Entry |
|
Gene name |
Ikbkb, AI132552, IKK, IKK-, IKK-2, IKK-be, IKK-beta, IKK2, IKK[b, IKK[b], IKKbe, IKKbeta
|
Definition |
(RefSeq) inhibitor of kappaB kinase beta
|
KO |
K07209 | inhibitor of nuclear factor kappa-B kinase subunit beta [EC:2.7.11.10] |
|
Organism |
|
Pathway |
mmu04620 | Toll-like receptor signaling pathway |
mmu04621 | NOD-like receptor signaling pathway |
mmu04622 | RIG-I-like receptor signaling pathway |
mmu04625 | C-type lectin receptor signaling pathway |
mmu04658 | Th1 and Th2 cell differentiation |
mmu04660 | T cell receptor signaling pathway |
mmu04662 | B cell receptor signaling pathway |
mmu04920 | Adipocytokine signaling pathway |
mmu04932 | Non-alcoholic fatty liver disease |
mmu05163 | Human cytomegalovirus infection |
mmu05166 | Human T-cell leukemia virus 1 infection |
mmu05167 | Kaposi sarcoma-associated herpesvirus infection |
mmu05168 | Herpes simplex virus 1 infection |
mmu05170 | Human immunodeficiency virus 1 infection |
mmu05235 | PD-L1 expression and PD-1 checkpoint pathway in cancer |
mmu05418 | Fluid shear stress and atherosclerosis |
|
Brite |
KEGG Orthology (KO) [BR:mmu00001]
09130 Environmental Information Processing
09132 Signal transduction
04010 MAPK signaling pathway
16150 (Ikbkb)
04014 Ras signaling pathway
16150 (Ikbkb)
04064 NF-kappa B signaling pathway
16150 (Ikbkb)
04668 TNF signaling pathway
16150 (Ikbkb)
04068 FoxO signaling pathway
16150 (Ikbkb)
04151 PI3K-Akt signaling pathway
16150 (Ikbkb)
04150 mTOR signaling pathway
16150 (Ikbkb)
09140 Cellular Processes
09143 Cell growth and death
04210 Apoptosis
16150 (Ikbkb)
09150 Organismal Systems
09151 Immune system
04620 Toll-like receptor signaling pathway
16150 (Ikbkb)
04621 NOD-like receptor signaling pathway
16150 (Ikbkb)
04622 RIG-I-like receptor signaling pathway
16150 (Ikbkb)
04623 Cytosolic DNA-sensing pathway
16150 (Ikbkb)
04625 C-type lectin receptor signaling pathway
16150 (Ikbkb)
04660 T cell receptor signaling pathway
16150 (Ikbkb)
04658 Th1 and Th2 cell differentiation
16150 (Ikbkb)
04659 Th17 cell differentiation
16150 (Ikbkb)
04657 IL-17 signaling pathway
16150 (Ikbkb)
04662 B cell receptor signaling pathway
16150 (Ikbkb)
04062 Chemokine signaling pathway
16150 (Ikbkb)
09152 Endocrine system
04910 Insulin signaling pathway
16150 (Ikbkb)
04920 Adipocytokine signaling pathway
16150 (Ikbkb)
09156 Nervous system
04722 Neurotrophin signaling pathway
16150 (Ikbkb)
09158 Development and regeneration
04380 Osteoclast differentiation
16150 (Ikbkb)
09160 Human Diseases
09161 Cancer: overview
