KEGG   Mus musculus (mouse): 13649
Entry
13649             CDS       T01002                                 

Gene name
Egfr, 9030024J15Rik, AI552599, Erb, Erbb, Err, Errb1, Errp, Wa, Wa5, wa-2, wa2
Definition
(RefSeq) epidermal growth factor receptor
  KO
K04361  epidermal growth factor receptor [EC:2.7.10.1]
Organism
mmu  Mus musculus (mouse)
Pathway
mmu01521  EGFR tyrosine kinase inhibitor resistance
mmu01522  Endocrine resistance
mmu04010  MAPK signaling pathway
mmu04012  ErbB signaling pathway
mmu04014  Ras signaling pathway
mmu04015  Rap1 signaling pathway
mmu04020  Calcium signaling pathway
mmu04066  HIF-1 signaling pathway
mmu04068  FoxO signaling pathway
mmu04072  Phospholipase D signaling pathway
mmu04144  Endocytosis
mmu04151  PI3K-Akt signaling pathway
mmu04510  Focal adhesion
mmu04520  Adherens junction
mmu04540  Gap junction
mmu04630  JAK-STAT signaling pathway
mmu04810  Regulation of actin cytoskeleton
mmu04912  GnRH signaling pathway
mmu04915  Estrogen signaling pathway
mmu04921  Oxytocin signaling pathway
mmu04926  Relaxin signaling pathway
mmu04928  Parathyroid hormone synthesis, secretion and action
mmu04934  Cushing syndrome
mmu05160  Hepatitis C
mmu05163  Human cytomegalovirus infection
mmu05165  Human papillomavirus infection
mmu05171  Coronavirus disease - COVID-19
mmu05200  Pathways in cancer
mmu05205  Proteoglycans in cancer
mmu05206  MicroRNAs in cancer
mmu05210  Colorectal cancer
mmu05212  Pancreatic cancer
mmu05213  Endometrial cancer
mmu05214  Glioma
mmu05215  Prostate cancer
mmu05218  Melanoma
mmu05219  Bladder cancer
mmu05223  Non-small cell lung cancer
mmu05224  Breast cancer
mmu05225  Hepatocellular carcinoma
mmu05226  Gastric cancer
mmu05230  Central carbon metabolism in cancer
mmu05231  Choline metabolism in cancer
mmu05235  PD-L1 expression and PD-1 checkpoint pathway in cancer
Brite
KEGG Orthology (KO) [BR:mmu00001]
 09130 Environmental Information Processing
  09132 Signal transduction
   04010 MAPK signaling pathway
    13649 (Egfr)
   04012 ErbB signaling pathway
    13649 (Egfr)
   04014 Ras signaling pathway
    13649 (Egfr)
   04015 Rap1 signaling pathway
    13649 (Egfr)
   04630 JAK-STAT signaling pathway
    13649 (Egfr)
   04066 HIF-1 signaling pathway
    13649 (Egfr)
   04068 FoxO signaling pathway
    13649 (Egfr)
   04020 Calcium signaling pathway
    13649 (Egfr)
   04072 Phospholipase D signaling pathway
    13649 (Egfr)
   04151 PI3K-Akt signaling pathway
    13649 (Egfr)
 09140 Cellular Processes
  09141 Transport and catabolism
   04144 Endocytosis
    13649 (Egfr)
  09144 Cellular community - eukaryotes
   04510 Focal adhesion
    13649 (Egfr)
   04520 Adherens junction
    13649 (Egfr)
   04540 Gap junction
    13649 (Egfr)
  09142 Cell motility
   04810 Regulation of actin cytoskeleton
    13649 (Egfr)
 09150 Organismal Systems
  09152 Endocrine system
   04912 GnRH signaling pathway
    13649 (Egfr)
   04915 Estrogen signaling pathway
    13649 (Egfr)
   04921 Oxytocin signaling pathway
    13649 (Egfr)
   04926 Relaxin signaling pathway
    13649 (Egfr)
   04928 Parathyroid hormone synthesis, secretion and action
    13649 (Egfr)
 09160 Human Diseases
  09161 Cancer: overview
   05200 Pathways in cancer
    13649 (Egfr)
   05206 MicroRNAs in cancer
    13649 (Egfr)
   05205 Proteoglycans in cancer
    13649 (Egfr)
   05230 Central carbon metabolism in cancer
    13649 (Egfr)
   05231 Choline metabolism in cancer
    13649 (Egfr)
   05235 PD-L1 expression and PD-1 checkpoint pathway in cancer
    13649 (Egfr)
  09162 Cancer: specific types
   05210 Colorectal cancer
    13649 (Egfr)
   05212 Pancreatic cancer
    13649 (Egfr)
   05225 Hepatocellular carcinoma
    13649 (Egfr)
   05226 Gastric cancer
    13649 (Egfr)
   05214 Glioma
    13649 (Egfr)
   05218 Melanoma
    13649 (Egfr)
   05219 Bladder cancer
    13649 (Egfr)
   05215 Prostate cancer
    13649 (Egfr)
   05213 Endometrial cancer
    13649 (Egfr)
   05224 Breast cancer
    13649 (Egfr)
   05223 Non-small cell lung cancer
    13649 (Egfr)
  09172 Infectious disease: viral
   05160 Hepatitis C
    13649 (Egfr)
   05171 Coronavirus disease - COVID-19
    13649 (Egfr)
   05163 Human cytomegalovirus infection
    13649 (Egfr)
   05165 Human papillomavirus infection
    13649 (Egfr)
  09167 Endocrine and metabolic disease
   04934 Cushing syndrome
    13649 (Egfr)
  09176 Drug resistance: antineoplastic
   01521 EGFR tyrosine kinase inhibitor resistance
    13649 (Egfr)
   01522 Endocrine resistance
    13649 (Egfr)
 09180 Brite Hierarchies
  09181 Protein families: metabolism
   01001 Protein kinases [BR:mmu01001]
    13649 (Egfr)
  09183 Protein families: signaling and cellular processes
   04147 Exosome [BR:mmu04147]
    13649 (Egfr)
Enzymes [BR:mmu01000]
 2. Transferases
  2.7  Transferring phosphorus-containing groups
   2.7.10  Protein-tyrosine kinases
    2.7.10.1  receptor protein-tyrosine kinase
     13649 (Egfr)
Protein kinases [BR:mmu01001]
 Receptor tyrosine kinases (RTK)
  EGFR family [OT]
   13649 (Egfr)
Exosome [BR:mmu04147]
 Exosomal proteins
  Exosomal proteins of colorectal cancer cells
   13649 (Egfr)
  Exosomal proteins of pancreatic cancer cells
   13649 (Egfr)
  Exosomal proteins of bladder cancer cells
   13649 (Egfr)
SSDB
Motif
Pfam: PK_Tyr_Ser-Thr Recep_L_domain GF_recep_IV Pkinase Furin-like APH Kinase-like ABC1
Other DBs
NCBI-GeneID: 13649
NCBI-ProteinID: NP_997538
MGI: 95294
Ensembl: ENSMUSG00000020122
Vega: OTTMUSG00000005185
UniProt: Q01279 Q9WVF5 Q9EP98 Q3TQS6
Position
11 A2; 11 9.41 cM
AA seq 1210 aa
MRPSGTARTTLLVLLTALCAAGGALEEKKVCQGTSNRLTQLGTFEDHFLSLQRMYNNCEV
VLGNLEITYVQRNYDLSFLKTIQEVAGYVLIALNTVERIPLENLQIIRGNALYENTYALA
ILSNYGTNRTGLRELPMRNLQEILIGAVRFSNNPILCNMDTIQWRDIVQNVFMSNMSMDL
QSHPSSCPKCDPSCPNGSCWGGGEENCQKLTKIICAQQCSHRCRGRSPSDCCHNQCAAGC
TGPRESDCLVCQKFQDEATCKDTCPPLMLYNPTTYQMDVNPEGKYSFGATCVKKCPRNYV
VTDHGSCVRACGPDYYEVEEDGIRKCKKCDGPCRKVCNGIGIGEFKDTLSINATNIKHFK
YCTAISGDLHILPVAFKGDSFTRTPPLDPRELEILKTVKEITGFLLIQAWPDNWTDLHAF
ENLEIIRGRTKQHGQFSLAVVGLNITSLGLRSLKEISDGDVIISGNRNLCYANTINWKKL
FGTPNQKTKIMNNRAEKDCKAVNHVCNPLCSSEGCWGPEPRDCVSCQNVSRGRECVEKCN
ILEGEPREFVENSECIQCHPECLPQAMNITCTGRGPDNCIQCAHYIDGPHCVKTCPAGIM
GENNTLVWKYADANNVCHLCHANCTYGCAGPGLQGCEVWPSGPKIPSIATGIVGGLLFIV
VVALGIGLFMRRRHIVRKRTLRRLLQERELVEPLTPSGEAPNQAHLRILKETEFKKIKVL
GSGAFGTVYKGLWIPEGEKVKIPVAIKELREATSPKANKEILDEAYVMASVDNPHVCRLL
GICLTSTVQLITQLMPYGCLLDYVREHKDNIGSQYLLNWCVQIAKGMNYLEDRRLVHRDL
AARNVLVKTPQHVKITDFGLAKLLGAEEKEYHAEGGKVPIKWMALESILHRIYTHQSDVW
SYGVTVWELMTFGSKPYDGIPASDISSILEKGERLPQPPICTIDVYMIMVKCWMIDADSR
PKFRELILEFSKMARDPQRYLVIQGDERMHLPSPTDSNFYRALMDEEDMEDVVDADEYLI
PQQGFFNSPSTSRTPLLSSLSATSNNSTVACINRNGSCRVKEDAFLQRYSSDPTGAVTED
NIDDAFLPVPEYVNQSVPKRPAGSVQNPVYHNQPLHPAPGRDLHYQNPHSNAVGNPEYLN
TAQPTCLSSGFNSPALWIQKGSHQMSLDNPDYQQDFFPKETKPNGIFKGPTAENAEYLRV
APPSSEFIGA
NT seq 3633 nt   +upstreamnt  +downstreamnt
atgcgaccctcagggaccgcgagaaccacactgctggtgttgctgaccgcgctctgcgcc
gcaggtggggcgttggaggaaaagaaagtctgccaaggcacaagtaacaggctcacccaa
ctgggcacttttgaagaccactttctgagcctgcagaggatgtacaacaactgtgaagtg
gtccttgggaacttggaaattacctatgtgcaaaggaattacgacctttccttcttaaag
accatccaggaggtggccggctatgtcctcattgccctcaacaccgtggagagaatccct
ttggagaacctgcagatcatcaggggaaatgctctttatgaaaacacctatgccttagcc
atcctgtccaactatgggacaaacagaactgggcttagggaactgcccatgcggaactta
caggaaatcctgattggtgctgtgcgattcagcaacaaccccatcctctgcaatatggat
actatccagtggagggacatcgtccaaaacgtctttatgagcaacatgtcaatggactta
cagagccatccgagcagttgccccaaatgtgatccaagctgtcccaatggaagctgctgg
ggaggaggagaggagaactgccagaaattgaccaaaatcatctgtgcccagcaatgttcc
catcgctgtcgtggcaggtcccccagtgactgctgccacaaccaatgtgctgcggggtgt
acagggccccgagagagtgactgtctggtctgccaaaagttccaagatgaggccacatgc
aaagacacctgcccaccactcatgctgtacaaccccaccacctatcagatggatgtcaac
cctgaagggaagtacagctttggtgccacctgtgtgaagaagtgcccccgaaactacgtg
gtgacagatcatggctcatgtgtccgagcctgtgggcctgactactacgaagtggaagaa
gatggcatccgcaagtgtaaaaaatgtgatgggccctgtcgcaaagtttgtaatggcata
ggcattggtgaatttaaagacacactctccataaatgctacaaacatcaaacacttcaaa
tactgcactgccatcagcggggaccttcacatcctgccagtggcctttaagggggattct
ttcacgcgcactcctcctctagacccacgagaactagaaattctaaaaaccgtaaaggaa
ataacaggctttttgctgattcaggcttggcctgataactggactgacctccatgctttc
gagaacctagaaataatacgtggcagaacaaagcaacatggtcagttttctttggcggtc
gttggcctgaacatcacatcactggggctgcgttccctcaaggagatcagtgatggggat
gtgatcatttctggaaaccgaaatttgtgctacgcaaacacaataaactggaaaaaactc
ttcgggacacccaatcagaaaaccaaaatcatgaacaacagagctgagaaagactgcaag
gccgtgaaccacgtctgcaatcctttatgctcctcggaaggctgctggggccctgagccc
agggactgtgtctcctgccagaatgtgagcagaggcagggagtgcgtggagaaatgcaac
atcctggagggggaaccaagggagtttgtggaaaattctgaatgcatccagtgccatcca
gaatgtctgccccaggccatgaacatcacctgtacaggcaggggaccagacaactgcatc
cagtgtgcccactacattgatggcccacactgtgtcaagacctgcccagctggcatcatg
ggagagaacaacactctggtctggaagtatgcagatgccaataatgtctgccacctatgc
cacgccaactgtacctatggatgtgctgggccaggtcttcaaggatgtgaagtgtggcca
tctgggccaaagataccatctattgccactgggattgtgggtggcctcctcttcatagtg
gtggtggcccttgggattggcctattcatgcgaagacgtcacattgttcgaaagcgtaca
ctacgccgcctgcttcaagagagagagctcgtggaacctctcacacccagcggagaagct
ccaaaccaagcccacttgaggatattaaaggaaacagaattcaaaaagatcaaagttctg
ggttcgggagcatttggcacagtgtataagggtctctggatcccagaaggtgagaaagta
aaaatcccggtggccatcaaggagttaagagaagccacatctccaaaagccaacaaagaa
atccttgacgaagcctatgtgatggctagtgtggacaaccctcatgtatgccgcctcctg
ggcatctgtctgacctccactgtccagctcattacacagctcatgccctacggttgcctc
ctggactacgtccgagaacacaaggacaacattggctcccagtacctcctcaactggtgt
gtgcagattgcaaagggcatgaactacctggaagatcggcgtttggtgcaccgtgacttg
gcagccaggaatgtactggtgaagacaccacagcatgtcaagatcacagattttgggctg
gccaaactgcttggtgctgaagagaaagaatatcatgccgaggggggcaaagtgcctatc
aagtggatggctttggaatcaattttacaccgaatttatacacaccaaagtgatgtctgg
agctatggtgtcactgtgtgggaactgatgacctttgggtccaagccttatgatggaatc
ccagcaagtgacatctcatccatcctagagaaaggagagcgccttccacagccacctatc
tgcaccatcgatgtctacatgatcatggtcaagtgctggatgatagatgctgatagccgc
ccaaagttccgagagttgattcttgaattctccaaaatggcccgagacccacagcgctac
cttgttatccagggggatgaaagaatgcatttgccaagccctacagactccaacttttac
cgagccctgatggatgaagaggacatggaggatgtagttgatgctgatgagtatcttatc
ccacagcaaggcttcttcaacagcccgtccacgtcgaggactcccctcttgagttctctg
agtgcaactagcaacaattccactgtggcttgcattaatagaaatgggagctgccgtgtc
aaagaagacgccttcttgcagcggtacagctccgaccccacaggtgctgtaacagaggac
aacatagatgacgcattcctccctgtacctgaatatgtaaaccaatctgttcccaagagg
ccagcaggctctgtgcagaaccctgtctatcacaatcagcccctgcatccagctcctgga
agagacctgcattatcaaaatccccacagcaatgcagtgggcaaccctgagtatctcaac
actgcccagcctacctgtctcagtagtgggtttaacagccctgcactctggatccagaaa
ggcagtcaccaaatgagcctagacaaccctgactaccagcaggacttcttccccaaggaa
accaagccaaatggcatatttaagggccccacagctgaaaatgcagagtacctacgggtg
gcacctccaagcagtgagtttattggagcatga

