KEGG   PATHWAY: mmu00590
Entry
mmu00590                    Pathway                                
Name
Arachidonic acid metabolism - Mus musculus (house mouse)
Class
Metabolism; Lipid metabolism
Pathway map
mmu00590  Arachidonic acid metabolism
mmu00590

Other DBs
GO: 0019369
Organism
Mus musculus (house mouse) [GN:mmu]
Gene
26971  Pla2g2f; phospholipase A2, group IIF [KO:K01047] [EC:3.1.1.4]
18778  Pla2g1b; phospholipase A2, group IB, pancreas [KO:K01047] [EC:3.1.1.4]
18781  Pla2g2c; phospholipase A2, group IIC [KO:K01047] [EC:3.1.1.4]
18784  Pla2g5; phospholipase A2, group V [KO:K01047] [EC:3.1.1.4]
18782  Pla2g2d; phospholipase A2, group IID [KO:K01047] [EC:3.1.1.4]
26970  Pla2g2e; phospholipase A2, group IIE [KO:K01047] [EC:3.1.1.4]
66350  Pla2g12a; phospholipase A2, group XIIA [KO:K01047] [EC:3.1.1.4]
69836  Pla2g12b; phospholipase A2, group XIIB [KO:K01047] [EC:3.1.1.4]
26565  Pla2g10; phospholipase A2, group X [KO:K01047] [EC:3.1.1.4]
18780  Pla2g2a; phospholipase A2, group IIA (platelets, synovial fluid) [KO:K01047] [EC:3.1.1.4]
237625  Pla2g3; phospholipase A2, group III [KO:K01047] [EC:3.1.1.4]
329502  Pla2g4e; phospholipase A2, group IVE [KO:K16342] [EC:3.1.1.4]
18783  Pla2g4a; phospholipase A2, group IVA (cytosolic, calcium-dependent) [KO:K16342] [EC:3.1.1.4]
211429  Pla2g4b; phospholipase A2, group IVB (cytosolic) [KO:K16342] [EC:3.1.1.4]
232889  Pla2g4c; phospholipase A2, group IVC (cytosolic, calcium-independent) [KO:K16342] [EC:3.1.1.4]
78390  Pla2g4d; phospholipase A2, group IVD [KO:K16342] [EC:3.1.1.4]
271844  Pla2g4f; phospholipase A2, group IVF [KO:K16342] [EC:3.1.1.4]
53357  Pla2g6; phospholipase A2, group VI [KO:K16343] [EC:3.1.1.4]
665270  Plb1; phospholipase B1 [KO:K14621] [EC:3.1.1.4 3.1.1.5]
225845  Plaat3; phospholipase A and acyltransferase 3 [KO:K16817] [EC:3.1.1.32 3.1.1.4]
19224  Ptgs1; prostaglandin-endoperoxide synthase 1 [KO:K00509] [EC:1.14.99.1]
19225  Ptgs2; prostaglandin-endoperoxide synthase 2 [KO:K11987] [EC:1.14.99.1]
64292  Ptges; prostaglandin E synthase [KO:K15729] [EC:5.3.99.3]
96979  Ptges2; prostaglandin E synthase 2 [KO:K05309] [EC:5.3.99.3]
56351  Ptges3; prostaglandin E synthase 3 [KO:K15730] [EC:5.3.99.3]
12408  Cbr1; carbonyl reductase 1 [KO:K00079] [EC:1.1.1.184 1.1.1.189 1.1.1.197]
12409  Cbr2; carbonyl reductase 2 [KO:K00081] [EC:1.1.1.184]
109857  Cbr3; carbonyl reductase 3 [KO:K00084] [EC:1.1.1.184]
66469  Prxl2b; peroxiredoxin like 2B [KO:K15717] [EC:1.11.1.20]
15446  Hpgd; hydroxyprostaglandin dehydrogenase 15 (NAD) [KO:K00069] [EC:1.1.1.141]
