Entry |
|
Symbol |
Itpr2, InsP3R-2, InsP3R-5, Ip3r2, Itpr5, insP3R2
|
Name |
(RefSeq) inositol 1,4,5-triphosphate receptor 2
|
KO |
K04959 | inositol 1,4,5-triphosphate receptor type 2 |
|
Organism |
mmu Mus musculus (house mouse)
|
Pathway |
mmu04070 | Phosphatidylinositol signaling system |
mmu04270 | Vascular smooth muscle contraction |
mmu04621 | NOD-like receptor signaling pathway |
mmu04625 | C-type lectin receptor signaling pathway |
mmu04723 | Retrograde endocannabinoid signaling |
mmu04750 | Inflammatory mediator regulation of TRP channels |
mmu04925 | Aldosterone synthesis and secretion |
mmu04927 | Cortisol synthesis and secretion |
mmu04928 | Parathyroid hormone synthesis, secretion and action |
mmu04935 | Growth hormone synthesis, secretion and action |
mmu05022 | Pathways of neurodegeneration - multiple diseases |
mmu05163 | Human cytomegalovirus infection |
mmu05167 | Kaposi sarcoma-associated herpesvirus infection |
mmu05170 | Human immunodeficiency virus 1 infection |
|
Brite |
KEGG Orthology (KO) [BR:mmu00001]
09130 Environmental Information Processing
09132 Signal transduction
04371 Apelin signaling pathway
16439 (Itpr2)
04020 Calcium signaling pathway
16439 (Itpr2)
04070 Phosphatidylinositol signaling system
16439 (Itpr2)
04022 cGMP-PKG signaling pathway
16439 (Itpr2)
09140 Cellular Processes
09143 Cell growth and death
04114 Oocyte meiosis
16439 (Itpr2)
04210 Apoptosis
16439 (Itpr2)
04218 Cellular senescence
16439 (Itpr2)
09144 Cellular community - eukaryotes
04540 Gap junction
16439 (Itpr2)
09150 Organismal Systems
09151 Immune system
04611 Platelet activation
16439 (Itpr2)
04621 NOD-like receptor signaling pathway
16439 (Itpr2)
04625 C-type lectin receptor signaling pathway
16439 (Itpr2)
09152 Endocrine system
04922 Glucagon signaling pathway
16439 (Itpr2)
04929 GnRH secretion
16439 (Itpr2)
04912 GnRH signaling pathway
16439 (Itpr2)
04915 Estrogen signaling pathway
16439 (Itpr2)
04921 Oxytocin signaling pathway
16439 (Itpr2)
04935 Growth hormone synthesis, secretion and action
16439 (Itpr2)
04918 Thyroid hormone synthesis
16439 (Itpr2)
04928 Parathyroid hormone synthesis, secretion and action
16439 (Itpr2)
04924 Renin secretion
16439 (Itpr2)
04925 Aldosterone synthesis and secretion
16439 (Itpr2)
04927 Cortisol synthesis and secretion
16439 (Itpr2)
09153 Circulatory system
04270 Vascular smooth muscle contraction
16439 (Itpr2)
09154 Digestive system
04970 Salivary secretion
16439 (Itpr2)
04971 Gastric acid secretion
16439 (Itpr2)
