KEGG   Mus musculus (mouse): 15277Help
Entry
15277             CDS       T01002                                 

Gene name
Hk2, AI642394, HKII
Definition
(RefSeq) hexokinase 2
  KO
K00844  hexokinase [EC:2.7.1.1]
Organism
mmu  Mus musculus (mouse)
Pathway
mmu00010  Glycolysis / Gluconeogenesis
mmu00051  Fructose and mannose metabolism
mmu00052  Galactose metabolism
mmu00500  Starch and sucrose metabolism
mmu00520  Amino sugar and nucleotide sugar metabolism
mmu00524  Neomycin, kanamycin and gentamicin biosynthesis
mmu01100  Metabolic pathways
mmu01200  Carbon metabolism
mmu04066  HIF-1 signaling pathway
mmu04910  Insulin signaling pathway
mmu04930  Type II diabetes mellitus
mmu04973  Carbohydrate digestion and absorption
mmu05230  Central carbon metabolism in cancer
Module
mmu_M00001  Glycolysis (Embden-Meyerhof pathway), glucose => pyruvate
mmu_M00549  Nucleotide sugar biosynthesis, glucose => UDP-glucose
Brite
KEGG Orthology (KO) [BR:mmu00001]
 09100 Metabolism
  09101 Carbohydrate metabolism
   00010 Glycolysis / Gluconeogenesis
    15277 (Hk2)
   00051 Fructose and mannose metabolism
    15277 (Hk2)
   00052 Galactose metabolism
    15277 (Hk2)
   00500 Starch and sucrose metabolism
    15277 (Hk2)
   00520 Amino sugar and nucleotide sugar metabolism
    15277 (Hk2)
  09110 Biosynthesis of other secondary metabolites
   00524 Neomycin, kanamycin and gentamicin biosynthesis
    15277 (Hk2)
 09130 Environmental Information Processing
  09132 Signal transduction
   04066 HIF-1 signaling pathway
    15277 (Hk2)
 09150 Organismal Systems
  09152 Endocrine system
   04910 Insulin signaling pathway
    15277 (Hk2)
  09154 Digestive system
   04973 Carbohydrate digestion and absorption
    15277 (Hk2)
 09160 Human Diseases
  09161 Cancers: Overview
   05230 Central carbon metabolism in cancer
    15277 (Hk2)
  09167 Endocrine and metabolic diseases
   04930 Type II diabetes mellitus
    15277 (Hk2)
 09180 Brite Hierarchies
  09182 Protein families: genetic information processing
   04131 Membrane trafficking [BR:mmu04131]
    15277 (Hk2)
Enzymes [BR:mmu01000]
 2. Transferases
  2.7  Transferring phosphorus-containing groups
   2.7.1  Phosphotransferases with an alcohol group as acceptor
    2.7.1.1  hexokinase
     15277 (Hk2)
Membrane trafficking [BR:mmu04131]
 Autophagy
  Mitophagy
   Other mitophagy associated  proteins
    15277 (Hk2)
BRITE hierarchy
SSDB OrthologParalogGFIT
Motif
Pfam: Hexokinase_2 Hexokinase_1 FGGY_N CCDC66
Motif
Other DBs
NCBI-GeneID: 15277
NCBI-ProteinID: NP_038848
MGI: 1315197
Ensembl: ENSMUSG00000000628
Vega: OTTMUSG00000035991
UniProt: O08528
Position
6 C3; 6 35.94 cM
AA seq 917 aa AA seqDB search
MIASHMIACLFTELNQNQVQKVDQYLYHMRLSDETLLEISRRFRKEMEKGLGATTHPTAA
VKMLPTFVRSTPDGTEHGEFLALDLGGTNFRVLRVRVTDNGLQRVEMENQIYAIPEDIMR
GSGTQLFDHIAECLANFMDKLQIKEKKLPLGFTFSFPCHQTKLDESFLVSWTKGFKSSGV
EGRDVVDLIRKAIQRRGDFDIDIVAVVNDTVGTMMTCGYDDQNCEIGLIVGTGSNACYME
EMRHIDMVEGDEGRMCINMEWGAFGDDGTLNDIRTEFDREIDMGSLNPGKQLFEKMISGM
YMGELVRLILVKMAKAELLFQGKLSPELLTTGSFETKDVSDIEDDKDGIQKAYQILVRLG
LSPLQEDCVATHRICQIVSTRSASLCAATLAAVLWRIKENKGEERLRSTIGVDGSVYKKH
PHFAKRLHKAVRRLVPDCDVRFLRSEDGSGKGAAMVTAVAYRLADQHRARQKTLESLKLS
HEQLLEVKRRMKVEMEQGLSKETHEAAPVKMLPTYVCATPDGTEKGDFLALDLGGTNFRV
LLVRVRNGKRRGVEMHNKIYSIPQEVMHGTGEELFDHIVQCIADFLEYMGMKGVSLPLGF
