KEGG   Mus musculus (mouse): 104110
Entry
104110            CDS       T01002                                 

Gene name
Adcy4, mKIAA4004
Definition
(RefSeq) adenylate cyclase 4
  KO
K08044  adenylate cyclase 4 [EC:4.6.1.1]
Organism
mmu  Mus musculus (mouse)
Pathway
mmu00230  Purine metabolism
mmu01100  Metabolic pathways
mmu01522  Endocrine resistance
mmu04015  Rap1 signaling pathway
mmu04020  Calcium signaling pathway
mmu04022  cGMP-PKG signaling pathway
mmu04024  cAMP signaling pathway
mmu04062  Chemokine signaling pathway
mmu04072  Phospholipase D signaling pathway
mmu04114  Oocyte meiosis
mmu04211  Longevity regulating pathway
mmu04213  Longevity regulating pathway - multiple species
mmu04261  Adrenergic signaling in cardiomyocytes
mmu04270  Vascular smooth muscle contraction
mmu04371  Apelin signaling pathway
mmu04540  Gap junction
mmu04611  Platelet activation
mmu04713  Circadian entrainment
mmu04714  Thermogenesis
mmu04723  Retrograde endocannabinoid signaling
mmu04724  Glutamatergic synapse
mmu04725  Cholinergic synapse
mmu04727  GABAergic synapse
mmu04742  Taste transduction
mmu04750  Inflammatory mediator regulation of TRP channels
mmu04911  Insulin secretion
mmu04912  GnRH signaling pathway
mmu04913  Ovarian steroidogenesis
mmu04914  Progesterone-mediated oocyte maturation
mmu04915  Estrogen signaling pathway
mmu04916  Melanogenesis
mmu04918  Thyroid hormone synthesis
mmu04921  Oxytocin signaling pathway
mmu04923  Regulation of lipolysis in adipocytes
mmu04925  Aldosterone synthesis and secretion
mmu04926  Relaxin signaling pathway
mmu04927  Cortisol synthesis and secretion
mmu04928  Parathyroid hormone synthesis, secretion and action
mmu04934  Cushing syndrome
mmu04935  Growth hormone synthesis, secretion and action
mmu04970  Salivary secretion
mmu04971  Gastric acid secretion
mmu04972  Pancreatic secretion
mmu04976  Bile secretion
mmu05032  Morphine addiction
mmu05163  Human cytomegalovirus infection
mmu05166  Human T-cell leukemia virus 1 infection
mmu05200  Pathways in cancer
mmu05414  Dilated cardiomyopathy (DCM)
Brite
KEGG Orthology (KO) [BR:mmu00001]
 09100 Metabolism
  09104 Nucleotide metabolism
   00230 Purine metabolism
    104110 (Adcy4)
 09130 Environmental Information Processing
  09132 Signal transduction
   04015 Rap1 signaling pathway
    104110 (Adcy4)
   04371 Apelin signaling pathway
    104110 (Adcy4)
   04020 Calcium signaling pathway
    104110 (Adcy4)
   04072 Phospholipase D signaling pathway
    104110 (Adcy4)
   04024 cAMP signaling pathway
    104110 (Adcy4)
   04022 cGMP-PKG signaling pathway
    104110 (Adcy4)
 09140 Cellular Processes
  09143 Cell growth and death
   04114 Oocyte meiosis
    104110 (Adcy4)
  09144 Cellular community - eukaryotes
   04540 Gap junction
    104110 (Adcy4)
 09150 Organismal Systems
  09151 Immune system
   04611 Platelet activation
    104110 (Adcy4)
   04062 Chemokine signaling pathway
    104110 (Adcy4)
  09152 Endocrine system
   04911 Insulin secretion
    104110 (Adcy4)
   04923 Regulation of lipolysis in adipocytes
    104110 (Adcy4)
   04912 GnRH signaling pathway
    104110 (Adcy4)
   04913 Ovarian steroidogenesis
    104110 (Adcy4)
   04915 Estrogen signaling pathway
    104110 (Adcy4)
   04914 Progesterone-mediated oocyte maturation
    104110 (Adcy4)
   04921 Oxytocin signaling pathway
    104110 (Adcy4)
   04926 Relaxin signaling pathway
    104110 (Adcy4)
