KEGG   Mus musculus (mouse): 16408
Entry
16408             CDS       T01002                                 

Gene name
Itgal, (p180), Cd11, Cd11a, LFA, LFA-1, LFA-1A, Ly-1, Ly-15, Ly-2, Ly-21
Definition
(RefSeq) integrin alpha L
  KO
K05718  integrin alpha L
Organism
mmu  Mus musculus (mouse)
Pathway
mmu04015  Rap1 signaling pathway
mmu04514  Cell adhesion molecules
mmu04613  Neutrophil extracellular trap formation
mmu04650  Natural killer cell mediated cytotoxicity
mmu04670  Leukocyte transendothelial migration
mmu04810  Regulation of actin cytoskeleton
mmu05144  Malaria
mmu05150  Staphylococcus aureus infection
mmu05166  Human T-cell leukemia virus 1 infection
mmu05169  Epstein-Barr virus infection
mmu05323  Rheumatoid arthritis
mmu05416  Viral myocarditis
Brite
KEGG Orthology (KO) [BR:mmu00001]
 09130 Environmental Information Processing
  09132 Signal transduction
   04015 Rap1 signaling pathway
    16408 (Itgal)
  09133 Signaling molecules and interaction
   04514 Cell adhesion molecules
    16408 (Itgal)
 09140 Cellular Processes
  09142 Cell motility
   04810 Regulation of actin cytoskeleton
    16408 (Itgal)
 09150 Organismal Systems
  09151 Immune system
   04613 Neutrophil extracellular trap formation
    16408 (Itgal)
   04650 Natural killer cell mediated cytotoxicity
    16408 (Itgal)
   04670 Leukocyte transendothelial migration
    16408 (Itgal)
 09160 Human Diseases
  09172 Infectious disease: viral
   05166 Human T-cell leukemia virus 1 infection
    16408 (Itgal)
   05169 Epstein-Barr virus infection
    16408 (Itgal)
  09171 Infectious disease: bacterial
   05150 Staphylococcus aureus infection
    16408 (Itgal)
  09174 Infectious disease: parasitic
   05144 Malaria
    16408 (Itgal)
  09163 Immune disease
   05323 Rheumatoid arthritis
    16408 (Itgal)
  09166 Cardiovascular disease
   05416 Viral myocarditis
    16408 (Itgal)
 09180 Brite Hierarchies
  09183 Protein families: signaling and cellular processes
   04147 Exosome [BR:mmu04147]
    16408 (Itgal)
   04515 Cell adhesion molecules [BR:mmu04515]
    16408 (Itgal)
   04090 CD molecules [BR:mmu04090]
    16408 (Itgal)
Exosome [BR:mmu04147]
 Exosomal proteins
  Exosomal proteins of haemopoietic cells  (B-cell, T-cell, DC-cell, reticulocyte, and mast cell)
   16408 (Itgal)
Cell adhesion molecules [BR:mmu04515]
 Integrins
  Integrin alpha subunits
   16408 (Itgal)
CD molecules [BR:mmu04090]
 Proteins
  16408 (Itgal)
SSDB
Motif
Pfam: Integrin_alpha2 VWA FG-GAP VWA_2 FG-GAP_3 Integrin_alpha FG-GAP_2
Other DBs
NCBI-GeneID: 16408
NCBI-ProteinID: NP_001240801
MGI: 96606
Ensembl: ENSMUSG00000030830
