KEGG   Mus musculus (house mouse): 14450
Entry
14450             CDS       T01002                                 
Symbol
Gart, Gaps, Prgs
Name
(RefSeq) phosphoribosylglycinamide formyltransferase
  KO
K11787  phosphoribosylamine--glycine ligase / phosphoribosylglycinamide formyltransferase / phosphoribosylformylglycinamidine cyclo-ligase [EC:6.3.4.13 2.1.2.2 6.3.3.1]
Organism
mmu  Mus musculus (house mouse)
Pathway
mmu00230  Purine metabolism
mmu00670  One carbon pool by folate
mmu01100  Metabolic pathways
mmu01523  Antifolate resistance
Module
mmu_M00048  De novo purine biosynthesis, PRPP + glutamine => IMP
Brite
KEGG Orthology (KO) [BR:mmu00001]
 09100 Metabolism
  09104 Nucleotide metabolism
   00230 Purine metabolism
    14450 (Gart)
  09108 Metabolism of cofactors and vitamins
   00670 One carbon pool by folate
    14450 (Gart)
 09160 Human Diseases
  09176 Drug resistance: antineoplastic
   01523 Antifolate resistance
    14450 (Gart)
Enzymes [BR:mmu01000]
 2. Transferases
  2.1  Transferring one-carbon groups
   2.1.2  Hydroxymethyl-, formyl- and related transferases
    2.1.2.2  phosphoribosylglycinamide formyltransferase 1
     14450 (Gart)
 6. Ligases
  6.3  Forming carbon-nitrogen bonds
   6.3.3  Cyclo-ligases
    6.3.3.1  phosphoribosylformylglycinamidine cyclo-ligase
     14450 (Gart)
   6.3.4  Other carbon-nitrogen ligases
    6.3.4.13  phosphoribosylamine---glycine ligase
     14450 (Gart)
SSDB
Motif
Pfam: GARS_A Formyl_trans_N AIRS_C GARS_N GARS_C AIRS ATP-grasp CPSase_L_D2 ATP-grasp_3 ATP-grasp_4 ATP-grasp_2 Dala_Dala_lig_C RimK Sacchrp_dh_NADP
Other DBs
NCBI-GeneID: 14450
NCBI-ProteinID: NP_034386
MGI: 95654
Ensembl: ENSMUSG00000022962
UniProt: Q64737
Position
16:complement(91418283..91444505)
AA seq 1010 aa
MAARVLVIGSGGREHTLAWKLAQSPQVKQVLVAPGNAGTACAGKISNAAVSVNDHSALAQ
FCKDEKIELVVVGPEAPLAAGIVGDLTSAGVRCFGPTAQAAQLESSKKFAKEFMDRHEIP
TAQWRAFTNPEDACSFITSANFPALVVKASGLAAGKGVIVAKSQAEACRAVQEIMQEKSF
GAAGETVVVEEFLEGEEVSCLCFTDGKTVAEMPPAQDHKRLLDGDEGPNTGGMGAYCPAP
QVSKDLLVKIKNTILQRAVDGMQQEGAPYTGILYAGIMLTKDGPKVLEFNCRFGDPECQV
ILPLLKSDLYEVMQSTLDGLLSASLPVWLENHSAVTVVMASKGYPGAYTKGVEITGFPEA
QALGLQVFHAGTALKDGKVVTSGGRVLTVTAVQENLMSALAEARKGLAALKFEGAIYRKD
IGFRAVAFLQRPRGLTYKDSGVDIAAGNMLVKKIQPLAKATSRPGCSVDLGGFAGLFDLK
AAGFKDPLLASGTDGVGTKLKIAQLCNKHDSIGQDLVAMCVNDILAQGAEPLFFLDYFSC
GKLDLSTTEAVIAGIAAACQQAGCALLGGETAEMPNMYPPGEYDLAGFAVGAMERHQKLP
QLERITEGDAVIGVASSGLHSNGFSLVRKIVERSSLQYSSPAPGGCGDQTLGDLLLTPTR
IYSHSLLPIIRSGRVKAFAHITGGGLLENIPRVLPQKFGVDLDASTWRVPKVFSWLQQEG
ELSEEEMARTFNCGIGAALVVSKDQAEQVLHDVRRRQEEAWVIGSVVACPEDSPRVRVKN
LIETIQTNGSLVANGFLKSNFPVQQKKARVAVLISGTGSNLQALIDSTRDPKSSSHIVLV
ISNKAAVAGLDRAERAGIPTRVINHKLYKNRVEFDNAVDHVLEEFSVDIVCLAGFMRILS
GPFVRKWDGKMLNIHPSLLPSFKGSNAHEQVLEAGVTITGCTVHFVAEDVDAGQIILQEA
VPVRRGDTVATLSERVKVAEHKIFPAALQLVASGAVQLREDGKIHWAKEQ
NT seq 3033 nt   +upstreamnt  +downstreamnt
atggcagcccgagttcttgtcatcggtagcgggggaagggaacataccctggcctggaag
ctcgcacagtctcctcaggtcaagcaagtgttggttgccccaggaaacgcaggcactgcg
tgcgctgggaagatctccaatgctgctgtctctgtcaatgatcacagtgccctcgctcag
ttctgcaaggatgaaaagattgaactcgtagttgtcggaccagaggcccctctggctgca
ggaattgttggggacctgacctctgcaggagtacgatgctttggccccacagcacaagca
gctcaattagagtccagtaagaagtttgctaaagagtttatggaccgccatgaaatccca
