KEGG   Mus musculus (mouse): 13030
Entry
13030             CDS       T01002                                 

Gene name
Ctsb, CB
Definition
(RefSeq) cathepsin B
  KO
K01363  cathepsin B [EC:3.4.22.1]
Organism
mmu  Mus musculus (mouse)
Pathway
mmu04140  Autophagy - animal
mmu04142  Lysosome
mmu04210  Apoptosis
mmu04612  Antigen processing and presentation
mmu04621  NOD-like receptor signaling pathway
mmu04924  Renin secretion
Brite
KEGG Orthology (KO) [BR:mmu00001]
 09140 Cellular Processes
  09141 Transport and catabolism
   04142 Lysosome
    13030 (Ctsb)
   04140 Autophagy - animal
    13030 (Ctsb)
  09143 Cell growth and death
   04210 Apoptosis
    13030 (Ctsb)
 09150 Organismal Systems
  09151 Immune system
   04621 NOD-like receptor signaling pathway
    13030 (Ctsb)
   04612 Antigen processing and presentation
    13030 (Ctsb)
  09152 Endocrine system
   04924 Renin secretion
    13030 (Ctsb)
 09180 Brite Hierarchies
  09181 Protein families: metabolism
   01002 Peptidases and inhibitors [BR:mmu01002]
    13030 (Ctsb)
  09182 Protein families: genetic information processing
   03110 Chaperones and folding catalysts [BR:mmu03110]
    13030 (Ctsb)
  09183 Protein families: signaling and cellular processes
   04147 Exosome [BR:mmu04147]
    13030 (Ctsb)
   00536 Glycosaminoglycan binding proteins [BR:mmu00536]
    13030 (Ctsb)
Enzymes [BR:mmu01000]
 3. Hydrolases
  3.4  Acting on peptide bonds (peptidases)
   3.4.22  Cysteine endopeptidases
    3.4.22.1  cathepsin B
     13030 (Ctsb)
Peptidases and inhibitors [BR:mmu01002]
 Cysteine peptidases
  Family C1: papain family
   13030 (Ctsb)
Chaperones and folding catalysts [BR:mmu03110]
 Intramolecular chaperones
  Papain family
   13030 (Ctsb)
Exosome [BR:mmu04147]
 Exosomal proteins
  Exosomal proteins of microglial cells
   13030 (Ctsb)
Glycosaminoglycan binding proteins [BR:mmu00536]
 Heparan sulfate / Heparin
  Others
   13030 (Ctsb)
SSDB
Motif
Pfam: Peptidase_C1 Propeptide_C1
Other DBs
NCBI-GeneID: 13030
NCBI-ProteinID: NP_031824
MGI: 88561
Ensembl: ENSMUSG00000021939
UniProt: P10605
Position
14 D1; 14 33.24 cM
AA seq 339 aa
MWWSLILLSCLLALTSAHDKPSFHPLSDDLINYINKQNTTWQAGRNFYNVDISYLKKLCG
TVLGGPKLPGRVAFGEDIDLPETFDAREQWSNCPTIGQIRDQGSCGSCWAFGAVEAISDR
TCIHTNGRVNVEVSAEDLLTCCGIQCGDGCNGGYPSGAWSFWTKKGLVSGGVYNSHVGCL
PYTIPPCEHHVNGSRPPCTGEGDTPRCNKSCEAGYSPSYKEDKHFGYTSYSVSNSVKEIM
AEIYKNGPVEGAFTVFSDFLTYKSGVYKHEAGDMMGGHAIRILGWGVENGVPYWLAANSW
NLDWGDNGFFKILRGENHCGIESEIVAGIPRTDQYWGRF
NT seq 1020 nt   +upstreamnt  +downstreamnt
atgtggtggtccttgatccttctttcttgcctgctggcactgaccagtgcccatgacaag
ccttccttccacccgctgtcggatgacctgattaactatatcaacaaacagaatacaaca
tggcaggctggacgcaacttctacaatgttgacataagctatctgaagaagctgtgtggc
actgtcctgggtggacccaaactgccaggaagggttgcgttcggtgaggacatagatcta
cctgaaacctttgatgcacgggaacaatggtccaactgcccgaccattggacagattaga
gaccagggctcctgcggctcttgttgggcatttggggcagtggaagccatttctgaccga
acctgcattcacaccaatggccgagtcaacgtggaggtgtctgctgaagacctgcttact
tgctgtggtatccagtgtggggacggctgtaatggtggctatccctctggagcatggagc
ttctggacaaaaaaaggcctggtttcaggtggagtctacaattctcatgtaggctgctta
ccatacaccatccctccctgcgagcaccatgtcaatggctcccgtcccccatgcactgga
gaaggagatactcccaggtgcaacaagagctgtgaagctggctactccccatcctacaaa
gaggataagcactttgggtacacttcctacagcgtgtctaacagtgtgaaggagatcatg
gcagaaatctacaaaaatggcccagtggagggtgccttcactgtgttttctgacttcttg
acttacaaatcaggagtatacaagcatgaagccggtgatatgatgggtggccacgccatc
cgcatcctgggctggggagtagagaatggagttccctactggctggcagccaactcttgg
aaccttgactggggtgataatggcttctttaaaatcctcagaggagagaaccactgtggc
attgaatcagaaattgtggctggaatcccacgcactgaccagtactggggaagattctaa

