KEGG   Mus musculus (house mouse): 14056
Entry
14056             CDS       T01002                                 
Symbol
Ezh2, Enx-1, Enx1h, KMT6, mKIAA4065
Name
(RefSeq) enhancer of zeste 2 polycomb repressive complex 2 subunit
  KO
K11430  [histone H3]-lysine27 N-trimethyltransferase EZH2 [EC:2.1.1.356]
Organism
mmu  Mus musculus (house mouse)
Pathway
mmu00310  Lysine degradation
mmu01100  Metabolic pathways
mmu03083  Polycomb repressive complex
mmu05206  MicroRNAs in cancer
Brite
KEGG Orthology (KO) [BR:mmu00001]
 09100 Metabolism
  09105 Amino acid metabolism
   00310 Lysine degradation
    14056 (Ezh2)
 09120 Genetic Information Processing
  09126 Chromosome
   03083 Polycomb repressive complex
    14056 (Ezh2)
 09160 Human Diseases
  09161 Cancer: overview
   05206 MicroRNAs in cancer
    14056 (Ezh2)
 09180 Brite Hierarchies
  09182 Protein families: genetic information processing
   03036 Chromosome and associated proteins [BR:mmu03036]
    14056 (Ezh2)
Enzymes [BR:mmu01000]
 2. Transferases
  2.1  Transferring one-carbon groups
   2.1.1  Methyltransferases
    2.1.1.356  [histone H3]-lysine27 N-trimethyltransferase
     14056 (Ezh2)
Chromosome and associated proteins [BR:mmu03036]
 Eukaryotic type
  Histone modification proteins
   HMTs (histone methyltransferases)
    HKMTs (histone lysine methyltransferases)
     14056 (Ezh2)
   Polycomb repressive complex (PRC) and associated proteins
    PRC2.1
     14056 (Ezh2)
    PRC2.2
     14056 (Ezh2)
SSDB
Motif
Pfam: Ezh2_MCSS PRC2_HTH_1 SET EZH2_WD-Binding preSET_CXC
Other DBs
NCBI-GeneID: 14056
NCBI-ProteinID: NP_031997
MGI: 107940
Ensembl: ENSMUSG00000029687
UniProt: Q61188 Q6AXH7 Q571L5 Q3TZH6
Structure
Position
6:complement(47507208..47613843)
AA seq 746 aa
MGQTGKKSEKGPVCWRKRVKSEYMRLRQLKRFRRADEVKTMFSSNRQKILERTETLNQEW
KQRRIQPVHIMTSVSSLRGTRECSVTSDLDFPAQVIPLKTLNAVASVPIMYSWSPLQQNF
MVEDETVLHNIPYMGDEVLDQDGTFIEELIKNYDGKVHGDRECGFINDEIFVELVNALGQ
YNDDDDDDDGDDPDEREEKQKDLEDNRDDKETCPPRKFPADKIFEAISSMFPDKGTAEEL
KEKYKELTEQQLPGALPPECTPNIDGPNAKSVQREQSLHSFHTLFCRRCFKYDCFLHPFH
ATPNTYKRKNTETALDNKPCGPQCYQHLEGAKEFAAALTAERIKTPPKRPGGRRRGRLPN
NSSRPSTPTISVLESKDTDSDREAGTETGGENNDKEEEEKKDETSSSSEANSRCQTPIKM
KPNIEPPENVEWSGAEASMFRVLIGTYYDNFCAIARLIGTKTCRQVYEFRVKESSIIAPV
PTEDVDTPPRKKKRKHRLWAAHCRKIQLKKDGSSNHVYNYQPCDHPRQPCDSSCPCVIAQ
NFCEKFCQCSSECQNRFPGCRCKAQCNTKQCPCYLAVRECDPDLCLTCGAADHWDSKNVS
CKNCSIQRGSKKHLLLAPSDVAGWGIFIKDPVQKNEFISEYCGEIISQDEADRRGKVYDK
YMCSFLFNLNNDFVVDATRKGNKIRFANHSVNPNCYAKVMMVNGDHRIGIFAKRAIQTGE
ELFFDYRYSQADALKYVGIEREMEIP
NT seq 2241 nt   +upstreamnt  +downstreamnt
atgggccagactgggaagaaatctgagaagggaccggtttgttggcggaagcgtgtaaaa
tcagagtacatgagactgagacagctcaagaggttcagaagagctgatgaagtaaagact
