KEGG   Mus musculus (house mouse): 12638
Entry
12638             CDS       T01002                                 
Symbol
Cftr, Abcc7
Name
(RefSeq) cystic fibrosis transmembrane conductance regulator
  KO
K05031  cystic fibrosis transmembrane conductance regulator [EC:5.6.1.6]
Organism
mmu  Mus musculus (house mouse)
Pathway
mmu02010  ABC transporters
mmu04024  cAMP signaling pathway
mmu04152  AMPK signaling pathway
mmu04530  Tight junction
mmu04971  Gastric acid secretion
mmu04972  Pancreatic secretion
mmu04976  Bile secretion
Brite
KEGG Orthology (KO) [BR:mmu00001]
 09130 Environmental Information Processing
  09131 Membrane transport
   02010 ABC transporters
    12638 (Cftr)
  09132 Signal transduction
   04024 cAMP signaling pathway
    12638 (Cftr)
   04152 AMPK signaling pathway
    12638 (Cftr)
 09140 Cellular Processes
  09144 Cellular community - eukaryotes
   04530 Tight junction
    12638 (Cftr)
 09150 Organismal Systems
  09154 Digestive system
   04971 Gastric acid secretion
    12638 (Cftr)
   04972 Pancreatic secretion
    12638 (Cftr)
   04976 Bile secretion
    12638 (Cftr)
 09180 Brite Hierarchies
  09183 Protein families: signaling and cellular processes
   02000 Transporters [BR:mmu02000]
    12638 (Cftr)
Enzymes [BR:mmu01000]
 5. Isomerases
  5.6  Isomerases altering macromolecular conformation
   5.6.1  Enzymes altering polypeptide conformation or assembly
    5.6.1.6  channel-conductance-controlling ATPase
     12638 (Cftr)
Transporters [BR:mmu02000]
 ABC transporters, eukaryotic type
  ABCC (CFTR/MRP) subfamily
   ABCC7 subgroup
    12638 (Cftr)
SSDB
Motif
Pfam: ABC_membrane CFTR_R ABC_tran SMC_N AAA_29 AAA_21 T2SSE DUF87 NB-ARC NTPase_1 nSTAND3 MMR_HSR1 AAA_30 MeaB AAA_23 Intein_splicing
Other DBs
NCBI-GeneID: 12638
NCBI-ProteinID: NP_066388
MGI: 88388
Ensembl: ENSMUSG00000041301
UniProt: P26361
Structure
Position
6:18170686..18322769
AA seq 1476 aa
MQKSPLEKASFISKLFFSWTTPILRKGYRHHLELSDIYQAPSADSADHLSEKLEREWDRE
QASKKNPQLIHALRRCFFWRFLFYGILLYLGEVTKAVQPVLLGRIIASYDPENKVERSIA
IYLGIGLCLLFIVRTLLLHPAIFGLHRIGMQMRTAMFSLIYKKTLKLSSRVLDKISIGQL
VSLLSNNLNKFDEGLALAHFIWIAPLQVTLLMGLLWDLLQFSAFCGLGLLIILVIFQAIL
GKMMVKYRDQRAAKINERLVITSEIIDNIYSVKAYCWESAMEKMIENLREVELKMTRKAA
YMRFFTSSAFFFSGFFVVFLSVLPYTVINGIVLRKIFTTISFCIVLRMSVTRQFPTAVQI
WYDSFGMIRKIQDFLQKQEYKVLEYNLMTTGIIMENVTAFWEEGFGELLEKVQQSNGDRK
HSSDENNVSFSHLCLVGNPVLKNINLNIEKGEMLAITGSTGSGKTSLLMLILGELEASEG
IIKHSGRVSFCSQFSWIMPGTIKENIIFGVSYDEYRYKSVVKACQLQQDITKFAEQDNTV
LGEGGVTLSGGQRARISLARAVYKDADLYLLDSPFGYLDVFTEEQVFESCVCKLMANKTR
ILVTSKMEHLRKADKILILHQGSSYFYGTFSELQSLRPDFSSKLMGYDTFDQFTEERRSS
ILTETLRRFSVDDSSAPWSKPKQSFRQTGEVGEKRKNSILNSFSSVRKISIVQKTPLCID
GESDDLQEKRLSLVPDSEQGEAALPRSNMIATGPTFPGRRRQSVLDLMTFTPNSGSSNLQ
RTRTSIRKISLVPQISLNEVDVYSRRLSQDSTLNITEEINEEDLKECFLDDVIKIPPVTT
WNTYLRYFTLHKGLLLVLIWCVLVFLVEVAASLFVLWLLKNNPVNSGNNGTKISNSSYVV