Vega: OTTMUSG00000031314
UniProt: E9Q5M7
Position
7 F3; 7 69.44 cM
AA seq 1162 aa
MSFRIAGPRLLLLGLQLFAKAWSYNLDTRPTQSFLAQAGRHFGYQVLQIEDGVVVGAPGE
GDNTGGLYHCRTSSEFCQPVSLHGSNHTSKYLGMTLATDAAKGSLLACDPGLSRTCDQNT
YLSGLCYLFPQSLEGPMLQNRPAYQECMKGKVDLVFLFDGSQSLDRKDFEKILEFMKDVM
RKLSNTSYQFAAVQFSTDCRTEFTFLDYVKQNKNPDVLLGSVQPMFLLTNTFRAINYVVA
HVFKEESGARPDATKVLVIITDGEASDKGNISAAHDITRYIIGIGKHFVSVQKQKTLHIF
ASEPVEEFVKILDTFEKLKDLFTDLQRRIYAIEGTNRQDLTSFNMELSSSGISADLSKGH
AVVGAVGAKDWAGGFLDLREDLQGATFVGQEPLTSDVRGGYLGYTVAWMTSRSSRPLLAA
GAPRYQHVGQVLLFQAPEAGGRWNQTQKIEGTQIGSYFGGELCSVDLDQDGEAELLLIGA
PLFFGEQRGGRVFTYQRRQSLFEMVSELQGDPGYPLGRFGAAITALTDINGDRLTDVAVG
APLEEQGAVYIFNGKPGGLSPQPSQRIQGAQVFPGIRWFGRSIHGVKDLGGDRLADVVVG
AEGRVVVLSSRPVVDVVTELSFSPEEIPVHEVECSYSAREEQKHGVKLKACFRIKPLTPQ
FQGRLLANLSYTLQLDGHRMRSRGLFPDGSHELSGNTSITPDKSCLDFHFHFPICIQDLI
SPINVSLNFSLLEEEGTPRDQKVGRAMQPILRPSIHTVTKEIPFEKNCGEDKKCEANLTL
SSPARSGPLRLMSSASLAVEWTLSNSGEDAYWVRLDLDFPRGLSFRKVEMLQPHSRMPVS
CEELTEGSSLLTKTLKCNVSSPIFKAGQEVSLQVMFNTLLNSSWEDFVELNGTVHCENEN
SSLQEDNSAATHIPVLYPVNILTKEQENSTLYISFTPKGPKTQQVQHVYQVRIQPSAYDH
NMPTLEALVGVPWPHSEDPITYTWSVQTDPLVTCHSEDLKRPSSEAEQPCLPGVQFRCPI
VFRREILIQVTGTVELSKEIKASSTLSLCSSLSVSFNSSKHFHLYGSKASEAQVLVKVDL
IHEKEMLHVYVLSGIGGLVLLFLIFLALYKVGFFKRNLKEKMEADGGVPNGSPPEDTDPL
AVPGEETKDMGCLEPLRESDKD
NT seq 3489 nt   +upstreamnt  +downstreamnt
atgagtttccggattgcgggccccagacttttgctactgggactccagctgtttgccaag
gcctggagctacaacctggacacacggcctacgcagagcttcttggcacaagctggaaga
cattttgggtaccaggtcttgcagattgaagatggggttgtcgtgggagccccaggtgag
ggggacaacacgggaggcctctatcactgccgaacaagcagcgagttctgccagccagtc
agcctacatggttctaaccatacctccaagtacttgggaatgacgctggcaacagatgcc
gccaagggaagccttttggcctgtgaccctggactgtctcggacatgcgatcagaacact
tacctcagtggcctctgctacctcttcccccagagtctggagggacctatgttacaaaat
cgtcccgcctatcaggaatgtatgaagggcaaagtcgacctggtgtttctgttcgatggc
tcacagagcttggatagaaaggactttgaaaaaatcctggaattcatgaaggatgtgatg
aggaagctcagcaatacttcctaccagtttgctgccgtccagttctccacagactgcaga
acagaatttactttcttggactacgttaagcagaacaagaaccccgatgttctgctaggc
agcgtgcagcccatgttcttgctgaccaatacctttcgtgccatcaactatgtggtggca
cacgtgttcaaagaagagtctggtgccaggccggatgctaccaaggtgcttgtcatcatt
acagacggggaggcaagtgataaaggcaacatcagtgcggcccacgacataacccgctac
atcatcgggattggcaagcattttgtgagcgtacaaaagcaaaagacgctccacatattt
gcctcagaacctgtagaggaatttgtgaagattctggacacctttgagaagctgaaggat
ctttttactgacctgcagaggaggatttatgctattgagggcacaaacagacaggacctg
acatcctttaacatggaactctcctccagcgggatcagcgcagacctcagcaagggccat
gcagttgtgggagctgttggggctaaggattgggccgggggctttctggacctgcgtgaa
gacctgcagggtgccacatttgttgggcaggaaccgctgacctcagatgtgagagggggc
tacctgggttacactgtggcctggatgacctcccggagctccagacccctgctggcagca
