| Entry |
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| Gene name |
Ptpn6, 70Z-SHP, Hcph, PTPTY-42, Ptp, Ptp1C, SH-PTP1, SHP, SHP-1, hc, hcp, me
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| Definition |
(RefSeq) protein tyrosine phosphatase, non-receptor type 6
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| KO |
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| Organism |
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| Pathway |
| mmu04650 | Natural killer cell mediated cytotoxicity |
| mmu04660 | T cell receptor signaling pathway |
| mmu04662 | B cell receptor signaling pathway |
| mmu05235 | PD-L1 expression and PD-1 checkpoint pathway in cancer |
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| Brite |
KEGG Orthology (KO) [BR:mmu00001]
09130 Environmental Information Processing
09132 Signal transduction
04630 JAK-STAT signaling pathway
15170 (Ptpn6)
09140 Cellular Processes
09144 Cellular community - eukaryotes
04520 Adherens junction
15170 (Ptpn6)
09150 Organismal Systems
09151 Immune system
04650 Natural killer cell mediated cytotoxicity
15170 (Ptpn6)
04660 T cell receptor signaling pathway
15170 (Ptpn6)
04662 B cell receptor signaling pathway
15170 (Ptpn6)
09160 Human Diseases
09161 Cancer: overview
05205 Proteoglycans in cancer
15170 (Ptpn6)
05235 PD-L1 expression and PD-1 checkpoint pathway in cancer
15170 (Ptpn6)
09174 Infectious disease: parasitic
05140 Leishmaniasis
15170 (Ptpn6)
09180 Brite Hierarchies
09181 Protein families: metabolism
01009 Protein phosphatases and associated proteins [BR:mmu01009]
15170 (Ptpn6)
Enzymes [BR:mmu01000]
3. Hydrolases
3.1 Acting on ester bonds
3.1.3 Phosphoric-monoester hydrolases
3.1.3.48 protein-tyrosine-phosphatase
15170 (Ptpn6)
Protein phosphatases and associated proteins [BR:mmu01009]
Protein tyrosine phosphatases (PTPs)
Class I PTPs (Classical)
Non-receptor PTPs
15170 (Ptpn6)
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| SSDB |
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| Motif |
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| Other DBs |
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| Position |
6 F2; 6 59.17 cM
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| AA seq |
595 aa
MVRWFHRDLSGPDAETLLKGRGVPGSFLARPSRKNQGDFSLSVRVDDQVTHIRIQNSGDF
YDLYGGEKFATLTELVEYYTQQQGILQDRDGTIIHLKYPLNCSDPTSERWYHGHISGGQA
ESLLQAKGEPWTFLVRESLSQPGDFVLSVLNDQPKAGPGSPLRVTHIKVMCEGGRYTVGG
SETFDSLTDLVEHFKKTGIEEASGAFVYLRQPYYATRVNAADIENRVLELNKKQESEDTA
KAGFWEEFESLQKQEVKNLHQRLEGQRPENKSKNRYKNILPFDHSRVILQGRDSNIPGSD
YINANYVKNQLLGPDENSKTYIASQGCLDATVNDFWQMAWQENTRVIVMTTREVEKGRNK
CVPYWPEVGTQRVYGLYSVTNSREHDTAEYKLRTLQISPLDNGDLVREIWHYQYLSWPDH
GVPSEPGGVLSFLDQINQRQESLPHAGPIIVHCSAGIGRTGTIIVIDMLMESISTKGLDC
DIDIQKTIQMVRAQRSGMVQTEAQYKFIYVAIAQFIETTKKKLEIIQSQKGQESEYGNIT
YPPAVRSAHAKASRTSSKHKEEVYENVHSKSKKEEKVKKQRSADKEKNKGSLKRK |
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| NT seq |
1788 nt +upstreamnt +downstreamnt
atggtgaggtggtttcaccgggacctcagcgggcctgatgcagagaccctgctgaagggc
cggggagtccctgggagcttcctggctcggcccagccgcaagaaccagggtgacttctcc
ctctcagtcagggtggatgatcaggtgactcatattcggatccagaactcaggggacttc
tatgacctgtacggaggggagaagtttgcgacgctgacagagctggtcgagtattacacg
cagcagcagggcatcctgcaggaccgagatggcaccatcatccaccttaagtacccactg
aactgctcggaccccaccagtgagaggtggtaccacggccacatatctggagggcaggcg
gagtcactgctgcaggccaagggcgagccctggacatttcttgtgcgtgagagtctcagc
caacctggtgattttgtgctctctgtgctcaatgaccagcccaaggctggcccaggttcc
ccgctcagggtcactcatatcaaggttatgtgtgagggtggacgctatactgtgggtggc
tcagagacgtttgacagcctcacagacctggtggagcacttcaagaagacagggattgag
gaggcctcgggtgcctttgtctacctgcggcagccttactacgctactcgggtaaacgca
gctgacattgagaatcgggtcttggaactgaacaagaagcaggagtcggaggacacagcc
aaggctggcttctgggaggagtttgagagtctacaaaagcaggaggtaaagaatctacac
caacgtctggaagggcagcggccagagaacaagagcaagaaccgctacaagaacattctt
ccctttgaccacagccgagtgatcctgcagggacgtgacagtaacatcccaggctctgac
tacatcaatgccaactacgtgaagaaccagctgctaggtccagatgagaactctaagacc
tacatcgccagccagggctgtctggatgccacagtcaatgacttctggcagatggcttgg
caggagaacactcgtgtcatcgtcatgactaccagagaggtggagaaaggccggaacaaa
tgtgtcccatactggcccgaggtgggcactcagcgtgtctatggtctctactctgtgacc
aacagtagggagcatgacacagcagaatacaaactgcgaacattacagatctccccacta
gacaatggggacctggttcgggagatatggcactaccagtacctgagctggcctgaccat
ggggttcccagtgagcctgggggtgtcctcagctttctggatcagatcaaccagcgacag
gaaagtttgcctcatgcagggcccatcattgtgcattgcagcgctggcatcggccgcacg
ggcaccatcatcgtcattgatatgcttatggaaagcatctccaccaaggggctagactgt
gacattgatatccagaagaccatccagatggtacgagcacagcgctccggcatggtgcag
accgaggcccagtacaagtttatttacgtggccattgcccagttcatcgaaacgaccaag
aagaaactggagatcatacaatcccagaagggccaggagtcggagtatgggaatatcacg
taccctcccgctgtgaggagtgcccacgccaaagcctcgcgtacttcctccaagcacaag
gaggaggtgtacgaaaacgtgcatagcaagagcaagaaggaagagaaagtaaagaagcag
cggtcggcagacaaggagaagaacaaaggttctctcaagaggaagtga |
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