KEGG   Mus musculus (house mouse): 17769
Entry
17769             CDS       T01002                                 
Symbol
Mthfr
Name
(RefSeq) methylenetetrahydrofolate reductase
  KO
K25004  methylenetetrahydrofolate reductase (NADPH) [EC:1.5.1.53]
Organism
mmu  Mus musculus (house mouse)
Pathway
mmu00670  One carbon pool by folate
mmu01100  Metabolic pathways
mmu01523  Antifolate resistance
mmu04981  Folate transport and metabolism
Brite
KEGG Orthology (KO) [BR:mmu00001]
 09100 Metabolism
  09108 Metabolism of cofactors and vitamins
   00670 One carbon pool by folate
    17769 (Mthfr)
 09150 Organismal Systems
  09154 Digestive system
   04981 Folate transport and metabolism
    17769 (Mthfr)
 09160 Human Diseases
  09176 Drug resistance: antineoplastic
   01523 Antifolate resistance
    17769 (Mthfr)
Enzymes [BR:mmu01000]
 1. Oxidoreductases
  1.5  Acting on the CH-NH group of donors
   1.5.1  With NAD+ or NADP+ as acceptor
    1.5.1.53  methylenetetrahydrofolate reductase (NADPH)
     17769 (Mthfr)
SSDB
Motif
Pfam: MTHFR_C MTHFR DUF6919
Other DBs
NCBI-GeneID: 17769
NCBI-ProteinID: NP_034970
MGI: 106639
Ensembl: ENSMUSG00000029009
UniProt: Q9WU20 Q497H7
Position
4:148123534..148144019
AA seq 654 aa
MVNEARGSGSPNPRSEGSSSGSESSKDSSRCSTPSLDPERHERLREKMRRRMDSGDKWFS
LEFFPPRTAEGAVNLISRFDRMAAGGPLFVDVTWHPAGDPGSDKETSSMMIASTAVNYCG
LETILHMTCCQQRPEEITGHLHRAKQLGLKNIMALRGDPVGDHWEAEEGGFSYATDLVKH
IRTEFADYFDICVAGYPRGHPDAESFEDDLKHLKEKVSAGADFIITQLFFEASTFFSFVK
ACTEIGISCPILPGIFPIQGYTSLRQLVKLSKLEVPQKIKDVIEPIKDNDAAIRNYGIEL
AVSLCRELLDSGLVPGLHFYTLNREVATMEVLKQLGMWTEDPRRPLPWALSAHPKRREED
VRPIFWASRPKSYIYRTQDWDEFPNGRWGNSSSPAFGELKDYYLFYLKSKSPREELLKMW
GEELTSEESVFEVFEHYLSGEPNRHGYRVTCLPWNDEPLAAETSLMKEELLRVNRLGILT
INSQPNINAKPSSDPVVGWGPSGGYVFQKAYLEFFTSRETVEALLQVLKTYELRVNYHIV
DVKGENITNAPELQPNAVTWGIFPGREIIQPTVVDPISFMFWKDEAFALWIEQWGKLYEE
ESPSRMIIQYIHDNYFLVNLVDNEFPLDSCLWQVVEDTFELLNRHPTERETQAP
NT seq 1965 nt   +upstreamnt  +downstreamnt
atggtgaacgaggccagaggaagtggcagtcccaacccgcgatctgagggcagcagcagt
ggcagcgagagttccaaggacagttcaagatgttccacccccagcctggacccagagcgg
cacgagagactccgggagaagatgaggcgcagaatggactctggtgacaagtggttctcc
ctggagttcttcccccctcgaactgctgagggagctgttaacctcatctccaggtttgac
cggatggcagcagggggccccctcttcgtagatgttacctggcacccagctggagaccct
ggctcagacaaggagacctcctccatgatgatcgccagcacagcagtaaactactgcggc
ttggaaaccatcctgcatatgacctgctgccagcagcgcccggaggagatcacaggccat
ctgcacagagccaagcagctgggcctgaagaacataatggcgctgaggggagaccctgta
ggtgaccactgggaagcagaggaaggaggcttcagctatgccacagacctggtgaagcac
atccggaccgagtttgctgactattttgacatctgtgtggcaggttaccccagaggccac
cccgatgcagagagcttcgaggatgacctgaagcatttgaaggagaaggtatctgcaggc
gccgacttcattatcactcagctcttctttgaggccagcaccttcttcagctttgtgaag
gcctgcacagagataggcatctcttgccctatcctgcctgggatcttccctattcagggc
tacacttcccttcggcagcttgtaaaactgtccaagctggaggtgccacagaagatcaag
gatgtaattgagcccatcaaagacaacgatgctgccatccgcaactacggcattgagctg
gctgtaagcctgtgccgggagctgctggacagtggcttggtgccaggcctccacttctat
accctcaaccgcgaggtggccaccatggaggtgctaaagcaactgggcatgtggaccgag
gaccccaggcgtcccttgccctgggctctcagtgcgcatcccaagcgccgggaggaagat
gtccgtcccatcttctgggcctccagaccaaagagctacatctaccgcacacaggactgg
gatgagtttcctaacggccgctggggtaattcttcctcaccagcctttggggagctgaaa
gactactacctcttctacctgaaaagcaagtcccccagggaggagctgctgaagatgtgg
ggcgaggagctcaccagcgaagagagtgtctttgaagtctttgaacactacctctctgga
gagccgaatcgccatggctacagagtaacctgcctgccctggaacgatgaacccctggca
gcggaaaccagcctgatgaaggaagagctgctccgcgtgaacaggctgggcatcctcacc
atcaactctcagcccaacatcaacgcaaaaccatcctcagaccctgttgtgggctggggc
cccagtgggggttatgtcttccagaaggcctacctcgaattcttcacctcccgtgaaact
gtggaggcgcttctgcaggtgctgaagacatacgagctgcgggtcaactaccacatcgtg
gacgtgaagggagagaacatcactaatgcccctgagctgcagcccaatgccgtgacgtgg
ggcatcttcccgggtcgagagatcatccagcctactgtggtggaccccatcagcttcatg
ttctggaaggatgaggcctttgccctgtggatcgagcagtggggcaagctatacgaggag
gagtcgccatcccgcatgatcatccaatacatccatgacaactatttcctggtcaacctg
gtggacaacgagttcccgctggacagctgcctgtggcaggtggtggaggacacgtttgag
ctgctcaacaggcatcccacggagagagagacacaggctccatga

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Ontology (2)   
   KEGG BRITE (2)   
Pathway (4)   
   KEGG PATHWAY (4)   
Chemical substance (5)   
   KEGG COMPOUND (5)   
Chemical reaction (2)   
   KEGG ENZYME (1)   
   KEGG REACTION (1)   
Genome (1)   
   KEGG GENOME (1)   
Gene (20)   
   KEGG ORTHOLOGY (1)   
   KEGG GENES (1)   
   RefGene (13)   
   NCBI-PROTEINID (1)   
   NCBI-Gene (1)   
   Ensembl (1)   
   RIKEN BRC-DNA (1)   
   OC (1)   
Protein sequence (5)   
   UniProt (2)   
   SWISS-PROT (1)   
   RefSeq(pep) (2)   
DNA sequence (37)   
   RefSeq(nuc) (3)   
   GenBank (17)   
   EMBL (17)   
Protein domain (3)   
   Pfam (3)   
All databases (79)   

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