ggagccccacggtaccagcatgtgggacaagtactgcttttccaagccccagaggctgga
ggacgttggaaccaaacccagaagatagaagggactcagatcggatcttactttggtggg
gaactatgtagtgttgacctggaccaagatggcgaggcagagctgctgctgattggagca
cccctgttctttggggagcagagaggaggccgagtgttcacttaccagagaagacagtcg
ctgtttgaaatggtctcagagctacagggtgaccctggctacccgcttggtcggtttgga
gccgccataactgccctgacggacatcaatggggataggctgactgatgtggctgtggga
gcccctttggaggagcagggggctgtgtacatcttcaatgggaagcctggtgggctcagt
ccccagccaagccagcgtatacaaggagcccaggtgttcccaggaatccggtggtttggc
cgctccatccatggggtgaaggaccttggaggggacaggctggcagatgtggttgtagga
gctgagggtcgggtggttgtgctgagctccaggccggtggtggatgtggtcactgagctg
tcgttctccccagaggaaatcccagtgcacgaggtggagtgctcctactcagccagggag
gagcagaaacacggagtcaagctcaaggcatgcttccggatcaagcccctcacgccacag
tttcaaggtcgcctgcttgccaacctcagctacaccctgcagctggatggccatcggatg
aggagccgagggttgttcccagatggaagccacgagctcagtggaaacacctccatcacc
ccagataaatcctgcttggacttccacttccacttcccgatctgcattcaagacctcatc
tcccctatcaatgtctccctgaatttctctcttttggaggaagaaggaacaccaagggac
caaaaggtgggcagggccatgcagcctatcctgagaccttcaatccacacagtgactaag
gagatcccttttgagaagaactgtggtgaagataagaagtgtgaggcaaacctgaccctg
tcatcccctgccagatctggacccctgcgtctgatgtcctctgccagccttgctgtggag
tggacactgagcaactcaggggaagatgcctactgggtgcgattagacctggacttccct
cggggactctccttccggaaagtggagatgcttcagccacacagccgaatgcctgtgagc
tgcgaggagctcaccgaggggtcaagtctcctgactaagacactgaaatgcaatgtaagc
tctcccatcttcaaagcaggccaggaggtgagcctccaggtgatgtttaacacgctactc
aacagctcctgggaagacttcgttgagctgaatggcactgtgcactgtgagaatgagaac
tcaagcctccaggaggacaactcagccgccacccacattcctgtcctgtaccctgtcaac
atccttactaaggagcaggagaactccactctctatatcagtttcacccctaaaggtccc
aagacccaacaagtccagcatgtctaccaggtgaggattcagccatctgcctatgaccac
aacatgcccacactagaggccttggttggggtgccctggcctcacagtgaggaccccatc
acatacacatggagtgtacagacggatccccttgtcacttgccacagcgaggacctgaag
aggccgtccagcgaagctgagcagccttgtctgcctggagtccagttccgctgtccaatt
gtcttcaggcgggagatcctcatccaagtgacggggaccgtggaactctccaaggaaatc
aaggcctcctccacactcagcctctgcagctcactctccgtctccttcaacagcagcaag
catttccatttgtatggcagcaaagcctccgaggcccaggtcctcgtgaaggttgacctg
atccacgagaaggagatgcttcacgtgtacgtactcagcggcattgggggcctcgtgctt
ctgttcctgattttcctggcgctctacaaggttggcttcttcaaacggaacctgaaggag
aagatggaggctgatggaggtgttccaaatggaagccctccagaagacactgaccctctg
gcagtacctggggaagagaccaaagatatgggctgtctagagcccctccgggagagtgac
aaggactaa

KEGG   Mus musculus (mouse): 16409
Entry
16409             CDS       T01002                                 

Gene name
Itgam, CD11b/CD18, CR, CR3, CR3A, Cd11b, F730045J24Rik, Ly-4, Ly-40, MAC1, Mac-, Mac-1, Mac-1a
Definition
(RefSeq) integrin alpha M
  KO
K06461  integrin alpha M
Organism
mmu  Mus musculus (mouse)
Pathway
mmu04015  Rap1 signaling pathway
