLEDLVIQPCPEVQAPLQAGHMRVAVAAVGVNFRDVVAALGMY
PGQAPPLGAEGAGVVIEIGPEVTGVAVGDAVMGFLGGAGPLAVVHQQLITQMPQGWSLAE
AAAVPVVFLTALFGLADLAGIRAGESVLIHAGTGGVGMAAVQFARHWGVEIFVTASRGKW
DTLRDMGFDDDHIGDSRTLEFEEKFLAVTDGRGVDVVLDSLAGDFVDASLRLLVRGGRFL
EMGKTDIRDAQEIAANYPGVQYRAFDLSEAGPVRMQEMLCEVRELFDTQVLHRLPVTSWD
VRCAPAAFRFMSQARHIGKVVLTMPSALADGLAEGTVLITGASGAIGGVLARHMVSAYGV
RHLVLASRRGDRAEGAVELAAELVGAGAKIQVVACDVADNDAVRGLFAQLSREFPPVRGV
IHAAGVLDDGAITSLTPDRVDTVLRAKVDAAWNLHEATRDLDLLMFVLCSSIAATVGSPG
QGNYSAANAFLDGLAAYRQAAGLAGTSLAWGLWEQPGGMNAHLSSRDLARISRSGLAPMN
PAQALELFDAALVIDHPFMVTALLDRAALDAQAQAGALPPLFSRLVRRSRRRQIEDPGDA
TQSKLALVQRLQGLAANRQLELLVGVVCLQAAAVLGRPSPEDIDPNTKFQDLGFDSLTAV
ELRNRLKSATGLTLPPTVIFDHPTPTAVAEYVAQQMLKSRPAESGDETSQAVEPKVEEVS
VHA
NT seq 6312 nt   +upstreamnt  +downstreamnt
atgactgcgagcgttgaaggggctgaccagaagagcgaaaagcttataagttatctcaaa
aaagttgttgtcgaacttgatgagacacgtgctcggttacgggaatacgaacaacgcgca
acagagccggtcgcggtggtcgggatcgggtgtcggttcccaggcggcgtggatagtcca
gacaggctgtgggatgttgtttcggagtgccgcgatgtcgtgtcggagtttccgacggac
cggggttgggacgtcgatgggctgtttgatcctgatcccgatgcggaaggcaagacctac
acgcggtggggtgcgtttttagacgacgcggccggctttgacgccgggttctttggcatc
gcccctagcgaggtgctggcgatggaccctcagcagcgattgatgctggaggtttcatgg
gaggcgttagaatacgcggggattgacccattgtcgttgcgcgggtccgcgactggggtg
tttacagggattttcgcgccgagttatggcagcagggacactgggggcctgcagggctat
ggattgaccggcaccgcggttagtgtggcctcggggcgcgtgtcgtatgtgttggggctg
gagggcccggcggtatcggtggacacggcgtgttcgtcgtcgttggtagcgatccattgg
gcgatgtcgtcgttgcgctcaggtgagtgcgatttggctttggccggtggggtgacggtg
atggggttgccgtcgatttttgtgggcttcagtcggcagcgggggttggctgctgatggg
cgttgtaaagcgtttgcgagagcggccgacgggactggctggggcgagggtgccggagtg
gtcgtgctcgagcggctctcggacgcacaaagattgggccatacggtgttggcggtggtg
cgtggtagtgcggtcaatcaggatggcgcatctaatgggttgactgcacccaacgggctt
gcccagcagcgggtgatccaggcagcgttaactaatgcagggctgtcctcggcagacgtg
gatgtggttgaggcacatgggaccgccactacgttgggtgatcctatcgaagcgcaggca
ttgctggccacgtatgggcagggacgtccggcagaccagccgttgtgggtgggctcaatt
aagtcgaatatgggccacactcaggccgccgcaggggtggccggggtgatcaagatggtg
caagctatgcgtcaccacgtgatgccggcgacgctgcatgtggatgagccttccccgcgg
gtggattggaccaccggcgcggtgtcggtgttgaccgaggcccgggattggtcggttgaa
gggcgcccgcgccgggcgggggtgtcgtcgtttgggatcagtggcaccaacgcgcatgtg
atcttggaagaggctccaaccccggttgaggcgagttatagcaccgctgaccagcagcgg
ttgtcggtagtgccctgggtggtttcgggtagatcgacagcggcgttgatggcgcaagcg
agtcggttggcgttctatgtgcaggctgacccggaggtggatccagttgatgtggggtgc
gcgctggcggcgcgttcggtgtttgagcatagagcagtggtcgtcggcgaaagccgtgag
caactaattgcggggctagctgggctcgcagttggcgagtcgggcgctggcgtggcgatc
ggtcaagcagcgccgctgggcaagacggtggtcgtgtttcccggacagggtgcgcagcgt