04972 Pancreatic secretion
16439 (Itpr2)
09156 Nervous system
04724 Glutamatergic synapse
16439 (Itpr2)
04725 Cholinergic synapse
16439 (Itpr2)
04728 Dopaminergic synapse
16439 (Itpr2)
04726 Serotonergic synapse
16439 (Itpr2)
04720 Long-term potentiation
16439 (Itpr2)
04730 Long-term depression
16439 (Itpr2)
04723 Retrograde endocannabinoid signaling
16439 (Itpr2)
09157 Sensory system
04750 Inflammatory mediator regulation of TRP channels
16439 (Itpr2)
09158 Development and regeneration
04380 Osteoclast differentiation
16439 (Itpr2)
09160 Human Diseases
09161 Cancer: overview
05205 Proteoglycans in cancer
16439 (Itpr2)
09172 Infectious disease: viral
05170 Human immunodeficiency virus 1 infection
16439 (Itpr2)
05163 Human cytomegalovirus infection
16439 (Itpr2)
05167 Kaposi sarcoma-associated herpesvirus infection
16439 (Itpr2)
09164 Neurodegenerative disease
05010 Alzheimer disease
16439 (Itpr2)
05012 Parkinson disease
16439 (Itpr2)
05017 Spinocerebellar ataxia
16439 (Itpr2)
05020 Prion disease
16439 (Itpr2)
05022 Pathways of neurodegeneration - multiple diseases
16439 (Itpr2)
09167 Endocrine and metabolic disease
04934 Cushing syndrome
16439 (Itpr2)
09180 Brite Hierarchies
09183 Protein families: signaling and cellular processes
04040 Ion channels [BR:mmu04040]
16439 (Itpr2)
Ion channels [BR:mmu04040]
Ligand-gated channels
IP3 receptor
16439 (Itpr2)
|
SSDB |
|
Motif |
|
Other DBs |
|
Position |
6:complement(146009797..146403757)
|
AA seq |
2701 aa
MSDKMSSFLYIGDIVSLYAEGSVNGFISTLGLVDDRCVVHPEAGDLANPPKKFRDCLFKV
CPMNRYSAQKQYWKAKQAKQGNHTEAALLKKLQHAAELEQKQNESENRKLLGEIVKYSNV
IQLLHIKSNKYLTVNKRLPALLEKNAMRVSLDAAGNEGSWFYIHPFWKLRSEGDNIVVGD
KVVLMPVNAGQPLHASNVELLDNPGCKEVNAVNCNTSWKITLFMKFSSYREDVLKGGDVV
RLFHAEQEKFLTCDDYEKKQHIFLRTTLRQSATSATSSKALWEIEVVHHDPCRGGAGQWN
SLFRFKHLATGNYLAAELNPDYRDAQNEGKNVKDGEIPTPKKKRQAGEKIMYTLVSVPHG
NDIASLFELDATTLQRADCLVPRNSYVRLRHLCTNTWVTSTTIPIDTEEERPVMLKIGTC
QTKEDKEAFAIVCVPLSEVRDLDFANDANKVLATTVKKLENGSITQNERRFVTKLLEDLI
FFVADVTNNGQDVLDVVITKPNRERQKLMREQNILAQVFGILKAPFKEKAGEGSMLRLED
LGDQRYAPYKYVLRLCYRVLRHSQQDYRKNQEYIAKNFCVMQSQIGYDILAEDTITALLH
NNRKLLEKHITAKEIETFVSLLRRNREPRFLDYLSDLCVSNSTAIPVTQELICKFMLSPG
NADILIQTKLVSMQVENPMESSILPDDIDDEEVWLYWIDSNKEPHGKAIRHLAQEAREGT
KADLEVLTYYRYQLNLFARMCLDRQYLAINQISTQLSVDLILRCVSDESLPFDLRASFCR
LMLHMHVDRDPQESVVPVRYARLWTEIPTKITIHEYDSITDSSRNDMKRKFALTMEFVEE
YLKEVVNQPFPFGDKEKNKLTFEVVHLARNLIYFGFYSFSELLRLTRTLLAILDIVQAPM
SSYFERLSKFQDGSNNVMRTIHGVGEMMTQMVLSRGSIFPVSVPDAQPIVHPSKQASPGE
QEDVTVMDTKLKVIEILQFILSVRLDYRISYMLSIYKKEFGDNNDNGDPSASGTPDTLLP