21391  Tbxas1; thromboxane A synthase 1, platelet [KO:K01832] [EC:5.3.99.5]
19215  Ptgds; prostaglandin D2 synthase (brain) [KO:K01830] [EC:5.3.99.2]
54486  Hpgds; hematopoietic prostaglandin D synthase [KO:K04097] [EC:5.3.99.2 2.5.1.18]
19223  Ptgis; prostaglandin I2 (prostacyclin) synthase [KO:K01831] [EC:5.3.99.4]
11689  Alox5; arachidonate 5-lipoxygenase [KO:K00461] [EC:1.13.11.34]
16993  Lta4h; leukotriene A4 hydrolase [KO:K01254] [EC:3.3.2.6]
225791  Ptgr3; prostaglandin reductase 3 [KO:K07119] [EC:1.3.1.48]
77219  Ptgr2; prostaglandin reductase 2 [KO:K13949] [EC:1.3.1.48]
67103  Ptgr1; prostaglandin reductase 1 [KO:K13948] [EC:1.3.1.74 1.3.1.48]
17001  Ltc4s; leukotriene C4 synthase [KO:K00807] [EC:4.4.1.20]
14598  Ggt1; gamma-glutamyltransferase 1 [KO:K18592] [EC:2.3.2.2 3.4.19.13 3.4.19.14]
23887  Ggt5; gamma-glutamyltransferase 5 [KO:K18592] [EC:2.3.2.2 3.4.19.13 3.4.19.14]
625249  Gpx4; glutathione peroxidase 4 [KO:K05361] [EC:1.11.1.12]
13106  Cyp2e1; cytochrome P450, family 2, subfamily e, polypeptide 1 [KO:K07415] [EC:1.14.14.-]
665095  Cyp2j8; cytochrome P450, family 2, subfamily j, polypeptide 8 [KO:K07418] [EC:1.14.14.1 1.14.14.73 1.14.14.74 1.14.14.75]
230459  Cyp2j13; cytochrome P450, family 2, subfamily j, polypeptide 13 [KO:K07418] [EC:1.14.14.1 1.14.14.73 1.14.14.74 1.14.14.75]
100066  Cyp2j11; cytochrome P450, family 2, subfamily j, polypeptide 11 [KO:K07418] [EC:1.14.14.1 1.14.14.73 1.14.14.74 1.14.14.75]
74519  Cyp2j9; cytochrome P450, family 2, subfamily j, polypeptide 9 [KO:K07418] [EC:1.14.14.1 1.14.14.73 1.14.14.74 1.14.14.75]
13109  Cyp2j5; cytochrome P450, family 2, subfamily j, polypeptide 5 [KO:K07418] [EC:1.14.14.1 1.14.14.73 1.14.14.74 1.14.14.75]
242546  Cyp2j12; cytochrome P450, family 2, subfamily j, polypeptide 12 [KO:K07418] [EC:1.14.14.1 1.14.14.73 1.14.14.74 1.14.14.75]
13110  Cyp2j6; cytochrome P450, family 2, subfamily j, polypeptide 6 [KO:K07418] [EC:1.14.14.1 1.14.14.73 1.14.14.74 1.14.14.75]
546837  Cyp2j7; cytochrome P450, family 2, subfamily j, polypeptide 7 [KO:K07418] [EC:1.14.14.1 1.14.14.73 1.14.14.74 1.14.14.75]
71519  Cyp2u1; cytochrome P450, family 2, subfamily u, polypeptide 1 [KO:K07422] [EC:1.14.14.80]
13118  Cyp4a12b; cytochrome P450, family 4, subfamily a, polypeptide 12B [KO:K07425] [EC:1.14.14.80]
13117  Cyp4a10; cytochrome P450, family 4, subfamily a, polypeptide 10 [KO:K07425] [EC:1.14.14.80]
13119  Cyp4a14; cytochrome P450, family 4, subfamily a, polypeptide 14 [KO:K07425] [EC:1.14.14.80]
435802  Cyp4a30b; cytochrome P450, family 4, subfamily a, polypeptide 30b [KO:K07425] [EC:1.14.14.80]