KEGG   Mus musculus (mouse): 13866
Entry
13866             CDS       T01002                                 

Gene name
Erbb2, ErbB-, Erbb-2, HER, HER-, HER-2, HER2, Ne, Neu, c-erbB, c-erbB2, c-ne, c-neu, l11Ju, l11Jus8, mKIAA3023
Definition
(RefSeq) erb-b2 receptor tyrosine kinase 2
  KO
K05083  receptor tyrosine-protein kinase erbB-2 [EC:2.7.10.1]
Organism
mmu  Mus musculus (mouse)
Pathway
mmu01521  EGFR tyrosine kinase inhibitor resistance
mmu01522  Endocrine resistance
mmu01524  Platinum drug resistance
mmu04010  MAPK signaling pathway
mmu04012  ErbB signaling pathway
mmu04020  Calcium signaling pathway
mmu04066  HIF-1 signaling pathway
mmu04151  PI3K-Akt signaling pathway
mmu04510  Focal adhesion
mmu04520  Adherens junction
mmu04530  Tight junction
mmu05200  Pathways in cancer
mmu05205  Proteoglycans in cancer
mmu05206  MicroRNAs in cancer
mmu05212  Pancreatic cancer
mmu05213  Endometrial cancer
mmu05215  Prostate cancer
mmu05219  Bladder cancer
mmu05223  Non-small cell lung cancer
mmu05224  Breast cancer
mmu05226  Gastric cancer
mmu05230  Central carbon metabolism in cancer
Brite
KEGG Orthology (KO) [BR:mmu00001]
 09130 Environmental Information Processing
  09132 Signal transduction
   04010 MAPK signaling pathway
    13866 (Erbb2)
   04012 ErbB signaling pathway
    13866 (Erbb2)
   04066 HIF-1 signaling pathway
    13866 (Erbb2)
   04020 Calcium signaling pathway
    13866 (Erbb2)
   04151 PI3K-Akt signaling pathway
    13866 (Erbb2)
 09140 Cellular Processes
  09144 Cellular community - eukaryotes
   04510 Focal adhesion
    13866 (Erbb2)
   04520 Adherens junction
    13866 (Erbb2)
   04530 Tight junction
    13866 (Erbb2)
 09160 Human Diseases
  09161 Cancer: overview
   05200 Pathways in cancer
    13866 (Erbb2)
   05206 MicroRNAs in cancer
    13866 (Erbb2)
   05205 Proteoglycans in cancer
    13866 (Erbb2)
   05230 Central carbon metabolism in cancer
    13866 (Erbb2)
  09162 Cancer: specific types
   05212 Pancreatic cancer
    13866 (Erbb2)
   05226 Gastric cancer
    13866 (Erbb2)
   05219 Bladder cancer
    13866 (Erbb2)
   05215 Prostate cancer
    13866 (Erbb2)
   05213 Endometrial cancer
    13866 (Erbb2)
   05224 Breast cancer
    13866 (Erbb2)
   05223 Non-small cell lung cancer
    13866 (Erbb2)
  09176 Drug resistance: antineoplastic
   01521 EGFR tyrosine kinase inhibitor resistance
    13866 (Erbb2)
   01524 Platinum drug resistance
    13866 (Erbb2)
   01522 Endocrine resistance
    13866 (Erbb2)
 09180 Brite Hierarchies
  09181 Protein families: metabolism
   01001 Protein kinases [BR:mmu01001]
    13866 (Erbb2)
  09183 Protein families: signaling and cellular processes
   04147 Exosome [BR:mmu04147]
    13866 (Erbb2)
   04090 CD molecules [BR:mmu04090]
    13866 (Erbb2)
Enzymes [BR:mmu01000]
 2. Transferases
  2.7  Transferring phosphorus-containing groups
   2.7.10  Protein-tyrosine kinases
    2.7.10.1  receptor protein-tyrosine kinase
     13866 (Erbb2)
Protein kinases [BR:mmu01001]
 Receptor tyrosine kinases (RTK)
  EGFR family [OT]
   13866 (Erbb2)
Exosome [BR:mmu04147]
 Exosomal proteins
  Exosomal proteins of breast cancer cells
   13866 (Erbb2)
CD molecules [BR:mmu04090]
 Proteins
  13866 (Erbb2)
SSDB
Motif
Pfam: PK_Tyr_Ser-Thr Recep_L_domain GF_recep_IV Pkinase Furin-like APH Haspin_kinase DUF5849 Kinase-like GAPT
Other DBs
NCBI-GeneID: 13866
NCBI-ProteinID: NP_001003817
MGI: 95410
Ensembl: ENSMUSG00000062312
Vega: OTTMUSG00000002711
UniProt: P70424
Position
11 61.75 cM; 11 D
AA seq 1256 aa
MELAAWCRWGFLLALLSPGAAGTQVCTGTDMKLRLPASPETHLDMLRHLYQGCQVVQGNL
ELTYLPANASLSFLQDIQEVQGYMLIAHNRVKHVPLQRLRIVRGTQLFEDKYALAVLDNR
DPLDNVTTAAPGRTPEGLRELQLRSLTEILKGGVLIRGNPQLCYQDMVLWKDVLRKNNQL
APVDMDTNRSRACPPCAPTCKDNHCWGESPEDCQILTGTICTSGCARCKGRLPTDCCHEQ
CAAGCTGPKHSDCLACLHFNHSGICELHCPALITYNTDTFESMLNPEGRYTFGASCVTTC
PYNYLSTEVGSCTLVCPPNNQEVTAEDGTQRCEKCSKPCAGVCYGLGMEHLRGARAITSD
NIQEFAGCKKIFGSLAFLPESFDGNPSSGVAPLKPEHLQVFETLEEITGYLYISAWPESF
QDLSVFQNLRVIRGRILHDGAYSLTLQGLGIHSLGLRSLRELGSGLALIHRNTHLCFVNT
VPWDQLFRNPHQALLHSGNRPEEACGLEGLVCNSLCARGHCWGPGPTQCVNCSQFLRGQE
CVEECRVWKGLPREYVRGKHCLPCHPECQPQNSSETCYGSEADQCEACAHYKDSSSCVAR
CPSGVKPDLSYMPIWKYPDEEGICQPCPINCTHSCVDLDERGCPAEQRASPVTFIIATVV
GVLLFLIIVVVIGILIKRRRQKIRKYTMRRLLQETELVEPLTPSGAVPNQAQMRILKETE
LRKLKVLGSGAFGTVYKGIWIPDGENVKIPVAIKVLRENTSPKANKEILDEAYVMAGVGS
PYVSRLLGICLTSTVQLVTQLMPYGCLLDHVREHRGRLGSQDLLNWCVQIAKGMSYLEEV
RLVHRDLAARNVLVKSPNHVKITDFGLARLLDIDETEYHADGGKVPIKWMALESILRRRF
THQSDVWSYGVTVWELMTFGAKPYDGIPAREIPDLLEKGERLPQPPICTIDVYMIMVKCW
MIDSECRPRFRELVSEFSRMARDPQRFVVIQNEDLGPSSPMDSTFYRSLLEDDDMGELVD
AEEYLVPQQGFFSPDPALGTGSTAHRRHRSSSARSGGGELTLGLEPSEEEPPRSPLAPSE
GAGSDVFDGDLAVGVTKGLQSLSPHDLSPLQRYSEDPTLPLPPETDGYVAPLACSPQPEY
VNQPEVRPQSPLTPEGPPPPIRPAGATLERPKTLSPGKNGVVKDVFAFGGAVENPEYLAP
RAGTASQPHPSPAFSPAFDNLYYWDQNSSEQGPPPSTFEGTPTAENPEYLGLDVPV
NT seq 3771 nt   +upstreamnt  +downstreamnt
atggagctggcggcctggtgccgttgggggttcctcctcgccctcctgtcccccggagcc
gcgggtacccaagtgtgtaccggtaccgacatgaagttgcgactccctgccagtcctgag
acccacctggacatgcttcgccacctctaccagggctgtcaggtggtgcagggcaatttg
gagcttacctacctgcccgccaatgccagcctctcattcctgcaggacatccaggaagtc
cagggatacatgctcatcgctcacaaccgagtgaaacacgtcccactgcagaggttgcgc
atcgtgagagggactcagctctttgaggacaagtatgccctggctgtgctagacaaccga
gaccctttggacaacgtcaccaccgccgccccaggcagaaccccagaagggctgcgggag
ctgcagcttcgaagtctcacagagatcttgaagggaggagttttgatccgtgggaaccct
cagctctgctaccaggacatggttttgtggaaggatgtcctccgtaagaataaccagctg
gctcctgtcgacatggacaccaatcgttcccgggcctgtccaccttgtgccccaacctgc
aaagacaatcactgttggggtgagagtcctgaagactgtcagatcttgactggcaccatc
tgtactagtggctgtgcccggtgcaagggccggctgcccactgactgttgccatgagcag
tgtgctgcaggctgcacgggtcccaagcattctgactgcctggcctgcctccacttcaat
catagtggtatctgtgagctgcactgcccggccctcatcacctacaacacagacaccttc
gagtccatgctcaaccctgagggtcgctacacctttggtgccagctgtgtgaccacctgc
ccctacaactacctctccacggaagtgggatcctgcactctggtctgtcccccgaacaac
caagaggtcacagctgaggacggaacacagcggtgtgagaaatgcagcaagccctgtgct
ggagtatgctatggtctgggcatggagcacctccgaggggcgagggccatcaccagtgac
aatatccaggagtttgctggctgcaagaagatctttgggagcctggcatttttgccggag
agctttgatgggaacccctcctccggcgttgccccactgaagccagagcatctccaagtg
ttcgaaaccctggaggagatcacaggttacctatacatttcagcatggccagagagcttc
caagacctcagtgtcttccagaaccttcgggtcattcggggacggattctccatgatggt
gcttactcattgacgttgcaaggcctggggattcactcactggggctacgctcactgcgg
gagctgggcagtggattggctctcattcaccgcaacacccatctctgctttgtaaacact
gtaccttgggaccagctcttccggaacccgcaccaggccctactccacagtgggaaccgg
ccagaagaggcatgtggtcttgagggcttggtctgtaactcactgtgtgcccgtgggcac
tgctgggggccagggcccacccagtgtgtcaactgcagtcagttcctccggggccaggag
tgtgtggaggagtgccgagtatggaaggggctccccagggagtatgtgaggggcaagcac
tgtctgccatgccaccccgagtgtcagcctcaaaacagctcggagacctgctatggatcg
gaggctgaccagtgtgaggcttgtgcccactacaaggactcatcttcctgtgtggctcgc
tgccccagtggtgtgaagccagacctctcctacatgcctatctggaagtacccggatgag
gagggcatatgtcagccatgccccatcaactgcacccactcatgtgtggacctggacgaa
cgaggctgcccagcagagcagagagccagcccagtgacattcatcattgcaactgtggtg
ggcgtcctgttgttcctgatcatagtggtggtcattggaatcctaatcaaacgaaggcga
cagaagatccggaagtataccatgcgtaggctgctgcaggagaccgagctggtggagccg
ctgacgcccagtggagctgtgcccaaccaggctcagatgcggatcctaaaggagacagag
ctaaggaagctgaaggtgcttgggtcaggagccttcggcactgtctacaagggcatctgg
atcccagatggggagaacgtgaaaatccccgtggccatcaaggtgttgagggaaaacaca
tctcctaaagctaacaaagaaatcctagatgaagcgtacgtcatggctggtgtgggttct
ccatatgtgtcccgcctcctgggcatctgcctgacatccacagtgcagctggtgacacag
cttatgccctatggctgccttctggaccatgtccgagaacaccgaggtcgcttaggctcc
caggacctgctcaactggtgtgttcagattgccaaggggatgagctacctggaggaagtt
cggcttgttcacagggacctagctgcccgaaacgtgctagtcaagagtcccaaccacgtc
aagattaccgacttcgggctggcacggctgctggacattgatgagactgaataccatgca
gatgggggcaaggtgcccatcaagtggatggcattggaatctattctcagacgccggttc
acccatcagagtgatgtgtggagctatggtgtgactgtgtgggagctgatgacctttggg
gccaaaccttacgatgggatcccagctcgggagatccctgatttgctggagaagggagaa
cgcctacctcagcctccaatctgcaccatcgacgtctacatgatcatggtcaaatgttgg
atgattgactccgaatgtcgcccgagattccgggagttggtatcagaattctcccgtatg
gcaagggacccccagcgctttgtggtcatccagaacgaggacttaggcccctccagcccc
atggacagcaccttctaccgttcactgctggaggatgatgacatgggggagctggtcgat
gctgaagagtacctggtaccccagcagggattcttctccccagaccctgccctaggtact
gggagcacagcccaccgcagacaccgcagctcgtcggccaggagtggcggtggtgagctg
acactgggcctggagccctcggaagaagagccccccagatctccactggctccctccgaa
ggggctggctccgatgtgtttgatggtgacctggcagtgggggtaaccaaaggactgcag
agcctctctccacatgacctcagccctctacagcggtacagtgaggatcccacattacct
ctgccccccgagactgatggctacgttgctcccctggcctgcagcccccagcccgagtat
gtgaaccagccagaggttcggcctcagtctcccttgaccccagagggtcctccgcctccc
atccgacctgctggtgctactctagaaagacccaagactctctctcctgggaaaaatggg
gttgtcaaagacgtttttgcctttgggggtgctgtggagaaccctgaatacttagcaccc
agagcaggcactgcctctcagccccacccttctcctgccttcagcccagcctttgacaac
ctctattactgggaccagaactcatcggagcagggtcctccaccaagtacctttgaaggg
acccccactgcagagaaccctgagtacctaggcctggatgtgccagtatga