SALVPDIDEIAAQAETMFAGRKEKTPVQLDDEGGRTFLRVLIHLIMHDYAPLLSGALQLL
FKHFSQRAEVLQAFKQVQLLVSNQDVDNYKQIKADLDQLRLTVEKSELWVEKSGSYENGD
VGEGQAKGGEEANEESNLLSPVQDGAKTPQIDSNKGNNYRIVKEILIRLSKLCVQNKKCR
NQHQRLLKNMGAHSVVLDLLQIPYEKTDEKMNEVMDLAHTFLQNFCRGNPQNQVLLHKHL
NLFLTPGLLEAETMRHIFMNNYHLCNEISERVVQHFVHCIETHGRHVEYLRFLQTIVKAD
GKYVKKCQDMVMTELINGGEDVLIFYNDRASFPILLNMMCSERARGDESGPLAYHITLVE
LLAACTEGKNVYTEIKCNSLLPLDDIVRVVTHDDCIPEVKIAYVNFVNHCYVDTEVEMKE
IYTSNHIWKLFENFLVDMARVCNTTTDRKHADTFLERCVTESVMNIVSGFFNSPFSDNST
SLQTHQPVFIQLLQSAFRIYNCTWPNPAQKASVESCIRALAEVAKNRGIAIPVDLDSQVN
TLFMKNHSSTVQRAAMGWRLSARSGPRFKEALGGPAWDYRNIIEKLQDVVASLEQQFSPM
MQAEFSVLVDVLYSPELLFPEGSDARIRCGAFMSKLINHTKKLMEKEEKLCIKILQTLRE
MLEKKDSFMEEGSTLRRILLNRYFKGDHSISVNGPLSGAYAKTAQVGGSFSGQDSDKKGI
SMSDIQCLLDKEGASELVIDVIVNTKNDRIFSEGILLGIALLEGGNTQTQYSFYQQLHEQ
KKSEKFFKVLYDRMKAAQKEIRSTVTVNTIDLGSKKREEDSDVMALGPRMRVRDSSLHLR
EGMKGQLTEASSATSKAYCVYRREMDPEIDTMCPGQEAGSAEEKSAEEVTMSPAITIMRP
ILRFLQLLCENHNRELQNFLRNQNNKTNYNLVCETLQFLDCICGSTTGGLGLLGLYINER
NVALVNQTLESLTEYCQGPCHENQTCIATHESNGIDIIIALILNDINPLGKYRMDLVLQL
KNNASKLLLAIMESRHDSENAERILFNMRPRELVDVMKNAYNQGLECDHGDEEGGDDGVS
PKDVGHNIYILAHQLARHNKLLQQMLKPGSDPEEGDEALKYYANHTAQIEIVRHDRTMEQ
IVFPVPNICEFLTRESKYRVFNTTERDEQGSKVNDFFQQTEDLYNEMKWQKKIRNNPALF
WFSRHISLWGSISFNLAVFINLAVALFYPFGDDGDEGTLSPMFSVLLWVAVAICTSMLFF
FSKPVGIRPFLVSVMLRSIYTIGLGPTLILLGAANLCNKIVFLVSFVGNRGTFTRGYRAV
ILDMAFLYHVAYVLVCMLGLFVHEFFYSFLLFDLVYREETLLNVIKSVTRNGRSIILTAV
LALILVYLFSIIGFLFLKDDFTMEVDRLKNRTPVTGNHGVPTMTLSSMMETCQKENCSPT
IPSSNTAGEEGEDGIERTCDTLLMCIVTVLNQGLRNGGGVGDVLRRPSKDEPLFAARVVY
DLLFFFIVIIIVLNLIFGVIIDTFADLRSEKQKKEEILKTTCFICGLERDKFDNKTVSFE
EHIKSEHNMWHYLYFIVLVKVKDPTEYTGPESYVAQMITEKNLDWFPRMRAMSLVSNEGD
SEQNEIRNLQEKLESTMSLVKQLSGQLAELKEQMTEQRKNKQRLGFLGSNTPHVNHHMPP
H |
NT seq |
8106 nt +upstreamnt +downstreamnt
atgtctgacaaaatgtccagcttcctctacattggggacatcgtgtccctgtacgcggag
ggctcggtcaatggcttcatcagcaccctggggttggtggatgaccgttgtgtggtgcac
ccagaggcgggagaccttgccaacccacccaagaagttcagagactgcctgttcaaggtg
tgccctatgaatcgatactctgcccagaagcaatactggaaagccaagcaggcgaaacag
gggaaccatacagaggctgccctgctgaagaagctccagcatgctgcagagctggaacaa
aaacagaatgagtcggagaacaggaaacttttgggagaaatcgtgaaatacagcaacgtt
atccaactgctgcacataaaaagcaacaagtacctgacggtgaacaagaggttacctgcc
ttgctggagaagaatgccatgcgagtgtcactggatgctgcagggaacgaaggctcctgg
ttctacatccatccgttctggaagctgagaagcgagggtgataatatcgtcgtaggagat
aaagtcgttctgatgcctgtaaatgctgggcagcccctgcatgccagcaacgtggagctc
ttggacaacccaggctgcaaagaggtgaatgctgttaattgtaacactagctggaaaatc
actttattcatgaaattcagttcctatcgagaggatgtattaaaggggggtgatgttgtg
