KEGG   Mus musculus (house mouse): 18607
Entry
18607             CDS       T01002                                 
Symbol
Pdpk1, Pdk1
Name
(RefSeq) 3-phosphoinositide dependent protein kinase 1
  KO
K06276  3-phosphoinositide dependent protein kinase-1 [EC:2.7.11.1]
Organism
mmu  Mus musculus (house mouse)
Pathway
mmu01524  Platinum drug resistance
mmu03320  PPAR signaling pathway
mmu04068  FoxO signaling pathway
mmu04071  Sphingolipid signaling pathway
mmu04140  Autophagy - animal
mmu04150  mTOR signaling pathway
mmu04151  PI3K-Akt signaling pathway
mmu04152  AMPK signaling pathway
mmu04210  Apoptosis
mmu04360  Axon guidance
mmu04510  Focal adhesion
mmu04660  T cell receptor signaling pathway
mmu04664  Fc epsilon RI signaling pathway
mmu04722  Neurotrophin signaling pathway
mmu04910  Insulin signaling pathway
mmu04919  Thyroid hormone signaling pathway
mmu04931  Insulin resistance
mmu04960  Aldosterone-regulated sodium reabsorption
mmu05145  Toxoplasmosis
mmu05205  Proteoglycans in cancer
mmu05208  Chemical carcinogenesis - reactive oxygen species
mmu05213  Endometrial cancer
mmu05215  Prostate cancer
mmu05223  Non-small cell lung cancer
mmu05231  Choline metabolism in cancer
mmu05417  Lipid and atherosclerosis
Brite
KEGG Orthology (KO) [BR:mmu00001]
 09130 Environmental Information Processing
  09132 Signal transduction
   04068 FoxO signaling pathway
    18607 (Pdpk1)
   04071 Sphingolipid signaling pathway
    18607 (Pdpk1)
   04151 PI3K-Akt signaling pathway
    18607 (Pdpk1)
   04152 AMPK signaling pathway
    18607 (Pdpk1)
   04150 mTOR signaling pathway
    18607 (Pdpk1)
 09140 Cellular Processes
  09141 Transport and catabolism
   04140 Autophagy - animal
    18607 (Pdpk1)
 09150 Organismal Systems
  09151 Immune system
   04660 T cell receptor signaling pathway
    18607 (Pdpk1)
   04664 Fc epsilon RI signaling pathway
    18607 (Pdpk1)
  09152 Endocrine system
   04919 Thyroid hormone signaling pathway
    18607 (Pdpk1)
  09155 Excretory system
   04960 Aldosterone-regulated sodium reabsorption
    18607 (Pdpk1)
  09156 Nervous system
   04722 Neurotrophin signaling pathway
    18607 (Pdpk1)
  09158 Development and regeneration
   04360 Axon guidance
    18607 (Pdpk1)
 09160 Human Diseases
  09161 Cancer: overview
   05205 Proteoglycans in cancer
    18607 (Pdpk1)
   05208 Chemical carcinogenesis - reactive oxygen species
    18607 (Pdpk1)
   05231 Choline metabolism in cancer
    18607 (Pdpk1)
  09162 Cancer: specific types
   05215 Prostate cancer
    18607 (Pdpk1)
   05213 Endometrial cancer
    18607 (Pdpk1)
   05223 Non-small cell lung cancer
    18607 (Pdpk1)
  09174 Infectious disease: parasitic
   05145 Toxoplasmosis
    18607 (Pdpk1)
  09166 Cardiovascular disease
   05417 Lipid and atherosclerosis
    18607 (Pdpk1)
  09167 Endocrine and metabolic disease
   04931 Insulin resistance
    18607 (Pdpk1)
  09176 Drug resistance: antineoplastic
   01524 Platinum drug resistance
    18607 (Pdpk1)
 09180 Brite Hierarchies
  09181 Protein families: metabolism
   01001 Protein kinases [BR:mmu01001]
    18607 (Pdpk1)
  09182 Protein families: genetic information processing
   04131 Membrane trafficking [BR:mmu04131]
    18607 (Pdpk1)
Enzymes [BR:mmu01000]
 2. Transferases
  2.7  Transferring phosphorus-containing groups
   2.7.11  Protein-serine/threonine kinases