mmu04145  Phagosome
mmu04514  Cell adhesion molecules
mmu04610  Complement and coagulation cascades
mmu04613  Neutrophil extracellular trap formation
mmu04640  Hematopoietic cell lineage
mmu04670  Leukocyte transendothelial migration
mmu04810  Regulation of actin cytoskeleton
mmu05133  Pertussis
mmu05134  Legionellosis
mmu05140  Leishmaniasis
mmu05146  Amoebiasis
mmu05150  Staphylococcus aureus infection
mmu05152  Tuberculosis
mmu05202  Transcriptional misregulation in cancer
mmu05221  Acute myeloid leukemia
Brite
KEGG Orthology (KO) [BR:mmu00001]
 09130 Environmental Information Processing
  09132 Signal transduction
   04015 Rap1 signaling pathway
    16409 (Itgam)
  09133 Signaling molecules and interaction
   04514 Cell adhesion molecules
    16409 (Itgam)
 09140 Cellular Processes
  09141 Transport and catabolism
   04145 Phagosome
    16409 (Itgam)
  09142 Cell motility
   04810 Regulation of actin cytoskeleton
    16409 (Itgam)
 09150 Organismal Systems
  09151 Immune system
   04640 Hematopoietic cell lineage
    16409 (Itgam)
   04610 Complement and coagulation cascades
    16409 (Itgam)
   04613 Neutrophil extracellular trap formation
    16409 (Itgam)
   04670 Leukocyte transendothelial migration
    16409 (Itgam)
 09160 Human Diseases
  09161 Cancer: overview
   05202 Transcriptional misregulation in cancer
    16409 (Itgam)
  09162 Cancer: specific types
   05221 Acute myeloid leukemia
    16409 (Itgam)
  09171 Infectious disease: bacterial
   05133 Pertussis
    16409 (Itgam)
   05134 Legionellosis
    16409 (Itgam)
   05150 Staphylococcus aureus infection
    16409 (Itgam)
   05152 Tuberculosis
    16409 (Itgam)
  09174 Infectious disease: parasitic
   05146 Amoebiasis
    16409 (Itgam)
   05140 Leishmaniasis
    16409 (Itgam)
 09180 Brite Hierarchies
  09182 Protein families: genetic information processing
   04131 Membrane trafficking [BR:mmu04131]
    16409 (Itgam)
  09183 Protein families: signaling and cellular processes
   04147 Exosome [BR:mmu04147]
    16409 (Itgam)
   04515 Cell adhesion molecules [BR:mmu04515]
    16409 (Itgam)
   04090 CD molecules [BR:mmu04090]
    16409 (Itgam)
   00536 Glycosaminoglycan binding proteins [BR:mmu00536]
    16409 (Itgam)
Membrane trafficking [BR:mmu04131]
 Endocytosis
  Phagocytosis
   Integrins (complement receptors)
    16409 (Itgam)
Exosome [BR:mmu04147]
 Exosomal proteins
  Exosomal proteins of haemopoietic cells  (B-cell, T-cell, DC-cell, reticulocyte, and mast cell)
   16409 (Itgam)
Cell adhesion molecules [BR:mmu04515]
 Integrins
  Integrin alpha subunits
   16409 (Itgam)
CD molecules [BR:mmu04090]