agactctttcatgcggaacaagagaaatttctgacctgtgatgactatgagaaaaaacag
cacattttccttcggacgaccttgcgtcaatcagcaacttcggccactagttctaaagca
ctctgggaaatagaggtggttcaccacgatccatgccgcggaggtgcgggacagtggaac
agcctgttcaggtttaagcatcttgccactgggaactacttagctgcagagcttaatcct
gactatcgagatgctcaaaatgaaggaaaaaatgtgaaagacggggagattccaacacca
aagaaaaaacgccaggcaggggagaagatcatgtacaccctggtttcagtcccacacgga
aatgacatcgcgtccctttttgaacttgatgccacaactctgcagagagccgactgcctg
gttccgaggaactcctacgtgcggttaaggcacttgtgcaccaacacctgggtaacaagc
accaccatccccatagacacagaggaagagaggcctgtcatgttgaaaattgggacctgc
cagaccaaggaagacaaagaagcctttgccattgtgtgcgtcccgctgtctgaggtccgt
gacttggactttgccaacgatgccaacaaagtgctggccaccacggtgaagaagctggag
aatggcagcatcacacagaacgagaggaggtttgtgactaagttgttggaagacctcatt
ttctttgtggctgatgtgaccaacaatgggcaggacgttctggatgtggtcatcaccaag
ccaaaccgggaacggcagaaactaatgagggaacagaatatactggcacaggtgtttggg
atccttaaagcacctttcaaggagaaggctggagaaggttcgatgctgaggctggaggac
ctgggcgaccagcgctacgccccgtacaagtatgtgctgcgtctctgctaccgtgtgctg
cggcattcgcagcaggactacaggaagaaccaggagtacattgctaagaacttctgcgtt
atgcagtcccagatcggctatgatatcttggcagaagatacgattacagccttgttacac
aacaaccgcaaactactggagaaacacatcacagccaaagaaattgagactttcgtcagc
ctgctcaggaggaaccgggagccgaggtttctggactatttgtctgacctctgtgtgtcc
aatagcacggccatccccgtcactcaggaactcatctgcaaattcatgctgagccctggc
aatgcggacatcctcattcagacaaagctggtgtccatgcaagtggagaaccccatggag
agctccatccttcctgatgacattgacgatgaggaggtctggctttactggattgacagc
aacaaggagcctcacggcaaggccatcaggcaccttgcccaggaagccagggaaggcacc
aaagctgacctggaagttctgacctattacaggtaccagctaaacctctttgcaaggatg
tgcttggaccgccagtatctggccatcaaccagatttcaacacagttgtccgtagacctg
atcctgcggtgtgtgtctgacgagagtctgccctttgacctcagagcatctttctgccga
ctcatgctccacatgcacgttgaccgcgacccccaggagtctgtagtgcctgttcgctat
gcccgcctctggaccgaaatccccacaaagatcacgattcatgagtatgactccattaca
gactcttccagaaatgacatgaagaggaagtttgccctgacgatggaatttgtcgaagaa
tatttgaaagaagttgtaaatcaaccatttccttttggagacaaagagaaaaataaactg
acatttgaggtggttcacctagcccggaacctcatctatttcggattctacagcttcagc
gagttactgcggctgacgagaactctgctggcgatcctagacatcgtccaggcccccatg
tcctcatatttcgaaagattaagcaagttccaagatggaagcaacaatgtcatgaggacc
atccacggagtgggagagatgatgacacagatggtgctcagcagaggctccatcttccca
gtgagtgtgcccgacgcacagcccatcgtccaccccagcaagcaggcgagccccggcgag
caggaggatgtgacagtgatggacaccaagctgaaggttatcgagattttacagttcatc
ctgagcgtcaggctggactaccggatctcttacatgctgtccatatacaagaaggaattt
ggagacaacaacgacaatggtgacccctctgccagcggcaccccagacacactgctacca
tcagctcttgtccctgacatcgacgagattgcggctcaggcagaaacaatgttcgctgga
agaaaagaaaaaactccagttcagcttgatgatgaaggaggcaggacgttcttacgcgtc