   04935 Growth hormone synthesis, secretion and action
    104110 (Adcy4)
   04918 Thyroid hormone synthesis
    104110 (Adcy4)
   04928 Parathyroid hormone synthesis, secretion and action
    104110 (Adcy4)
   04916 Melanogenesis
    104110 (Adcy4)
   04925 Aldosterone synthesis and secretion
    104110 (Adcy4)
   04927 Cortisol synthesis and secretion
    104110 (Adcy4)
  09153 Circulatory system
   04261 Adrenergic signaling in cardiomyocytes
    104110 (Adcy4)
   04270 Vascular smooth muscle contraction
    104110 (Adcy4)
  09154 Digestive system
   04970 Salivary secretion
    104110 (Adcy4)
   04971 Gastric acid secretion
    104110 (Adcy4)
   04972 Pancreatic secretion
    104110 (Adcy4)
   04976 Bile secretion
    104110 (Adcy4)
  09156 Nervous system
   04724 Glutamatergic synapse
    104110 (Adcy4)
   04727 GABAergic synapse
    104110 (Adcy4)
   04725 Cholinergic synapse
    104110 (Adcy4)
   04723 Retrograde endocannabinoid signaling
    104110 (Adcy4)
  09157 Sensory system
   04742 Taste transduction
    104110 (Adcy4)
   04750 Inflammatory mediator regulation of TRP channels
    104110 (Adcy4)
  09149 Aging
   04211 Longevity regulating pathway
    104110 (Adcy4)
   04213 Longevity regulating pathway - multiple species
    104110 (Adcy4)
  09159 Environmental adaptation
   04713 Circadian entrainment
    104110 (Adcy4)
   04714 Thermogenesis
    104110 (Adcy4)
 09160 Human Diseases
  09161 Cancer: overview
   05200 Pathways in cancer
    104110 (Adcy4)
  09165 Substance dependence
   05032 Morphine addiction
    104110 (Adcy4)
  09166 Cardiovascular disease
   05414 Dilated cardiomyopathy (DCM)
    104110 (Adcy4)
  09167 Endocrine and metabolic disease
   04934 Cushing syndrome
    104110 (Adcy4)
  09172 Infectious disease: viral
   05166 Human T-cell leukemia virus 1 infection
    104110 (Adcy4)
   05163 Human cytomegalovirus infection
    104110 (Adcy4)
  09176 Drug resistance: antineoplastic
   01522 Endocrine resistance
    104110 (Adcy4)
Enzymes [BR:mmu01000]
 4. Lyases
  4.6  Phosphorus-oxygen lyases
   4.6.1  Phosphorus-oxygen lyases (only sub-subclass identified to date)
    4.6.1.1  adenylate cyclase
     104110 (Adcy4)
SSDB
Motif
Pfam: Guanylate_cyc DUF1053 AC_N CD52
Other DBs
NCBI-GeneID: 104110
NCBI-ProteinID: NP_536683
MGI: 99674
Ensembl: ENSMUSG00000022220
UniProt: Q91WF3
Position
14; 14 C3
AA seq 1077 aa
MARLFSPRPPPSEDLFYETYYSLSQQYPLLILLLVIVLCALVALPAVAWASGRELTSDPS
FLTTVLCALGGFSLLLGLASREQQLQRWTRPLSGLIWVALLALGYGFLFTGGVVSAWDQV
SFFLFIIFTVYAMLPLGMRDAAAAGVISSLSHLLVLGLYLGWQPESQRALLPQLAANAVL
FLCGNVVGAYHKALMERALRATFREALSSLHSRRRLDTEKKHQEHLLLSILPAYLAREMK
AEIMARLQAGQRSRPENTNNFHSLYVKRHQGVSVLYADIVGFTRLASECSPKELVLMLNE
LFGKFDQIAKEHECMRIKILGDCYYCVSGLPLSLPDHAINCVRMGLDMCRAIRKLRVATG
VDINMRVGVHSGSVLCGVIGLQKWQYDVWSHDVTLANHMEAGGVPGRVHITGATLALLAG
AYAVERADTEHRDPYLRELGEPTYLVIDPRAEEEDEKGTAKGLLSSLEGHTMRPSLLMTR
YLESWGAAKPFAHLSHLDSPVSTSTPLPEKAFSPQWSLDRSRTPRGLDDELDTGDAKFFQ
VIEQLNSQKQWKQSKDFNLLTLYFREKEMEKQYRLSALPAFKYYAACTFLVFLSNFTIQM
LVTTRPPALIITYSITFLLFFLLLFVCFSEHLTKCVQKGPKMLHWLPALSVLVATRPGFR
VALGTATILLVFTMAIASLLFLPVSSDCLFLASNVSSVTFNASWEMPGSLPLISIPLISI
PYSMHCCVLGFLSCSLFLHMSFELKLLLLLLWLVASCSLFLHSHAWLSDCLIARLYQSPS
DSRPGVLKEPKLMGAIYFFIFFFTLLVLARQNEYYCRLDFLWKKKLRQEREETETMENLT
RLLLENVLPAHVAPQFIGQNRRNEDLYHQSYECVCVLFASVPDFKEFYSESNINHEGLEC
LRLLNEIIADFDELLSKPKFSGVEKIKTIGSTYMAATGLNATSGQDTQQDSERSCSHLGT
MVEFAVALGSKLGVINKHSFNNFRLRVGLNHGPVVAGVIGAQKPQYDIWGNTVNVASRME