atcggtatgggccgcgagttgtgcagccagttgccagtgtttgctgaggagttcgatgcg
gtgaccggtgagttggatcgccacatgcgattgccgttgcgcgacgttgtgtggggagcc
gacgcgggtttgctcgacagcactgagtttgctcagccggcgttgttcgcggtggaggtg
gcgttgttcgcggtgttgcagcactggggcctgcaaccggattttgtgatggggcactcc
attggggagttggcggcggcttacgtggctggagtattggctcctgccgacgcggcaatg
ctggtggtggcgcgaggccggttgatgcagtcgatgccggcaggcggcacgatgtgggcg
gttgctgcttcggaagacgaggtggtgtcgctgttaggtgagggtgttgggatcgctgcg
atcaacgcgcctgaatcagtggtgatctccggtccgcaggccgcggtgagcgccattgcg
gataagttcgctgcgcagggccggcgggtgcatcagctggcggtctcgcatgcgtttcat
tcgccgttaatggagccgatgctcgaggagtttgtgcgcgttgcggctcaggttgaggtg
cgcaagccgcagattggtctggtgtcaaatgtgacgggcgagttggctggccctgatttc
ggttctccgcagtactggggggagcacgttagccgggcggtgcgttttgtcgacagtgct
cgtcatttgcagactttgggtgcgacccacttcattgagtctggccccagtagtggtttg
atgggcgctattgagcagtccttggctccggctgaggctgtggtggtgtcgatgatgggt
aaagaccggcctgagctggcctcggtgctcggtgctgccggtcagttattcgctaccggt
atgccagtggagtggcctgcggtgtttgccggttcaagtaggcggcgggtgacgttgccc
acctatgcgttccagcgccgtcgattttgggaaactccgggaactgatggtaccgcctct
gtgtctggtttaggcctgggctcgaccgaacatgcgctgttgggtgcggtggtcgagcga
cccgattctggcggggtggtgttgaccggcaggttatcgctggcgaatcagccgtggttg
gctgatcacgtgattggcggggtcgtgctgtttcctggggcgggttttgtcgagttggtg
atccgcgccggtgatgaggtcggttgtgcgggtgtcgaggagttggtgctggcggcaccg
ctggtgctgcacccagggtcgggggtgcaggtgcaggtggtcgtggcagccgctgatgag
tcgagtcgtcgggcagtgtcggtgtattcccggggtgatcaatcccacgggggttggttg
ctaaacgccgagggcttgttggaggtggatgccgcggaggccacggtggatttgtcattg
tggccgccggaaggtgccgagagcgtggatatctcggacgcctatcctcagttagccgag
cgcggttacgcctacggcccggcgtttcagggtttggtggcaatctggcggcgcggttcg
gagctgttcgccgaggtagtcgctcccactggtgtggttgtcgacgggatggggatgcac
ccggcgttactagacgcagtgctgcatgctttggggttggctatcgagaacactcaggcg
accaccgagatgcgactgccattttgttggcgcggtgtgtcgctgcatgccggtggtgct
gggcgggtgcgtgctcgcttcacctcggcaggggcggatgcgatcgcagtggatatcgca
gactccgcggggttgccggttttgaccgtgcgttcgctggtcactcgtgcgatgactgct
gaacagctgcgcaccgccgtgaccgcggctggtggtgcgctcgaacaggggccgatggac
ctagtgtggtcgccaataccgcttagcagcgacggtcacggcggtggcctgccttccgta
gtgtcttgggcagactattgcgccggcagaggcaatgatacgggcgtcgtggtgtgggaa
ttcgggtctgcgtctgctggtgcccaagcacctgtggactcggtagccgcggtatattcg
gccacccacgccgcccttcaggtgctgcagttttggtttggccaggatagagccggtacg
ctggtggtgttgacccgtggtgctgtcgggttggtcggtgagggtatcagtgacctggcc
gccgctgcggtatggggcatggtgcggtcggcgcagagcgaacattccggcaagattgtg
ttgatcgacaccgactcggcagtggacgtggcggtgttggcagaccttggcgaatcccaa
ctgttggtgcgctgcaacaccgtgcatgcggctcgtttgtccccggccccgcaactgctg
gctctgccggtcggggagtcaatgtggcgtttggctgccgatggcggtgggactttggag
gatctggtgatccagccctgcccagaagtgcaagcaccgctgcaggcggggcatatgcgg
