KEGG   Mus musculus (house mouse): 12289
Entry
12289             CDS       T01002                                 
Symbol
Cacna1d, 8430418G19Rik, Cach3, Cacn4, Cacnl1a2, Cav1.3, Cchl1a, Cchl1a2, D-LTCC
Name
(RefSeq) calcium channel, voltage-dependent, L type, alpha 1D subunit
  KO
K04851  voltage-dependent calcium channel L type alpha-1D
Organism
mmu  Mus musculus (house mouse)
Pathway
mmu04010  MAPK signaling pathway
mmu04020  Calcium signaling pathway
mmu04022  cGMP-PKG signaling pathway
mmu04024  cAMP signaling pathway
mmu04218  Cellular senescence
mmu04260  Cardiac muscle contraction
mmu04261  Adrenergic signaling in cardiomyocytes
mmu04270  Vascular smooth muscle contraction
mmu04530  Tight junction
mmu04713  Circadian entrainment
mmu04723  Retrograde endocannabinoid signaling
mmu04724  Glutamatergic synapse
mmu04725  Cholinergic synapse
mmu04726  Serotonergic synapse
mmu04727  GABAergic synapse
mmu04728  Dopaminergic synapse
mmu04911  Insulin secretion
mmu04912  GnRH signaling pathway
mmu04921  Oxytocin signaling pathway
mmu04924  Renin secretion
mmu04925  Aldosterone synthesis and secretion
mmu04927  Cortisol synthesis and secretion
mmu04929  GnRH secretion
mmu04930  Type II diabetes mellitus
mmu04934  Cushing syndrome
mmu04935  Growth hormone synthesis, secretion and action
mmu04973  Carbohydrate digestion and absorption
mmu05010  Alzheimer disease
mmu05020  Prion disease
mmu05022  Pathways of neurodegeneration - multiple diseases
mmu05031  Amphetamine addiction
mmu05207  Chemical carcinogenesis - receptor activation
mmu05410  Hypertrophic cardiomyopathy
mmu05412  Arrhythmogenic right ventricular cardiomyopathy
mmu05414  Dilated cardiomyopathy
Brite
KEGG Orthology (KO) [BR:mmu00001]
 09130 Environmental Information Processing
  09132 Signal transduction
   04010 MAPK signaling pathway
    12289 (Cacna1d)
   04020 Calcium signaling pathway
    12289 (Cacna1d)
   04024 cAMP signaling pathway
    12289 (Cacna1d)
   04022 cGMP-PKG signaling pathway
    12289 (Cacna1d)
 09140 Cellular Processes
  09143 Cell growth and death
   04218 Cellular senescence
    12289 (Cacna1d)
  09144 Cellular community - eukaryotes
   04530 Tight junction
    12289 (Cacna1d)
 09150 Organismal Systems
  09152 Endocrine system
   04911 Insulin secretion
    12289 (Cacna1d)
   04929 GnRH secretion
    12289 (Cacna1d)
   04912 GnRH signaling pathway
    12289 (Cacna1d)
   04921 Oxytocin signaling pathway
    12289 (Cacna1d)
   04935 Growth hormone synthesis, secretion and action
    12289 (Cacna1d)
   04924 Renin secretion
    12289 (Cacna1d)
   04925 Aldosterone synthesis and secretion
    12289 (Cacna1d)
   04927 Cortisol synthesis and secretion
    12289 (Cacna1d)
  09153 Circulatory system
   04260 Cardiac muscle contraction
    12289 (Cacna1d)
   04261 Adrenergic signaling in cardiomyocytes
