KEGG   Mus musculus (house mouse): 110891
Entry
110891            CDS       T01002                                 
Symbol
Slc8a2, Ncx2
Name
(RefSeq) solute carrier family 8 (sodium/calcium exchanger), member 2
  KO
K05849  solute carrier family 8 (sodium/calcium exchanger)
Organism
mmu  Mus musculus (house mouse)
Pathway
mmu04020  Calcium signaling pathway
mmu04022  cGMP-PKG signaling pathway
mmu04260  Cardiac muscle contraction
mmu04261  Adrenergic signaling in cardiomyocytes
mmu04371  Apelin signaling pathway
mmu04740  Olfactory transduction
mmu04961  Endocrine and other factor-regulated calcium reabsorption
mmu04974  Protein digestion and absorption
mmu04978  Mineral absorption
mmu05410  Hypertrophic cardiomyopathy
mmu05412  Arrhythmogenic right ventricular cardiomyopathy
mmu05414  Dilated cardiomyopathy
Brite
KEGG Orthology (KO) [BR:mmu00001]
 09130 Environmental Information Processing
  09132 Signal transduction
   04371 Apelin signaling pathway
    110891 (Slc8a2)
   04020 Calcium signaling pathway
    110891 (Slc8a2)
   04022 cGMP-PKG signaling pathway
    110891 (Slc8a2)
 09150 Organismal Systems
  09153 Circulatory system
   04260 Cardiac muscle contraction
    110891 (Slc8a2)
   04261 Adrenergic signaling in cardiomyocytes
    110891 (Slc8a2)
  09154 Digestive system
   04974 Protein digestion and absorption
    110891 (Slc8a2)
   04978 Mineral absorption
    110891 (Slc8a2)
  09155 Excretory system
   04961 Endocrine and other factor-regulated calcium reabsorption
    110891 (Slc8a2)
  09157 Sensory system
   04740 Olfactory transduction
    110891 (Slc8a2)
 09160 Human Diseases
  09166 Cardiovascular disease
   05410 Hypertrophic cardiomyopathy
    110891 (Slc8a2)
   05412 Arrhythmogenic right ventricular cardiomyopathy
    110891 (Slc8a2)
   05414 Dilated cardiomyopathy
    110891 (Slc8a2)
 09180 Brite Hierarchies
  09183 Protein families: signaling and cellular processes
   02000 Transporters [BR:mmu02000]
    110891 (Slc8a2)
   00536 Glycosaminoglycan binding proteins [BR:mmu00536]
    110891 (Slc8a2)
Transporters [BR:mmu02000]
 Solute carrier family (SLC)
  SLC8: Na+/Ca2+ exchanger
   110891 (Slc8a2)
Glycosaminoglycan binding proteins [BR:mmu00536]
 Heparan sulfate / Heparin
  Others
   110891 (Slc8a2)
SSDB
Motif
Pfam: Calx-beta Na_Ca_ex Na_Ca_ex_C
Other DBs
NCBI-GeneID: 110891
NCBI-ProteinID: NP_683748
MGI: 107996
Ensembl: ENSMUSG00000030376
UniProt: Q8K596
Position
7:15861540..15894988
AA seq 921 aa
MAPLALMGVVLLLGVPHCLGEATPTPSLPPPTANDSDASPEGCQGSYRCQPGVLLPVWEP
EDPSLGDKVARAVVYFVAMVYMFLGVSIIADRFMASIEVITSKEKEITITKANGETSVGT
VRIWNETVSNLTLMALGSSAPEILLTVIEVCGHNFQAGELGPGTIVGSAAFNMFVVIAVC
VYVIPAGESRKIKHLRVFFVTASWSIFAYVWLYLILAVFSPGVVQVWEALLTLIFFPVCV
VFAWMADKRLLFYKYVYKRYRTDPRSGIIIGAEGDPPKSIELDGTFVGTEVPGELGALGT
GPAEARELDASRREVIQILKDLKQKHPDKDLEQLMGIAKYYALLHQQKSRAFYRIQATRL
MTGAGNVLRRHAADAARRPGATDGAPDDEDDGASRIFFEPSLYHCLENCGSVLLSVACQG
GEGNSTFYVDYRTEDGSAKAGSDYEYSEGTLVFKPGETQKDLRIGIIDDDIFEEDEHFFV
RLLNLRVGDAQGMFEPDGGGRPKGRLVAPLLATVTILDDDHAGIFSFQDRLLHVSECMGT
VDVRVVRSSGARGTVRLPYRTVDGTARGGGVHYEDACGELEFGDDETMKTLQVKIVDDEE
YEKKDNFFIELGQPQWLKRGISALLLNQGNGDKKITAEQEEAQRIAEMGKPVLGENNRLE