ctcatccacctgatcatgcacgactatgctccgctgctgtccggagccctgcagctgctc
ttcaagcatttcagccagagagcagaagtgcttcaggcctttaaacaggtgcagttacta
gtgtcgaaccaagatgttgataactacaagcaaatcaaggcagacctcgaccaacttcgg
ctgacggtggagaaatctgagctgtgggtagaaaagagcggcagctatgagaatggagat
gtgggtgagggccaggccaaaggaggcgaagaggcaaatgaggaatccaacctcttgagc
ccggtgcaggatggcgcgaagacacctcagatcgacagcaacaagggcaacaactaccgg
atcgtcaaggagatcttgattaggctgagtaagctctgtgtgcagaacaagaaatgccgt
aatcaacaccagcggctgctgaaaaacatgggggctcactccgtggtgctggaccttctg
cagatcccctatgagaagaccgacgagaagatgaacgaggtgatggacttagcccacacc
ttcctgcagaacttctgccgtgggaatccgcagaaccaagttctccttcacaagcatctc
aatctgttcctaactcctggcctcctggaggcagaaaccatgcggcacatcttcatgaac
aattatcacctgtgcaacgagatcagcgagagggtggtccagcacttcgtgcactgcatt
gagacacatggccgccatgtggagtacctgaggttcctgcagacgatcgtgaaagcagat
ggcaaatacgtgaagaaatgccaggacatggtgatgacggagttgatcaatgggggcgag
gatgtgttgatattctacaatgacagagcttcatttcccatcctcctcaacatgatgtgc
tctgagagagcccgtggggacgagagcggccccctcgcctaccacatcacccttgtggag
ttgctggcagcgtgcaccgaaggcaaaaatgtctacacagaaatcaagtgcaattctctc
ttgcctctggacgacatagtgagagtggtgacccacgatgactgcattcctgaggtcaaa
atcgcgtacgtgaactttgtcaaccattgctacgttgacactgaagtggagatgaaggag
atctacacaagtaaccacatttggaagttatttgagaatttcttggtggatatggcgagg
gtctgtaacaccaccacagacaggaaacacgcagacacctttctggagaggtgtgtgaca
gagtcagtcatgaacattgtgagcggcttcttcaactcgccattttccgacaacagtacc
agcctccagacccaccagccagtctttatccagctgctgcagtctgccttcagaatttac
aactgtacctggcccaacccagcccagaaagcctccgtagaatcctgtatcagagccctg
gctgaagtggccaaaaaccgtgggattgcgatcccagtcgatttggacagccaggtcaac
acgctcttcatgaagaaccactcaagtacggtgcagagggcagccatgggctggagactc
tcagctcgctctggacctcgcttcaaggaagctcttggaggaccagcctgggattacaga
aatattattgaaaagttacaggatgtcgtggcctccctggaacagcagttcagccccatg
atgcaggccgagttctctgtgcttgtggatgtgctgtacagcccggagctactgttccca
gagggaagcgacgccaggatccgatgtggtgccttcatgtccaagctgattaatcacaca
aagaaactgatggagaaagaagaaaagctgtgcattaaaatcctccagactttacgggag
atgctggagaagaaagacagcttcatggaagagggtagcacattacggcgaatcctcctg
aatcggtacttcaagggtgatcatagcattagtgtgaacggacctctgtcaggagcctat
gccaagacagcacaagtgggaggaagcttctctggacaggattcagataagaagggcatt
tcaatgtccgatatccagtgtttgctggacaaagaaggagcatccgaacttgtcatcgat
gtcattgtgaacaccaaaaacgacaggatcttttccgaaggaattttgcttggcattgcc
ttgctggaaggaggaaacacacagacccagtattctttctaccagcagttgcatgaacaa
aaaaagtcagagaaatttttcaaagtcctttatgatcggatgaaggctgctcagaaagag
atcagatccacggtgaccgtcaacaccatagacttagggagcaagaagagagaagaggac
agtgacgtcatggccctgggccctcggatgagagtgagagactcatcactacatttgaga
gaaggaatgaaagggcagttaacagaagcgtcttcagccacatccaaagcatactgtgtg