KEGG   Mus musculus (mouse): 14254
Entry
14254             CDS       T01002                                 

Gene name
Flt1, AI323757, Flt-, Flt-1, VEGF, VEGFR, VEGFR-1, VEGFR1, sFl, sFlt1
Definition
(RefSeq) FMS-like tyrosine kinase 1
  KO
K05096  FMS-like tyrosine kinase 1 [EC:2.7.10.1]
Organism
mmu  Mus musculus (mouse)
Pathway
mmu04010  MAPK signaling pathway
mmu04014  Ras signaling pathway
mmu04015  Rap1 signaling pathway
mmu04020  Calcium signaling pathway
mmu04066  HIF-1 signaling pathway
mmu04151  PI3K-Akt signaling pathway
mmu04510  Focal adhesion
mmu05202  Transcriptional misregulation in cancer
mmu05323  Rheumatoid arthritis
Brite
KEGG Orthology (KO) [BR:mmu00001]
 09130 Environmental Information Processing
  09132 Signal transduction
   04010 MAPK signaling pathway
    14254 (Flt1)
   04014 Ras signaling pathway
    14254 (Flt1)
   04015 Rap1 signaling pathway
    14254 (Flt1)
   04066 HIF-1 signaling pathway
    14254 (Flt1)
   04020 Calcium signaling pathway
    14254 (Flt1)
   04151 PI3K-Akt signaling pathway
    14254 (Flt1)
 09140 Cellular Processes
  09144 Cellular community - eukaryotes
   04510 Focal adhesion
    14254 (Flt1)
 09160 Human Diseases
  09161 Cancer: overview
   05202 Transcriptional misregulation in cancer
    14254 (Flt1)
  09163 Immune disease
   05323 Rheumatoid arthritis
    14254 (Flt1)
 09180 Brite Hierarchies
  09181 Protein families: metabolism
   01001 Protein kinases [BR:mmu01001]
    14254 (Flt1)
Enzymes [BR:mmu01000]
 2. Transferases
  2.7  Transferring phosphorus-containing groups
   2.7.10  Protein-tyrosine kinases
    2.7.10.1  receptor protein-tyrosine kinase
     14254 (Flt1)
Protein kinases [BR:mmu01001]
 Receptor tyrosine kinases (RTK)
  VEGFR family [OT]
   14254 (Flt1)
SSDB
Motif
Pfam: PK_Tyr_Ser-Thr Ig_3 I-set Pkinase ig Ig_2 V-set VEGFR-2_TMD Ig_6 C1-set Ig_4 Ig_5 Izumo-Ig Herpes_gE Haspin_kinase TCAD9 ABC1
Other DBs
NCBI-GeneID: 14254
NCBI-ProteinID: NP_034358
MGI: 95558
Ensembl: ENSMUSG00000029648
Vega: OTTMUSG00000021385
UniProt: P35969 A0A0R4J0A4
Position
5 G3; 5 87.01 cM
AA seq 1333 aa
MVSCWDTAVLPYALLGCLLLTGYGSGSKLKVPELSLKGTQHVMQAGQTLFLKCRGEAAHS
WSLPTTVSQEDKRLSITPPSACGRDNRQFCSTLTLDTAQANHTGLYTCRYLPTSTSKKKK
AESSIYIFVSDAGSPFIEMHTDIPKLVHMTEGRQLIIPCRVTSPNVTVTLKKFPFDTLTP
DGQRITWDSRRGFIIANATYKEIGLLNCEATVNGHLYQTNYLTHRQTNTILDVQIRPPSP
VRLLHGQTLVLNCTATTELNTRVQMSWNYPGKATKRASIRQRIDRSHSHNNVFHSVLKIN
NVESRDKGLYTCRVKSGSSFQSFNTSVHVYEKGFISVKHRKQPVQETTAGRRSYRLSMKV
KAFPSPEIVWLKDGSPATLKSARYLVHGYSLIIKDVTTEDAGDYTILLGIKQSRLFKNLT
ATLIVNVKPQIYEKSVSSLPSPPLYPLGSRQVLTCTVYGIPRPTITWLWHPCHHNHSKER
YDFCTENEESFILDPSSNLGNRIESISQRMTVIEGTNKTVSTLVVADSQTPGIYSCRAFN
KIGTVERNIKFYVTDVPNGFHVSLEKMPAEGEDLKLSCVVNKFLYRDITWILLRTVNNRT
MHHSISKQKMATTQDYSITLNLVIKNVSLEDSGTYACRARNIYTGEDILRKTEVLVRDSE
APHLLQNLSDYEVSISGSTTLDCQARGVPAPQITWFKNNHKIQQEPGIILGPGNSTLFIE
RVTEEDEGVYRCRATNQKGAVESAAYLTVQGTSDKSNLELITLTCTCVAATLFWLLLTLF
IRKLKRSSSEVKTDYLSIIMDPDEVPLDEQCERLPYDASKWEFARERLKLGKSLGRGAFG
KVVQASAFGIKKSPTCRTVAVKMLKEGATASEYKALMTELKILTHIGHHLNVVNLLGACT
KQGGPLMVIVEYCKYGNLSNYLKSKRDLFCLNKDAALHMELKKESLEPGLEQGQKPRLDS
VSSSSVTSSSFPEDRSVSDVEGDEDYSEISKQPLTMEDLISYSFQVARGMEFLSSRKCIH
RDLAARNILLSENNVVKICDFGLARDIYKNPDYVRRGDTRLPLKWMAPESIFDKVYSTKS
DVWSYGVLLWEIFSLGGSPYPGVQMDEDFCSRLKEGMRMRTPEYATPEIYQIMLDCWHKD
PKERPRFAELVEKLGDLLQANVQQDGKDYIPLNAILTRNSGFTYSTPTFSEDLFKDGFAD
PHFHSGSSDDVRYVNAFKFMSLERIKTFEELSPNSTSMFEDYQLDTSTLLGSPLLKRFTW
TETKPKASMKIDLRIASKSKEAGLSDLPRPSFCFSSCGHIRPVQDDESELGKESCCSPPP
DYNSVVLYSSPPA
NT seq 4002 nt   +upstreamnt  +downstreamnt
atggtcagctgctgggacaccgcggtcttgccttacgcgctgctcgggtgtctgcttctc
acaggatatggctcagggtcgaagttaaaagtgcctgaactgagtttaaaaggcacccag
catgtcatgcaagcaggccagactctctttctcaagtgcagaggggaggcagcccactca
tggtctctgcccacgaccgtgagccaggaggacaaaaggctgagcatcactcccccatcg
gcctgtgggagggataacaggcaattctgcagcaccttgaccttggacacggcgcaggcc
aaccacacgggcctctacacctgtagatacctccctacatctacttcgaagaaaaagaaa
gcggaatcttcaatctacatatttgttagtgatgcagggagtcctttcatagagatgcac
actgacatacccaaacttgtgcacatgacggaaggaagacagctcatcatcccctgccgg
gtgacgtcacccaacgtcacagtcaccctaaaaaagtttccatttgatactcttacccct
gatgggcaaagaataacatgggacagtaggagaggctttataatagcaaatgcaacgtac
aaagagataggactgctgaactgcgaagccaccgtcaacgggcacctgtaccagacaaac
tatctgacccatcggcagaccaatacaatcctagatgtccaaatacgcccgccgagccca
gtgagactgctccacgggcagactcttgtcctcaactgcaccgccaccacggagctcaat
acgagggtgcaaatgagctggaattaccctggtaaagcaactaagagagcatctataagg
cagcggattgaccggagccattcccacaacaatgtgttccacagtgttcttaagatcaac
aatgtggagagccgagacaaggggctctacacctgtcgcgtgaagagtgggtcctcgttc
cagtctttcaacacctccgtgcatgtgtatgaaaaaggattcatcagtgtgaaacatcgg
aagcagccggtgcaggaaaccacagcaggaagacggtcctatcggctgtccatgaaagtg
aaggccttcccctccccagaaatcgtatggttaaaagatggctcgcctgcaacattgaag
tctgctcgctatttggtacatggctactcattaattatcaaagatgtgacaaccgaggat
gcaggggactatacgatcttgctgggcataaagcagtcaaggctatttaaaaacctcact
gccactctcattgtaaacgtgaaacctcagatctacgaaaagtccgtgtcctcgcttcca
agcccacctctctatccgctgggcagcagacaagtcctcacttgcaccgtgtatggcatc
cctcggccaacaatcacgtggctctggcacccctgtcaccacaatcactccaaagaaagg
tatgacttctgcactgagaatgaagaatcctttatcctggatcccagcagcaacttagga
aacagaattgagagcatctctcagcgcatgacggtcatagaaggaacaaataagacggtt
agcacattggtggtggctgactctcagacccctggaatctacagctgccgggccttcaat
aaaatagggactgtggaaagaaacataaaattttatgtcacagatgtgccgaatggcttt
cacgtttccttggaaaagatgccagccgaaggagaggacctgaaactgtcctgtgtggtc
aataaattcctgtacagagacattacctggattctgctacggacagttaacaacagaacc
atgcaccatagtatcagcaagcaaaaaatggccaccactcaagattactccatcactctg
aaccttgtcatcaagaacgtgtctctagaagactcgggcacctatgcgtgcagagccagg
aacatatacacaggggaagacatccttcggaagacagaagttctcgttagagattcggaa
gcgccacacctgcttcaaaacctcagtgactacgaggtctccatcagtggctctacgacc
ttagactgtcaagctagaggtgtccccgcgcctcagatcacttggttcaaaaacaaccac
aaaatacaacaagaaccgggaattattttaggaccaggaaacagcacgctgtttattgaa
agagtcacagaggaggatgagggtgtctataggtgccgagccaccaaccagaagggggcc
gtggaaagcgcagcctacctcaccgtgcaaggaacctcagacaagtcaaacctggagctg
atcacgctcacgtgcacatgcgtggctgcgaccctcttttggctccttctaactctcttc
atcagaaaactgaagcggtcttcttccgaagtaaagacagactacctgtcaatcattatg
gacccagatgaagttcccctggatgagcagtgtgaacggctgccctatgatgccagcaag
tgggagtttgcacgggagagactgaaactaggcaaatcgctcggaagaggggcttttggg
aaagtcgttcaagcctctgcatttggcattaagaaatcacccacctgccggactgtggct
gtgaagatgttgaaagagggggccacagccagtgagtacaaagctctgatgaccgaactc
aagatcttgacccacatcggccatcatctgaatgtggttaacctcctgggagcctgcacg
aagcaaggagggcctctgatggtgatcgtggaatactgcaaatacggaaacctgtccaac
tacctcaagagcaaacgtgacttattctgtctcaacaaggacgcagccttgcatatggag
ctcaagaaagagagcctggaaccaggcctggagcagggccagaagccccgcctagacagt
gtcagcagctcaagtgtcaccagctccagcttccctgaagaccgaagcgtgagcgatgtg
gaaggagacgaggattacagtgagatctccaagcagcccctcaccatggaagacctgatt
tcctacagtttccaagtggccagaggcatggagtttctgtcctccagaaagtgcattcat
cgggacctggcagcgagaaacatccttttatctgagaacaatgtggtgaagatttgcgac
tttggcctggcccgggatatttataagaaccctgattatgtgaggagaggagatactcga
cttcccctaaaatggatggctcctgaatccatctttgacaaggtctacagcaccaagagc
gatgtgtggtcctatggcgtgttgctgtgggagatcttctccttagggggttctccatac
ccaggagtgcaaatggatgaagacttctgcagccgcctgaaggaaggcatgcggatgaga
accccggagtatgccacacctgaaatctaccaaatcatgttggattgctggcacaaagac
cccaaagagaggccccggtttgctgaacttgtggagaaacttggtgacctgcttcaagcc
aacgtccaacaggatgggaaagattacatccccctcaatgccatactgactagaaacagt
ggcttcacatactcgacccccaccttctctgaggaccttttcaaggacggctttgcagat
ccacattttcattccggaagctctgatgatgtgagatatgtaaacgctttcaaattcatg
agcctggaaagaatcaaaacctttgaggagctttcaccgaactccacctccatgtttgag
gactatcagctggacactagcactctgctgggctcccccttgctgaagcggttcacctgg
actgagaccaagcccaaggcctccatgaagatagacttgagaatagcgagtaaaagcaag
gaggcgggactttccgatctgccgaggcccagcttctgcttctccagctgtggccacatc
aggcccgtgcaggacgatgaatctgagctgggaaaggagtcctgctgttctccaccccca
gactacaactccgtggtgttgtactcctccccgcccgcctaa