TFSFPCQQNSLDQSILLKWTKGFKASGCEGEDVVTLLKEAIRRREEFDLDVVAVVNDTVG
TMMTCGYEDPHCEVGLIVGTGSNACYMEEMRNVELVDGEEGRMCVNMEWGAFGDNGCLDD
LRTVFDVAVDELSLNPGKQRFEKMISGMYLGEIVRNILIDFTKRGLLFRGRISERLKTRG
IFETKFLSQIESDCLALLQVRAILRHLGLESTCDDSIIVKEVCTVVARRAAQLCGAGMAA
VVDKIRENRGLDNLKVTVGVDGTLYKLHPHFAKVMHETVRDLAPKCDVSFLESEDGSGKG
AALITAVACRIREAGQR
NT seq 2754 nt NT seq  +upstreamnt  +downstreamnt
atgatcgcctcgcatatgatcgcctgcttattcacggagctcaaccaaaaccaagtgcag
aaggttgaccagtatctctaccacatgcgtctctcagatgagacccttctggagatttct
aggcggttccggaaggagatggagaaggggctaggagctaccacacaccctacagcagct
gtgaagatgctgcccacctttgtgaggtcaactccggatgggacagaacatggcgagttc
ctggctctggaccttggaggaaccaacttccgtgtgctccgagtaagggtgacagacaat
ggtctccagagggtggagatggagaaccagatctacgccattcccgaggacatcatgcgg
ggcagtggaacccagctgtttgaccacattgccgaatgcctggccaacttcatggacaag
ctacagatcaaagagaagaagctcccgctgggtttcaccttctcgttcccctgccaccag
acgaaactggatgagagtttcttggtctcatggactaaggggttcaagtccagtggcgtg
gaaggcagagatgtggtggatctgatccggaaggccatccagcgcagaggggactttgac
attgacattgtggctgtggtgaatgacacggttgggaccatgatgacttgtggttatgat
gatcagaactgcgagattggtctcattgtgggtactggcagtaatgcctgctacatggag
gagatgcgtcacattgacatggtggagggcgacgagggacggatgtgcatcaacatggag
tggggggcctttggggacgacggtacactcaatgacatccgaactgagtttgacagagag
atcgacatgggctcactgaaccctgggaagcagctgtttgagaagatgatcagcgggatg
tacatgggggagctggtcagactcatcctggtgaagatggccaaggccgagctgctgttc
caagggaaactcagcccagagctccttaccactggctccttcgagaccaaagatgtctcg
gatattgaagacgataaggacggaattcagaaggcctaccagatcctggtgcgcctgggt
ctgagcccgctgcaggaggactgtgtggccacgcaccgaatctgccagattgtgtccacg
cgctcagccagcctgtgtgcagccaccctggccgcggtgctgtggcggatcaaagagaac
aagggcgaggagcgactccgctccaccatcggcgtggatggctctgtctacaagaaacat
ccccattttgccaagcgtctccataaggcagtgaggaggctggtgcccgattgtgatgtc
cgcttcctccgctctgaggatggcagcggcaagggggcggctatggtgacggcggtggct
taccgtctggctgaccaacaccgggcccgccagaagaccctggagtctctgaagctgagc
catgaacagctgctggaggttaagagaaggatgaaggtggaaatggagcagggtctgagc
aaggagacgcatgaggccgcccctgtgaagatgttgcccacttatgtgtgtgccactcca
gacggtacagagaaaggagacttcctggccttggatcttggaggaacaaacttccgggtc
ctgctggtgcgcgtgcgtaatggcaagcgaaggggcgtagagatgcataacaagatctac
tccatcccacaggaagtcatgcatggcactggagaagagcttttcgaccacattgtccag
tgcatcgcggacttccttgagtacatgggcatgaagggcgtgtccctacctttgggtttc
accttctccttcccttgccagcagaacagcctggaccagagcatcctcctcaagtggaca
aagggattcaaggcatccggctgcgagggtgaagatgtggtcaccttgctgaaggaagcc
attcgccggcgagaggagtttgacctggatgtggtggccgtggtaaatgacacagttggg
actatgatgacttgtggctatgaagaccctcactgtgaagttggcctcattgttggcact
ggaagcaatgcctgctacatggaggagatgcgtaatgtggaactggtggacggagaggag
gggcggatgtgtgtcaacatggagtggggagcgttcggggacaacggctgcctggatgac
ctgcgcacagtgtttgacgtcgctgtggacgagctctctctcaaccctggcaaacagagg
tttgagaagatgatcagcggcatgtacttgggcgagattgtgcgcaacatcctgatcgat
ttcacaaagcgggggctgctcttccgtggccgcatctcagagcgcctcaagacaagggga
atcttcgaaactaagttcctgtctcagatcgagagtgactgcctggccctgctacaggtc
cgagccatcttgcgccacctagggctggagagcacgtgtgacgacagcatcattgtgaag
gaggtgtgcactgtggtcgcccggcgcgcggcccagctctgtggcgcaggcatggccgcc
gtggtggacaagataagagagaaccgtggactggacaacctcaaagtgacggtgggcgtg
gacgggacactgtacaagcttcatcctcactttgccaaagtcatgcatgagacggtgaga
gatctggctccgaaatgtgacgtgtccttcctggaatccgaggacggcagtgggaaggga
gcggctctcatcactgctgtggcctgtcgcatccgggaggccgggcagagatag

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