    12289 (Cacna1d)
   04270 Vascular smooth muscle contraction
    12289 (Cacna1d)
  09154 Digestive system
   04973 Carbohydrate digestion and absorption
    12289 (Cacna1d)
  09156 Nervous system
   04724 Glutamatergic synapse
    12289 (Cacna1d)
   04727 GABAergic synapse
    12289 (Cacna1d)
   04725 Cholinergic synapse
    12289 (Cacna1d)
   04728 Dopaminergic synapse
    12289 (Cacna1d)
   04726 Serotonergic synapse
    12289 (Cacna1d)
   04723 Retrograde endocannabinoid signaling
    12289 (Cacna1d)
  09159 Environmental adaptation
   04713 Circadian entrainment
    12289 (Cacna1d)
 09160 Human Diseases
  09161 Cancer: overview
   05207 Chemical carcinogenesis - receptor activation
    12289 (Cacna1d)
  09164 Neurodegenerative disease
   05010 Alzheimer disease
    12289 (Cacna1d)
   05020 Prion disease
    12289 (Cacna1d)
   05022 Pathways of neurodegeneration - multiple diseases
    12289 (Cacna1d)
  09165 Substance dependence
   05031 Amphetamine addiction
    12289 (Cacna1d)
  09166 Cardiovascular disease
   05410 Hypertrophic cardiomyopathy
    12289 (Cacna1d)
   05412 Arrhythmogenic right ventricular cardiomyopathy
    12289 (Cacna1d)
   05414 Dilated cardiomyopathy
    12289 (Cacna1d)
  09167 Endocrine and metabolic disease
   04930 Type II diabetes mellitus
    12289 (Cacna1d)
   04934 Cushing syndrome
    12289 (Cacna1d)
 09180 Brite Hierarchies
  09183 Protein families: signaling and cellular processes
   04040 Ion channels [BR:mmu04040]
    12289 (Cacna1d)
Ion channels [BR:mmu04040]
 Voltage-gated cation channels
  Calcium channel, voltage-gated (Cav)
   12289 (Cacna1d)
SSDB
Motif
Pfam: Ion_trans CAC1F_C Ca_chan_IQ GPHH PKD_channel
Other DBs
NCBI-GeneID: 12289
NCBI-ProteinID: NP_001289566
MGI: 88293
Ensembl: ENSMUSG00000015968
UniProt: Q99246
Position
14:complement(29761898..30213113)
AA seq 2179 aa
MMMMMMMKKMQHQRQHQEDHANEANYARGTRLPISGEGPTSQPNSSKQTVLSWQAAIDAA
RQAKAAQTMSTSAPPPVGSLSQRKRQQYAKSKKQGNSSNSRPARALFCLSLNNPIRRACI
SIVEWKPFDIFILLAIFANCVALAIYIPFPEDDSNSTNHNLEKVEYAFLIIFTVETFLKI
IAYGLLLHPNAYVRNGWNLLDFVIVIVGLFSVILEQLTKETEGGNHSSGKSGGFDVKALR
AFRVLRPLRLVSGVPSLQVVLNSIIKAMVPLLHIALLVLFVIIIYAIIGLELFIGKMHKT
CFFADSDIVAEEDPAPCAFSGNGRQCTANGTECRSGWVGPNGGITNFDNFAFAMLTVFQC
ITMEGWTDVLYWVNDAIGWEWPWVYFVSLIILGSFFVLNLVLGVLSGEFSKEREKAKARG
DFQKLREKQQLEEDLKGYLDWITQAEDIDPENEEEGGEEGKRNTSMPTSETESVNTENVS
GEGETQGCCGTLWCWWKRRGAAKTGPSGCRRWGQAISKSKLSRRWRRWNRFNRRRCRAAV
KSVTFYWLVIVLVFLNTLTISSEHYNQPDWLTQIQDIANKVLLALFTCEMLVKMYSLGLQ
AYFVSLFNRFDCFVVCGGITETILVELELMSPLGVSVFRCVRLLRIFKVTRHWTSLSNLV
ASLLNSMKSIASLLLLLFLFIIIFSLLGMQLFGGKFNFDETQTKRSTFDNFPQALLTVFQ
ILTGEDWNAVMYDGIMAYGGPSSSGMIVCIYFIILFICGNYILLNVFLAIAVDNLADAES
LNTAQKEEAEEKERKKIARKESLENKKNNKPEVNQIANSDNKVTIDDYQEDAEDKDPYPP
CDVPVGEEEEEEEEDEPEVPAGPRPRRISELNMKEKIAPIPEGSAFFILSKTNPIRVGCH
KLINHHIFTNLILVFIMLSSAALAAEDPIRSHSFRNTILGYFDYAFTAIFTVEILLKMTT