KEGG   Mus musculus (mouse): 14257
Entry
14257             CDS       T01002                                 

Gene name
Flt4, AI323512, Chy, Flt-, Flt-4, VEGF, VEGFR, VEGFR-3, VEGFR3
Definition
(RefSeq) FMS-like tyrosine kinase 4
  KO
K05097  FMS-like tyrosine kinase 4 [EC:2.7.10.1]
Organism
mmu  Mus musculus (mouse)
Pathway
mmu04010  MAPK signaling pathway
mmu04014  Ras signaling pathway
mmu04015  Rap1 signaling pathway
mmu04020  Calcium signaling pathway
mmu04151  PI3K-Akt signaling pathway
mmu04510  Focal adhesion
mmu05200  Pathways in cancer
mmu05224  Breast cancer
Brite
KEGG Orthology (KO) [BR:mmu00001]
 09130 Environmental Information Processing
  09132 Signal transduction
   04010 MAPK signaling pathway
    14257 (Flt4)
   04014 Ras signaling pathway
    14257 (Flt4)
   04015 Rap1 signaling pathway
    14257 (Flt4)
   04020 Calcium signaling pathway
    14257 (Flt4)
   04151 PI3K-Akt signaling pathway
    14257 (Flt4)
 09140 Cellular Processes
  09144 Cellular community - eukaryotes
   04510 Focal adhesion
    14257 (Flt4)
 09160 Human Diseases
  09161 Cancer: overview
   05200 Pathways in cancer
    14257 (Flt4)
  09162 Cancer: specific types
   05224 Breast cancer
    14257 (Flt4)
 09180 Brite Hierarchies
  09181 Protein families: metabolism
   01001 Protein kinases [BR:mmu01001]
    14257 (Flt4)
Enzymes [BR:mmu01000]
 2. Transferases
  2.7  Transferring phosphorus-containing groups
   2.7.10  Protein-tyrosine kinases
    2.7.10.1  receptor protein-tyrosine kinase
     14257 (Flt4)
Protein kinases [BR:mmu01001]
 Receptor tyrosine kinases (RTK)
  VEGFR family [OT]
   14257 (Flt4)
SSDB
Motif
Pfam: PK_Tyr_Ser-Thr Ig_3 I-set Pkinase Ig_2 ig VEGFR-2_TMD V-set C1-set TCAD9 Haspin_kinase
Other DBs
NCBI-GeneID: 14257
NCBI-ProteinID: NP_032055
MGI: 95561
Ensembl: ENSMUSG00000020357
Vega: OTTMUSG00000005554
UniProt: P35917 Q5SU94
Position
11 B1.2; 11 29.69 cM
AA seq 1363 aa
MQPGAALNLRLWLCLGLLQGLANGYSMTPPTLNITEDSYVIDTGDSLSISCRGQHPLEWT
WPGAQEVLTTGGKDSEDTRVVHDCEGTEARPYCKVLLLAQTHANNTGSYHCYYKYIKARI
EGTTAASTYVFVRDFKHPFINKPDTLLVNRKDSMWVPCLVSIPGLNITLRSQSSALHPDG
QEVLWDDRRGMRVPTQLLRDALYLQCETTWGDQNFLSNLFVVHITGNELYDIQLYPKKSM
ELLVGEKLVLNCTVWAEFDSGVTFDWDYPGKQAERAKWVPERRSQQTHTELSSILTIHNV
SQNDLGPYVCEANNGIQRFRESTEVIVHEKPFISVEWLKGPVLEATAGDELVKLPVKLAA
YPPPEFQWYKDRKAVTGRHNPHALVLKEVTEASAGVYTLALWNSAAGLRQNISLELVVNV
PPHIHEKEASSPSIYSRHSRQTLTCTAYGVPQPLSVQWHWRPWTPCKTFAQRSLRRRQQR
DGMPQCRDWKEVTTQDAVNPIESLDSWTEFVEGKNKTVSKLVIQDANVSAMYKCVVVNKV
GQDERLIYFYVTTIPDGFSIESEPSEDPLEGQSVRLSCRADNYTYEHLRWYRLNLSTLHD
AQGNPLLLDCKNVHLFATPLEANLEEAEPGARHATLSLNIPRVAPEDEGDYVCEVQDRRS
QDKHCHKKYLSVQALEAPRLTQNLTDLLVNVSDSLEMRCPVAGAHVPSIVWYKDERLLEK
ESGIDLADSNQRLSIQRVREEDAGRYLCSVCNAKGCVNSSASVAVEGSEDKGSMEIVILI
GTGVIAVFFWVLLLLIFCNMKRPAHADIKTGYLSIIMDPGEVPLEEQCEYLSYDASQWEF
PRERLHLGRVLGHGAFGKVVEASAFGINKGSSCDTVAVKMLKEGATASEHRALMSELKIL
IHIGNHLNVVNLLGACTKPNGPLMVIVEFCKYGNLSNFLRVKRDTFNPYAEKSPEQRRRF
RAMVEGAKADRRRPGSSDRALFTRFLMGKGSARRAPLVQEAEDLWLSPLTMEDLVCYSFQ
VARGMEFLASRKCIHRDLAARNILLSESDIVKICDFGLARDIYKDPDYVRKGSARLPLKW
MAPESIFDKVYTTQSDVWSFGVLLWEIFSLGASPYPGVQINEEFCQRLKDGTRMRAPELA
TPAIRHIMQSCWSGDPKARPAFSDLVEILGDLLQGGGWQEEEEERMALHSSQSSEEDGFM
QASTTALHITEADADDSPPSMHCHSLAARYYNCVSFPGRLARGTKTPGSSRMKTFEELPM
TPTTYKASMDNQTDSGMVLASEEFEELESRHRPEGSFSCKGPGQHMDIPRGHPDPQGRRR
RPTQGAQGGKVFYNNEYGEVSQPCTEGDCCPSAGSTFFADSSY
NT seq 4092 nt   +upstreamnt  +downstreamnt
atgcagccgggcgctgcgctgaacctgcgcctgtggctctgcctcggactcctccaaggc
ctggcaaatggttactccatgacccctccaaccctgaacatcacagaggattcatatgtg
attgacaccggggacagcctatccatatcctgcaggggacagcaccccctcgagtggacc
tggccaggggcccaggaggtactgaccacaggtgggaaggacagtgaagacacacgggtt
gtgcatgactgtgaaggcacagaagctaggccctactgcaaggtgctactgctggcccag
actcacgccaacaacacgggcagctaccactgctactacaagtacatcaaggcccggatt
gagggcaccacagctgccagcacctatgtgtttgtaagagactttaaacaccctttcatc
aacaaacctgacacgctcctggtcaacaggaaggactcgatgtgggtgccctgcttggtg
tccattcccggcctcaacatcacactgcgctcgcaaagctcagcgctgcaccccgacggg
caggaggtgctgtgggatgaccgccggggcatgcgggtgcccactcaactgttgcgcgat
gccctgtacctgcagtgcgagaccacctggggtgaccagaacttcctttccaatctcttc
gtcgtgcacatcacaggcaatgagctctatgacatccagctgtaccccaagaagtcaatg
gagctgttggttggagagaagctggttttgaactgtacagtgtgggctgagttcgactca
ggtgtcaccttcgactgggattatccagggaagcaggcagagcgggctaagtgggtacct
gagcggcgttcccagcagacccacacagaactctccagcatcctgaccatccacaatgtc
agccagaatgacctgggcccctatgtgtgtgaggccaacaatgggattcagcggttccgg
gaaagcacagaggtcattgtgcacgaaaagcccttcatcagtgtcgagtggctcaaagga
cctgtcctggaggccacagccggtgacgagctggtgaagctacccgtgaagctggcagct
tatcccccaccggagttccaatggtacaaggacagaaaggcagtgactgggcgccacaat
ccccatgctctggtgctcaaagaggtgaccgaggccagcgcaggggtctacactctcgcc
ctgtggaactctgcagctggtctgaggcaaaacatcagtctggagctggtggtgaatgtg
cctcctcacatccacgaaaaggaagcctcttcacccagcatctactcccgccacagtcgc
cagaccctcacctgcaccgcctatggagtaccccaacccctcagtgtccagtggcactgg
aggccctggacaccctgcaagacgtttgcccagcgcagcctccggaggcggcagcagcgg
gatggcatgccacagtgccgagactggaaggaggtgaccactcaggatgctgtgaacccc
atcgagagtctggacagctggacggagtttgtggaggggaagaataagacggtgagcaag
ctggtgatccaggatgccaatgtgtcagccatgtacaagtgtgtggtcgtcaacaaagtg
ggccaggatgagagactcatctacttctatgtgaccaccatcccggacggtttcagtatc
gagtcggagccttctgaggatcccttagaaggccagtccgtgcgcctcagctgccgggcg
gacaactacacgtacgaacatctgcgctggtaccggctcaacctctccacactgcacgat
gctcaagggaaccccctattgctggactgcaaaaacgtgcacctgtttgccacgccccta
gaggccaacctagaggaggcagagcccggggcccgccacgccaccctcagtttgaatatc
ccccgagtggcgcccgaggacgagggtgactacgtgtgtgaagtgcaggataggcgcagc
caggacaagcactgccacaagaagtacctgtccgtgcaggccctggaagctcctcggctc
acgcagaacttgaccgacctcctggtgaacgtgagtgactccctggagatgcgatgcccg
gtggctggagcgcatgtgcccagtattgtgtggtacaaagatgaaaggctcctggagaaa
gagtcgggaatcgacctggcagactccaatcagaggctgagcatccagcgcgtgcgcgag
gaggacgcaggtcgttatctgtgcagcgtgtgcaatgccaagggctgcgtaaactcctct
gccagcgtggcagtggaaggctctgaagataaaggcagcatggagattgtgatactcatt
ggcactggcgtcatcgcagttttcttctgggtcctcctcctgctcatcttctgtaacatg
aaaaggcctgcccatgcagacatcaagacgggctacctgtccatcatcatggaccccggg
gaggtgcctttggaggagcagtgtgaatacctgtcctatgacgccagccagtgggagttc
cccagggaaaggttgcacctcgggagagtcctaggccacggggcttttgggaaggtggtg
gaagcctcagcttttggcatcaataaaggcagcagctgtgacaccgtggctgtgaagatg
ctgaaagagggcgctactgccagcgagcaccgtgccctgatgtcggagctcaagatccta
attcacatcggcaaccatctcaacgtggtcaacctcctaggggcgtgcaccaagcccaac
ggccctctcatggtgatcgtggagttttgcaaatacggcaacctctccaacttcttgcgt
gtcaagcgggacacgttcaacccctacgcggagaagtctccggagcaacgcaggcgcttc
cgcgccatggtagaaggcgccaaagctgataggaggagacctggaagcagcgacagggcc
ctgttcacgcggttcctgatgggcaaaggaagtgcacggcgagccccacttgtccaagaa
gctgaggacctatggctgagcccactgaccatggaagaccttgtatgctacagcttccaa
gttgcccggggaatggagttcctggcttcccgcaagtgcattcacagagacctggctgct
cggaacatcctactgtcagaaagtgacatagtgaagatctgcgactttggcctcgctcgg
gacatctacaaagaccccgactatgtccgaaagggcagtgcccgacttcctctgaaatgg
atggcccccgagagcatctttgataaggtgtacaccacgcagagtgatgtgtggtccttc
ggcgtgctgctgtgggagatcttctcattgggggcctctccataccctggggtacagatc
aatgaggagttctgccagcggctgaaggatggcactcgaatgagagccccggaactggcc
actcctgccatacgccacatcatgcagagttgctggtctggagaccctaaagcaagacct
gctttctctgacctagtggagatcctgggggacctgcttcagggcggaggctggcaggag
gaggaagaggagcgcatggccctgcacagctctcagagctccgaggaggatggcttcatg
caggcatccaccacagctctacatatcaccgaagcagacgctgatgatagtccacccagc
atgcattgccacagcctggcagccagatattacaactgtgtgtcctttcctgggcgcctg
gccagaggcactaagactccaggctcttccaggatgaagacatttgaagaattgcccatg
acccctacaacctacaaagcctccatggataaccagacagacagcgggatggtgctggcc
tcagaagagtttgaggagctagaaagcaggcatagaccagaaggcagcttcagctgtaaa
ggtcctggccagcacatggatattcccagaggacaccctgacccccaggggaggcggcga
cggcccactcaaggggcacaaggaggcaaggtgttttataacaacgagtatggggaggtc
tcccagccatgtacagaaggtgactgctgcccgtctgctggctccaccttcttcgcagac
agcagctactaa

KEGG   Mus musculus (mouse): 16001
Entry
16001             CDS       T01002                                 

Gene name
Igf1r, A330103N21Rik, CD221, D930020L01, IGF-, IGF-1R, hyft
Definition
(RefSeq) insulin-like growth factor I receptor
  KO
K05087  insulin-like growth factor 1 receptor [EC:2.7.10.1]
Organism
mmu  Mus musculus (mouse)
Pathway
mmu01521  EGFR tyrosine kinase inhibitor resistance
mmu01522  Endocrine resistance
mmu04010  MAPK signaling pathway
mmu04014  Ras signaling pathway
mmu04015  Rap1 signaling pathway
mmu04066  HIF-1 signaling pathway
mmu04068  FoxO signaling pathway
mmu04114  Oocyte meiosis
mmu04140  Autophagy - animal
mmu04144  Endocytosis
mmu04150  mTOR signaling pathway
mmu04151  PI3K-Akt signaling pathway
mmu04152  AMPK signaling pathway
mmu04211  Longevity regulating pathway
mmu04213  Longevity regulating pathway - multiple species
mmu04510  Focal adhesion
mmu04520  Adherens junction
mmu04550  Signaling pathways regulating pluripotency of stem cells
mmu04730  Long-term depression
mmu04913  Ovarian steroidogenesis
mmu04914  Progesterone-mediated oocyte maturation
mmu05200  Pathways in cancer
mmu05202  Transcriptional misregulation in cancer
mmu05205  Proteoglycans in cancer
mmu05214  Glioma
mmu05215  Prostate cancer
mmu05218  Melanoma
mmu05224  Breast cancer
mmu05225  Hepatocellular carcinoma
Brite
KEGG Orthology (KO) [BR:mmu00001]
 09130 Environmental Information Processing
  09132 Signal transduction
   04010 MAPK signaling pathway
    16001 (Igf1r)
   04014 Ras signaling pathway
    16001 (Igf1r)
   04015 Rap1 signaling pathway
    16001 (Igf1r)
   04066 HIF-1 signaling pathway
    16001 (Igf1r)
   04068 FoxO signaling pathway
    16001 (Igf1r)
   04151 PI3K-Akt signaling pathway
    16001 (Igf1r)
   04152 AMPK signaling pathway
    16001 (Igf1r)
   04150 mTOR signaling pathway
    16001 (Igf1r)
 09140 Cellular Processes
  09141 Transport and catabolism
   04144 Endocytosis
    16001 (Igf1r)
   04140 Autophagy - animal
    16001 (Igf1r)
  09143 Cell growth and death
   04114 Oocyte meiosis
    16001 (Igf1r)
  09144 Cellular community - eukaryotes
   04510 Focal adhesion
    16001 (Igf1r)
   04520 Adherens junction
    16001 (Igf1r)
   04550 Signaling pathways regulating pluripotency of stem cells
    16001 (Igf1r)
 09150 Organismal Systems
  09152 Endocrine system
   04913 Ovarian steroidogenesis
    16001 (Igf1r)
   04914 Progesterone-mediated oocyte maturation
    16001 (Igf1r)
  09156 Nervous system
   04730 Long-term depression
    16001 (Igf1r)
  09149 Aging
   04211 Longevity regulating pathway
    16001 (Igf1r)
   04213 Longevity regulating pathway - multiple species
    16001 (Igf1r)
 09160 Human Diseases
  09161 Cancer: overview
   05200 Pathways in cancer
    16001 (Igf1r)
   05202 Transcriptional misregulation in cancer
    16001 (Igf1r)
   05205 Proteoglycans in cancer
    16001 (Igf1r)
  09162 Cancer: specific types
   05225 Hepatocellular carcinoma
    16001 (Igf1r)
   05214 Glioma
    16001 (Igf1r)
   05218 Melanoma
    16001 (Igf1r)
   05215 Prostate cancer
    16001 (Igf1r)
   05224 Breast cancer
    16001 (Igf1r)
  09176 Drug resistance: antineoplastic
   01521 EGFR tyrosine kinase inhibitor resistance
    16001 (Igf1r)
   01522 Endocrine resistance
    16001 (Igf1r)
 09180 Brite Hierarchies
  09181 Protein families: metabolism
   01001 Protein kinases [BR:mmu01001]
    16001 (Igf1r)
  09183 Protein families: signaling and cellular processes
   04090 CD molecules [BR:mmu04090]
    16001 (Igf1r)
Enzymes [BR:mmu01000]
 2. Transferases
  2.7  Transferring phosphorus-containing groups
   2.7.10  Protein-tyrosine kinases
    2.7.10.1  receptor protein-tyrosine kinase
     16001 (Igf1r)
Protein kinases [BR:mmu01001]
 Receptor tyrosine kinases (RTK)
  INSR family [OT]
   16001 (Igf1r)
CD molecules [BR:mmu04090]
 Proteins
  16001 (Igf1r)
SSDB
Motif
Pfam: PK_Tyr_Ser-Thr Recep_L_domain Pkinase Furin-like fn3 Kinase-like Insulin_TMD B2 DUF4476
Other DBs
NCBI-GeneID: 16001
NCBI-ProteinID: NP_034643
MGI: 96433
Ensembl: ENSMUSG00000005533
Vega: OTTMUSG00000059602
UniProt: Q60751 E9QNX9
Structure
PDB: 
6PYH