 Proteins
  16409 (Itgam)
Glycosaminoglycan binding proteins [BR:mmu00536]
 Heparan sulfate / Heparin
  Adhesion molecules of cell surface
   16409 (Itgam)
SSDB
Motif
Pfam: VWA Integrin_alpha2 FG-GAP VWA_2 FG-GAP_3 Integrin_alpha FG-GAP_2 AbfS_sensor
Other DBs
NCBI-GeneID: 16409
NCBI-ProteinID: NP_001076429
MGI: 96607
Ensembl: ENSMUSG00000030786
Vega: OTTMUSG00000058643
UniProt: G5E8F1
Position
7; 7 F3
AA seq 1154 aa
MTLKALLVTALALCHGFNLDTEHPMTFQENAKGFGQSVVQLGGTSVVVAAPQEAKAVNQT
GALYQCDYSTSRCHPIPLQVPPEAVNMSLGLSLAVSTVPQQLLACGPTVHQNCKENTYVN
GLCYLFGSNLLRPPQQFPEALRECPQQESDIVFLIDGSGSINNIDFQKMKEFVSTVMEQF
KKSKTLFSLMQYSDEFRIHFTFNDFKRNPSPRSHVSPIKQLNGRTKTASGIRKVVRELFH
KTNGARENAAKILVVITDGEKFGDPLDYKDVIPEADRAGVIRYVIGVGNAFNKPQSRREL
DTIASKPAGEHVFQVDNFEALNTIQNQLQEKIFAIEGTQTGSTSSFEHEMSQEGFSASIT
SNGPLLGSVGSFDWAGGAFLYTSKDKVTFINTTRVDSDMNDAYLGYASAVILRNRVQSLV
LGAPRYQHIGLVVMFRENFGTWEPHTSIKGSQIGSYFGASLCSVDMDADGNTNLILIGAP
HYYEKTRGGQVSVCPLPRGQRARWQCEALLHGDQGHPWGRFGAALTVLGDVNGDKLTDVA
IGAPGEQENQGAVYIFYGASIASLSASHSQRIIGAHFSPGLQYFGQSLSGGKDLTMDGLM
DLAVGAQGHLLLLRAQPVLRLEATMEFSPKKVARSVFACQEQVLKNKDAGEVRVCLRVRK
NTKDRLREGDIQSTVTYDLALDPGRSRIRAFFDETKNNTRRRTQVFGLMQKCETLKLILP
DCVDDSVSPIILRLNYTLVGEPLRSFGNLRPVLAMDAQRFFTAMFPFEKNCGNDSICQDD
LSITMSAMGLDTLVVGGPQDFNMSVTLRNDGEDSYGTQVTVYYPSGLSYRKDSASQNPLT
KKPWFVKPAESSSSSEGHGALKSTTWNINHPIFPANSEVTFNVTFDVDSHASFGNKLLLK
AIVASENNMSRTHKTKFQLELPVKYAIYMIVTSDESSIRYLNFTASEMTSKVIQHQYQFN
NLGQRSLPVSVVFWIPVQINNVTVWDHPQVIFSQNLSSACHTEQKSPPHSNFRDQLERTP
VLNCSVAVCKRIQCDLPSFNTQEIFNVTLKGNLSFDWYIKTSHGHLLLVSSTEILFNDSA
FALLPGQESYVRSKTETKVEPYEVHNPVPLIVGSSIGGLVLLALITAGLYKLGFFKRQYK
DMMNEAAPQDAPPQ
NT seq 3465 nt   +upstreamnt  +downstreamnt
atgactcttaaagctcttctggtcacagccctagccttgtgtcatggcttcaatctggac
actgaacatcccatgaccttccaagagaatgcaaaaggctttggacagagtgtggtccag
cttggcggaaccagtgtggttgttgcagccccccaggaggcaaaggctgttaaccagaca
ggtgccctctaccagtgtgactacagcacaagccggtgtcaccccatccccctgcaagta
cctccagaggctgtgaatatgtccttgggcctgtccctggctgtttctactgtcccccag
cagctgctggcctgtggccccacggtgcaccaaaactgcaaggagaatacttatgtgaat
ggattgtgctatttgttcggctccaacctgctgaggccgccccagcagttcccagaggct
ctcagagaatgtcctcagcaggagagtgacattgtcttcttgattgatggctccggtagc
atcaacaacattgactttcagaagatgaaggagtttgtctcaactgtgatggagcagttc
aaaaagtctaaaaccttgttctctttgatgcagtactcggacgagttccggattcacttc
accttcaatgacttcaagagaaaccctagcccaagatcacatgtgagccccataaagcag
ctgaatgggaggacaaaaactgcctcagggatccggaaagtagtgagagaactgtttcac
aaaaccaatggggcccgggagaatgctgcgaagatcctagttgtcatcacagatggagaa
aaattcggtgatcccttggattataaggatgtcatccccgaggcagacagagcaggggtc
attcgctacgtaattggggtgggaaatgccttcaacaaaccacagtcccgcagagagctc
gacaccatcgcatctaagccagctggtgaacacgtgttccaagtggacaactttgaagcc
