KEGG   Mus musculus (house mouse): 12322
Entry
12322             CDS       T01002                                 
Symbol
Camk2a, CaMKII, mKIAA0968
Name
(RefSeq) calcium/calmodulin-dependent protein kinase II alpha
  KO
K04515  calcium/calmodulin-dependent protein kinase (CaM kinase) II [EC:2.7.11.17]
Organism
mmu  Mus musculus (house mouse)
Pathway
mmu04012  ErbB signaling pathway
mmu04020  Calcium signaling pathway
mmu04024  cAMP signaling pathway
mmu04066  HIF-1 signaling pathway
mmu04114  Oocyte meiosis
mmu04148  Efferocytosis
mmu04217  Necroptosis
mmu04261  Adrenergic signaling in cardiomyocytes
mmu04310  Wnt signaling pathway
mmu04360  Axon guidance
mmu04713  Circadian entrainment
mmu04720  Long-term potentiation
mmu04722  Neurotrophin signaling pathway
mmu04725  Cholinergic synapse
mmu04728  Dopaminergic synapse
mmu04740  Olfactory transduction
mmu04750  Inflammatory mediator regulation of TRP channels
mmu04911  Insulin secretion
mmu04912  GnRH signaling pathway
mmu04916  Melanogenesis
mmu04921  Oxytocin signaling pathway
mmu04922  Glucagon signaling pathway
mmu04925  Aldosterone synthesis and secretion
mmu04934  Cushing syndrome
mmu04971  Gastric acid secretion
mmu05012  Parkinson disease
mmu05022  Pathways of neurodegeneration - multiple diseases
mmu05031  Amphetamine addiction
mmu05152  Tuberculosis
mmu05200  Pathways in cancer
mmu05205  Proteoglycans in cancer
mmu05214  Glioma
mmu05415  Diabetic cardiomyopathy
mmu05417  Lipid and atherosclerosis
Brite
KEGG Orthology (KO) [BR:mmu00001]
 09130 Environmental Information Processing
  09132 Signal transduction
   04012 ErbB signaling pathway
    12322 (Camk2a)
   04310 Wnt signaling pathway
    12322 (Camk2a)
   04066 HIF-1 signaling pathway
    12322 (Camk2a)
   04020 Calcium signaling pathway
    12322 (Camk2a)
   04024 cAMP signaling pathway
    12322 (Camk2a)
 09140 Cellular Processes
  09141 Transport and catabolism
   04148 Efferocytosis
    12322 (Camk2a)
  09143 Cell growth and death
   04114 Oocyte meiosis
    12322 (Camk2a)
   04217 Necroptosis
    12322 (Camk2a)
 09150 Organismal Systems
  09152 Endocrine system
   04911 Insulin secretion
    12322 (Camk2a)
   04922 Glucagon signaling pathway
    12322 (Camk2a)
   04912 GnRH signaling pathway
    12322 (Camk2a)
   04921 Oxytocin signaling pathway
    12322 (Camk2a)
   04916 Melanogenesis
    12322 (Camk2a)
   04925 Aldosterone synthesis and secretion
    12322 (Camk2a)
  09153 Circulatory system
   04261 Adrenergic signaling in cardiomyocytes
    12322 (Camk2a)
  09154 Digestive system
   04971 Gastric acid secretion
    12322 (Camk2a)
  09156 Nervous system
   04725 Cholinergic synapse
    12322 (Camk2a)
   04728 Dopaminergic synapse
    12322 (Camk2a)
   04720 Long-term potentiation
    12322 (Camk2a)
   04722 Neurotrophin signaling pathway
    12322 (Camk2a)
  09157 Sensory system
   04740 Olfactory transduction
    12322 (Camk2a)
   04750 Inflammatory mediator regulation of TRP channels
    12322 (Camk2a)
  09158 Development and regeneration
   04360 Axon guidance
    12322 (Camk2a)
  09159 Environmental adaptation
   04713 Circadian entrainment
    12322 (Camk2a)
 09160 Human Diseases
  09161 Cancer: overview
   05200 Pathways in cancer
    12322 (Camk2a)
   05205 Proteoglycans in cancer
    12322 (Camk2a)
  09162 Cancer: specific types
   05214 Glioma
    12322 (Camk2a)
  09171 Infectious disease: bacterial
   05152 Tuberculosis
    12322 (Camk2a)
  09164 Neurodegenerative disease
   05012 Parkinson disease