Position
7 C; 7 37.27 cM
AA seq 1369 aa
MKSGSGGGSPTSLWGLVFLSAALSLWPTSGEICGPGIDIRNDYQQLKRLENCTVIEGFLH
ILLISKAEDYRSYRFPKLTVITEYLLLFRVAGLESLGDLFPNLTVIRGWKLFYNYALVIF
EMTNLKDIGLYNLRNITRGAIRIEKNADLCYLSTIDWSLILDAVSNNYIVGNKPPKECGD
LCPGTLEEKPMCEKTTINNEYNYRCWTTNRCQKMCPSVCGKRACTENNECCHPECLGSCH
TPDDNTTCVACRHYYYKGVCVPACPPGTYRFEGWRCVDRDFCANIPNAESSDSDGFVIHD
DECMQECPSGFIRNSTQSMYCIPCEGPCPKVCGDEEKKTKTIDSVTSAQMLQGCTILKGN
LLINIRRGNNIASELENFMGLIEVVTGYVKIRHSHALVSLSFLKNLRLILGEEQLEGNYS
FYVLDNQNLQQLWDWNHRNLTVRSGKMYFAFNPKLCVSEIYRMEEVTGTKGRQSKGDINT
RNNGERASCESDVLRFTSTTTWKNRIIITWHRYRPPDYRDLISFTVYYKEAPFKNVTEYD
GQDACGSNSWNMVDVDLPPNKEGEPGILLHGLKPWTQYAVYVKAVTLTMVENDHIRGAKS
EILYIRTNASVPSIPLDVLSASNSSSQLIVKWNPPTLPNGNLSYYIVRWQRQPQDGYLYR
HNYCSKDKIPIRKYADGTIDVEEVTENPKTEVCGGDKGPCCACPKTEAEKQAEKEEAEYR
KVFENFLHNSIFVPRPERRRRDVMQVANTTMSSRSRNTTVADTYNITDPEEFETEYPFFE
SRVDNKERTVISNLRPFTLYRIDIHSCNHEAEKLGCSASNFVFARTMPAEGADDIPGPVT
WEPRPENSIFLKWPEPENPNGLILMYEIKYGSQVEDQRECVSRQEYRKYGGAKLNRLNPG
NYTARIQATSLSGNGSWTDPVFFYVPAKTTYENFMHLIIALPVAILLIVGGLVIMLYVFH
RKRNNSRLGNGVLYASVNPEYFSAADVYVPDEWEVAREKITMNRELGQGSFGMVYEGVAK
GVVKDEPETRVAIKTVNEAASMRERIEFLNEASVMKEFNCHHVVRLLGVVSQGQPTLVIM
ELMTRGDLKSYLRSLRPEVEQNNLVLIPPSLSKMIQMAGEIADGMAYLNANKFVHRDLAA
RNCMVAEDFTVKIGDFGMTRDIYETDYYRKGGKGLLPVRWMSPESLKDGVFTTHSDVWSF
GVVLWEIATLAEQPYQGLSNEQVLRFVMEGGLLDKPDNCPDMLFELMRMCWQYNPKMRPS
FLEIIGSIKDEMEPSFQEVSFYYSEENKPPEPEELEMEPENMESVPLDPSASSASLPLPE
RHSGHKAENGPGPGVLVLRASFDERQPYAHMNGGRANERALPLPQSSTC
NT seq 4110 nt   +upstreamnt  +downstreamnt
atgaagtctggctccggaggagggtccccgacctcgctgtgggggctcgtgtttctctcc
gccgcgctctctctctggccgacgagtggagaaatctgtgggcccggcattgacatccgc
aacgactatcagcagctgaagcgcctggaaaactgcacggtgatcgagggcttcctccac
atcctgctcatctccaaggccgaggactaccgaagctaccgcttccccaagctcaccgtc
atcactgagtacttgctgctcttccgagtcgctggcctcgagagcctgggagacctcttc
cccaacctcacagtcatccgtggctggaaactcttctacaactacgcactggtcatcttc
gagatgaccaatctcaaggatattgggctttataatctgaggaacattactcggggggcc
atcaggattgagaagaacgccgacctctgttacctctccaccatagactggtctctcatc
ttggatgcggtgtccaataactacattgtggggaacaagcccccgaaggaatgtggggac
ctgtgtccagggacattggaggagaagcccatgtgtgagaagaccaccatcaacaatgag
tacaactaccgctgctggaccacaaatcgctgccagaaaatgtgcccaagtgtgtgcggg
aagcgagcctgcaccgagaacaacgagtgctgccacccggagtgcctgggcagctgccac
acaccggacgacaacacaacctgcgtggcctgcagacactactactacaaaggcgtgtgt
gtgcctgcctgcccgcctggcacctacaggttcgagggctggcgctgtgtggatcgcgat
ttctgcgccaacatccccaacgctgagagcagtgactcggatggcttcgttatccacgac
gatgagtgcatgcaggagtgtccctcaggcttcatccgcaacagcacccagagcatgtac
tgtatcccctgcgaaggcccctgccccaaagtctgcggcgatgaagagaagaaaacgaaa
accatcgattcggtgacttctgctcaaatgctccaaggatgcaccatcctgaagggcaat
ctgcttattaacatccggagaggcaataacattgcctcggagttggagaacttcatgggg
ctcatcgaggtggtgaccggctacgtgaagatccgccattctcatgccttggtctccttg
tccttcctgaagaaccttcgtctcatcttaggagaggagcagctggaagggaactactcc
ttctatgtcctagacaaccagaacttgcagcagctgtgggactggaaccaccggaacctg
accgtcaggtccggaaagatgtactttgctttcaatcccaagctgtgtgtctccgaaatt
taccgcatggaggaagtgaccggaaccaagggacgccagagcaaaggggacataaacacc
aggaacaacggagagcgagcttcctgtgaaagtgatgttctccgtttcacctccaccacg
acctggaagaaccgaatcatcataacgtggcaccggtaccggccgccggactaccgggat
ctcatcagcttcacagtttactacaaggaggcaccatttaaaaacgttacggaatatgac
gggcaggatgcctgtggctccaacagctggaacatggtggatgtagacctgcctccgaac
aaggagggcgagcctggcattttactgcatgggctgaagccctggacccagtatgctgtc
tatgtcaaggctgtgaccctcaccatggtggaaaacgaccatatccgtggggccaaaagt
gaaatcttgtacattcgcaccaatgcttcagtcccttccattcccctagatgtcctctca
gcatcaaactcttcctctcagctgattgtgaagtggaatcctccaactctgcccaatggt
aacttgagttactacattgtgaggtggcagcggcagccccaggatggttacctgtaccgg
cacaactactgctccaaagacaaaatacccatcagaaagtacgccgatggtaccatcgac
gtggaggaggtgacggaaaatcccaagacagaagtgtgtggtggtgataaagggccatgc
tgcgcttgccctaaaactgaagctgagaagcaggctgagaaggaggaggctgagtaccgt
aaagtctttgagaatttccttcacaattccatctttgtgcccaggcccgaaaggaggcgg
agagacgtcatgcaagtggccaacacgaccatgtccagccgaagcaggaacaccacggta
gctgacacctacaatatcacagacccggaggagttcgagacagagtaccctttctttgag
agcagagtggataacaaggagaggactgtcatctccaacctccggcctttcactctgtac
cgcatcgatatccacagctgcaaccacgaggctgagaagctgggctgcagcgcctccaac
ttcgtctttgcgagaaccatgccagcagaaggagcagatgatatccctggtccggtgacc
tgggagccaagacccgaaaactccatctttttaaagtggccagaacccgagaaccccaac
ggattgatcctaatgtatgaaattaaatacgggtcgcaagtcgaggatcagcgggaatgt
gtgtccagacaggagtacaggaagtacggaggggccaaactcaaccgtctaaacccaggg
aactatacagcccggattcaggctacctccctctctgggaatgggtcatggacagatcct
gtgttcttctatgtccccgccaaaacgacgtatgagaacttcatgcatctgatcattgct
ctgccggttgccatcctgctgatcgttggggggctggttatcatgctgtatgtcttccat
agaaagagaaataacagcaggttgggcaatggagtgctgtatgcttctgtgaaccccgag
tatttcagcgcagctgatgtgtacgtgcctgatgaatgggaggtagctcgagagaagatc
accatgaaccgggagctcggacaagggtcctttgggatggtctatgaaggagtggccaag
ggtgtggtcaaggatgaacccgaaaccagagtggccatcaagacggtaaacgaggctgca
agtatgcgtgaaagaatcgagtttctcaacgaggcctcggtgatgaaggagttcaattgt
caccatgtggtccggttgctgggtgtggtatcccaaggccagcccaccctggtcatcatg
gaactaatgacacgcggtgatctcaaaagttatctccggtctctgaggccagaagtggag
cagaataatctagtcctcattcctccgagcttaagcaagatgatccagatggctggagag
attgcagatggcatggcctacctcaatgccaacaagttcgtccacagagaccttgctgct
aggaactgcatggtagccgaagatttcacagtcaaaattggagatttcggtatgacacga
gacatctacgagacggactactaccggaaaggcgggaaggggttgctgcctgtgcgctgg
atgtctcccgagtccctcaaggatggtgtcttcactactcattctgatgtctggtccttc
ggggtcgtcctctgggagatcgccacgctggctgagcagccctaccagggcttgtccaac
gagcaagttcttcgtttcgtcatggagggtggccttctggacaagccggacaactgccct
gatatgctgtttgaacttatgcgcatgtgctggcagtataaccccaagatgcggccctcc
ttcctggagatcatcggcagcatcaaggatgagatggagcccagcttccaggaggtctcc
ttctactacagcgaggagaacaagcctcccgagccagaggagctggagatggagcctgag
aacatggagagcgtcccactggacccttcggcctcctcagcctccctgcctctgcctgaa
agacactcaggacacaaggctgagaatggcccgggccctggcgtgctcgttctccgcgcc
agttttgatgagagacagccttacgctcacatgaacgggggacgcgccaacgagagggcc
ttgcctctgccccagtcctcgacctgctga