KEGG   Mus musculus (mouse): 13039
Entry
13039             CDS       T01002                                 

Gene name
Ctsl, 1190035F06Rik, CatL, Ctsl1, ME, MEP, fs, nkt
Definition
(RefSeq) cathepsin L
  KO
K01365  cathepsin L [EC:3.4.22.15]
Organism
mmu  Mus musculus (mouse)
Pathway
mmu04140  Autophagy - animal
mmu04142  Lysosome
mmu04145  Phagosome
mmu04210  Apoptosis
mmu04612  Antigen processing and presentation
mmu05205  Proteoglycans in cancer
mmu05323  Rheumatoid arthritis
mmu05418  Fluid shear stress and atherosclerosis
Brite
KEGG Orthology (KO) [BR:mmu00001]
 09140 Cellular Processes
  09141 Transport and catabolism
   04145 Phagosome
    13039 (Ctsl)
   04142 Lysosome
    13039 (Ctsl)
   04140 Autophagy - animal
    13039 (Ctsl)
  09143 Cell growth and death
   04210 Apoptosis
    13039 (Ctsl)
 09150 Organismal Systems
  09151 Immune system
   04612 Antigen processing and presentation
    13039 (Ctsl)
 09160 Human Diseases
  09161 Cancer: overview
   05205 Proteoglycans in cancer
    13039 (Ctsl)
  09163 Immune disease
   05323 Rheumatoid arthritis
    13039 (Ctsl)
  09166 Cardiovascular disease
   05418 Fluid shear stress and atherosclerosis
    13039 (Ctsl)
 09180 Brite Hierarchies
  09181 Protein families: metabolism
   01002 Peptidases and inhibitors [BR:mmu01002]
    13039 (Ctsl)
  09182 Protein families: genetic information processing
   03110 Chaperones and folding catalysts [BR:mmu03110]
    13039 (Ctsl)
  09183 Protein families: signaling and cellular processes
   00537 Glycosylphosphatidylinositol (GPI)-anchored proteins [BR:mmu00537]
    13039 (Ctsl)
Enzymes [BR:mmu01000]
 3. Hydrolases
  3.4  Acting on peptide bonds (peptidases)
   3.4.22  Cysteine endopeptidases
    3.4.22.15  cathepsin L
     13039 (Ctsl)
Peptidases and inhibitors [BR:mmu01002]
 Cysteine peptidases
  Family C1: papain family