FGAFLHKGAFCRNYFNLLDMLVVGVSLVSFGIQSSAISVVKILRVLRVLRPLRAINRAKG
LKHVVQCVFVAIRTIGNIMIVTTLLQFMFACIGVQLFKGKFYRCTDEAKSNPEECRGLFI
LYKDGDVDSPVVRERIWQNSDFNFDNVLSAMMALFTVSTFEGWPALLYKAIDSNGENVGP
VYNYRVEISIFFIIYIIIVAFFMMNIFVGFVIVTFQEQGEKEYKNCELDKNQRQCVEYAL
KARPLRRYIPKNPYQYKFWYVVNSSPFEYMMFVLIMLNTLCLAMQHYEQSKMFNDAMDIL
NMVFTGVFTVEMVLKVIAFKPKGYFSDAWNTFDSLIVIGSIIDVALSEADPSESETIPLP
TATPGNSEESNRISITFFRLFRVMRLVKLLSRGEGIRTLLWTFIKSFQALPYVALLIAML
FFIYAVIGMQMFGKVAMRDNNQINRNNNFQTFPQAVLLLFRCATGEAWQEIMLACLPGKL
CDPDSDYNPGEEYTCGSNFAIVYFISFYMLCAFLIINLFVAVIMDNFDYLTRDWSILGPH
HLDEFKRIWSEYDPEAKGRIKHLDVVTLLRRIQPPLGFGKLCPHRVACKRLVAMNMPLNS
DGTVMFNATLFALVRTALKIKTEGNLEQANEELRAVIKKIWKKTSMKLLDQVVPPAGDDE
VTVGKFYATFLIQDYFRKFKKRKEQGLVGKYPAKNTTIALQAGLRTLHDIGPEIRRAISC
DLQDDEPEDSKPEEEDVFKRNGALLGNHVNHVNSDRRDSLQQTNTTHRPLHVQRPSMPPA
SDTEKPLFPPAGNSGCHNHHNHNSIGKQAPTSTNANLNNANMSKAAHGKPPSIGNLEHVS
ENGHYSCKHDRELQRRSSIKRTRYYETYIRSESGDEQFPTICREDPEIHGYFRDPRCLGE
QEYFSSEECCEDDSSPTWSRQNYNYYNRYPGSSMDFERPRGYHHPQGFLEDDDSPTGYDS
RRSPRRRLLPPTPPSHRRSSFNFECLRRQSSQDDVLPSPALPHRAALPLHLMQQQIMAVA
GLDSSKAQKYSPSHSTRSWATPPATPPYRDWSPCYTPLIQVDRSESMDQVNGSLPSLHRS
SWYTDEPDISYRTFTPASLTVPSSFRNKNSDKQRSADSLVEAVLISEGLGRYARDPKFVS
ATKHEIADACDLTIDEMESAASTLLNGSVCPRANGDMGPISHRQDYELQDFGPGYSDEEP
DPGREEEDLADEMICITTL
NT seq 6540 nt   +upstreamnt  +downstreamnt
atgatgatgatgatgatgatgaaaaaaatgcaacatcaacggcagcaccaagaggaccat
gcgaacgaggcaaactatgcaagaggcaccagactccctatttctggtgaaggaccaact
tctcagcccaacagctccaagcaaactgtcctatcttggcaagctgcaatcgatgctgct
agacaggccaaggccgcccagaccatgagcacctctgcacccccacctgtaggatctctc
tcccaaagaaaacgtcagcaatacgccaagagcaaaaaacagggtaactcgtctaacagc
cgacctgcccgtgcccttttctgtttatccctcaataaccccatccgaagagcctgcatt
agtatagtggaatggaaaccatttgacatatttatattattggctatttttgccaattgt
gtggccttagctatttacatcccattccctgaagatgattctaattcaacaaatcataac
ttggaaaaagtagaatatgccttcctgattatttttacagtggagacatttctgaagatt
atagcgtatggactgttgctgcatcctaatgcttacgttaggaatggatggaatttactg
gattttgttatagtaattgtaggattgtttagtgtaattctggaacaattaaccaaagaa
acagaaggcgggaaccactctagtggcaaatcaggaggctttgatgtcaaagccctccgt
gccttccgagtgttaagaccacttcgacttgtatcaggagtgcccagtttacaagttgtt
ctgaactccattataaaagccatggtccccctccttcacatagcccttttggtattattt
gtaattatcatctatgctattataggattggaactttttattggaaaaatgcacaaaaca
tgtttttttgctgactcagatatagtagctgaagaggacccagctccgtgtgcgttctca
gggaatggacgccagtgcaccgccaatggcacggaatgtaggagtggctgggttggcccc
aatggaggcatcactaactttgataactttgcctttgccatgctcactgtgttccagtgc
attaccatggagggctggacagatgtgctctactgggttaatgatgcgataggatgggaa
tggccatgggtgtattttgttagtctgatcatccttggctcatttttcgtccttaacctg
gttcttggtgtccttagtggagaattctccaaggaaagagagaaggctaaagctcgtgga
gatttccagaagcttcgggaaaaacagcagctggaagaggacctcaagggctacctggac
tggatcacccaggcagaagacatcgatcccgagaacgaggaggagggtggcgaggaaggc
aaacgaaacactagcatgcccaccagcgagactgaatctgtcaacacagagaacgtaagt
ggtgaaggcgagacccagggatgctgtggaactctctggtgctggtggaaaagaagaggc
gcggccaagaccgggccctctgggtgtcggcggtggggtcaggccatctcgaaatccaaa