STGVLGKIQVTEETARALQSLGYTCYSRGSIKVKGKGELCTYFLNTDLTRTGSPSAS
NT seq 3234 nt   +upstreamnt  +downstreamnt
atggcccgcctcttcagtccccggcctcctcccagcgaagatctcttctacgaaacttac
tacagcctgagccaacagtacccactgctgatactgcttttggtcattgtgctctgcgcg
ctggtggcactgcccgccgtcgcctgggccagcggcagggagctgacctcagacccaagc
ttcctgacaactgtgctgtgtgctttgggtggcttctctctgctattggggcttgcttcc
cgggagcagcaactgcagcgatggacacgacctctttctggtctcatatgggttgcatta
ctggctctgggctatggatttctgttcactgggggtgtggtgagcgcctgggaccaggtg
tcttttttcctcttcatcatcttcaccgtgtacgccatgctgcccttgggcatgcgggat
gctgctgctgcgggagtcatctcatccctctcgcacctgctggtccttggactgtatctt
gggtggcagcctgagtcacagagagctctgctaccacagttggcagcaaacgcggtattg
ttcctgtgtgggaacgtggtgggagcgtaccacaaggccctgatggagcgagcattgcgg
gccacgttccgggaggctcttagctctctgcactcacgccggaggctggacactgagaaa
aagcaccaggagcacctcctcttgtctatccttcctgcctacctggcccgagagatgaaa
gcagagatcatggcccggctgcaggctggacagcgctcacggccagagaacacaaacaac
tttcacagcctgtatgtcaagaggcaccaaggagtgagtgtgctgtatgctgacatcgtg
ggcttcacgcggctggccagcgagtgttccccgaaggagctggtgctcatgctgaatgag
ctctttggcaagttcgaccaaattgccaaggagcacgaatgcatgcggatcaagatcctg
ggagactgttactactgtgtctccgggctgcccctctcgctgcctgaccacgctatcaat
tgtgtgcgcatggggctggacatgtgccgggccatcaggaaacttcgggtagccaccggt
gtggatatcaacatgcgtgtgggcgtgcactcgggcagcgttctctgtggagtcattggg
ctacagaagtggcagtatgatgtctggtcccatgatgtcacattggccaaccatatggaa
gcaggcggtgtaccaggacgagtgcacatcacaggggccacgctggccctgctagcagga
gcttatgctgtggagagggcagacacggaacaccgagacccataccttcgggagctagga
gaacctacatacctggtcattgatcctcgggctgaggaggaagacgagaagggcaccgca
aaaggattgctgtcttctctggaggggcacacgatgcgtccgtcactactgatgactcgc
tatctggagtcttggggtgcagccaagcctttcgcccacctaagccaccttgacagtccc
gtgtccacctccactccactcccggagaaagccttcagcccccagtggagcctggaccgg
agtcgcaccccccggggactagatgatgaactggacactggtgatgctaagttcttccag
gtcatcgaacaactcaactctcagaaacagtggaagcagtcgaaggacttcaacctcctg
acgctgtacttcagagagaaggagatggagaaacagtatcggctctctgcactccccgcc
ttcaaatactacgcagcctgcaccttcctggtttttctgtccaacttcactatccaaatg
ctggtgacaaccaggcccccagctctgatcatcacctacagcatcaccttccttctcttc
tttctcctcctcttcgtctgcttctcagagcacctgacgaagtgtgtccagaaaggtccc
aagatgttgcactggctgcctgcactgtctgtcctggtggccacacggccaggatttcga
gtagccctgggtacggccaccatcctcctggtattcactatggccatcgccagcctgctc
ttcttaccagtgtcatcagactgccttttcctggcttccaatgtgtcatctgtgactttc
aatgcttcctgggagatgccaggatccctgcccctcatcagcatccccctcatcagcatc
ccatactccatgcattgctgcgtgttgggtttcctctcctgctccctttttctgcacatg
agcttcgaactgaagctgctcctacttctgctgtggctggtggcatcttgttccctattt
ctgcattcccacgcctggctgtctgactgcctcattgcccgcctttatcaaagcccttcg
gactccagaccaggggtactgaaggaacccaagctgatgggagcgatctacttcttcatc
ttcttcttcacactcctggtcctggctcggcagaatgagtattactgccgcctggacttc
ctgtggaaaaagaaactgaggcaggagcgagaggagactgagacaatggagaacctgacc
cggctcctcctggagaatgtactccctgcacacgtggccccccagttcatcggccagaac
cggcgcaatgaggacctctaccaccagtcgtacgaatgcgtttgtgtcctcttcgcgtcg
gtcccagactttaaggaattctactctgaatccaacatcaaccacgaggggctggagtgc
ctgcggctgctcaatgagatcattgctgactttgatgagctgctctccaagccaaagttc
agtggagtagagaagatcaaaactattggcagtacctacatggcggccacaggcttaaat
gccacctctggacaggatactcagcaggattctgagagaagctgcagtcatctgggcacc
atggtggaatttgcagtggccctggggtctaagctgggagtcatcaacaagcactcgttc
aataacttccgcctgcgtgtggggttgaaccacggaccagtagtagcaggggtgattggg
gcgcagaagccacagtacgacatctgggggaacacagtgaatgtggccagccgaatggag
agcacaggcgttctcggcaagatccaagtgactgaggagacagcgcgggccctgcagtcc
ctgggttacacgtgctatagcagaggcagcatcaaggtcaaaggcaaaggggaactctgt
acctacttcctgaacacagacctgacgcggaccggatctccctcagcatcctag

DBGET integrated database retrieval system