   13039 (Ctsl)
Chaperones and folding catalysts [BR:mmu03110]
 Intramolecular chaperones
  Papain family
   13039 (Ctsl)
Glycosylphosphatidylinositol (GPI)-anchored proteins [BR:mmu00537]
 Others
  13039 (Ctsl)
SSDB
Motif
Pfam: Peptidase_C1 Inhibitor_I29 Peptidase_C1_2
Other DBs
NCBI-GeneID: 13039
NCBI-ProteinID: NP_034114
MGI: 88564
Ensembl: ENSMUSG00000021477
UniProt: P06797 Q543M3
Position
13 B3; 13 33.26 cM
AA seq 334 aa
MNLLLLLAVLCLGTALATPKFDQTFSAEWHQWKSTHRRLYGTNEEEWRRAIWEKNMRMIQ
LHNGEYSNGQHGFSMEMNAFGDMTNEEFRQVVNGYRHQKHKKGRLFQEPLMLKIPKSVDW
REKGCVTPVKNQGQCGSCWAFSASGCLEGQMFLKTGKLISLSEQNLVDCSHAQGNQGCNG
GLMDFAFQYIKENGGLDSEESYPYEAKDGSCKYRAEFAVANDTGFVDIPQQEKALMKAVA
TVGPISVAMDASHPSLQFYSSGIYYEPNCSSKNLDHGVLLVGYGYEGTDSNKNKYWLVKN
SWGSEWGMEGYIKIAKDRDNHCGLATAASYPVVN
NT seq 1005 nt   +upstreamnt  +downstreamnt
atgaatcttttactccttttggctgtcctctgcttgggaacagccttagctactccaaaa
tttgatcaaacctttagtgcagagtggcaccagtggaagtccacacacagaagactgtat
ggcacgaatgaggaagagtggaggagagcgatatgggagaagaacatgagaatgatccag
ctacacaacggggaatacagcaacgggcagcacggcttttccatggagatgaacgccttc
ggtgacatgaccaatgaggaattcaggcaggtggtgaatggctaccgccaccagaagcac
aagaaggggaggctttttcaggaaccgctgatgcttaagatccccaagtctgtggactgg
agagaaaagggttgtgtgactcctgtgaagaaccagggccagtgcgggtcttgttgggcg
tttagcgcatcgggttgcctagaaggacagatgttccttaagaccggcaaactgatctca
ctgagtgaacagaaccttgtggactgttctcacgctcaaggcaatcagggctgtaacgga
ggcctgatggattttgctttccagtacattaaggaaaatggaggtctggactcggaggag
tcttacccctatgaagcgaaggacggatcttgtaaatacagagccgagttcgctgtggct
aatgacacagggttcgtggatatccctcagcaagagaaagccctcatgaaggctgtggcg
actgtggggcctatttctgttgctatggacgcaagccatccgtctctccagttctatagt
tcaggcatctactatgaacccaactgtagcagcaagaacctcgaccatggggttctgttg
gtgggctatggctatgaaggaacagattcaaataagaataaatattggcttgtcaagaac
agctggggaagtgaatggggtatggaaggctacatcaaaatagccaaagaccgggacaac
cactgtggacttgccaccgcggccagctatcctgtcgtgaattga