tacagaagagagatggacccggaaatagacacaatgtgcccgggacaggaagcaggaagt
gcggaggaaaagtctgcggaggaagttaccatgagcccggccatcaccatcatgcgtccc
atcctcaggttcctgcagttactgtgtgagaatcataaccgggagcttcagaacttcttg
aggaaccagaacaacaaaacaaactacaaccttgtctgtgaaacgcttcagttcctggac
tgtatctgcggaagtaccacagggggtctaggcctgctggggctctacatcaatgagagg
aatgtagctctggtcaaccagactctggagagcttgaccgagtactgccaaggcccgtgc
cacgagaaccagacctgtatcgccactcacgaatccaatgggattgatatcatcatcgcc
ttgattctgaatgacatcaaccccctgggcaagtacagaatggacttggtgttgcagctg
aagaacaacgcctccaagcttctgctggccattatggagagcagacatgacagtgagaat
gcagagagaattcttttcaacatgagacccagggaactggtggatgtcatgaagaatgcc
tataaccaaggcctggaatgtgaccatggggacgaggagggaggggatgatggtgtttct
ccaaaagacgttggacacaacatctacattctggcccatcagttggcccgccacaacaaa
ctgctgcagcagatgctcaagccgggatctgacccagaggaaggggatgaagctttgaag
tattacgccaaccacaccgcgcagatcgagattgtgcggcatgaccggactatggagcag
attgttttcccggtccccaacatctgtgaattcctcactcgggaatccaagtaccgagtg
ttcaacacaacggagagggatgagcaaggaagcaaggtgaacgacttcttccagcaaacg
gaagatctctacaacgagatgaaatggcaaaagaagatcagaaacaaccccgccctgttc
tggttctccaggcacatctcactctgggggagcatctccttcaacctggctgtgttcatc
aacctggctgtggctctcttctacccattcggggatgacggtgatgaaggcacactctcc
ccgatgttctcagtcctcctttgggtagcagtggcgatctgcacatctatgctgttcttc
ttctccaagcccgtgggcatccggccattcctcgtgtctgtcatgctcagatcgatatac
accatcggtctggggccaacgctaatactacttggtgctgccaatctatgtaataaaatc
gtgttcctggtgagttttgtgggaaaccgaggcacattcaccagaggctaccgagcagtc
attctggacatggcctttctttaccacgtggcctatgtcctggtttgcatgcttggcctc
tttgtccacgagttcttctacagcttcctgctttttgatttggtatatagagaagagacc
ctgctgaatgtcatcaaaagcgtcacacggaacggccgctccatcatcctgaccgcggtc
ttggctcttatcttggtctacctgttctccatcatcggcttccttttcttaaaggacgac
ttcaccatggaggtggacagactgaaaaacagaactccagtcacaggtaatcacggggtt
cccactatgaccttatcttccatgatggaaacctgccagaaggaaaactgctcacccacg
atcccctcttccaacacagccggcgaggaaggtgaggatggcatagaaaggacatgtgat
accctgctcatgtgcattgtcaccgtgctgaaccagggcctcaggaatggcggcggagtt
ggggatgtgctgagacgaccctcgaaagatgagcccttgtttgctgcccgggtagtctac
gacctcctgttcttcttcatcgtcatcatcatcgttctcaacctgatctttggagtgatc
attgacacgtttgctgacctcagaagtgagaagcagaagaaagaagaaatcctcaagaca
acctgcttcatctgtggcctggagagagacaagtttgataacaagacagtgtcctttgag
gagcacatcaagtcagagcacaacatgtggcattacctgtacttcatcgtcctggtgaag
gtgaaggacccgacagaatacacagggcctgagagctacgtggctcagatgatcacggag
aagaatttggactggtttcctcggatgcgagccatgtcacttgtcagcaacgaaggtgac
agtgagcaaaatgagatccggaacctgcaggagaagctggagtctacgatgagtctggtg
aagcagctgtcagggcagctggcagagctgaaggagcagatgacagaacaaaggaaaaac
aagcaaaggctgggctttcttggatcaaacacaccccatgtgaaccatcacatgccaccg
cactga |