05200 Pathways in cancer
16150 (Ikbkb)
05206 MicroRNAs in cancer
16150 (Ikbkb)
05235 PD-L1 expression and PD-1 checkpoint pathway in cancer
16150 (Ikbkb)
09162 Cancer: specific types
05212 Pancreatic cancer
16150 (Ikbkb)
05221 Acute myeloid leukemia
16150 (Ikbkb)
05220 Chronic myeloid leukemia
16150 (Ikbkb)
05215 Prostate cancer
16150 (Ikbkb)
05222 Small cell lung cancer
16150 (Ikbkb)
09164 Neurodegenerative disease
05010 Alzheimer disease
16150 (Ikbkb)
09166 Cardiovascular disease
05418 Fluid shear stress and atherosclerosis
16150 (Ikbkb)
09167 Endocrine and metabolic disease
04930 Type II diabetes mellitus
16150 (Ikbkb)
04932 Non-alcoholic fatty liver disease
16150 (Ikbkb)
04931 Insulin resistance
16150 (Ikbkb)
09171 Infectious disease: bacterial
05132 Salmonella infection
16150 (Ikbkb)
05135 Yersinia infection
16150 (Ikbkb)
09172 Infectious disease: viral
05166 Human T-cell leukemia virus 1 infection
16150 (Ikbkb)
05170 Human immunodeficiency virus 1 infection
16150 (Ikbkb)
05161 Hepatitis B
16150 (Ikbkb)
05160 Hepatitis C
16150 (Ikbkb)
05171 Coronavirus disease - COVID-19
16150 (Ikbkb)
05164 Influenza A
16150 (Ikbkb)
05162 Measles
16150 (Ikbkb)
05168 Herpes simplex virus 1 infection
16150 (Ikbkb)
05163 Human cytomegalovirus infection
16150 (Ikbkb)
05167 Kaposi sarcoma-associated herpesvirus infection
16150 (Ikbkb)
05169 Epstein-Barr virus infection
16150 (Ikbkb)
05165 Human papillomavirus infection
16150 (Ikbkb)
09174 Infectious disease: parasitic
05145 Toxoplasmosis
16150 (Ikbkb)
05142 Chagas disease
16150 (Ikbkb)
09176 Drug resistance: antineoplastic
01523 Antifolate resistance
16150 (Ikbkb)
09180 Brite Hierarchies
09181 Protein families: metabolism
01001 Protein kinases [BR:mmu01001]
16150 (Ikbkb)
Enzymes [BR:mmu01000]
2. Transferases
2.7 Transferring phosphorus-containing groups
2.7.11 Protein-serine/threonine kinases
2.7.11.10 IkappaB kinase
16150 (Ikbkb)
Protein kinases [BR:mmu01001]
Serine/threonine kinases: Other
IKK family [OT]
16150 (Ikbkb)
|
SSDB |
|
Motif |
|
Other DBs |
|
Position |
8; 8 A2
|
AA seq |
738 aa
MSWSPSLPTQTCGAWEMKERLGTGGFGNVIRWHNQATGEQIAIKQCRQELSPKNRDRWCL
EIQIMRRLNHPNVVAARDVPEGMQNLAPNDLPLLAMEYCQGGDLRRYLNQFENCCGLREG
AVLTLLSDIASALRYLHENRIIHRDLKPENIVLQQGEKRLIHKIIDLGYAKELDQGSLCT
SFVGTLQYLAPELLEQQKYTVTVDYWSFGTLAFECITGFRPFLPNWQPVQWHSKVRQKSE
VDIVVSEDLNGAVKFSSSLPFPNNLNSVLAERLEKWLQLMLMWHPRQRGTDPQYGPNGCF
RALDDILNLKLVHVLNMVTGTVHTYPVTEDESLQSLKTRIQEDTGILETDQELLQEAGLV
LLPDKPATQCISDSKTNEGLTLDMDLVFLFDNSKINYETQITPRPQPESVSCILQEPKRN
LSFFQLRKVWGQVWHSIQTLKEDCNRLQQGQRAAMMSLLRNNSCLSKMKNAMASTAQQLK