KEGG   Mus musculus (mouse): 13040
Entry
13040             CDS       T01002                                 

Gene name
Ctss, Cats
Definition
(RefSeq) cathepsin S
  KO
K01368  cathepsin S [EC:3.4.22.27]
Organism
mmu  Mus musculus (mouse)
Pathway
mmu04142  Lysosome
mmu04145  Phagosome
mmu04210  Apoptosis
mmu04612  Antigen processing and presentation
mmu05152  Tuberculosis
Brite
KEGG Orthology (KO) [BR:mmu00001]
 09140 Cellular Processes
  09141 Transport and catabolism
   04145 Phagosome
    13040 (Ctss)
   04142 Lysosome
    13040 (Ctss)
  09143 Cell growth and death
   04210 Apoptosis
    13040 (Ctss)
 09150 Organismal Systems
  09151 Immune system
   04612 Antigen processing and presentation
    13040 (Ctss)
 09160 Human Diseases
  09171 Infectious disease: bacterial
   05152 Tuberculosis
    13040 (Ctss)
 09180 Brite Hierarchies
  09181 Protein families: metabolism
   01002 Peptidases and inhibitors [BR:mmu01002]
    13040 (Ctss)
  09182 Protein families: genetic information processing
   03110 Chaperones and folding catalysts [BR:mmu03110]
    13040 (Ctss)
Enzymes [BR:mmu01000]
 3. Hydrolases
  3.4  Acting on peptide bonds (peptidases)
   3.4.22  Cysteine endopeptidases
    3.4.22.27  cathepsin S
     13040 (Ctss)
Peptidases and inhibitors [BR:mmu01002]
 Cysteine peptidases
  Family C1: papain family
   13040 (Ctss)
Chaperones and folding catalysts [BR:mmu03110]
 Intramolecular chaperones
  Papain family
   13040 (Ctss)
SSDB
Motif
Pfam: Peptidase_C1 Inhibitor_I29 Peptidase_C1_2
Other DBs
NCBI-GeneID: 13040
NCBI-ProteinID: NP_067256
MGI: 107341
Ensembl: ENSMUSG00000038642
Vega: OTTMUSG00000022029
UniProt: O70370 Q8BSZ5
Structure
PDB: 

Position
3 F2.1; 3 40.74 cM
AA seq 340 aa
MRAPGHAAIRWLFWMPLVCSVAMEQLQRDPTLDYHWDLWKKTHEKEYKDKNEEEVRRLIW
EKNLKFIMIHNLEYSMGMHTYQVGMNDMGDMTNEEILCRMGALRIPRQSPKTVTFRSYSN
RTLPDTVDWREKGCVTEVKYQGSCGACWAFSAVGALEGQLKLKTGKLISLSAQNLVDCSN
EEKYGNKGCGGGYMTEAFQYIIDNGGIEADASYPYKATDEKCHYNSKNRAATCSRYIQLP
FGDEDALKEAVATKGPVSVGIDASHSSFFFYKSGVYDDPSCTGNVNHGVLVVGYGTLDGK
DYWLVKNSWGLNFGDQGYIRMARNNKNHCGIASYCSYPEI
NT seq 1023 nt   +upstreamnt  +downstreamnt
atgagggctcctggccacgctgccataagatggctgttttggatgcccctggtgtgctct
gtggcaatggagcaactgcagagagaccctaccctggactaccattgggatctctggaag
aaaacccatgagaaagaatacaaggataagaatgaagaagaagtacggcgtctcatctgg
gaaaagaatctgaagtttataatgattcacaatctcgaatattctatgggaatgcatacc
taccaagtgggcatgaacgatatgggagacatgaccaatgaagaaatcttgtgtcggatg
ggtgctctgagaattccccgacagtctccgaagactgtcactttcaggtcatactctaat
cggacattgcctgacactgtggactggagagagaagggctgcgtcactgaggtgaaatac
cagggttcttgtggtgcctgctgggctttcagtgctgtgggggcccttgaagggcagctg
aagctgaaaacggggaagctgatatccctcagtgctcagaacctggtggactgctcaaat
gaagaaaagtatgggaataaaggctgtggaggcggctacatgaccgaagctttccagtac
atcattgataatgggggcatagaggcagacgcttcctatccctacaaagccacggatgaa
aagtgtcactataactcaaaaaatcgagctgccacgtgttcaaggtacattcagctcccg
tttggtgacgaggatgccctgaaagaagcagtggccactaaagggcctgtctctgtgggc
atcgacgccagccattcctccttcttcttctacaaaagcggtgtctatgacgacccctcc
tgtacgggcaatgtgaatcatggtgttcttgtggttggctatgggactcttgatggcaaa
gattactggcttgtgaaaaacagttggggccttaactttggtgatcaaggatacattcgg
atggcaagaaataataaaaatcactgcggaattgctagttattgctcttacccagaaatc
taa

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