ctcagccgtcgatggcgtcgctggaaccggttcaatcgcaggaggtgcagggctgccgtg
aagtctgtcacgttttactggctggtgattgtcctggtgtttctcaacactttaactatt
tcctctgagcattacaatcagccagactggctgacacagattcaagacatcgcaaacaaa
gtcctcttggctctgttcacctgtgagatgctggtgaagatgtacagcctgggcctccag
gcttactttgtctccctcttcaaccgcttcgattgctttgtggtgtgtgggggcatcacc
gaaaccatcctggtggaactggagctcatgtctcccctgggggtctccgtgttccggtgt
gtgcgcctcctgagaatcttcaaagtgaccaggcactggacctccctgagcaacttggtg
gcatccttgttaaactccatgaagtccatcgcctctctgctgttactcctcttcctcttc
atcatcatcttctccttgctggggatgcagttgtttggtgggaagtttaattttgacgag
actcaaaccaagcgaagcacctttgacaactttccgcaagcactcctgacggtgttccag
atcctgacaggtgaagactggaatgcggtgatgtatgacggcatcatggcctatggaggc
ccttcctcttccgggatgattgtctgtatctacttcatcatccttttcatctgtggtaac
tatatcctgctgaatgtcttcttggccatcgctgtggacaatttggctgatgctgaaagt
ctgaacactgctcagaaagaggaagctgaagaaaaagaaaggaaaaagattgccagaaaa
gaaagcctagaaaacaaaaagaacaacaaaccagaagtcaaccagatagccaacagtgac
aacaaggttacaattgatgattatcaggaagatgctgaagacaaggacccttacccgccc
tgtgatgtgccagtaggtgaagaggaagaggaggaggaagaggatgagcccgaagttcct
gctggtccccgccctcgcagaatctcagagttgaacatgaaggagaagattgcgcccatc
ccagaaggaagcgccttcttcattcttagcaagaccaacccgatacgtgtgggttgccac
aagctcattaaccaccacatcttcaccaaccttatcctggtcttcatcatgctgagcagc
gctgccctggctgcagaggaccccatccgtagccactcattccgcaacacgatactgggc
tactttgactatgccttcacagccatctttacggttgaaatcctgttaaagatgacaact
tttggagccttcttgcacaaaggggctttctgcaggaactacttcaatttgctggacatg
ctggttgttggggtgtcgctggtgtcctttgggattcagtccagcgccatctccgttgtg
aagattctgagggttttgagggtcttgcggcctctcagagcaatcaacagagcaaaggga
cttaagcacgtggtccagtgtgtctttgtggccatccgaaccattggcaacatcatgatc
gtcacgaccctgctccagttcatgtttgcatgcattggggtccagctgttcaaggggaag
ttctaccgttgcacagatgaagccaaaagtaaccctgaggagtgcagggggcttttcatt
ctttataaggacggcgatgttgacagtcctgtggtccgtgagaggatctggcaaaatagt
gatttcaattttgacaatgtcctttcggctatgatggcgctgttcacagtctcaactttt
gagggctggcccgcgttgctgtacaaagctattgattcaaacggtgagaacgttggtcct
gtctacaactaccgtgtggagatctccatcttcttcatcatctacatcatcatcgttgcc
ttcttcatgatgaacatctttgtgggcttcgtcatcgtcaccttccaggaacagggagaa
aaagagtataagaactgtgagctggacaaaaatcagcgtcagtgtgttgaatatgccttg
aaagcacgccccttaaggagatacatccccaaaaacccataccagtacaagttctggtat
gtggtgaactcctcgcctttcgaatacatgatgttcgtcctcatcatgctcaacacgctc
tgcctggccatgcagcactatgagcagtccaagatgttcaatgatgccatggacattctg
aacatggtcttcacaggggtcttcactgttgagatggttttgaaagtcattgctttcaag
cccaaggggtattttagtgacgcctggaacacgtttgactccctcatcgtaatcggcagc
attatagacgtggccctcagcgaagccgacccatctgaaagtgagactatccctctccca
actgccacacctgggaactctgaagagagcaatagaatctccatcacctttttccgtctt
ttccgagtgatgcggttggtgaaacttctcagcaggggggaaggcatccggacactgctg
tggaccttcatcaagtcctttcaggcgctgccgtatgttgccctcctcattgccatgctc
ttcttcatctacgctgtcataggcatgcagatgtttgggaaagttgccatgagagataac
aaccagatcaataggaacaacaacttccagacctttcctcaggcagtgctcctactcttc
aggtgtgcaacaggggaagcctggcaggagatcatgcttgcctgcctcccaggaaagctg