    12322 (Camk2a)
   05022 Pathways of neurodegeneration - multiple diseases
    12322 (Camk2a)
  09165 Substance dependence
   05031 Amphetamine addiction
    12322 (Camk2a)
  09166 Cardiovascular disease
   05417 Lipid and atherosclerosis
    12322 (Camk2a)
   05415 Diabetic cardiomyopathy
    12322 (Camk2a)
  09167 Endocrine and metabolic disease
   04934 Cushing syndrome
    12322 (Camk2a)
 09180 Brite Hierarchies
  09181 Protein families: metabolism
   01001 Protein kinases [BR:mmu01001]
    12322 (Camk2a)
Enzymes [BR:mmu01000]
 2. Transferases
  2.7  Transferring phosphorus-containing groups
   2.7.11  Protein-serine/threonine kinases
    2.7.11.17  Ca2+/calmodulin-dependent protein kinase
     12322 (Camk2a)
Protein kinases [BR:mmu01001]
 Serine/threonine kinases: CAMK group
  CAMK2 family
   12322 (Camk2a)
SSDB
Motif
Pfam: Pkinase CaMKII_AD PK_Tyr_Ser-Thr DUF4440 SnoaL_3 SnoaL_2 Kdo SnoaL_4
Other DBs
NCBI-GeneID: 12322
NCBI-ProteinID: NP_803126
MGI: 88256
Ensembl: ENSMUSG00000024617
UniProt: P11798
Structure
Position
18:61058704..61121224
AA seq 478 aa
MATITCTRFTEEYQLFEELGKGAFSVVRRCVKVLAGQEYAAKIINTKKLSARDHQKLERE
ARICRLLKHPNIVRLHDSISEEGHHYLIFDLVTGGELFEDIVAREYYSEADASHCIQQIL
EAVLHCHQMGVVHRDLKPENLLLASKLKGAAVKLADFGLAIEVEGEQQAWFGFAGTPGYL
SPEVLRKDPYGKPVDLWACGVILYILLVGYPPFWDEDQHRLYQQIKAGAYDFPSPEWDTV
TPEAKDLINKMLTINPSKRITAAEALKHPWISHRSTVASCMHRQETVDCLKKFNARRKLK
GAILTTMLATRNFSGGKSGGNKKNDGVKESSESTNTTIEDEDTKVRKQEIIKVTEQLIEA
ISNGDFESYTKMCDPGMTAFEPEALGNLVEGLDFHRFYFENLWSRNSKPVHTTILNPHIH
LMGDESACIAYIRITQYLDAGGIPRTAQSEETRVWHRRDGKWQIVHFHRSGAPSVLPH
NT seq 1437 nt   +upstreamnt  +downstreamnt
atggctaccatcacctgcacccgattcacagaagagtaccagctctttgaggaactggga
aagggagccttctctgtggtgcgcaggtgtgtgaaggtgctggctggtcaggagtatgct
gccaagattatcaacaccaagaagctttcagccagagatcaccagaagctggagcgtgag
gcccgcatctgccgcttgttgaagcaccccaatatcgtccgactccatgacagcatctcc
gaggaggggcaccactaccttatcttcgatctggttactggtggggaactgtttgaagac
attgtggcccgggagtattacagtgaagctgatgccagccactgtatccagcagatcttg
gaggctgtgctacactgtcaccagatgggggtggtgcatcgtgacctgaagcctgagaat
ctgttgctggcctcgaagctcaagggcgctgctgtgaagctggcagactttggcctggcc
atagaggtggagggggagcagcaggcatggtttgggttcgcagggacacctggatacctc
tccccagaagtgctgaggaaggacccgtacgggaagcccgtggacctgtgggcctgtggc
gtcatcctgtatatcttgctggttgggtatcccccgttctgggatgaagaccagcatcgc
ctgtaccagcagatcaaagctggtgcctatgatttcccatcaccagaatgggacaccgtc
accccagaagccaaggatctgatcaataagatgctgaccatcaacccgtccaaacgcatc
acggccgctgaggctctcaagcacccatggatctcgcaccgctccaccgtggcctcctgc
atgcacagacaggagaccgtggactgcctgaagaagttcaatgccaggaggaaactgaag
ggagccatcctcaccactatgctggccaccaggaacttctccggagggaagagcggagga
aacaagaagaacgatggtgtgaaggaatcttctgagagcaccaacaccaccattgaggac
gaagacaccaaagtgcgcaaacaggaaattatcaaagtgacagagcagctgatcgaagcc
ataagcaatggagactttgagtcctacacgaagatgtgcgaccctggaatgacagccttt
gaaccagaggccctggggaacctggtggagggcctggactttcatcgattctattttgaa
aacctgtggtcccggaacagcaagcccgtgcacaccaccatcctgaaccctcacatccac
ctgatgggtgacgagtcagcctgcatcgcctatatccgcatcactcagtacctggatgca
ggcggcataccccgcacggcccagtcagaggagacccgcgtctggcaccgcagggacggc
aaatggcagatcgtccacttccacagatctggggcgccctccgtcctgccgcattga

  All links  
Gene (10)   
   RefGene (6)   
   NCBI-PROTEINID (1)   
   NCBI-Gene (1)   
   Ensembl (1)   
   OC (1)   
Protein sequence (7)   
   UniProt (1)   
   SWISS-PROT (1)   
   RefSeq(pep) (5)   
DNA sequence (25)   
   RefSeq(nuc) (5)   
   GenBank (10)   
   EMBL (10)   
3D Structure (6)   
   PDB (6)   
Protein domain (8)   
   Pfam (8)   
All databases (56)   

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