ctgaataccattcagaaccagcttcaggaaaagatctttgcaattgagggcacgcagaca
ggaagtaccagctcctttgagcatgagatgtctcaagaaggcttcagtgcttccattacc
tctaatggtcccttgctgggctctgtggggagctttgactgggcaggtggagccttcctg
tatacatcgaaggataaagtcaccttcatcaacacaaccagagtggattcagacatgaat
gatgcttacctgggttatgcttctgcagtcatcttgaggaaccgtgtccaaagcttggtt
ttaggagcacctcggtatcagcatattggcttggtggtgatgttcagggagaatttcggt
acctgggagccccacactagcatcaagggcagccagattggctcttattttggggcctcc
ctttgctctgtggacatggacgctgatggcaataccaacttgatcctcattggggcccct
cattactatgagaagacccgaggaggccaggtgtcagtgtgtcccttgcctcgagggcag
agggcacggtggcagtgtgaagctcttctccacggtgatcagggtcatccctggggtcgc
tttggggcagccctgacagtgctgggagacgtgaatggggacaaactgacagatgtggcc
attggggccccaggagagcaggagaatcagggcgctgtctacattttttatggagcatca
atagccagcctcagtgcctcccacagccagcggatcataggcgcccacttctcccctggg
ctccagtacttcgggcagtctctgagtgggggtaaggatctcacaatggatggcttgatg
gacctggctgttggggcgcaggggcatcttctgctgctcagagcccagccggtgctgaga
ctggaggcaaccatggaattcagccccaagaaagtagcaaggagtgtgtttgcatgtcaa
gaacaagtattaaaaaacaaggatgctggggaggtcagagtctgcctccgtgtccgcaag
aacaccaaggaccgtctgcgcgaaggagatatccagagcactgtcacttatgacctggct
ttagaccctggccgctcacgtatccgtgccttctttgatgagacaaagaacaacacacgc
aggcgcacccaggtctttggattgatgcagaaatgtgaaacactgaagctaattttaccg
gactgcgtggacgactcagtgagccccatcatcctgcgcctcaattatacactggttggg
gagcccttgaggtcctttgggaacctccgaccagttctggctatggatgctcagaggttc
ttcacagctatgtttccctttgagaaaaattgcggcaatgacagcatctgccaagacgat
ctcagcatcaccatgagtgccatgggcttggacactttggtggtgggaggcccccaggac
tttaacatgagtgtgactctgagaaatgacggtgaggattcctacgggacccaggttacc
gtctactacccatctggcttatcttaccggaaggattcagcaagccagaacccgctcacc
aagaagccttggtttgtaaagcctgctgagtccagctcttcttctgaagggcatggggct
ctgaagagtaccacctggaacataaaccatcccatctttcctgctaattctgaggtcaca
tttaatgtcacatttgatgtggactctcatgcctcctttgggaacaaactgctcctcaaa
gccattgtggccagtgagaacaacatgtccaggacccacaaaaccaagtttcagttggag
ctgcctgtgaagtacgccatctacatgattgtcaccagtgatgagagttctatcagatat
ctcaacttcacggcttcagagatgaccagtaaggtcatacagcatcagtaccagttcaac
aacctgggccagaggagcctccctgtcagtgtagtcttctggatccctgttcagatcaac
aatgtgaccgtatgggatcatccccaggtcatcttctcccagaacctctcaagtgcctgt
cacactgagcagaaatccccccctcactccaatttccgggatcagcttgaaaggacccca
gtgctgaactgctctgttgcagtctgtaagagaattcagtgtgaccttccatccttcaac
actcaggaaatattcaatgtcaccctcaagggcaacctatcatttgactggtacatcaag
acttctcatggtcacctcctgcttgtgagcagcactgagatcctgtttaatgactctgcg
tttgccctgcttccagggcaggagtcgtatgtgaggtctaagacagagaccaaagtggag
ccatatgaagttcacaatcctgtaccactcattgtgggcagctccattgggggcctggtg
ctcttggctctcatcactgctggcctatacaagcttggctttttcaagcggcagtacaag
gacatgatgaatgaagctgccccccaagacgccccacctcagtaa

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