230639  Cyp4a29; cytochrome P450, family 4, subfamily a, polypeptide 29 [KO:K07425] [EC:1.14.14.80]
666168  Cyp4a31; cytochrome P450, family 4, subfamily a, polypeptide 31 [KO:K07425] [EC:1.14.14.80]
100040843  Cyp4a32; cytochrome P450, family 4, subfamily a, polypeptide 32 [KO:K07425] [EC:1.14.14.80]
277753  Cyp4a12a; cytochrome P450, family 4, subfamily a, polypeptide 12a [KO:K07425] [EC:1.14.14.80]
11684  Alox12; arachidonate 12-lipoxygenase [KO:K00458] [EC:1.13.11.31]
11685  Alox12e; arachidonate lipoxygenase, epidermal [KO:K00458] [EC:1.13.11.31]
23801  Aloxe3; arachidonate lipoxygenase 3 [KO:K18684] [EC:4.2.1.152 5.4.4.7]
11686  Alox12b; arachidonate 12-lipoxygenase, 12R type [KO:K08021] [EC:1.13.11.-]
11688  Alox8; arachidonate 8-lipoxygenase [KO:K08022] [EC:1.13.11.33 1.13.11.-]
13088  Cyp2b10; cytochrome P450, family 2, subfamily b, polypeptide 10 [KO:K07412] [EC:1.14.14.1]
13089  Cyp2b13; cytochrome P450, family 2, subfamily b, polypeptide 13 [KO:K07412] [EC:1.14.14.1]
13090  Cyp2b19; cytochrome P450, family 2, subfamily b, polypeptide 19 [KO:K07412] [EC:1.14.14.1]
13094  Cyp2b9; cytochrome P450, family 2, subfamily b, polypeptide 9 [KO:K07412] [EC:1.14.14.1]
243881  Cyp2b23; cytochrome P450, family 2, subfamily b, polypeptide 23 [KO:K07412] [EC:1.14.14.1]
13097  Cyp2c38; cytochrome P450, family 2, subfamily c, polypeptide 38 [KO:K07413] [EC:1.14.14.1]
13098  Cyp2c39; cytochrome P450, family 2, subfamily c, polypeptide 39 [KO:K07413] [EC:1.14.14.1]
13099  Cyp2c40; cytochrome P450, family 2, subfamily c, polypeptide 40 [KO:K07413] [EC:1.14.14.1]
226143  Cyp2c23; cytochrome P450, family 2, subfamily c, polypeptide 23 [KO:K07413] [EC:1.14.14.1]
13095  Cyp2c29; cytochrome P450, family 2, subfamily c, polypeptide 29 [KO:K07413] [EC:1.14.14.1]
226105  Cyp2c70; cytochrome P450, family 2, subfamily c, polypeptide 70 [KO:K07413] [EC:1.14.14.1]
13096  Cyp2c37; cytochrome P450, family 2. subfamily c, polypeptide 37 [KO:K07413] [EC:1.14.14.1]
72082  Cyp2c55; cytochrome P450, family 2, subfamily c, polypeptide 55 [KO:K07413] [EC:1.14.14.1]
72303  Cyp2c65; cytochrome P450, family 2, subfamily c, polypeptide 65 [KO:K07413] [EC:1.14.14.1]
69888  Cyp2c66; cytochrome P450, family 2, subfamily c, polypeptide 66 [KO:K07413] [EC:1.14.14.1]
107141  Cyp2c50; cytochrome P450, family 2, subfamily c, polypeptide 50 [KO:K07413] [EC:1.14.14.1]
404195  Cyp2c54; cytochrome P450, family 2, subfamily c, polypeptide 54 [KO:K07413] [EC:1.14.14.1]
433247  Cyp2c68; cytochrome P450, family 2, subfamily c, polypeptide 68 [KO:K07413] [EC:1.14.14.1]