gtggcggtggctgcggtcggggtcaacttccgcgacgtggtggccgcactgggaatgtat
cccggccaagccccgccactgggtgcagaaggcgccggggtggtgatcgaaatcggtccc
gaggttaccggtgtggccgtcggtgacgcggtgatgggtttcctcggtggggcgggtccg
ctggcagttgtgcaccaacaactgattacccagatgccgcagggctggtcgttggctgag
gccgccgccgtgccggtggtgtttttgacggccttgttcgggttggcggatttggccggc
atccgggccggggaatcggtgcttatacatgccggaaccggtggtgtgggcatggcagca
gtgcagtttgctcgccactggggtgtggaaattttcgtcaccgccagccgcggtaagtgg
gacacgctacgcgacatggggtttgacgacgaccacatcggtgattcccggacgttggag
ttcgaggagaagttccttgcagtgactgatggtcgcggggttgatgtagtgctcgattca
ctggccggtgatttcgtggatgcttcgttgcgcttgttagtccgtggtgggcgttttctc
gagatgggcaagaccgatatccgcgatgcgcaggagatcgctgccaactatcctggtgtg
cagtatcgggcgttcgatctgtcggaggccggcccggtgcgcatgcaggagatgctatgc
gaggtgcgtgagctcttcgatacccaggtgctgcatcggttgccggtcactagctgggat
gtacgctgcgcgccggcagccttccggttcatgagtcaggcccgccacatcggcaaggtt
gtcttgaccatgccttcggcgctggctgatggattggccgaaggcaccgttctaatcact
ggcgcttccggggcgatcggtggggtattggcacgccacatggtcagcgcctacggtgtg
cgccatctggtgttggctagtaggcggggtgatcgtgctgagggagcggttgagttggcc
gctgaattggttggggccggcgccaagatacaggtggtagcttgtgacgtggccgataat
gatgctgtacgaggattgttcgctcagctgtcgcgggagtttccgccggtgcgcggcgtg
attcatgccgccggtgtgctcgatgacggggcgatcacttcattgacaccggatcgggtc
gatacggtgttgcgagccaaggtggacgcggcgtggaacctacacgaggccacccgcgat
ctggacttgttgatgtttgttttgtgctcctcgatcgcggccacggtcggctcgccgggg
cagggcaactactccgcggcaaacgcgttcctcgatgggttggccgcttatcggcaggcc
gccgggttggccgggacatcgctggcgtgggggttatgggagcagcccggcggcatgaac
gctcatttgagcagccgtgacctagcccgtataagtcgtagcgggctggctccgatgaac
cctgcccaggcgctggaattgtttgacgctgcgttggtgatcgatcacccctttatggtg
actgcccttctggaccgggccgcacttgatgcccaggcccaggctggcgcgttgccgcca
ttattcagtaggctggtgcgacgttcgcggcgacgccaaattgaggaccccggggatgcc
acccagtcgaagttggctctggtccagcgcctacaaggactggctgcgaacaggcaactc
gagctgctggtaggggtcgtgtgcttgcaggcagcggcggtactgggccggccctctcct
gaggacatcgaccccaacaccaagtttcaggacctcggtttcgactcgctgacagccgtc
gaattgcgcaacaggctaaagtcagcgaccgggttgactttgccgccaaccgtgatcttc
gatcaccccactcccaccgcggtcgccgagtacgtcgctcagcaaatgctgaaaagccgc
ccagcggaatccggtgatgaaacgtcacaggctgtcgaaccgaaggttgaggaagtgtcc
gtacacgcttaa

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Ontology (3)   
   KEGG BRITE (3)   
Chemical substance (10)   
   KEGG COMPOUND (10)   
Chemical reaction (3)   
   KEGG ENZYME (1)   
   KEGG REACTION (2)   
Genome (1)   
   KEGG GENOME (1)   
Gene (4)   
   KEGG ORTHOLOGY (1)   
   NCBI-PROTEINID (1)   
   OC (1)   
   PASTEUR (1)   
Protein sequence (1)   
   UniProt (1)   
Protein domain (18)   
   Pfam (18)   
All databases (40)   

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