KEGG   Mus musculus (mouse): 16542
Entry
16542             CDS       T01002                                 

Gene name
Kdr, 6130401C07, Flk, Flk-, Flk-1, Flk1, Krd-1, Ly73, VEGF, VEGFR, VEGFR-2, VEGFR2, orv, sVEGFR-2
Definition
(RefSeq) kinase insert domain protein receptor
  KO
K05098  kinase insert domain protein receptor [EC:2.7.10.1]
Organism
mmu  Mus musculus (mouse)
Pathway
mmu01521  EGFR tyrosine kinase inhibitor resistance
mmu04010  MAPK signaling pathway
mmu04014  Ras signaling pathway
mmu04015  Rap1 signaling pathway
mmu04020  Calcium signaling pathway
mmu04151  PI3K-Akt signaling pathway
mmu04370  VEGF signaling pathway
mmu04510  Focal adhesion
mmu05205  Proteoglycans in cancer
mmu05418  Fluid shear stress and atherosclerosis
Brite
KEGG Orthology (KO) [BR:mmu00001]
 09130 Environmental Information Processing
  09132 Signal transduction
   04010 MAPK signaling pathway
    16542 (Kdr)
   04014 Ras signaling pathway
    16542 (Kdr)
   04015 Rap1 signaling pathway
    16542 (Kdr)
   04370 VEGF signaling pathway
    16542 (Kdr)
   04020 Calcium signaling pathway
    16542 (Kdr)
   04151 PI3K-Akt signaling pathway
    16542 (Kdr)
 09140 Cellular Processes
  09144 Cellular community - eukaryotes
   04510 Focal adhesion
    16542 (Kdr)
 09160 Human Diseases
  09161 Cancer: overview
   05205 Proteoglycans in cancer
    16542 (Kdr)
  09166 Cardiovascular disease
   05418 Fluid shear stress and atherosclerosis
    16542 (Kdr)
  09176 Drug resistance: antineoplastic
   01521 EGFR tyrosine kinase inhibitor resistance
    16542 (Kdr)
 09180 Brite Hierarchies
  09181 Protein families: metabolism
   01001 Protein kinases [BR:mmu01001]
    16542 (Kdr)
  09183 Protein families: signaling and cellular processes
   04090 CD molecules [BR:mmu04090]
    16542 (Kdr)
Enzymes [BR:mmu01000]
 2. Transferases
  2.7  Transferring phosphorus-containing groups
   2.7.10  Protein-tyrosine kinases
    2.7.10.1  receptor protein-tyrosine kinase
     16542 (Kdr)
Protein kinases [BR:mmu01001]
 Receptor tyrosine kinases (RTK)
  VEGFR family [OT]
   16542 (Kdr)
CD molecules [BR:mmu04090]
 Proteins
  16542 (Kdr)
SSDB
Motif
Pfam: PK_Tyr_Ser-Thr Ig_3 I-set Pkinase Ig_2 ig V-set VEGFR-2_TMD C2-set_2 Ig_4 Ig_5 TCAD9 Haspin_kinase
Other DBs
NCBI-GeneID: 16542
NCBI-ProteinID: NP_034742
MGI: 96683
Ensembl: ENSMUSG00000062960
Vega: OTTMUSG00000021297
UniProt: P35918
Position
5 C3.3; 5 40.23 cM
AA seq 1345 aa
MESKALLAVALWFCVETRAASVGLPGDFLHPPKLSTQKDILTILANTTLQITCRGQRDLD
WLWPNAQRDSEERVLVTECGGGDSIFCKTLTIPRVVGNDTGAYKCSYRDVDIASTVYVYV
RDYRSPFIASVSDQHGIVYITENKNKTVVIPCRGSISNLNVSLCARYPEKRFVPDGNRIS
WDSEIGFTLPSYMISYAGMVFCEAKINDETYQSIMYIVVVVGYRIYDVILSPPHEIELSA
GEKLVLNCTARTELNVGLDFTWHSPPSKSHHKKIVNRDVKPFPGTVAKMFLSTLTIESVT
KSDQGEYTCVASSGRMIKRNRTFVRVHTKPFIAFGSGMKSLVEATVGSQVRIPVKYLSYP
APDIKWYRNGRPIESNYTMIVGDELTIMEVTERDAGNYTVILTNPISMEKQSHMVSLVVN
VPPQIGEKALISPMDSYQYGTMQTLTCTVYANPPLHHIQWYWQLEEACSYRPGQTSPYAC
KEWRHVEDFQGGNKIEVTKNQYALIEGKNKTVSTLVIQAANVSALYKCEAINKAGRGERV
ISFHVIRGPEITVQPAAQPTEQESVSLLCTADRNTFENLTWYKLGSQATSVHMGESLTPV
CKNLDALWKLNGTMFSNSTNDILIVAFQNASLQDQGDYVCSAQDKKTKKRHCLVKQLIIL
ERMAPMITGNLENQTTTIGETIEVTCPASGNPTPHITWFKDNETLVEDSGIVLRDGNRNL
TIRRVRKEDGGLYTCQACNVLGCARAETLFIIEGAQEKTNLEVIILVGTAVIAMFFWLLL
VIVLRTVKRANEGELKTGYLSIVMDPDELPLDERCERLPYDASKWEFPRDRLKLGKPLGR
GAFGQVIEADAFGIDKTATCKTVAVKMLKEGATHSEHRALMSELKILIHIGHHLNVVNLL
GACTKPGGPLMVIVEFCKFGNLSTYLRGKRNEFVPYKSKGARFRQGKDYVGELSVDLKRR
LDSITSSQSSASSGFVEEKSLSDVEEEEASEELYKDFLTLEHLICYSFQVAKGMEFLASR
KCIHRDLAARNILLSEKNVVKICDFGLARDIYKDPDYVRKGDARLPLKWMAPETIFDRVY
TIQSDVWSFGVLLWEIFSLGASPYPGVKIDEEFCRRLKEGTRMRAPDYTTPEMYQTMLDC
WHEDPNQRPSFSELVEHLGNLLQANAQQDGKDYIVLPMSETLSMEEDSGLSLPTSPVSCM
EEEEVCDPKFHYDNTAGISHYLQNSKRKSRPVSVKTFEDIPLEEPEVKVIPDDSQTDSGM
VLASEELKTLEDRNKLSPSFGGMMPSKSRESVASEGSNQTSGYQSGYHSDDTDTTVYSSD
EAGLLKMVDAAVHADSGTTLRSPPV
NT seq 4038 nt   +upstreamnt  +downstreamnt
atggagagcaaggcgctgctagctgtcgctctgtggttctgcgtggagacccgagccgcc
tctgtgggtttgcctggcgattttctccatccccccaagctcagcacacagaaagacata
ctgacaattttggcaaatacaacccttcagattacttgcaggggacagcgggacctggac
tggctttggcccaatgctcagcgtgattctgaggaaagggtattggtgactgaatgcggc
ggtggtgacagtatcttctgcaaaacactcaccattcccagggtggttggaaatgatact
ggagcctacaagtgctcgtaccgggacgtcgacatagcctccactgtttatgtctatgtt
cgagattacagatcaccattcatcgcctctgtcagtgaccagcatggcatcgtgtacatc
accgagaacaagaacaaaactgtggtgatcccctgccgagggtcgatttcaaacctcaat
gtgtctctttgcgctaggtatccagaaaagagatttgttccggatggaaacagaatttcc
tgggacagcgagataggctttactctccccagttacatgatcagctatgccggcatggtc
ttctgtgaggcaaagatcaatgatgaaacctatcagtctatcatgtacatagttgtggtt
gtaggatataggatttatgatgtgattctgagccccccgcatgaaattgagctatctgcc
ggagaaaaacttgtcttaaattgtacagcgagaacagagctcaatgtggggcttgatttc
acctggcactctccaccttcaaagtctcatcataagaagattgtaaaccgggatgtgaaa
ccctttcctgggactgtggcgaagatgtttttgagcaccttgacaatagaaagtgtgacc
aagagtgaccaaggggaatacacctgtgtagcgtccagtggacggatgatcaagagaaat
agaacatttgtccgagttcacacaaagccttttattgctttcggtagtgggatgaaatct
ttggtggaagccacagtgggcagtcaagtccgaatccctgtgaagtatctcagttaccca
gctcctgatatcaaatggtacagaaatggaaggcccattgagtccaactacacaatgatt
gttggcgatgaactcaccatcatggaagtgactgaaagagatgcaggaaactacacggtc
atcctcaccaaccccatttcaatggagaaacagagccacatggtctctctggttgtgaat
gtcccaccccagatcggtgagaaagccttgatctcgcctatggattcctaccagtatggg
accatgcagacattgacatgcacagtctacgccaaccctcccctgcaccacatccagtgg
tactggcagctagaagaagcctgctcctacagacccggccaaacaagcccgtatgcttgt
aaagaatggagacacgtggaggatttccaggggggaaacaagatcgaagtcaccaaaaac
caatatgccctgattgaaggaaaaaacaaaactgtaagtacgctggtcatccaagctgcc
aacgtgtcagcgttgtacaaatgtgaagccatcaacaaagcgggacgaggagagagggtc
atctccttccatgtgatcaggggtcctgaaattactgtgcaacctgctgcccagccaact
gagcaggagagtgtgtccctgttgtgcactgcagacagaaatacgtttgagaacctcacg
tggtacaagcttggctcacaggcaacatcggtccacatgggcgaatcactcacaccagtt
tgcaagaacttggatgctctttggaaactgaatggcaccatgttttctaacagcacaaat
gacatcttgattgtggcatttcagaatgcctctctgcaggaccaaggcgactatgtttgc
tctgctcaagataagaagaccaagaaaagacattgcctggtcaaacagctcatcatccta
gagcgcatggcacccatgatcaccggaaatctggagaatcagacaacaaccattggcgag
accattgaagtgacttgcccagcatctggaaatcctaccccacacattacatggttcaaa
gacaacgagaccctggtagaagattcaggcattgtactgagagatgggaaccggaacctg
actatccgcagggtgaggaaggaggatggaggcctctacacctgccaggcctgcaatgtc
cttggctgtgcaagagcggagacgctcttcataatagaaggtgcccaggaaaagaccaac
ttggaagtcattatcctcgtcggcactgcagtgattgccatgttcttctggctccttctt
gtcattgtcctacggaccgttaagcgggccaatgaaggggaactgaagacaggctacttg
tctattgtcatggatccagatgaattgcccttggatgagcgctgtgaacgcttgccttat
gatgccagcaagtgggaattccccagggaccggctgaaactaggaaaacctcttggccgc
ggtgccttcggccaagtgattgaggcagacgcttttggaattgacaagacagcgacttgc
aaaacagtagccgtcaagatgttgaaagaaggagcaacacacagcgagcatcgagccctc
atgtctgaactcaagatcctcatccacattggtcaccatctcaatgtggtgaacctccta
ggcgcctgcaccaagccgggagggcctctcatggtgattgtggaattctgcaagtttgga
aacctatcaacttacttacggggcaagagaaatgaatttgttccctataagagcaaaggg
gcacgcttccgccagggcaaggactacgttggggagctctccgtggatctgaaaagacgc
ttggacagcatcaccagcagccagagctctgccagctcaggctttgttgaggagaaatcg
ctcagtgatgtagaggaagaagaagcttctgaagaactgtacaaggacttcctgaccttg
gagcatctcatctgttacagcttccaagtggctaagggcatggagttcttggcatcaagg
aagtgtatccacagggacctggcagcacgaaacattctcctatcggagaagaatgtggtt
aagatctgtgacttcggcttggcccgggacatttataaagacccggattatgtcagaaaa
ggagatgcccgactccctttgaagtggatggccccggaaaccatttttgacagagtatac
acaattcagagcgatgtgtggtctttcggtgtgttgctctgggaaatattttccttaggt
gcctccccataccctggggtcaagattgatgaagaattttgtaggagattgaaagaagga
actagaatgcgggctcctgactacactaccccagaaatgtaccagaccatgctggactgc
tggcatgaggaccccaaccagagaccctcgttttcagagttggtggagcatttgggaaac
ctcctgcaagcaaatgcgcagcaggatggcaaagactatattgttcttccaatgtcagag
acactgagcatggaagaggattctggactctccctgcctacctcacctgtttcctgtatg
gaggaagaggaagtgtgcgaccccaaattccattatgacaacacagcaggaatcagtcat
tatctccagaacagtaagcgaaagagccggccagtgagtgtaaaaacatttgaagatatc
ccattggaggaaccagaagtaaaagtgatcccagatgacagccagacagacagtgggatg
gtccttgcatcagaagagctgaaaactctggaagacaggaacaaattatctccatctttt
ggtggaatgatgcccagtaaaagcagggagtctgtggcctcggaaggctccaaccagacc
agtggctaccagtctgggtatcactcagatgacacagacaccaccgtgtactccagcgac
gaggcaggacttttaaagatggtggatgctgcagttcacgctgactcagggaccacactg
cgctcacctcctgtttaa

KEGG   Mus musculus (mouse): 17295
Entry
17295             CDS       T01002                                 

Gene name
Met, AI838057, HGF, HGFR, P, Par4, c-Met
Definition
(RefSeq) met proto-oncogene
  KO
K05099  proto-oncogene tyrosine-protein kinase Met [EC:2.7.10.1]
Organism
mmu  Mus musculus (mouse)
Pathway
mmu01521  EGFR tyrosine kinase inhibitor resistance
mmu04010  MAPK signaling pathway
mmu04014  Ras signaling pathway
mmu04015  Rap1 signaling pathway
mmu04020  Calcium signaling pathway
mmu04151  PI3K-Akt signaling pathway
mmu04360  Axon guidance
mmu04510  Focal adhesion
mmu04520  Adherens junction
mmu05100  Bacterial invasion of epithelial cells
mmu05144  Malaria
mmu05200  Pathways in cancer
mmu05202  Transcriptional misregulation in cancer
mmu05205  Proteoglycans in cancer
mmu05206  MicroRNAs in cancer
mmu05211  Renal cell carcinoma
mmu05218  Melanoma
mmu05223  Non-small cell lung cancer
mmu05225  Hepatocellular carcinoma
mmu05226  Gastric cancer
mmu05230  Central carbon metabolism in cancer
Brite
KEGG Orthology (KO) [BR:mmu00001]
 09130 Environmental Information Processing
  09132 Signal transduction
   04010 MAPK signaling pathway
    17295 (Met)
   04014 Ras signaling pathway
    17295 (Met)
   04015 Rap1 signaling pathway
    17295 (Met)
   04020 Calcium signaling pathway
    17295 (Met)
   04151 PI3K-Akt signaling pathway
    17295 (Met)
 09140 Cellular Processes
  09144 Cellular community - eukaryotes
   04510 Focal adhesion
    17295 (Met)
   04520 Adherens junction
    17295 (Met)
 09150 Organismal Systems
  09158 Development and regeneration
   04360 Axon guidance
    17295 (Met)
 09160 Human Diseases
  09161 Cancer: overview
   05200 Pathways in cancer
    17295 (Met)
   05202 Transcriptional misregulation in cancer
    17295 (Met)
   05206 MicroRNAs in cancer
    17295 (Met)
   05205 Proteoglycans in cancer
    17295 (Met)
   05230 Central carbon metabolism in cancer
    17295 (Met)
  09162 Cancer: specific types
   05225 Hepatocellular carcinoma
    17295 (Met)
   05226 Gastric cancer
    17295 (Met)
   05218 Melanoma
    17295 (Met)
   05211 Renal cell carcinoma
    17295 (Met)
   05223 Non-small cell lung cancer
    17295 (Met)
  09171 Infectious disease: bacterial
   05100 Bacterial invasion of epithelial cells
    17295 (Met)
  09174 Infectious disease: parasitic
   05144 Malaria
    17295 (Met)
  09176 Drug resistance: antineoplastic
   01521 EGFR tyrosine kinase inhibitor resistance
    17295 (Met)
 09180 Brite Hierarchies
  09181 Protein families: metabolism
   01001 Protein kinases [BR:mmu01001]
    17295 (Met)
Enzymes [BR:mmu01000]
 2. Transferases
  2.7  Transferring phosphorus-containing groups
   2.7.10  Protein-tyrosine kinases
    2.7.10.1  receptor protein-tyrosine kinase
     17295 (Met)
Protein kinases [BR:mmu01001]
 Receptor tyrosine kinases (RTK)
  MET family
   17295 (Met)
SSDB
Motif
Pfam: PK_Tyr_Ser-Thr Sema Pkinase TIG PSI Kinase-like Pkinase_fungal SKG6
Other DBs
NCBI-GeneID: 17295
NCBI-ProteinID: NP_032617
MGI: 96969
Ensembl: ENSMUSG00000009376
Vega: OTTMUSG00000024024
UniProt: F8VQL0 A4FUV6
Position
6 A2; 6 7.83 cM
AA seq 1379 aa
MKAPTVLAPGILVLLLSLVQRSHGECKEALVKSEMNVNMKYQLPNFTAETPIQNVVLHGH
HIYLGATNYIYVLNDKDLQKVSEFKTGPVLEHPDCLPCRDCSSKANSSGGVWKDNINMAL
LVDTYYDDQLISCGSVNRGTCQRHVLPPDNSADIQSEVHCMFSPEEESGQCPDCVVSALG
AKVLLSEKDRFINFFVGNTINSSYPPGYSLHSISVRRLKETQDGFKFLTDQSYIDVLPEF
QDSYPIKYIHAFESNHFIYFLTVQKETLDAQTFHTRIIRFCSVDSGLHSYMEMPLECILT
EKRRKRSTREEVFNILQAAYVSKPGANLAKQIGASPSDDILFGVFAQSKPDSAEPVNRSA
VCAFPIKYVNDFFNKIVNKNNVRCLQHFYGPNHEHCFNRTLLRNSSGCEARSDEYRTEFT
TALQRVDLFMGRLNQVLLTSISTFIKGDLTIANLGTSEGRFMQVVLSRTAHLTPHVNFLL
DSHPVSPEVIVEHPSNQNGYTLVVTGKKITKIPLNGLGCGHFQSCSQCLSAPYFIQCGWC
HNQCVRFDECPSGTWTQEICLPAVYKVFPTSAPLEGGTVLTICGWDFGFRKNNKFDLRKT
KVLLGNESCTLTLSESTTNTLKCTVGPAMSEHFNVSVIISNSRETTQYSAFSYVDPVITS
ISPRYGPQAGGTLLTLTGKYLNSGNSRHISIGGKTCTLKSVSDSILECYTPAQTTSDEFP
VKLKIDLANRETSSFSYREDPVVYEIHPTKSFISGGSTITGIGKTLNSVSLPKLVIDVHE
VGVNYTVACQHRSNSEIICCTTPSLKQLGLQLPLKTKAFFLLDGILSKHFDLTYVHNPVF
EPFEKPVMISIGNENVVEIKGNNIDPEAVKGEVLKVGNQSCESLHWHSGAVLCTVPSDLL
KLNSELNIEWKQAVSSTVLGKVIVQPDQNFAGLIIGAVSISVVVLLLSGLFLWMRKRKHK
DLGSELVRYDARVHTPHLDRLVSARSVSPTTEMVSNESVDYRATFPEDQFPNSSQNGACR
QVQYPLTDLSPILTSGDSDISSPLLQNTVHIDLSALNPELVQAVQHVVIGPSSLIVHFNE
VIGRGHFGCVYHGTLLDNDGKKIHCAVKSLNRITDIEEVSQFLTEGIIMKDFSHPNVLSL
LGICLRSEGSPLVVLPYMKHGDLRNFIRNETHNPTVKDLIGFGLQVAKGMKYLASKKFVH
RDLAARNCMLDEKFTVKVADFGLARDMYDKEYYSVHNKTGAKLPVKWMALESLQTQKFTT
KSDVWSFGVLLWELMTRGAPPYPDVNTFDITIYLLQGRRLLQPEYCPDALYEVMLKCWHP
KAEMRPSFSELVSRISSIFSTFIGEHYVHVNATYVNVKCVAPYPSLLPSQDNIDGEGNT
NT seq 4140 nt   +upstreamnt  +downstreamnt
atgaaggctcccaccgtgctggcacctggcattctggtgctgctgttgtccttggtgcag
aggagccatggggagtgcaaggaggccctagtgaagtctgagatgaacgtgaacatgaag
tatcagctccccaacttcacggcagaaacccccatccagaatgtcgtcctacacggccat
catatttatctcggagccacaaactacatttatgttttaaatgacaaagaccttcagaag
gtatccgaattcaagaccgggcccgtgttggaacacccagattgtttaccttgtcgggac
tgcagcagcaaagccaattcatcaggaggggtttggaaagacaacatcaacatggctctg
cttgttgacacatactatgatgatcaactcattagctgtggcagtgtcaacagagggact
tgccagcggcatgtccttcctcctgacaattctgctgacatccagtctgaggtccactgc
atgttctccccagaagaggagtcagggcagtgtcctgactgtgtagtgagtgccctcgga
gccaaagtcctcctgtcggaaaaggaccggttcatcaatttctttgtggggaatacgatc
aattcctcctatcctcctggttattcactgcattcgatatcggtgagacggctgaaggaa
acccaagatggttttaagtttttgacagaccagtcctatattgatgtcttaccagaattc
caagattcctaccccataaagtacatacatgccttcgaaagcaaccattttatttacttt
ctgactgtccaaaaggaaactctagatgctcagacttttcatacaagaataatcaggttc
tgttccgtagactctgggttgcactcctacatggaaatgcccctggaatgcatcctgaca
gaaaaaagaaggaagagatccacaagggaagaagtgtttaatatcctccaagccgcgtat
gtcagtaaaccaggggccaatcttgctaagcaaataggagctagcccttctgatgacatt
ctcttcggggtgtttgcacaaagcaagccagattctgctgaacctgtgaatcgatcagca
gtctgtgcattccccatcaaatatgtcaatgacttcttcaacaagattgtcaacaaaaac
aacgtgagatgtctccagcatttttacggacccaaccatgagcactgtttcaataggacc
ctgctgagaaactcttccggctgtgaagcgcgcagtgacgagtatcggacagagtttacc
acggctttgcagcgcgtcgacttattcatgggccggcttaaccaagtgctcctgacatcc
atctccaccttcatcaaaggtgacctcaccattgctaatctagggacgtcagaaggtcgc
ttcatgcaggtggtgctctctcgaacagcacacctcactcctcatgtgaacttcctcctg
gactcccatcctgtatctccagaagttattgttgagcatccatcaaatcaaaatggctat
acattggttgtcacaggaaagaagatcaccaagattccattgaatggcctgggctgtgga
catttccaatcctgcagtcagtgcctctctgccccttactttatacagtgtggctggtgc
cacaatcaatgtgtgcgttttgatgaatgccccagcggtacatggactcaagagatctgt
ctgccggcggtttataaggtgttccccaccagcgcgccccttgaaggaggaacagtgttg
accatatgtggctgggactttggattcaggaagaataataaatttgatttaaggaaaacc
aaagttctgcttggcaacgagagctgtaccttgaccttaagcgagagcacgacaaatacg
ttgaaatgcacagttggtcccgcgatgagtgagcacttcaatgtgtctgtaattatctca
aacagtcgagagacgacgcaatacagtgcattctcctatgtagatcctgtaataacaagc
atttctccgaggtacggccctcaggctggaggcaccttactcactcttactgggaaatac
ctcaacagtggcaattctagacacatttcaattggagggaaaacatgtactttaaaaagt
gtatcagatagtattcttgaatgctacaccccagcccaaactacctctgatgagtttcct
gtgaaattgaagattgacttggctaaccgagagaccagcagcttcagttaccgggaagac
cccgttgtctatgaaatccacccgaccaaatcttttattagtggtggaagcacaataacg
ggtattgggaagaccctgaactcggttagcctcccaaagctggtaatagatgtgcatgaa
gtgggtgtgaactacacagtggcatgtcagcatcgctcaaattcagagatcatctgctgc
actactccttcactgaaacagctgggcctgcaactccccctgaagaccaaagccttcttc
ctgttagacgggattctttccaaacactttgatctcacttatgtgcataatcctgtgttt
gagccttttgaaaagccagtaatgatctcaataggcaatgaaaatgtagtggaaattaag
ggaaacaatattgaccctgaagcagttaaaggtgaagtgttaaaagttggaaatcagagc
tgcgagagtctccactggcactctggagctgtgttgtgtacagtccccagtgacctgctc
aaactgaacagcgagctaaatatagagtggaagcaagcagtctcttcaactgttcttgga
aaagtgatcgttcaaccggatcagaattttgcaggattgatcattggtgcggtctcaata
tcagtagtagttttgttattatccgggctcttcctgtggatgagaaagagaaagcataaa
gatctgggcagtgaattagttcgctatgacgcaagagtacacactcctcatttggatagg
cttgtaagtgcccgaagtgtaagtccaactacagagatggtttcaaatgagtctgtagac
tacagagctacttttccagaagaccagtttcccaactcctctcagaatggagcatgcaga
caagtgcaataccctctgacagacctgtcccctatcctgacaagtggagactctgatata
tccagcccattactacaaaatactgttcacattgacctcagtgctctaaatccagagctg
gtccaagcagttcagcacgtagtgattggacccagcagcctgattgtgcatttcaatgaa
gtcataggaagagggcattttggctgtgtctatcatgggactttgctggacaatgacgga
aagaaaattcactgtgctgtgaaatccttaaatagaatcacagatatagaagaggtctcc
cagtttctgactgagggaatcatcatgaaagacttcagccatcccaatgttctctcactc
ttgggaatctgcctgaggagtgaagggtctcctctggtggtcctgccctatatgaagcat
ggagatctgcgaaatttcattcgaaacgagactcataatccaactgtgaaagatcttata
ggatttggccttcaagtagccaaaggcatgaaatatcttgccagcaaaaagtttgtccac
agagacttagctgcaagaaactgcatgttggatgaaaaattcactgtcaaggttgctgat
ttcggtcttgccagagacatgtacgataaagagtactatagtgtccacaacaagacgggt
gccaagctaccagtaaagtggatggctttagagagtctgcaaacgcagaagttcaccacc
aagtcagatgtgtggtcctttggtgtgctcctctgggagctcatgacgagaggagcccct
ccttatcccgacgtgaacacatttgatatcactatctacctgttgcaaggcagaagactc
ttgcaaccagaatactgtccagacgccttgtacgaagtgatgctaaaatgctggcacccc
aaagcggaaatgcgcccgtccttttccgaactggtctccaggatatcctcaatcttctcc
acgttcattggggaacactacgtccacgtgaacgctacttatgtgaatgtaaaatgtgtt
gctccatatccttctctgttgccatcccaagacaacattgatggcgaggggaacacatga

