KEGG   Mus musculus (house mouse): 18597
Entry
18597             CDS       T01002                                 
Symbol
Pdha1, Pdha-1
Name
(RefSeq) pyruvate dehydrogenase E1 component subunit alpha, somatic form, mitochondrial precursor
  KO
K00161  pyruvate dehydrogenase E1 component subunit alpha [EC:1.2.4.1]
Organism
mmu  Mus musculus (house mouse)
Pathway
mmu00010  Glycolysis / Gluconeogenesis
mmu00020  Citrate cycle (TCA cycle)
mmu00620  Pyruvate metabolism
mmu00785  Lipoic acid metabolism
mmu01100  Metabolic pathways
mmu01200  Carbon metabolism
mmu01210  2-Oxocarboxylic acid metabolism
mmu04066  HIF-1 signaling pathway
mmu04922  Glucagon signaling pathway
mmu05230  Central carbon metabolism in cancer
mmu05415  Diabetic cardiomyopathy
Module
mmu_M00307  Pyruvate oxidation, pyruvate => acetyl-CoA
Brite
KEGG Orthology (KO) [BR:mmu00001]
 09100 Metabolism
  09101 Carbohydrate metabolism
   00010 Glycolysis / Gluconeogenesis
    18597 (Pdha1)
   00020 Citrate cycle (TCA cycle)
    18597 (Pdha1)
   00620 Pyruvate metabolism
    18597 (Pdha1)
  09108 Metabolism of cofactors and vitamins
   00785 Lipoic acid metabolism
    18597 (Pdha1)
 09130 Environmental Information Processing
  09132 Signal transduction
   04066 HIF-1 signaling pathway
    18597 (Pdha1)
 09150 Organismal Systems
  09152 Endocrine system
   04922 Glucagon signaling pathway
    18597 (Pdha1)
 09160 Human Diseases
  09161 Cancer: overview
   05230 Central carbon metabolism in cancer
    18597 (Pdha1)
  09166 Cardiovascular disease
   05415 Diabetic cardiomyopathy
    18597 (Pdha1)
Enzymes [BR:mmu01000]
 1. Oxidoreductases
  1.2  Acting on the aldehyde or oxo group of donors
   1.2.4  With a disulfide as acceptor
    1.2.4.1  pyruvate dehydrogenase (acetyl-transferring)
     18597 (Pdha1)
SSDB
Motif
Pfam: E1_dh DXP_synthase_N TPP_enzyme_C
Other DBs
NCBI-GeneID: 18597
NCBI-ProteinID: NP_032836
MGI: 97532
Ensembl: ENSMUSG00000031299
UniProt: P35486 Q3UFJ3
Position
X:complement(158905215..158921426)
AA seq 390 aa
MRKMLAAVSRVLAGSAQKPASRVLVASRNFANDATFEIKKCDLHRLEEGPPVTTVLTRED
GLKYYRMMQTVRRMELKADQLYKQKIIRGFCHLCDGQEACCVGLEAGINPTDHLITAYRA
HGFTFTRGLPVRAILAELTGRRGGCAKGKGGSMHMYAKNFYGGNGIVGAQVPLGAGIALA
CKYNGKDEVCLTLYGDGAANQGQIFEAYNMAALWKLPCIFICENNRYGMGTSVERAAAST
DYYKRGDFIPGLRVDGMDILCVREATKFAAAYCRSGKGPILMELQTYRYHGHSMSDPGVS
YRTREEIQEVRSKSDPIMLLKDRMVNSNLASVEELKEIDVEVRKEIEDAAQFATADPEPP
LEELGYHIYSSDPPFEVRGANQWIKFKSVS
NT seq 1173 nt   +upstreamnt  +downstreamnt
atgaggaagatgcttgccgctgtatcccgcgtgttggcaggctctgcgcagaagccggca
agccgagtgctggttgcttcccgtaattttgcaaatgatgctacatttgagattaagaaa
tgtgaccttcatcggctagaagagggccccccagtcaccacagtgctcaccagagaggat
gggctcaagtactacaggatgatgcagactgtgcgccggatggagctaaaggcggatcag
ctgtataagcagaaaatcattcgtggtttctgtcacttgtgtgatggtcaggaagcctgc
tgcgtgggcctggaggctggcataaaccctacggaccacctcatcactgcctatcgagca
catggcttcaccttcactcggggcctgcctgtgcgagcaattcttgcagagctaacagga
cgaagaggaggttgtgctaaagggaaaggcgggtcaatgcacatgtacgccaagaacttc
tatggaggcaacggcatcgttggagctcaggtgcccctgggagcaggaattgccctggcc
tgcaagtacaatggaaaagatgaggtctgtttgacattatacggcgatggtgctgctaat
cagggtcagatctttgaagcttacaatatggcagcactgtggaaattaccttgcattttt
atctgtgagaacaaccgctatggcatggggacgtctgttgagagagcagcagccagcacg
gactactacaaaagaggagattttattcctggactcagggtagatggaatggatatcttg
tgcgtccgagaggcaacaaagtttgcggctgcctattgcaggtctggtaaggggcccatc
ctgatggagctccagacttaccgctaccatggacacagcatgagtgaccctggagtaagc
taccgcactcgagaagaaatccaggaagtaagaagtaagagtgaccctattatgcttctc
aaggatagaatggtgaacagcaatcttgcaagtgttgaagaattaaaggagattgatgtg
gaagtgaggaaagaaatcgaggatgctgcccagtttgccacggctgatcctgagcccccg
ttggaggaactaggctatcacatctacagcagtgatcctccctttgaagtgcgtggtgcc
aaccagtggatcaagtttaagtcagtcagttaa

  All links  
Gene (15)   
   RefGene (9)   
   NCBI-PROTEINID (1)   
   NCBI-Gene (1)   
   Ensembl (1)   
   RIKEN BRC-DNA (2)   
   OC (1)   
Protein sequence (4)   
   UniProt (2)   
   SWISS-PROT (1)   
   RefSeq(pep) (1)   
DNA sequence (31)   
   RefSeq(nuc) (1)   
   GenBank (15)   
   EMBL (15)   
Protein domain (3)   
   Pfam (3)   
All databases (53)   

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