actgcacagtggagagcattcaccaaccctgaagatgcctgcagctttattacaagcgcg
aactttcctgctttggttgtgaaggccagtggccttgcagcagggaagggagtgattgtg
gccaagagccaagcggaggcctgcagagctgtacaggagatcatgcaagaaaagtctttc
ggagcagctggtgaaacagttgttgtggaagagtttctggaaggggaagaagtgtcttgc
ctttgcttcactgacgggaagacggtggccgaaatgcccccagcacaagaccataagcga
ttgctggatggagacgaaggccccaacaccggggggatgggagcctactgcccagcacct
caggtttctaaggacttgttagtaaaaattaagaacactattcttcagagagcagtagac
ggcatgcagcaggagggtgcgccgtacacaggaattctttatgctggtataatgctgacc
aaagatggcccaaaagtgttggagtttaattgccgctttggtgatccggaatgccaggtc
atcctcccacttcttaaaagtgacctctatgaggtgatgcagtccaccttggatggcctg
ctgagcgcgtctctgcctgtttggctagaaaaccacagtgccgtaaccgtcgtcatggcg
agtaaagggtaccctggagcctacaccaaaggcgtggagattacagggtttcctgaggcc
caggctttaggactgcaggtattccatgcaggcactgctcttaaagatggcaaagtagtg
accagcgggggcagggtcctcaccgtgacagctgtccaggaaaatctcatgtcagccctt
gctgaggccaggaaaggactcgctgctctaaagtttgagggagccatctatagaaaggac
attggcttccgtgctgtggccttcctccagcggcccaggggcttgacttacaaggactcc
ggagtagacatcgcagctggaaatatgctggttaagaaaattcagcctttagcaaaagcc
acctccagaccaggctgcagtgttgaccttgggggctttgctggtctttttgatttgaaa
gcagctggtttcaaagatcctcttctggcctctggaacagatggtgtgggaactaaacta
aagattgcgcagctgtgcaataagcatgattccatcgggcaggatctggtggccatgtgt
gtgaacgacatcctcgcccagggagcagagcccctcttcttccttgactacttttcctgt
gggaagctcgacctcagtacaactgaagccgtcattgctggaattgctgcagcttgccag
caggctggctgtgccctgctgggtggggagacagcagagatgcccaacatgtaccctcct
ggagagtatgatcttgctgggtttgctgttggtgctatggagagacaccagaagctccct
cagctagaaaggatcaccgaaggggatgctgttattggagtggcttcatctggtcttcac
agcaatgggtttagccttgtgaggaaaatcgtggagaggtcttcgctccaatactcctcc
ccagcacctggtggttgtggagatcagaccttaggggacttacttctaactccaaccagg
atctacagccattcactgctgcccatcatacgttcaggacgtgtcaaagcttttgctcat
atcactggaggcgggttgctggaaaacatccccagagtcctccctcagaagtttggagta
gatttagatgccagcacctggagggtccccaaggtcttctcgtggctacagcaggaagga
gagctctctgaagaagaaatggccaggacattcaactgtgggattggagctgccctggtg
gtgtcaaaggaccaggccgagcaggttctgcatgacgttcggcggcggcaggaggaagcc
tgggtgataggcagtgtcgttgcgtgtcctgaagattcccctcgtgtcagagttaagaat
ctgattgaaaccatacaaacgaatgggtcattggtggcaaatggcttcctgaaaagtaat
ttccctgtgcaacaaaagaaggcaagagtggctgtcttgatatctggaacagggtcgaac
ctccaggcgctcatagatagcacccgggatcccaagagctcctcacatattgttcttgtc
atctccaacaaagccgccgtagccggcttagaccgagctgagcgagctggtattcccacc
agggtaattaatcacaaattatataaaaatcgtgttgagtttgacaatgcagttgaccac
gtcctggaagagttctctgtagacatcgtctgtcttgcagggttcatgaggatcctctct
gggcccttcgtcagaaaatgggacgggaaaatgctcaacatccacccatccttgctccct
tcctttaagggttcaaatgcccacgagcaagtcctggaagctggagtcacaatcactggg
tgtaccgtacactttgtcgctgaagatgtagatgccggacaaatcatcctgcaggaagct
gtccctgtgcggaggggtgacactgtggcaacgctgtctgaacgggtcaaagtggcagaa
cataagatctttcctgccgctcttcagctggtggccagcggggctgtgcagctgcgagaa
gatggcaagatccactgggccaaggagcagtga

  All links  
Gene (20)   
   RefGene (13)   
   NCBI-PROTEINID (1)   
   NCBI-Gene (1)   
   Ensembl (1)   
   RIKEN BRC-DNA (3)   
   OC (1)   
Protein sequence (7)   
   UniProt (1)   
   SWISS-PROT (1)   
   RefSeq(pep) (5)   
DNA sequence (75)   
   RefSeq(nuc) (5)   
   GenBank (35)   
   EMBL (35)   
Protein domain (14)   
   Pfam (14)   
All databases (116)   

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