KEGG   Mus musculus (mouse): 18595
Entry
18595             CDS       T01002                                 

Gene name
Pdgfra, AI115593, CD140, CD140a, Pdgfr, Pdgfr-2
Definition
(RefSeq) platelet derived growth factor receptor, alpha polypeptide
  KO
K04363  platelet-derived growth factor receptor alpha [EC:2.7.10.1]
Organism
mmu  Mus musculus (mouse)
Pathway
mmu01521  EGFR tyrosine kinase inhibitor resistance
mmu04010  MAPK signaling pathway
mmu04014  Ras signaling pathway
mmu04015  Rap1 signaling pathway
mmu04020  Calcium signaling pathway
mmu04072  Phospholipase D signaling pathway
mmu04144  Endocytosis
mmu04151  PI3K-Akt signaling pathway
mmu04510  Focal adhesion
mmu04540  Gap junction
mmu04630  JAK-STAT signaling pathway
mmu04810  Regulation of actin cytoskeleton
mmu05163  Human cytomegalovirus infection
mmu05200  Pathways in cancer
mmu05206  MicroRNAs in cancer
mmu05214  Glioma
mmu05215  Prostate cancer
mmu05218  Melanoma
mmu05230  Central carbon metabolism in cancer
mmu05231  Choline metabolism in cancer
Brite
KEGG Orthology (KO) [BR:mmu00001]
 09130 Environmental Information Processing
  09132 Signal transduction
   04010 MAPK signaling pathway
    18595 (Pdgfra)
   04014 Ras signaling pathway
    18595 (Pdgfra)
   04015 Rap1 signaling pathway
    18595 (Pdgfra)
   04630 JAK-STAT signaling pathway
    18595 (Pdgfra)
   04020 Calcium signaling pathway
    18595 (Pdgfra)
   04072 Phospholipase D signaling pathway
    18595 (Pdgfra)
   04151 PI3K-Akt signaling pathway
    18595 (Pdgfra)
 09140 Cellular Processes
  09141 Transport and catabolism
   04144 Endocytosis
    18595 (Pdgfra)
  09144 Cellular community - eukaryotes
   04510 Focal adhesion
    18595 (Pdgfra)
   04540 Gap junction
    18595 (Pdgfra)
  09142 Cell motility
   04810 Regulation of actin cytoskeleton
    18595 (Pdgfra)
 09160 Human Diseases
  09161 Cancer: overview
   05200 Pathways in cancer
    18595 (Pdgfra)
   05206 MicroRNAs in cancer
    18595 (Pdgfra)
   05230 Central carbon metabolism in cancer
    18595 (Pdgfra)
   05231 Choline metabolism in cancer
    18595 (Pdgfra)
  09162 Cancer: specific types
   05214 Glioma
    18595 (Pdgfra)
   05218 Melanoma
    18595 (Pdgfra)
   05215 Prostate cancer
    18595 (Pdgfra)
  09172 Infectious disease: viral
   05163 Human cytomegalovirus infection
    18595 (Pdgfra)
  09176 Drug resistance: antineoplastic
   01521 EGFR tyrosine kinase inhibitor resistance
    18595 (Pdgfra)
 09180 Brite Hierarchies
  09181 Protein families: metabolism
   01001 Protein kinases [BR:mmu01001]
    18595 (Pdgfra)
  09183 Protein families: signaling and cellular processes
   04090 CD molecules [BR:mmu04090]
    18595 (Pdgfra)
Enzymes [BR:mmu01000]
 2. Transferases
  2.7  Transferring phosphorus-containing groups
   2.7.10  Protein-tyrosine kinases
    2.7.10.1  receptor protein-tyrosine kinase
     18595 (Pdgfra)
Protein kinases [BR:mmu01001]
 Receptor tyrosine kinases (RTK)
  PDGFR family [OT]
   18595 (Pdgfra)
CD molecules [BR:mmu04090]
 Proteins
  18595 (Pdgfra)
SSDB
Motif
Pfam: PK_Tyr_Ser-Thr Pkinase Ig_3 I-set ig Ig_2 V-set Herpes_gE Ig_6 C2-set_2 DUF3475 C1-set Kinase-like
Other DBs
NCBI-GeneID: 18595
NCBI-ProteinID: NP_001076785
MGI: 97530
Ensembl: ENSMUSG00000029231
Vega: OTTMUSG00000056081
UniProt: P26618
Position
5 C3.3; 5 39.55 cM
AA seq 1089 aa
MGTSHQVFLVLSCLLTGPGLISCQLLLPSILPNENEKIVQLNSSFSLRCVGESEVSWQHP
MSEEDDPNVEIRSEENNSGLFVTVLEVVNASAAHTGWYTCYYNHTQTDESEIEGRHIYIY
VPDPDMAFVPLGMTDSLVIVEEDDSAIIPCRTTDPETQVTLHNNGRLVPASYDSRQGFNG
TFSVGPYICEATVKGRTFKTSEFNVYALKATSELNLEMDARQTVYKAGETIVVTCAVFNN
EVVDLQWTYPGEVRNKGITMLEEIKLPSIKLVYTLTVPKATVKDSGEYECAARQATKEVK
EMKRVTISVHEKGFVEIEPTFGQLEAVNLHEVREFVVEVQAYPTPRISWLKDNLTLIENL
TEITTDVQKSQETRYQSKLKLIRAKEEDSGHYTIIVQNEDDVKSYTFELSTLVPASILDL
VDDHHGSGGGQTVRCTAEGTPLPEIDWMICKHIKKCNNDTSWTVLASNVSNIITELPRRG
RSTVEGRVSFAKVEETIAVRCLAKNNLSVVARELKLVAPTLRSELTVAAAVLVLLVIVIV
SLIVLVVIWKQKPRYEIRWRVIESISPDGHEYIYVDPMQLPYDSRWEFPRDGLVLGRILG
SGAFGKVVEGTAYGLSRSQPVMKVAVKMLKPTARSSEKQALMSELKIMTHLGPHLNIVNL
LGACTKSGPIYIITEYCFYGDLVNYLHKNRDSFMSQHPEKPKKDLDIFGLNPADESTRSY
VILSFENNGDYMDMKQADTTQYVPMLERKEVSKYSDIQRSLYDRPASYKKKSMLDSEVKN
LLSDDDSEGLTLLDLLSFTYQVARGMEFLASKNCVHRDLAARNVLLAQGKIVKICDFGLA
RDIMHDSNYVSKGSTFLPVKWMAPESIFDNLYTTLSDVWSYGILLWEIFSLGGTPYPGMM
VDSTFYNKIKSGYRMAKPDHATSEVYEIMVQCWNSEPEKRPSFYHLSEIVENLLPGQYKK
SYEKIHLDFLKSDHPAVARMRVDSDNAYIGVTYKNEEDKLKDWEGGLDEQRLSADSGYII
PLPDIDPVPEEEDLGKRNRHSSQTSEESAIETGSSSSTFIKREDETIEDIDMMDDIGIDS
SDLVEDSFL
NT seq 3270 nt   +upstreamnt  +downstreamnt
atggggacctcccaccaggtctttctggtcctcagctgtctcctcacagggccgggcctc
atctcctgccagctcttattaccctctatcctcccaaacgagaatgagaagattgtgcag
ctgaattcgtccttttctctgagatgcgttggggagagtgaagtgagctggcagcacccc
atgtctgaagaagacgaccccaacgtggaaatcagaagtgaggagaacaacagtggcctc
tttgtcacagtgctggaagtggttaacgcctccgcagcccacaccggatggtacacttgc
tactacaaccacactcagacggatgagagtgagatcgaaggcaggcacatttacatctat
gtaccagacccagacatggcctttgtgcctctcgggatgaccgattccttagtcatcgtg
gaagaggatgactctgccatcataccttgccgcaccacagatccggagactcaagtaacc
ttgcacaataacgggaggctggtgcctgcctcctatgacagcaggcagggcttcaacgga
accttcagcgtggggccttacatctgtgaggccaccgtcaaagggaggacgttcaagacc
agcgagtttaatgtttatgccttgaaagcaacgtcagaactgaatctggagatggacgca
cgccagactgtgtataaggcaggagaaacgatcgtggtgacctgtgccgtctttaacaac
gaggtcgttgacctgcagtggacttaccctggagaagtgagaaacaaaggtatcaccatg
ctggaggagatcaaactcccatccatcaaactggtgtacactttgaccgtccccaaggcc
acggtgaaggacagtggagagtatgaatgtgctgcccgtcaggccactaaagaggtcaag
gaaatgaagagagtcaccatttctgtccacgagaaaggcttcgtcgagattgagcccacc
tttggccagctggaagctgtcaacttgcacgaagtcagagagttcgtggtggaggtgcag
gcctacccgacgcccaggatatcgtggctgaaggacaacttgactctgatagagaatctc
accgagatcaccactgatgtacagaagagtcaggaaacaaggtatcagagcaaattaaag
ctgatccgggctaaggaagaagacagtggccattacaccattatagttcaaaatgaggat
gacgtgaagagttacacgtttgagctgtcaaccctagttcctgcatccattttggatctc
gtagatgaccaccatggctctggcgggggacagactgtgaggtgtacagccgaaggcacc
cctcttccagaaatcgactggatgatctgcaagcatattaagaaatgtaataatgacact
tcgtggacagttttggccagcaatgtctcaaatattatcacagagctccctcgccgtggc
aggagtaccgtggagggacgagtgtccttcgccaaagtggaagagaccatcgcagttcga
tgcctggcaaagaacaacctcagcgttgtggcccgtgagctgaagctggtggctcccact
ctgcgatctgaactcacagtggcggccgcagtgttggtgctgttggtgattgtcattgtc
tctctcatcgtcctggtggtcatttggaagcagaaaccacggtatgaaattcgctggagg
gttatcgagtcaatcagccccgatggacatgagtatatctatgtggaccccatgcagttg
ccttacgactccagatgggaattcccgagagatggcctcgtgcttggtcggattttggga
tccggtgcatttgggaaagtggtcgaaggtacagcttatggattaagccggtcccaacct
gtaatgaaggtggctgtgaagatgctcaaacccacagccaggtctagtgaaaagcaggct
ctcatgtctgagctgaagataatgactcacctggggccacatttgaacattgtgaacttg
ctgggagcctgcaccaagtcaggtcccatttacatcatcacagaatactgcttctatggg
gatttggtcaactacttgcataagaacagagatagcttcatgagccaacacccagagaag
ccgaagaaagacctggacatctttggattgaatcctgcagacgagagcacaagaagttat
gtgattttgtcttttgaaaataacggcgactacatggacatgaagcaagctgataccaca
cagtatgtccccatgcttgaaaggaaagaggtttctaaatactctgacatccagagatcg
ctgtacgatcggccagcctcctacaagaagaaatccatgctagactcagaagtcaaaaac
ctcctttcggacgatgactccgagggtctgactttgctggatctattgagcttcacctat
caagttgctcgaggaatggaatttttggcttcgaaaaattgtgtccaccgggacctggct
gcccgcaacgtcctcctggcgcaaggaaaaattgtgaagatctgtgattttggcctggcc
agagacatcatgcacgattccaactacgtgtcaaaaggcagtactttcctgcctgtgaag
tggatggcacccgagagcatcttcgacaacctctacaccacgctgagtgacgtctggtcc
tatggcattctgctctgggaaatcttttcccttggtggcacaccctatcctggcatgatg
gtcgattctactttctacaataagatcaagagtggataccggatggccaaacctgaccat
gccaccagtgaagtctatgagatcatggtgcagtgctggaacagtgagcccgagaagaga
ccctccttctaccacctcagcgagatagtggagaacctgttgccgggacaatacaagaag
agttatgaaaagattcacctggacttcctaaagagtgaccatccggccgtggcacgcatg
cgggtggactctgataatgcgtacatcggtgtcacttacaaaaatgaagaggataagctg
aaggactgggaaggtggcctggacgaacagagactgagcgctgacagtggctacatcatc
cccctgccagacattgaccctgttccagaggaggaagacctgggcaagaggaacagacac
agctcacagacttcggaagagagtgccatcgagacaggttccagtagttccaccttcatc
aagagagaggacgagaccatcgaggacatcgacatgatggatgacattggtatagattcc
tcggacctggtggaggacagcttcctgtaa

