| Entry |
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| Symbol |
Cyp17a1, Cyp17, p450c17
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| Name |
(RefSeq) cytochrome P450, family 17, subfamily a, polypeptide 1
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| KO |
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| Organism |
mmu Mus musculus (house mouse)
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| Pathway |
| mmu04927 | Cortisol synthesis and secretion |
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| Module |
| mmu_M00109 | C21-Steroid hormone biosynthesis, progesterone => cortisol/cortisone |
| mmu_M00110 | C19/C18-Steroid hormone biosynthesis, pregnenolone => androstenedione => estrone |
| mmu_M00976 | C19-Steroid hormone biosynthesis, pregnenolone => testosterone => dihydrotestosterone |
| mmu_M00977 | C19-Steroid hormone biosynthesis (androgen backdoor pathway), pregnenolone => androsterone => dihydrotestosterone |
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| Brite |
KEGG Orthology (KO) [BR:mmu00001]
09100 Metabolism
09103 Lipid metabolism
00140 Steroid hormone biosynthesis
13074 (Cyp17a1)
09150 Organismal Systems
09152 Endocrine system
04913 Ovarian steroidogenesis
13074 (Cyp17a1)
04917 Prolactin signaling pathway
13074 (Cyp17a1)
04927 Cortisol synthesis and secretion
13074 (Cyp17a1)
09160 Human Diseases
09167 Endocrine and metabolic disease
04934 Cushing syndrome
13074 (Cyp17a1)
09180 Brite Hierarchies
09181 Protein families: metabolism
00199 Cytochrome P450 [BR:mmu00199]
13074 (Cyp17a1)
Enzymes [BR:mmu01000]
1. Oxidoreductases
1.14 Acting on paired donors, with incorporation or reduction of molecular oxygen
1.14.14 With reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen into the other donor
1.14.14.19 steroid 17alpha-monooxygenase
13074 (Cyp17a1)
1.14.14.32 17alpha-hydroxyprogesterone deacetylase
13074 (Cyp17a1)
Cytochrome P450 [BR:mmu00199]
Cytochrome P450, animal type
CYP17 family
13074 (Cyp17a1)
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| SSDB |
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| Motif |
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| Other DBs |
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| Position |
19:complement(46655604..46661439)
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| AA seq |
507 aa
MWELVGLLLLILAYFFWPKSKTPNAKFPRSLPFLPLVGSLPFLPRRGHMHANFFKLQEKY
GPIYSLRLGTTTAVIVGHYQLAREVLVKKGKEFSGRPQMVTLGLLSDQGKGVAFADSSSS
WQLHRKLVFSTFSLFRDDQKLEKMICQEANSLCDLILTYDGESRDLSTLIFKSVINIICT
ICFNISFENKDPILTTIQTFTEGIVDVLGHSDLVDIFPWLKIFPNKNLEMIKEHTKIREK
TLVEMFEKCKEKFNSESLSSLTDILIQAKMNAENNNTGEGQDPSVFSDKHILVTVGDIFG
AGIETTSSVLNWILAFLVHNPEVKRKIQKEIDQYVGFSRTPSFNDRTHLLMLEATIREVL
RIRPVAPLLIPHKANIDSSIGEFAIPKDTHVIINLWALHHDKNEWDQPDRFMPERFLDPT
GSHLITPTPSYLPFGAGPRSCIGEALARQELFIFMALLLQRFDFDVSDDKQLPCLVGDPK
VVFLIDPFKVKITVRQAWKDAQVEVST |
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| NT seq |
1524 nt +upstreamnt +downstreamnt
atgtgggaacttgtgggtctcttgctgctcatcctggcctatttcttttggcccaagtca
aagacacctaatgccaagttccccaggagccttccattcctgcccctggtgggtagtcta
ccgtttctccccagacgtggtcatatgcatgccaacttcttcaagctgcaggaaaagtat
ggtcccatctattctcttcgcctgggtaccacaactgcagtgattgtcggtcactatcag
ctggccagagaagtgctcgtgaagaaggggaaagaattctctggtcggccccagatggtg
actctaggcctcttgtcggaccaaggaaaaggcgtcgcctttgcggatagtagtagctcc
tggcagctgcaccggaagctggtattcagcaccttttccctgttcagggatgaccagaaa
ctggagaagatgatatgtcaggaagccaactcactgtgtgacttgatacttacatacgac
ggggagtcccgagatctgtctacgctcatcttcaagtcagtaatcaatatcatctgtacc
atctgcttcaacatctcttttgagaacaaggatccgatactgactaccatacagaccttt
acagagggtattgtggatgtcctgggccacagcgatctggtggacatattcccgtggttg
aagatttttcccaataaaaacttggaaatgataaaggaacacactaaaattcgagaaaaa
acactggttgaaatgtttgaaaaatgcaaggagaaattcaatagtgaatctctctccagc
ctgacagacattctgatacaagccaagatgaatgcagaaaataataacactggggaaggc
caggacccaagtgtgttctcagataagcatatccttgtcacggtgggagacatctttggg
gcaggcatagagacaactagctctgtgctgaactggatcctggctttcctggtgcacaat
cctgaggtgaagaggaagatccaaaaggagattgaccagtatgtaggcttcagtcgaaca
ccgtctttcaatgaccggactcacctcctcatgctggaggccactatccgagaagtgctt
cgtatcaggccggtggcccccttgctcatcccacacaaggctaacattgactccagcatt
ggagagtttgccatcccgaaggacacacatgtgatcatcaatctctgggcactgcatcac
gataaaaatgaatgggaccagccagatcggtttatgcctgagcgcttcttagatccaaca
ggaagccatctcattacacccacacccagttatttgcccttcggagctggtccccgatcg
tgcattggagaggctctggcccggcaggagctctttatcttcatggccttgctgctgcag
aggtttgactttgatgtgtcagatgacaaacagctgccctgtctggtgggtgaccccaag
gtggtctttctgatcgaccctttcaaagtgaaaatcacagtgcgacaagcatggaaggat
gcacaggttgaggttagcacctag |
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