VIIEESYDFKNTVDKLIKKTNLALVIGTHSWREQFIEAVTVSAGDEEEDEDGPREERLPS
CFDYVMHFLTVFWKVLFACVPPTEYCNGWACFGVCILVIGVLTALIGDLASHFGCTVGLK
DSVNAVVFVALGTSIPDTFASKVAALQDQCADASIGNVTGSNAVNVFLGLGVAWSVAAVY
WAVQGRPFEVRAGTLAFSVTLFTVFAFVCIAVLLYRRRPQIGGELGGPRGPKLATTALFL
GLWFLYILFSSLEAYCHIRGF
NT seq 2766 nt   +upstreamnt  +downstreamnt
atggctcccttggctttgatgggggttgttctccttctgggggtaccccactgcttgggg
gaagccactccgaccccttccctaccgcctcccacagctaatgacagcgatgccagccca
gaaggctgccaaggttcctaccgctgccaaccaggtgtgctgctgcctgtgtgggaaccc
gaggacccatcgctgggcgacaaggttgcacgggccgtggtgtactttgtggccatggtc
tacatgttcctgggtgtgtctatcattgccgatcgatttatggcatccattgaggtcatc
acatccaaggagaaagagatcaccatcaccaaggcaaatggggagaccagcgtgggcacg
gtgcgcatctggaacgagacggtgtccaaccttacactcatggccctgggctcctcagcg
cctgagattctgttgactgtcatcgaggtctgtggccacaacttccaggccggtgagcta
ggcccaggcaccatcgtgggcagtgccgccttcaacatgtttgtggtcattgctgtttgt
gtgtatgtcatcccggctggcgagagccgtaagatcaagcacctgagggtcttctttgtc
acagcctcctggagcatctttgcctatgtctggctttatctcattctagcagttttctcc
ccaggtgtagtccaggtgtgggaggcactgctcacactgatcttcttcccggtgtgtgtg
gtgtttgcctggatggcggacaagcgactgctcttctacaagtacgtgtacaagcgctac
cgcaccgaccctcgcagtggaatcatcatcggggcagagggagacccacccaagagcatc
gagctggacggcacattcgtgggcactgaggtccctggcgagctgggcgcattgggcaca
ggtcctgctgaggcgcgtgaactagatgccagccggcgtgaggtcatccagatccttaag
gacttgaagcagaagcacccggataaggacctggagcagctgatgggcatcgccaagtac
tatgcactgctgcaccagcagaagagccgcgccttctaccgcatccaggccacgcggctg
atgacaggtgcgggcaatgtgctgcgcagacatgctgcggatgctgcccgcaggccggga
gccaccgatggtgcccccgatgatgaggacgatggtgccagtcgcatcttctttgagccc
agcctctatcactgcctggaaaactgcgggtcagtgctgctgtccgtggcttgccagggc
ggtgagggcaacagcaccttctacgtggactaccgtaccgaggacggttctgcaaaggca
ggctccgattatgagtacagcgagggcacgctggtgttcaagcccggggagacgcagaag
gacctgcgcatcgggatcatcgacgacgacatcttcgaggaggatgagcacttcttcgtg
aggctgctgaacctgcgtgtgggcgatgctcagggcatgttcgagcccgacggcggtggg
cggcccaaggggcggctggtggcgccgctgctggccactgtcaccatcctggacgacgac
cacgcgggcatcttctccttccaggaccgcctgctgcatgtgagcgagtgcatgggcact
gtggatgtgcgcgtggttcgcagctcgggcgcccgtggcactgtacgcctcccctaccgc
acagtggacggcacggcccgtggcggtggtgtacattacgaggatgcttgtggagagctg
gagttcggcgatgatgagaccatgaaaactcttcaggtcaagatagtggatgatgaagag
tatgagaagaaggacaacttcttcattgagctgggccagccccagtggcttaagcgaggc
atctcagctctgctactcaaccaagggaatggagacaagaagataactgcagagcaggag
gaggcccagaggatagcagagatgggcaagccagttcttggggagaacaatcgcctcgag
gtcatcatcgaggagtcttatgactttaagaacacggtggataaactcataaagaaaacg
aacctggccttggtgattgggactcactcatggagggagcagtttatagaggcagttacc
gtaagcgcaggggacgaggaggaggatgaggatggacctcgtgaggagcggctgccgtcc
tgctttgactacgtgatgcacttcctgacggtattctggaaagttctattcgcctgcgtt
ccacccacggagtactgcaatggctgggcctgctttggtgtctgcatcctggtcattggt
gtgctcactgccctcatcggagacctggcctcacactttgggtgcaccgtgggcctcaag
gactcagtcaacgccgtggtcttcgtagccctgggcacctccatccctgacacgttcgcc
agcaaggtggccgcgctgcaggaccagtgtgccgacgcgtccatcggtaacgtgaccggc
tccaatgcggtgaacgtgttcctgggcctgggtgtggcctggtcggtggcagcggtatac
tgggcggtgcagggtcgccccttcgaggtgcgtgcaggcacgctggccttctcggtcacg
ctgttcaccgtcttcgccttcgtgtgcatcgcagtgctgttgtaccggcgccggccgcag
attggcggcgagctgggcggcccgcggggacccaagctggccaccaccgctctcttcctg
ggcctctggttcctctacattctcttctccagcctggaggcttactgccacatccggggc
ttctag

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