KEGG   Mus musculus (mouse): 18596
Entry
18596             CDS       T01002                                 

Gene name
Pdgfrb, AI528809, CD140b, PDGFR-1, Pdg, Pdgfr
Definition
(RefSeq) platelet derived growth factor receptor, beta polypeptide
  KO
K05089  platelet-derived growth factor receptor beta [EC:2.7.10.1]
Organism
mmu  Mus musculus (mouse)
Pathway
mmu01521  EGFR tyrosine kinase inhibitor resistance
mmu04010  MAPK signaling pathway
mmu04014  Ras signaling pathway
mmu04015  Rap1 signaling pathway
mmu04020  Calcium signaling pathway
mmu04072  Phospholipase D signaling pathway
mmu04151  PI3K-Akt signaling pathway
mmu04510  Focal adhesion
mmu04540  Gap junction
mmu04630  JAK-STAT signaling pathway
mmu04810  Regulation of actin cytoskeleton
mmu05165  Human papillomavirus infection
mmu05200  Pathways in cancer
mmu05206  MicroRNAs in cancer
mmu05214  Glioma
mmu05215  Prostate cancer
mmu05218  Melanoma
mmu05230  Central carbon metabolism in cancer
mmu05231  Choline metabolism in cancer
Brite
KEGG Orthology (KO) [BR:mmu00001]
 09130 Environmental Information Processing
  09132 Signal transduction
   04010 MAPK signaling pathway
    18596 (Pdgfrb)
   04014 Ras signaling pathway
    18596 (Pdgfrb)
   04015 Rap1 signaling pathway
    18596 (Pdgfrb)
   04630 JAK-STAT signaling pathway
    18596 (Pdgfrb)
   04020 Calcium signaling pathway
    18596 (Pdgfrb)
   04072 Phospholipase D signaling pathway
    18596 (Pdgfrb)
   04151 PI3K-Akt signaling pathway
    18596 (Pdgfrb)
 09140 Cellular Processes
  09144 Cellular community - eukaryotes
   04510 Focal adhesion
    18596 (Pdgfrb)
   04540 Gap junction
    18596 (Pdgfrb)
  09142 Cell motility
   04810 Regulation of actin cytoskeleton
    18596 (Pdgfrb)
 09160 Human Diseases
  09161 Cancer: overview
   05200 Pathways in cancer
    18596 (Pdgfrb)
   05206 MicroRNAs in cancer
    18596 (Pdgfrb)
   05230 Central carbon metabolism in cancer
    18596 (Pdgfrb)
   05231 Choline metabolism in cancer
    18596 (Pdgfrb)
  09162 Cancer: specific types
   05214 Glioma
    18596 (Pdgfrb)
   05218 Melanoma
    18596 (Pdgfrb)
   05215 Prostate cancer
    18596 (Pdgfrb)
  09172 Infectious disease: viral
   05165 Human papillomavirus infection
    18596 (Pdgfrb)
  09176 Drug resistance: antineoplastic
   01521 EGFR tyrosine kinase inhibitor resistance
    18596 (Pdgfrb)
 09180 Brite Hierarchies
  09181 Protein families: metabolism
   01001 Protein kinases [BR:mmu01001]
    18596 (Pdgfrb)
  09183 Protein families: signaling and cellular processes
   04090 CD molecules [BR:mmu04090]
    18596 (Pdgfrb)
Enzymes [BR:mmu01000]
 2. Transferases
  2.7  Transferring phosphorus-containing groups
   2.7.10  Protein-tyrosine kinases
    2.7.10.1  receptor protein-tyrosine kinase
     18596 (Pdgfrb)
Protein kinases [BR:mmu01001]
 Receptor tyrosine kinases (RTK)
  PDGFR family [OT]
   18596 (Pdgfrb)
CD molecules [BR:mmu04090]
 Proteins
  18596 (Pdgfrb)
SSDB
Motif
Pfam: PK_Tyr_Ser-Thr Pkinase ig Ig_3 I-set Ig_2 V-set TCAD9
Other DBs
NCBI-GeneID: 18596
NCBI-ProteinID: NP_032835
MGI: 97531
Ensembl: ENSMUSG00000024620
Vega: OTTMUSG00000014920
UniProt: P05622
Position
18 E1; 18 34.41 cM
AA seq 1098 aa
MGLPGVIPALVLRGQLLLSVLWLLGPQTSRGLVITPPGPEFVLNISSTFVLTCSGSAPVM
WEQMSQVPWQEAAMNQDGTFSSVLTLTNVTGGDTGEYFCVYNNSLGPELSERKRIYIFVP
DPTMGFLPMDSEDLFIFVTDVTETTIPCRVTDPQLEVTLHEKKVDIPLHVPYDHQRGFTG
TFEDKTYICKTTIGDREVDSDTYYVYSLQVSSINVSVNAVQTVVRQGESITIRCIVMGND
VVNFQWTYPRMKSGRLVEPVTDYLFGVPSRIGSILHIPTAELSDSGTYTCNVSVSVNDHG
DEKAINISVIENGYVRLLETLGDVEIAELHRSRTLRVVFEAYPMPSVLWLKDNRTLGDSG
AGELVLSTRNMSETRYVSELILVRVKVSEAGYYTMRAFHEDDEVQLSFKLQVNVPVRVLE
LSESHPANGEQTIRCRGRGMPQPNVTWSTCRDLKRCPRKLSPTPLGNSSKEESQLETNVT
FWEEDQEYEVVSTLRLRHVDQPLSVRCMLQNSMGGDSQEVTVVPHSLPFKVVVISAILAL
VVLTVISLIILIMLWQKKPRYEIRWKVIESVSSDGHEYIYVDPVQLPYDSTWELPRDQLV
LGRTLGSGAFGQVVEATAHGLSHSQATMKVAVKMLKSTARSSEKQALMSELKIMSHLGPH
LNVVNLLGACTKGGPIYIITEYCRYGDLVDYLHRNKHTFLQRHSNKHCPPSAELYSNALP
VGFSLPSHLNLTGESDGGYMDMSKDESIDYVPMLDMKGDIKYADIESPSYMAPYDNYVPS
APERTYRATLINDSPVLSYTDLVGFSYQVANGMDFLASKNCVHRDLAARNVLICEGKLVK
ICDFGLARDIMRDSNYISKGSTFLPLKWMAPESIFNSLYTTLSDVWSFGILLWEIFTLGG
TPYPELPMNDQFYNAIKRGYRMAQPAHASDEIYEIMQKCWEEKFETRPPFSQLVLLLERL
LGEGYKKKYQQVDEEFLRSDHPAILRSQARFPGIHSLRSPLDTSSVLYTAVQPNESDNDY
IIPLPDPKPDVADEGLPEGSPSLASSTLNEVNTSSTISCDSPLELQEEPQQAEPEAQLEQ
PQDSGCPGPLAEAEDSFL
NT seq 3297 nt   +upstreamnt  +downstreamnt
atggggcttccaggagtgataccagctttagtcctcagaggccagttgttgctgtccgtg
ttatggctcctgggaccgcagacctcccggggcctagtcatcacgccccctgggccagag
tttgttctcaacatctccagcacctttgttctgacctgctcgggctcagctccggtgatg
tgggaacagatgtcccaggtgccctggcaagaagcggccatgaatcaggacggcaccttc
tccagtgtgctgacactgaccaatgtcactgggggagacactggggaatacttttgtgtc
tacaacaactcactagggccggagctcagtgagaggaagcgtatctatatctttgtgcca
gatcccaccatgggcttcctccctatggactccgaggacctgttcatttttgtcacggat
gtcactgagacgacaattccgtgccgagtgacagacccccagctggaggtgacgctacat
gagaagaaagtggatatccccctacacgtaccctacgaccaccagcgaggtttcactggt
acttttgaggacaagacttacatttgcaaaaccaccattggggacagggaagtggactcc
gatacttactacgtctacagcctccaggtgtcatccatcaacgtctctgtgaatgccgtg
cagactgtggtccgccagggcgagagcatcaccatccggtgcattgtgatgggcaatgat
gtggtgaacttccaatggacgtacccccgcatgaagagtgggcggctggtggagccagtg
acagactacctctttggagtgccctcccgcattggctccatcctgcatatccccacggct
gagctgagtgattcgggcacctatacttgcaacgtgtcagtgagtgtgaacgaccatggc
gatgagaaagccatcaacatctctgtgatcgagaatggctacgtgcggctgctggagaca
ctgggagatgtagaaattgctgagctgcaccggagtcggacgctgcgggtggtgttcgag
gcttatccgatgccttctgtcctgtggctcaaggacaaccgtaccttgggtgactccggc
gctggcgagttagttttgtctactcgcaacatgtctgagacccggtacgtgtcagaactg
atcctggtacgtgtgaaggtgtcagaagcgggctactatactatgcgagccttccacgag
gacgatgaggtccagctctccttcaagctgcaggtcaatgtccccgtccgtgtgctggag
ctgagtgagagtcaccctgccaatggggagcagacaatccgctgtcgtggccggggcatg
cctcagccaaatgtcacctggtctacctgcagagacctcaaaaggtgtccacgaaaactg
tcacccacacccttggggaatagttccaaggaggagagccagctagaaacgaatgtgact
ttctgggaggaagatcaggaatacgaggtggtgagcacactgcgcctgcgccacgtggat
cagccactgtccgtacgctgcatgctgcagaactccatgggtggagattcgcaggaggtc
accgtggtcccacattccttgcccttcaaagtggtggtgatctcagccatcctggcctta
gtggtccttaccgtcatctctctcatcatcctcatcatgctgtggcagaagaagccacgc
tatgagatccgatggaaggtcattgagtctgtgagctctgacggtcatgagtacatctac
gtggaccctgtgcagttgccttacgactccacctgggagctgccacgggaccagcttgtt
ctgggacgcactcttggctctggggctttcggacaggtggtggaggccacagctcacggt
ctgagccattcgcaggccaccatgaaagtggctgtcaagatgctgaaatcgacagccaga
agtagcgagaagcaagccttaatgtccgagctgaagattatgagtcatcttggaccccac
ctgaacgtggtcaacctgctgggggcctgcaccaaaggagggcccatctacatcatcacg
gaatactgccgatacggtgatctggtggactacctgcaccggaacaaacacaccttcttg
cagcgacactccaacaagcattgtccgcccagtgctgagctctacagcaacgccctgcca
gtggggttctccctacccagccacttgaacctgactggggagagtgacggtggctacatg
gatatgagcaaggatgaatctatagattacgtgcccatgttggacatgaaaggagacatc
aaatacgcagacattgagtcccccagctacatggccccttatgataactatgtcccatct
gcccctgaaaggacctatcgcgccaccttaatcaacgactcaccagtgctcagctacaca
gacctcgtgggcttcagctaccaagtggccaacggcatggacttcttagcctctaagaac
tgtgttcaccgagacttggcggccaggaatgtgctcatctgcgagggcaagctggtcaag
atctgtgacttcggcctggctcgagacatcatgagggactcaaactacatctccaaaggc
agcaccttcctgcctctgaagtggatggccccagagagcatcttcaacagcctctacacc
actttgagtgatgtctggtcttttgggatcctactctgggagatcttcacactgggtggc
accccttacccagagctgcccatgaacgaccagttctacaatgccatcaagaggggctac
cgcatggcccagcctgctcatgcctccgacgagatctatgagatcatgcagaaatgctgg
gaagaaaagtttgagactcgaccccccttctcccagctggtgctgctcctggagaggctt
ctgggtgaaggctataaaaagaagtaccagcaggtagatgaggagttcctgaggagtgac
catcctgccatcctgaggtcccaagcccgctttccggggatccacagcctccgatcccct
ctggacaccagctctgttctctacactgccgtgcagcccaatgagagtgacaatgactac
atcatccccttacctgaccccaagcctgacgttgctgatgaaggtctcccagaggggtcc
cccagccttgccagttccaccttgaatgaagtcaacacttcctccaccatctcctgcgac
agtcccctggagctccaagaagagccacagcaagcagagcctgaggcacaactggagcag
ccacaggattcaggctgcccaggacctctggctgaagcagaggacagcttcctgtag

DBGET integrated database retrieval system