atgtttagttccaatcgtcagaaaattttggaaagaactgaaaccttaaaccaagagtgg
aagcagcggaggatacagcctgtgcacatcatgacttctgtgagctcattgcgcgggact
agggagtgttcagtcaccagtgacttggattttccagcacaagtcatcccgttaaagacc
ctgaatgcagtcgcctcggtgcctataatgtactcttggtcgcccttacaacagaatttt
atggtggaagacgaaactgttttacataacattccttatatgggggatgaagttctggat
caggatggcactttcattgaagaactaataaaaaattatgatggaaaagtgcatggtgac
agagaatgtggatttataaatgatgaaatttttgtggagttggtaaatgctcttggtcaa
tataatgatgatgatgatgacgatgatggagatgatccagatgaaagagaagaaaaacag
aaagatctagaggataatcgagatgataaagaaacttgcccacctcggaaatttcctgct
gataaaatatttgaagccatttcctcaatgtttccagataagggcaccgcagaagaactg
aaagaaaaatataaagaactcacggagcagcagctcccaggtgctctgcctcctgaatgt
actccaaacatcgatggaccaaatgccaaatctgttcagagggagcaaagcttgcattca
tttcatacgctcttctgtcgacgatgttttaagtatgactgcttcctacatcccttccat
gcaacacccaacacatataagaggaagaacacagaaacagctttggacaacaagccttgt
ggaccacagtgttaccagcatctggagggagctaaggagtttgctgctgctcttactgct
gagcgtataaagacaccacctaaacgcccagggggccgcagaagaggaagacttccgaat
aacagtagcagacccagcacccccaccatcagtgtgctggagtcaaaggatacagacagt
gacagagaagcagggactgaaactgggggagagaacaatgataaagaagaagaagagaaa
aaagatgagacgtccagctcctctgaagcaaattctcggtgtcaaacaccaataaagatg
aagccaaatattgaacctcctgagaatgtggagtggagtggtgctgaagcctccatgttt
agagtcctcattggtacttactacgataacttttgtgccattgctaggctaattgggacc
aaaacatgtagacaggtgtatgagtttagagtcaaggagtccagtatcatagcacctgtt
cccactgaggatgtagacactcctccaagaaagaagaaaaggaaacatcggttgtgggct
gcacactgcagaaagatacaactgaaaaaggacggctcctctaaccatgtttacaactat
caaccctgtgaccatccacggcagccttgtgacagttcgtgcccttgtgtgatagcacaa
aatttttgtgaaaagttttgtcaatgtagttcagagtgtcaaaaccgctttcctggatgt
cggtgcaaagcacaatgcaacaccaaacagtgtccatgctacctggctgtccgagagtgt
gaccctgacctctgtctcacgtgtggagctgctgaccattgggacagtaaaaatgtatcc
tgtaagaactgtagcattcagcggggctctaaaaagcacttactgctggcaccgtctgat
gtggcaggctggggcatctttatcaaagatcctgtacagaaaaatgaattcatctcagaa
tactgtggggagattatttctcaggatgaagcagacagaagaggaaaagtgtatgacaaa
tacatgtgcagctttctgttcaacttgaacaatgattttgtggtggatgcaacccgaaag
ggcaacaaaattcgttttgctaatcattcagtaaatccaaactgctatgcaaaagttatg
atggttaatggtgaccacaggataggcatctttgctaagagggctatccagactggtgaa
gagttgttttttgattacagatacagccaggctgatgccctgaagtatgtgggcatcgaa
cgagaaatggaaatcccttga

  All links  
Gene (16)   
   RefGene (11)   
   NCBI-PROTEINID (1)   
   NCBI-Gene (1)   
   Ensembl (1)   
   RIKEN BRC-DNA (1)   
   OC (1)   
Protein sequence (42)   
   UniProt (4)   
   SWISS-PROT (1)   
   RefSeq(pep) (37)   
DNA sequence (63)   
   RefSeq(nuc) (43)   
   GenBank (10)   
   EMBL (10)   
3D Structure (1)   
   PDB (1)   
Protein domain (5)   
   Pfam (5)   
All databases (127)   

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