100043108  Cyp2c69; cytochrome P450, family 2, subfamily c, polypeptide 69 [KO:K07413] [EC:1.14.14.1]
545288  Cyp2c67; cytochrome P450, family 2, subfamily c, polypeptide 67 [KO:K07413] [EC:1.14.14.1]
13850  Ephx2; epoxide hydrolase 2, cytoplasmic [KO:K08726] [EC:3.3.2.10 3.1.3.76]
11687  Alox15; arachidonate 15-lipoxygenase [KO:K00460] [EC:1.13.11.33]
Compound
C00157  Phosphatidylcholine
C00219  Arachidonate
C00427  Prostaglandin H2
C00584  Prostaglandin E2
C00639  Prostaglandin F2alpha
C00696  Prostaglandin D2
C00909  Leukotriene A4
C01312  Prostaglandin I2
C02165  Leukotriene B4
C02166  Leukotriene C4
C02198  Thromboxane A2
C03577  20-Hydroxyleukotriene E4
C04577  15-OxoETE
C04671  (5Z)-11alpha-Hydroxy-9,15-dioxoprostanoate
C04707  (5Z,13E)-11alpha-Hydroxy-9,15-dioxoprost-5,13-dienoate
C04742  (15S)-15-Hydroxy-5,8,11-cis-13-trans-eicosatetraenoate
C04758  (5Z,13E)-9alpha-Hydroxy-11,15-dioxoprosta-5,13-dienoate
C04805  5(S)-HETE
C04822  8(R)-HPETE
C04835  (5Z,13E)-6,9alpha-Epoxy-11alpha-hydroxy-15-oxoprosta-5,13-dienoate
C04853  20-OH-Leukotriene B4
C05356  5(S)-HPETE
C05949  12-Keto-leukotriene B4
C05950  20-COOH-Leukotriene B4
C05951  Leukotriene D4
C05952  Leukotriene E4
C05953  Prostaglandin A2
C05954  Prostaglandin B2
C05955  Prostaglandin C2
C05956  Prostaglandin G2
C05957  Prostaglandin J2
C05958  Delta-12-Prostaglandin J2
C05959  11-epi-Prostaglandin F2alpha
C05960  15-Keto-prostaglandin F2alpha
C05961  6-Keto-prostaglandin F1alpha
C05962  6-Keto-prostaglandin E1
C05963  Thromboxane B2
C05964  11-Dehydro-thromboxane B2
C05965  12(S)-HPETE
C05966  15(S)-HPETE
C06314  Lipoxin A4
C06315  Lipoxin B4
C06462  Leukotriene F4
C13809  9,11,15-Trihydroxy-prosta-5,13-dien-1-oic acid
C14717  15-Deoxy-Delta12,14-PGJ2
C14732  5-OxoETE
C14748  20-HETE
C14749  19(S)-HETE
C14768  5,6-EET
C14769  8,9-EET
C14770  11,12-EET
C14771  14,15-EET
C14772  5,6-DHET
C14773  8,9-DHET
C14774  11,12-DHET
C14775  14,15-DHET
C14776  8(S)-HETE
C14777  12(S)-HETE
C14778  16(R)-HETE
C14779  9(S)-HETE
C14780  11(R)-HETE
C14781  15H-11,12-EETA
C14782  11,12,15-THETA
C14794  2,3-Dinor-8-iso prostaglandin F2alpha
C14795  2,3-Dinor-8-iso prostaglandin F1alpha
C14807  12-OxoETE
C14808  Hepoxilin A3
C14809  Trioxilin A3
C14810  Hepoxilin B3
C14811  Trioxilin B3
C14812  12(R)-HPETE
C14813  11H-14,15-EETA
C14814  11,14,15-THETA
C14815  5,6-Epoxytetraene
C14820  11(R)-HPETE
C14821  9(S)-HPETE
C14822  12(R)-HETE
C14823  8(S)-HPETE
C14824  8(R)-HETE
Reference
  Authors
Spector AA, Fang X, Snyder GD, Weintraub NL.
