KEGG   Mus musculus (mouse): 17127
Entry
17127             CDS       T01002                                 

Gene name
Smad3, AU022421, Madh, Madh3
Definition
(RefSeq) SMAD family member 3
  KO
K23605  mothers against decapentaplegic homolog 3
Organism
mmu  Mus musculus (mouse)
Pathway
mmu04068  FoxO signaling pathway
mmu04110  Cell cycle
mmu04144  Endocytosis
mmu04218  Cellular senescence
mmu04310  Wnt signaling pathway
mmu04350  TGF-beta signaling pathway
mmu04371  Apelin signaling pathway
mmu04390  Hippo signaling pathway
mmu04520  Adherens junction
mmu04550  Signaling pathways regulating pluripotency of stem cells
mmu04659  Th17 cell differentiation
mmu04933  AGE-RAGE signaling pathway in diabetic complications
mmu05161  Hepatitis B
mmu05166  Human T-cell leukemia virus 1 infection
mmu05200  Pathways in cancer
mmu05210  Colorectal cancer
mmu05212  Pancreatic cancer
mmu05220  Chronic myeloid leukemia
mmu05225  Hepatocellular carcinoma
mmu05226  Gastric cancer
mmu05321  Inflammatory bowel disease
mmu05415  Diabetic cardiomyopathy
Brite
KEGG Orthology (KO) [BR:mmu00001]
 09130 Environmental Information Processing
  09132 Signal transduction
   04310 Wnt signaling pathway
    17127 (Smad3)
   04350 TGF-beta signaling pathway
    17127 (Smad3)
   04390 Hippo signaling pathway
    17127 (Smad3)
   04371 Apelin signaling pathway
    17127 (Smad3)
   04068 FoxO signaling pathway
    17127 (Smad3)
 09140 Cellular Processes
  09141 Transport and catabolism
   04144 Endocytosis
    17127 (Smad3)
  09143 Cell growth and death
   04110 Cell cycle
    17127 (Smad3)
   04218 Cellular senescence
    17127 (Smad3)
  09144 Cellular community - eukaryotes
   04520 Adherens junction
    17127 (Smad3)
   04550 Signaling pathways regulating pluripotency of stem cells
    17127 (Smad3)
 09150 Organismal Systems
  09151 Immune system
   04659 Th17 cell differentiation
    17127 (Smad3)
 09160 Human Diseases
  09161 Cancer: overview
   05200 Pathways in cancer
    17127 (Smad3)
  09162 Cancer: specific types
   05210 Colorectal cancer
    17127 (Smad3)
   05212 Pancreatic cancer
    17127 (Smad3)
   05225 Hepatocellular carcinoma
    17127 (Smad3)
   05226 Gastric cancer
    17127 (Smad3)
   05220 Chronic myeloid leukemia
    17127 (Smad3)
  09172 Infectious disease: viral
   05166 Human T-cell leukemia virus 1 infection
    17127 (Smad3)
   05161 Hepatitis B
    17127 (Smad3)
  09163 Immune disease
   05321 Inflammatory bowel disease
    17127 (Smad3)
  09166 Cardiovascular disease
   05415 Diabetic cardiomyopathy
    17127 (Smad3)
  09167 Endocrine and metabolic disease
   04933 AGE-RAGE signaling pathway in diabetic complications
    17127 (Smad3)
SSDB
Motif
Pfam: MH2 MH1 IRF-3
Other DBs
NCBI-GeneID: 17127
NCBI-ProteinID: NP_058049
MGI: 1201674
Ensembl: ENSMUSG00000032402
Vega: OTTMUSG00000021500
UniProt: Q8BUN5
Position
9; 9 C
AA seq 425 aa
MSSILPFTPPIVKRLLGWKKGEQNGQEEKWCEKAVKSLVKKLKKTGQLDELEKAITTQNV
NTKCITIPRSLDGRLQVSHRKGLPHVIYCRLWRWPDLHSHHELRAMELCEFAFNMKKDEV
CVNPYHYQRVETPVLPPVLVPRHTEIPAEFPPLDDYSHSIPENTNFPAGIEPQSNIPETP
PPGYLSEDGETSDHQMNHSMDAGSPNLSPNPMSPAHNNLDLQPVTYCEPAFWCSISYYEL
NQRVGETFHASQPSMTVDGFTDPSNSERFCLGLLSNVNRNAAVELTRRHIGRGVRLYYIG
GEVFAECLSDSAIFVQSPNCNQRYGWHPATVCKIPPGCNLKIFNNQEFAALLAQSVNQGF
EAVYQLTRMCTIRMSFVKGWGAEYRRQTVTSTPCWIELHLNGPLQWLDKVLTQMGSPSIR
CSSVS
NT seq 1278 nt   +upstreamnt  +downstreamnt
atgtcgtccatcctgcccttcacccccccgatcgtgaagcgcctgctgggttggaagaag
ggcgagcagaacgggcaggaggagaagtggtgcgagaaggcggtcaagagcttggtgaag
aagctcaagaagacggggcagttggacgagctggagaaggccatcaccacgcagaacgtg
aacaccaagtgcattaccatccccaggtcactggatggtcggctgcaggtgtcccatcgg
aaggggctccctcacgttatctactgccgcctgtggcgatggcccgacctgcacagccac
catgaattacgggccatggagctctgtgagtttgccttcaacatgaagaaggatgaagtg
tgtgtaaatccttaccactatcagagagtagagacgccagttctacctccagtgttggtg
ccacgccacaccgagatcccggccgagttccccccactggatgactacagccattccatt
cccgagaacactaacttccctgctggcattgagccccagagcaatattccagaaacccca
cctcctggctacctgagtgaagatggagaaaccagtgaccaccagatgaaccacagcatg
gacgcaggttctccaaacctctccccgaatccgatgtccccagcacacaataacttggac
ctacagccagtcacctactgtgagccggccttctggtgctccatctcctactacgagctg
aaccagcgagttggggagacattccacgcctcacagccatccatgacagtagatggcttc
actgacccctccaactcggagcgcttctgcctgggcctactgtccaatgtcaaccggaat
gcagccgtggaacttacaaggcgacacattgggagaggtgtgcggctctactacatcgga
ggggaggtctttgcggagtgcctcagtgacagtgctattttcgtccagtctcccaactgc
aaccagcgctatggctggcacccggccactgtctgcaagatcccaccaggctgcaacctg
aagatcttcaacaaccaggaatttgctgccctcctagctcagtctgtcaaccagggcttt
gaggctgtctaccagctgacgcgcatgtgcaccatccgtatgagcttcgtcaaaggctgg
ggagcagagtacaggagacagacagtgaccagcaccccctgctggattgagctacacctg
aatggacccttgcagtggcttgacaaggtcctcacccagatgggttccccgagcatccgc
tgttccagtgtgtcttag

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