tgcgacccagactccgattacaacccaggagaggagtacacttgtgggagcaactttgcc
attgtctacttcatcagcttttacatgctctgtgcattcctgatcatcaacctctttgtg
gctgtcatcatggacaattttgactatctgactcgggactggtctattctggggcctcac
cacttggacgaattcaaaagaatatggtcagaatatgaccctgaagcaaagggaaggata
aaacaccttgatgtggtcactctgctccggcggatccagcctcccctggggtttggaaaa
ttatgcccacaccgagtagcatgtaagagattggttgccatgaacatgcctctcaacagt
gatgggacagtcatgttcaatgcaaccctgtttgctttggtccggacagctctcaagatc
aagactgaagggaacctggagcaagctaatgaagaactccgagctgtgatcaagaaaatc
tggaagaagacaagcatgaagctgcttgaccaagttgtccctccagctggtgatgatgag
gtaaccgtggggaagttctatgccactttcctgatacaggactactttaggaaattcaag
aaacggaaagagcaaggactggtggggaagtaccctgcgaagaacaccacgattgcccta
caggcgggattaaggaccctgcatgacattgggccagaaatccgacgggctatatcctgt
gacttgcaagatgacgagccagaagactccaaaccagaagaagaagatgtattcaaaaga
aatggtgccctgcttggaaaccatgtcaatcatgttaatagtgataggagagattccctt
cagcagaccaataccacccaccgtcccctgcatgtccaaaggccttcaatgccacctgca
agtgatactgagaaaccgctgtttcctccagcaggaaattcggggtgtcataaccatcat
aaccataattccatagggaagcaagctcccacctcaacaaatgccaatctcaataatgcc
aatatgtccaaagctgcccacggaaagccgcccagcattgggaaccttgagcatgtgtct
gaaaatgggcattactcctgcaagcatgatcgagagcttcaaagaaggtccagtattaaa
agaacccgctattacgagacttacattaggtctgagtcaggagatgagcaatttccaacc
atttgccgtgaagatcctgagatacacggctacttccgagacccccgctgcttgggggaa
caggagtatttcagtagcgaggagtgctgtgaggacgacagctctcccacctggagcagg
caaaactacaactactacaacaggtacccaggcagctccatggactttgagaggccccga
ggctaccaccacccccaaggcttcttagaagatgatgactctcccactggctatgattca
cggagatctccgaggagacgtcttctacctcctaccccaccatcccatcggaggtcctcc
ttcaactttgagtgtctgcgcaggcaaagcagccaagacgatgtccttccatcgcctgcc
ctgcctcaccgcgctgccctgcccctgcacctgatgcagcagcagatcatggccgttgca
ggcctagattccagtaaagcccagaagtactcaccgagccactctacccggtcgtgggcc
acccctccagcaacccctccataccgagactggagcccatgctacacccctttgatccag
gtggaccgctcagaatctatggaccaggtcaatggcagcctgccatccctacaccgaagc
tcctggtacacagatgaacccgacatctcctataggactttcacgccagctagtctgact
gtccccagcagcttccggaacaagaacagcgacaagcagaggagtgcagacagcctggtg
gaggcagtcctgatatccgaaggcttgggacgctacgcgagggaccccaaatttgtctca
gcgacaaaacatgagattgccgatgcctgtgacctaaccatagacgagatggaaagtgct
gccagcaccctgctcaatggcagtgtgtgtcctcgagccaatggggacatgggccccatc
tcccaccgccaggactatgagctccaggactttggtcctggctacagtgacgaggagcca
gaccctgggcgagaggaagaggacctggcagatgagatgatttgcattaccaccttgtag

  All links  
Ontology (2)   
   KEGG BRITE (2)   
Pathway (35)   
   KEGG PATHWAY (35)   
Genome (1)   
   KEGG GENOME (1)   
Gene (40)   
   KEGG ORTHOLOGY (1)   
   KEGG GENES (1)   
   RefGene (31)   
   NCBI-PROTEINID (1)   
   NCBI-Gene (1)   
   Ensembl (1)   
   RIKEN BRC-DNA (3)   
   OC (1)   
Protein sequence (29)   
   UniProt (1)   
   SWISS-PROT (1)   
   RefSeq(pep) (27)   
DNA sequence (49)   
   RefSeq(nuc) (29)   
   GenBank (10)   
   EMBL (10)   
Protein domain (5)   
   Pfam (5)   
All databases (161)   

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