KEGG   Mus musculus (house mouse): 15483
Entry
15483             CDS       T01002                                 
Symbol
Hsd11b1
Name
(RefSeq) hydroxysteroid 11-beta dehydrogenase 1
  KO
K15680  corticosteroid 11-beta-dehydrogenase isozyme 1 [EC:1.1.1.146]
Organism
mmu  Mus musculus (house mouse)
Pathway
mmu00140  Steroid hormone biosynthesis
mmu00980  Metabolism of xenobiotics by cytochrome P450
mmu01100  Metabolic pathways
mmu05204  Chemical carcinogenesis - DNA adducts
Module
mmu_M00109  C21-Steroid hormone biosynthesis, progesterone => cortisol/cortisone
Brite
KEGG Orthology (KO) [BR:mmu00001]
 09100 Metabolism
  09103 Lipid metabolism
   00140 Steroid hormone biosynthesis
    15483 (Hsd11b1)
  09111 Xenobiotics biodegradation and metabolism
   00980 Metabolism of xenobiotics by cytochrome P450
    15483 (Hsd11b1)
 09160 Human Diseases
  09161 Cancer: overview
   05204 Chemical carcinogenesis - DNA adducts
    15483 (Hsd11b1)
Enzymes [BR:mmu01000]
 1. Oxidoreductases
  1.1  Acting on the CH-OH group of donors
   1.1.1  With NAD+ or NADP+ as acceptor
    1.1.1.146  11beta-hydroxysteroid dehydrogenase
     15483 (Hsd11b1)
SSDB
Motif
Pfam: adh_short adh_short_C2 KR DUF1776 THF_DHG_CYH_C 2-Hacid_dh_C Pyr_redox_2
Other DBs
NCBI-GeneID: 15483
NCBI-ProteinID: NP_001038216
MGI: 103562
Ensembl: ENSMUSG00000016194
UniProt: P50172 Q4JHD9
Structure
Position
1:complement(192903917..192946345)
AA seq 292 aa
MAVMKNYLLPILVLFLAYYYYSTNEEFRPEMLQGKKVIVTGASKGIGREMAYHLSKMGAH
VVLTARSEEGLQKVVSRCLELGAASAHYIAGTMEDMTFAEQFIVKAGKLMGGLDMLILNH
ITQTSLSLFHDDIHSVRRVMEVNFLSYVVMSTAALPMLKQSNGSIAVISSLAGKMTQPMI
APYSASKFALDGFFSTIRTELYITKVNVSITLCVLGLIDTETAMKEISGIINAQASPKEE
CALEIIKGTALRKSEVYYDKSPLTPILLGNPGRKIMEFFSLRYYNKDMFVSN
NT seq 879 nt   +upstreamnt  +downstreamnt
atggcagttatgaaaaattacctcctcccgatcctggtgctcttcctggcctactactac
tattctacaaatgaagagttcagaccagaaatgctccagggaaagaaagtgattgtcact
ggggccagcaaagggattggaagagaaatggcatatcatctgtcaaaaatgggagcccat
gtggtattgactgccaggtcggaggaaggtctccagaaggtagtgtctcgctgccttgaa
ctcggagcagcctctgctcactacattgctggcactatggaagacatgacatttgcggag
caatttattgtcaaggcgggaaagctcatgggcggactggacatgcttattctaaaccac
atcactcagacctcgctgtctctcttccatgacgacatccactctgtgcgaagagtcatg
gaggtcaacttcctcagctacgtggtcatgagcacagccgccttgcccatgctgaagcag
agcaatggcagcattgccgtcatctcctccttggctgggaaaatgacccagcctatgatt
gctccctactctgcaagcaagtttgctctggatgggttcttttccaccattagaacagaa
ctctacataaccaaggtcaacgtgtccatcactctctgtgtccttggcctcatagacaca
gaaacagctatgaaggaaatctctgggataattaacgcccaagcttctcccaaggaggag
tgcgccctggagatcatcaaaggcacagctctacgcaaaagcgaggtgtactatgacaaa
tcgcctttgactccaatcctgcttgggaacccaggaaggaagatcatggaatttttttca
ttacgatattataataaggacatgtttgtaagtaactag

  All links  
Gene (5)   
   RefGene (1)   
   NCBI-PROTEINID (1)   
   NCBI-Gene (1)   
   Ensembl (1)   
   OC (1)   
Protein sequence (11)   
   UniProt (2)   
   SWISS-PROT (1)   
   RefSeq(pep) (8)   
DNA sequence (34)   
   RefSeq(nuc) (8)   
   GenBank (13)   
   EMBL (13)   
3D Structure (7)   
   PDB (7)   
Protein domain (7)   
   Pfam (7)   
All databases (64)   

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