IITSTSFYYIFYIYVGVADTLLALSLFRGLPLVHTLITASKILHRKMLHSILHAPMSTIS
KLKAGGILNRFSKDIAILDDFLPLTIFDFIQLVFIVIGAIIVVSALQPYIFLATVPGLVV
FILLRAYFLHTAQQLKQLESEGRSPIFTHLVTSLKGLWTLRAFRRQTYFETLFHKALNLH
TANWFMYLATLRWFQMRIDMIFVLFFIVVTFISILTTGEGEGTAGIILTLAMNIMSTLQW
AVNSSIDTDSLMRSVSRVFKFIDIQTEESMYTQIIKELPREGSSDVLVIKNEHVKKSDIW
PSGGEMVVKDLTVKYMDDGNAVLENISFSISPGQRVGLLGRTGSGKSTLLSAFLRMLNIK
GDIEIDGVSWNSVTLQEWRKAFGVITQKVFIFSGTFRQNLDPNGKWKDEEIWKVADEVGL
KSVIEQFPGQLNFTLVDGGYVLSHGHKQLMCLARSVLSKAKIILLDEPSAHLDPITYQVI
RRVLKQAFAGCTVILCEHRIEAMLDCQRFLVIEESNVWQYDSLQALLSEKSIFQQAISSS
EKMRFFQGRHSSKHKPRTQITALKEETEEEVQETRL
NT seq 4431 nt   +upstreamnt  +downstreamnt
atgcagaagtcgcctttggagaaagccagctttatctccaaactcttcttcagctggacc
acaccaattttgaggaaagggtacagacaccacttggagttgtcagacatataccaagcc
ccttctgctgattcagctgaccacttgtctgaaaaactagaaagagaatgggacagagaa
caagcttcaaaaaagaatccccagcttatccacgcccttcggcgatgctttttctggaga
ttcctcttctatggaattttgctatacctaggggaagtcaccaaggctgtccagcctgtc
ttgctaggaagaatcatagcatcctatgatccagaaaacaaggtggaacgttccattgcc
atttaccttggcataggcttatgccttctcttcattgtcaggacactgcttcttcaccca
gctatttttggccttcatcgcattggaatgcagatgagaacagctatgtttagcttgatt
tataagaagactttaaagttgtcaagccgcgttcttgataaaataagtattggacaactt
gttagtcttctttccaacaacctgaacaaatttgatgaaggacttgccttggcacatttt
atatggattgctcctttacaagtgactcttctgatggggcttctctgggacttgttacag
ttctcagccttctgtggccttggtttactgataatcctggttatttttcaagctatccta
gggaagatgatggtgaagtacagagatcagagagctgcaaagatcaatgaaagactcgtg
atcacatcagaaattattgataatatctattctgttaaggcatattgttgggaatcagcg
atggagaaaatgattgaaaacttgagagaggtggagctgaaaatgacccggaaggcggcc
tatatgaggttcttcactagctctgccttcttcttttcagggttctttgtagtctttcta
tctgtgcttccctacacagtcatcaacggaatcgtcctacgaaaaatattcacaaccatt
tcattctgcattgtcctacgtatgtcagtcacacggcagttccccactgccgtacagata
tggtatgattcttttggaatgataagaaaaatacaggatttcctgcagaaacaagagtat
aaagtactggagtataacttaatgaccacaggcataatcatggaaaatgtaacagcattt
tgggaggagggatttggggaattactggagaaagtacaacaaagcaatggtgacagaaaa
cattccagtgatgagaacaatgtcagtttcagtcatctctgccttgtgggaaatcctgtg
ctgaaaaacatcaatttgaatatagagaaaggagagatgttggctattactggatctact
ggatcaggaaagacatcactcctgatgttgattttgggagaactggaagcttcagaggga
attattaagcacagtggaagagtttcattctgctctcaattttcttggattatgccgggt
actatcaaagaaaatatcatctttggtgtttcctatgatgagtacagatataagagtgtt
gtcaaagcttgccaactacagcaggacatcaccaagtttgcagaacaagacaacacagtt
cttggagaaggtggagtcacactgagtggaggtcagcgtgcaaggatttctttagcaaga
gcagtatataaagatgctgatttgtacctattagattccccttttggatatctagatgtt
tttactgaagaacaagtatttgaaagctgtgtttgtaaattgatggccaacaaaactagg
attttggttacatctaaaatggaacacttaaggaaagctgacaaaatactaattttgcat
cagggcagtagctatttttatgggacattttctgagctacaaagtctacgtccagacttc
agttcgaaactcatggggtatgatacttttgaccagtttactgaggaaagaagaagttca
attctaactgagaccttacgcaggttctcagtagacgattcctctgccccgtggagcaaa
cccaaacagtcgtttagacagactggagaggtgggagaaaaaaggaagaactctattcta