AKLDFFKTSIQIDLEKYKEQTEFGITSDKLLLAWREMEQAVEQCGRENDVKHLVERMMAL
QTDIVDLQRSPMGRKQGGTLDDLEEQARELYRRLREKPRDQRTEGDSQEMVRLLLQAIQS
FEKKVRVIYTQLSKTVVCKQKALELLPKVEEVVSLMNEDERTVVRLQEKRQKELWNLLKI
ACSKVRGPVSGSPDSMNVSRLSHPGQLMSQPSSACDSLPESDKKSEELVAEAHALCSRLE
SALQDTVKEQDRSFTVTA |
NT seq |
2217 nt +upstreamnt +downstreamnt
atgagctggtcaccgtccctcccaacccagacatgtggagcctgggaaatgaaagaacgc
ctggggaccgggggatttggaaacgtcatccggtggcacaatcaggcgacaggtgaacag
atcgccatcaagcaatgccgacaggagctcagcccaaagaacagagaccgctggtgcctc
gaaatccagatcatgagaaggctgaaccatcccaatgtggtggctgcccgggatgtccca
gaggggatgcagaacctggcacccaatgatttgccactgctggccatggagtactgccaa
ggaggagatctccgaagatacttgaaccagttcgagaactgctgtggcctgcgggaagga
gctgtccttaccctgctgagtgacatcgcatcggctcttagataccttcacgaaaacaga
atcatccatcgagacctgaagccagaaaacatcgttctgcagcaaggagagaaaagatta
atacacaaaattattgatctaggatatgccaaggagctggatcagggcagtctgtgcacg
tcatttgtggggactctgcaatacctggcgccagagcttctggagcagcagaagtacacc
gtgaccgttgactactggagcttcggcaccctggccttcgagtgcatcactggcttccgg
cccttcctccctaactggcagcctgtgcagtggcactccaaagtccggcagaagagcgaa
gtggacatcgttgttagtgaagacttgaatggagcagtgaagttttcaagttcgctaccc
ttccccaataatcttaacagtgtcttggctgaacggctggagaagtggctgcagctgatg
cttatgtggcaccctcggcaaaggggcacggatccccagtatggccccaacggctgcttc
agagccctggatgacatcttgaacttgaagctggttcatgtcttgaacatggtcacaggc
accgttcacacataccccgtgacggaggatgagagtctgcagagcttaaaaaccagaatc
caggaagacacggggatcctggagacagaccaggagctgctgcaagaggcagggctggtg
ctgctccctgacaagcctgctactcagtgcatctcagacagcaagacaaacgagggcctc
acgttggacatggatcttgtttttctctttgacaacagtaaaatcaactatgagactcag
atcaccccccgaccccaaccggaaagtgtcagctgtatccttcaggagcccaagcggaac
ctctccttcttccagctgaggaaagtgtggggccaagtctggcacagcatccagacgctg
aaggaagactgtaaccggctgcagcagggacagcgagcagccatgatgagtctcctccgg
aataacagctgcctctctaagatgaagaacgccatggcctccacggcccagcagctcaag
gccaagctggacttcttcaaaaccagcatccagatcgacctggagaagtataaagagcag
accgagtttgggatcacctcagataaattgctgctggcttggcgggagatggagcaggct
gtggagcagtgtgggcgggagaatgacgtgaagcatctagtagagcggatgatggcactg
cagactgacattgtggacctgcagaggagcccgatgggtcggaagcaggggggcaccctg
gatgacctagaggaacaagcgagggagctctaccgaagactcagggagaagccaagagac
caaaggacagaaggtgacagccaggagatggtacggctgctgcttcaggcaatccaaagc
tttgagaagaaagttcgggtgatttatacacagctcagtaagaccgtggtttgtaagcag
aaggcactggagttgctgcccaaggtagaagaggtagtgagccttatgaacgaggacgag
aggaccgtggtccggcttcaggagaagcggcagaaggaactctggaacctcctgaagatc
gcctgtagcaaagtccgaggtcccgtgagtggaagcccagacagcatgaatgtgtctcga
ctcagtcaccctggtcagctaatgtcccagccttccagtgcctgtgacagcttacctgaa
tcagacaagaaaagtgaagaactggtggccgaagcccacgccctctgctcccggctagaa
agtgcgctgcaggacactgtgaaggagcaagacagaagcttcacggtaaccgcctga |