  Title
Epoxyeicosatrienoic acids (EETs): metabolism and biochemical function.
  Journal
Prog Lipid Res 43:55-90 (2004)
DOI:10.1016/S0163-7827(03)00049-3
Reference
  Authors
Harman CA, Rieke CJ, Garavito RM, Smith WL.
  Title
Crystal structure of arachidonic acid bound to a mutant of prostaglandin endoperoxide H synthase-1 that forms predominantly 11-hydroperoxyeicosatetraenoic acid.
  Journal
J Biol Chem 279:42929-35 (2004)
DOI:10.1074/jbc.M403013200
Reference
  Authors
Poloyac SM, Tortorici MA, Przychodzin DI, Reynolds RB, Xie W, Frye RF, Zemaitis MA.
  Title
The effect of isoniazid on CYP2E1- and CYP4A-mediated hydroxylation of arachidonic acid in the rat liver and kidney.
  Journal
Drug Metab Dispos 32:727-33 (2004)
DOI:10.1124/dmd.32.7.727
Reference
  Authors
Chuang SS, Helvig C, Taimi M, Ramshaw HA, Collop AH, Amad M, White JA, Petkovich M, Jones G, Korczak B.
  Title
CYP2U1, a novel human thymus- and brain-specific cytochrome P450, catalyzes omega- and (omega-1)-hydroxylation of fatty acids.
  Journal
J Biol Chem 279:6305-14 (2004)
DOI:10.1074/jbc.M311830200
Reference
  Authors
Sacerdoti D, Gatta A, McGiff JC.
  Title
Role of cytochrome P450-dependent arachidonic acid metabolites in liver physiology and pathophysiology.
  Journal
Prostaglandins Other Lipid Mediat 72:51-71 (2003)
DOI:10.1016/S1098-8823(03)00077-7
Reference
  Authors
Pfister SL, Spitzbarth N, Zeldin DC, Lafite P, Mansuy D, Campbell WB.
  Title
Rabbit aorta converts 15-HPETE to trihydroxyeicosatrienoic acids: potential role of cytochrome P450.
  Journal
Arch Biochem Biophys 420:142-52 (2003)
DOI:10.1016/j.abb.2003.09.026
Reference
  Authors
Fleming I.
  Title
Cytochrome p450 and vascular homeostasis.
  Journal
Circ Res 89:753-62 (2001)
DOI:10.1161/hh2101.099268
Reference
  Authors
Qu W, Bradbury JA, Tsao CC, Maronpot R, Harry GJ, Parker CE, Davis LS, Breyer MD, Waalkes MP, Falck JR, Chen J, Rosenberg RL, Zeldin DC.
  Title
Cytochrome P450 CYP2J9, a new mouse arachidonic acid omega-1 hydroxylase predominantly expressed in brain.
  Journal
J Biol Chem 276:25467-79 (2001)
DOI:10.1074/jbc.M100545200
Reference
  Authors
Tsao CC, Foley J, Coulter SJ, Maronpot R, Zeldin DC, Goldstein JA.
  Title
CYP2C40, a unique arachidonic acid 16-hydroxylase, is the major CYP2C in murine intestinal tract.
  Journal
Mol Pharmacol 58:279-87 (2000)
DOI:10.1124/mol.58.2.279
Reference
PMID:9812980
  Authors
Pfister SL, Spitzbarth N, Nithipatikom K, Edgemond WS, Falck JR, Campbell WB.
  Title
Identification of the 11,14,15- and 11,12, 15-trihydroxyeicosatrienoic acids as endothelium-derived relaxing factors of rabbit aorta.
  Journal
J Biol Chem 273:30879-87 (1998)
DOI:10.1074/jbc.273.47.30879
Related
pathway
mmu00591  Linoleic acid metabolism
KO pathway
ko00590   

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