aattcattcagctctgtaaggaaaatttccattgtgcaaaagactccattatgtatcgat
ggagagtctgatgatctccaagaaaagagactgtccctagttccggattctgaacagggg
gaggctgctctgccgcgcagcaacatgatcgccaccggccccacatttccaggcagaaga
agacagtctgttttggatctgatgacgttcacacccaactcaggctccagcaatcttcag
aggaccagaacttctattcgaaaaatctccttagtccctcagataagcttaaatgaagtg
gatgtatattcaaggagattatcgcaagatagcacactgaacatcactgaagaaattaac
gaagaagatttaaaggagtgttttcttgatgatgtgatcaagatacccccggtgacaaca
tggaacacatacctacgatattttactctccataaaggcttactgctagtgctgatttgg
tgcgtactggtttttctggttgaggtggctgcttctttatttgtgttatggttgcttaaa
aacaaccctgttaacagtggaaacaatggtactaaaatttccaatagctcctatgttgtg
atcatcaccagtaccagtttctattatattttttacatttacgtgggagtggctgacact
ttgcttgccctgagcctcttcagaggtttgccgctggtgcatacgttaatcacagcatca
aaaattttgcacaggaaaatgttacactccattcttcacgcccctatgtcgaccatcagc
aagctgaaagcaggtgggattcttaacagattctccaaagatatagcaattttggatgac
tttctgcctcttaccatttttgacttcattcagttggtgttcattgtgattggagctata
atagtcgtctcggcattacaaccctacatcttcctagcaacggtgccagggctagtagtc
tttattttactgagggcctacttccttcatacagcacagcagctcaaacaactggaatct
gaaggcaggagtccaattttcacccaccttgtgacaagcttaaaaggactctggacactt
cgagccttccgacgccagacttactttgaaactctgttccacaaagctctgaatttgcac
actgccaactggtttatgtatctggcaaccttgcgctggttccaaatgagaatagacatg
atatttgtcctcttcttcattgttgttaccttcatctccattttaacaacaggtgaagga
gaaggaacagctggtattattctaactttagctatgaatatcatgagtactttgcagtgg
gctgtgaactcaagcattgatacagatagcttgatgcgatctgtgagcagagtgtttaag
tttattgatatacaaacagaagaaagtatgtacacacagataattaaagaactacctaga
gaaggatcatctgacgttttagtcattaagaatgagcatgtgaagaaaagtgatatctgg
ccctctggaggcgaaatggttgtcaaagaccttactgtgaaatacatggatgatggaaat
gccgtattagagaacatttctttttcaataagtcctggacagagggtggggctcttagga
agaactggatcaggaaaaagtactttgctttcagcatttttacgaatgttgaacattaaa
ggtgatatagagattgatggtgtctcatggaattcagtgaccttacaagaatggaggaaa
gctttcggagtgataacacagaaagtatttatcttttctggaacattcagacaaaacctg
gatcccaatggaaaatggaaagatgaagaaatatggaaagttgcagatgaggttggactc
aagtctgtaatagagcagtttcctggacagctcaactttacccttgtggatgggggttat
gtgctaagccatggccataagcaattaatgtgcttggcccgatcagttctcagtaaggcc
aagatcatactgcttgatgagcccagtgcccatctagaccccataacataccaagtcatt
cgacgagttctaaaacaagccttcgctggttgcacagtcatcctctgtgaacacaggata
gaagcgatgttggattgccagcgatttttggtcatagaagagagcaatgtctggcagtac
gactcccttcaggcacttctgagtgagaagagtatcttccagcaggccattagctcctcg
gaaaagatgaggttcttccagggccgccactccagcaagcacaagcctcggacgcaaatt
actgctctgaaagaggagacagaagaagaagttcaagaaacccgtctctag

  All links  
Gene (37)   
   RefGene (33)   
   NCBI-PROTEINID (1)   
   NCBI-Gene (1)   
   Ensembl (1)   
   OC (1)   
Protein sequence (3)   
   UniProt (1)   
   SWISS-PROT (1)   
   RefSeq(pep) (1)   
DNA sequence (15)   
   RefSeq(nuc) (1)   
   GenBank (7)   
   EMBL (7)   
3D Structure (9)   
   PDB (9)   
Protein domain (16)   
   Pfam (16)   
All databases (80)   

Download RDF
DBGET integrated database retrieval system