    2.7.11.1  non-specific serine/threonine protein kinase
     18607 (Pdpk1)
Protein kinases [BR:mmu01001]
 Serine/threonine kinases: AGC group
  PDK1 family
   18607 (Pdpk1)
Membrane trafficking [BR:mmu04131]
 Exocytosis
  Calcium ion-dependent exocytosis
   Acrosomal exocytosis proteins
    18607 (Pdpk1)
SSDB
Motif
Pfam: Pkinase PH_3 PK_Tyr_Ser-Thr Kinase-like Pkinase_fungal ABC1 Haspin_kinase APH Kdo
Other DBs
NCBI-GeneID: 18607
NCBI-ProteinID: NP_035192
MGI: 1338068
Ensembl: ENSMUSG00000024122
UniProt: Q9Z2A0 Q3UGN6 Q3UHZ0
Position
17:complement(24292654..24370957)
AA seq 559 aa
MARTTSQLYDAVPIQSSVVLCSCPSPSMVRSQTEPGSSPGIPSGVSRQGSTMDGTTAEAR
PSTNPLQQHPAQLPPQPRKKRPEDFKFGKILGEGSFSTVVLARELATSREYAIKILEKRH
IIKENKVPYVTRERDVMSRLDHPFFVKLYFTFQDDEKLYFGLSYAKNGELLKYIRKIGSF
DETCTRFYTAEIVSALEYLHGKGIIHRDLKPENILLNEDMHIQITDFGTAKVLSPESKQA
RANSFVGTAQYVSPELLTEKSACKSSDLWALGCIIYQLVAGLPPFRAGNEYLIFQKIIKL
EYHFPEKFFPKARDLVEKLLVLDATKRLGCEEMEGYGPLKAHPFFETITWENLHQQTPPK
LTAYLPAMSEDDEDCYGNYDNLLSQFGFMQVSSSSSSHSLSTVETSLPQRSGSNIEQYIH
DLDTNSFELDLQFSEDEKRLLLEKQAGGNPWHQFVENNLILKMGPVDKRKGLFARRRQLL
LTEGPHLYYVDPVNKVLKGEIPWSQELRPEAKNFKTFFVHTPNRTYYLMDPSGNAHKWCR
KIQEVWRQQYQSNPDAAVQ
NT seq 1680 nt   +upstreamnt  +downstreamnt
atggccaggaccaccagccagctgtatgacgctgtgcccattcagtccagtgtggtgcta
tgttcctgcccatccccatcaatggtgaggtcccagactgagcccggttcgtcccctggc
attcctagtggtgttagcaggcagggatccaccatggatggcaccacagctgaagcccga
ccaagcaccaaccccttgcagcagcaccctgcccagctgccaccacagcctcgcaagaaa
cgccctgaagacttcaagtttgggaaaattcttggcgagggctctttttcaacagttgtt
ctggcccgagaactggccacttccagagaatatgctattaaaattctggagaaacgtcat
attataaaagaaaacaaagttccgtatgtaactagagagagagatgtgatgtcacgcctg
gatcaccccttctttgtgaaactttattttacatttcaggacgacgaaaagctgtatttt
ggccttagttatgccaaaaatggagagctacttaaatacatccgcaaaattggctcattt
gatgagacctgtacccggttttacacggctgagattgtgtctgctttagagtacttgcat
ggcaagggcatcattcacagagaccttaaaccagaaaacattttgttaaatgaagacatg
cacatccagatcacagattttggaacagcaaaagtgttatccccagagagcaaacaagcc
agggccaactcatttgtaggaacagcacagtatgtttctccagagctgctcacagagaag
tcggcgtgtaaaagttcagacctttgggcccttggatgtataatctatcagctcgtggca
ggactcccaccattcagagccgggaatgaatatcttatatttcagaagatcattaagctg
gaatatcatttcccagaaaaattcttccctaaggctagagatcttgtggaaaaactcttg
gttttagatgccacaaagcgtttaggctgtgaagagatggaagggtacgggcctctcaaa
gctcatccattctttgagaccatcacttgggagaatttgcaccagcagacacctccgaag
ctcacagcttacctaccagccatgtcagaggatgatgaagactgctatggcaactacgac
aatctcctgagccagtttggcttcatgcaggtgtcatcctcctcctcttcccactccctg
tctacggtggaaaccagcctgccccagaggtcgggcagcaacatagagcagtacatccat
gatttggacactaactcttttgaactagacttacagttttcagaagatgaaaaaaggttg
ttattggaaaagcaagccggtggaaacccttggcaccagtttgtagaaaataatctaata
ttaaaaatgggtccagtggataagcgaaagggtttatttgcaagacgacgacagttatta
ctcacagaagggccacatttatattatgttgatcctgtcaacaaggtcttgaaaggtgaa
atcccatggtcacaagaactccgaccagaagccaagaattttaaaactttctttgtccac
acgcctaacaggacgtactacctgatggatccaagcgggaatgctcacaagtggtgcaga
aagatccaggaggtttggaggcagcagtaccagagcaatccagatgctgctgtgcagtga

  All links  
Gene (10)   
   RefGene (4)   
   NCBI-PROTEINID (1)   
   NCBI-Gene (1)   
   Ensembl (1)   
   RIKEN BRC-DNA (2)   
   OC (1)   
Protein sequence (15)   
   UniProt (3)   
   SWISS-PROT (1)   
   RefSeq(pep) (11)   
DNA sequence (59)   
   RefSeq(nuc) (11)   
   GenBank (24)   
   EMBL (24)   
Protein domain (9)   
   Pfam (9)   
All databases (93)   

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