KEGG   Mus musculus (mouse): 14960
Entry
14960             CDS       T01002                                 

Gene name
H2-Aa, Aalpha, H-2Aa, H2Aa, I-Aalpha, IAalpha, Ia-1, Ia1
Definition
(RefSeq) histocompatibility 2, class II antigen A, alpha
  KO
K06752  MHC class II antigen
Organism
mmu  Mus musculus (mouse)
Pathway
mmu04145  Phagosome
mmu04514  Cell adhesion molecules (CAMs)
mmu04612  Antigen processing and presentation
mmu04640  Hematopoietic cell lineage
mmu04658  Th1 and Th2 cell differentiation
mmu04659  Th17 cell differentiation
mmu04672  Intestinal immune network for IgA production
mmu04940  Type I diabetes mellitus
mmu05140  Leishmaniasis
mmu05145  Toxoplasmosis
mmu05150  Staphylococcus aureus infection
mmu05152  Tuberculosis
mmu05164  Influenza A
mmu05166  Human T-cell leukemia virus 1 infection
mmu05168  Herpes simplex virus 1 infection
mmu05169  Epstein-Barr virus infection
mmu05310  Asthma
mmu05320  Autoimmune thyroid disease
mmu05321  Inflammatory bowel disease (IBD)
mmu05322  Systemic lupus erythematosus
mmu05323  Rheumatoid arthritis
mmu05330  Allograft rejection
mmu05332  Graft-versus-host disease
mmu05416  Viral myocarditis
Brite
KEGG Orthology (KO) [BR:mmu00001]
 09130 Environmental Information Processing
  09133 Signaling molecules and interaction
   04514 Cell adhesion molecules (CAMs)
    14960 (H2-Aa)
 09140 Cellular Processes
  09141 Transport and catabolism
   04145 Phagosome
    14960 (H2-Aa)
 09150 Organismal Systems
  09151 Immune system
   04640 Hematopoietic cell lineage
    14960 (H2-Aa)
   04612 Antigen processing and presentation
    14960 (H2-Aa)
   04658 Th1 and Th2 cell differentiation
    14960 (H2-Aa)
   04659 Th17 cell differentiation
    14960 (H2-Aa)
   04672 Intestinal immune network for IgA production
    14960 (H2-Aa)
 09160 Human Diseases
  09163 Immune disease
   05310 Asthma
    14960 (H2-Aa)
   05322 Systemic lupus erythematosus
    14960 (H2-Aa)
   05323 Rheumatoid arthritis
    14960 (H2-Aa)
   05320 Autoimmune thyroid disease
    14960 (H2-Aa)
   05321 Inflammatory bowel disease (IBD)
    14960 (H2-Aa)
   05330 Allograft rejection
    14960 (H2-Aa)
   05332 Graft-versus-host disease
    14960 (H2-Aa)
  09166 Cardiovascular disease
   05416 Viral myocarditis
    14960 (H2-Aa)
  09167 Endocrine and metabolic disease
   04940 Type I diabetes mellitus
    14960 (H2-Aa)
  09171 Infectious disease: bacterial
   05150 Staphylococcus aureus infection
    14960 (H2-Aa)
   05152 Tuberculosis
    14960 (H2-Aa)
  09172 Infectious disease: viral
   05166 Human T-cell leukemia virus 1 infection
    14960 (H2-Aa)
   05164 Influenza A
    14960 (H2-Aa)
   05168 Herpes simplex virus 1 infection
    14960 (H2-Aa)
   05169 Epstein-Barr virus infection
    14960 (H2-Aa)
  09174 Infectious disease: parasitic
   05145 Toxoplasmosis
    14960 (H2-Aa)
   05140 Leishmaniasis
    14960 (H2-Aa)
 09180 Brite Hierarchies
  09183 Protein families: signaling and cellular processes
   04147 Exosome [BR:mmu04147]
    14960 (H2-Aa)
Exosome [BR:mmu04147]
 Exosomal proteins
  Exosomal proteins of haemopoietic cells  (B-cell, T-cell, DC-cell, reticulocyte, and mast cell)
   14960 (H2-Aa)
  Exosomal proteins of epithelial cells
   14960 (H2-Aa)
  Exosomal proteins of breast milk
   14960 (H2-Aa)
SSDB
Motif
Pfam: MHC_II_alpha C1-set Ig_3 Marek_A SKG6 C2-set_2
Other DBs
NCBI-GeneID: 14960
NCBI-ProteinID: NP_034508
MGI: 95895
Ensembl: ENSMUSG00000036594
Vega: OTTMUSG00000037121
UniProt: P14434
Structure
PDB: 

Position
17 B1; 17 17.98 cM
AA seq 256 aa
MPRSRALILGVLALTTMLSLCGGEDDIEADHVGTYGISVYQSPGDIGQYTFEFDGDELFY
VDLDKKETVWMLPEFGQLASFDPQGGLQNIAVVKHNLGVLTKRSNSTPATNEAPQATVFP
KSPVLLGQPNTLICFVDNIFPPVINITWLRNSKSVADGVYETSFFVNRDYSFHKLSYLTF
IPSDDDIYDCKVEHWGLEEPVLKHWEPEIPAPMSELTETVVCALGLSVGLVGIVVGTIFI
IQGLRSGGTSRHPGPL
NT seq 771 nt   +upstreamnt  +downstreamnt
atgccgcgcagcagagctctgattctgggggtcctcgccctgaccaccatgctcagcctc
tgtggaggtgaagacgacattgaggccgaccacgtaggcacctatggtataagtgtatat
cagtctcctggagacattggccagtacacatttgaatttgatggtgatgagttgttctat
gtggacttggataagaaggagactgtctggatgcttcctgagtttggccaattggcaagc
tttgacccccaaggtggactgcaaaacatagctgtagtaaaacacaacttgggagtcttg
actaagaggtcaaattccaccccagctaccaatgaggctcctcaagcgactgtgttcccc
aagtcccctgtgctgctgggtcagcccaacaccctcatctgctttgtggacaacatcttc
cctcctgtgatcaacatcacatggctcagaaatagcaagtcagtcgcagacggtgtttat
gagaccagcttcttcgtcaaccgtgactattccttccacaagctgtcttatctcaccttc
atcccttctgacgatgacatttatgactgcaaggtggaacactggggcctggaggagccg
gttctgaaacactgggaacctgagattccagcccccatgtcagagctgacagagactgtg
gtctgtgccctggggttgtctgtgggccttgtgggcatcgtggtgggcaccatcttcatc
attcaaggcctgcgatcaggtggcacctccagacacccagggcctttatga

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