KEGG   Mus musculus (mouse): 18747Help
Entry
18747             CDS       T01002                                 

Gene name
Prkaca, PKCD, Pkaca
Definition
(RefSeq) protein kinase, cAMP dependent, catalytic, alpha
  KO
K04345  protein kinase A [EC:2.7.11.11]
Organism
mmu  Mus musculus (mouse)
Pathway
mmu01522  Endocrine resistance
mmu04010  MAPK signaling pathway
mmu04014  Ras signaling pathway
mmu04020  Calcium signaling pathway
mmu04024  cAMP signaling pathway
mmu04062  Chemokine signaling pathway
mmu04114  Oocyte meiosis
mmu04140  Autophagy - animal
mmu04211  Longevity regulating pathway
mmu04213  Longevity regulating pathway - multiple species
mmu04261  Adrenergic signaling in cardiomyocytes
mmu04270  Vascular smooth muscle contraction
mmu04310  Wnt signaling pathway
mmu04340  Hedgehog signaling pathway
mmu04371  Apelin signaling pathway
mmu04530  Tight junction
mmu04540  Gap junction
mmu04611  Platelet activation
mmu04713  Circadian entrainment
mmu04714  Thermogenesis
mmu04720  Long-term potentiation
mmu04723  Retrograde endocannabinoid signaling
mmu04724  Glutamatergic synapse
mmu04725  Cholinergic synapse
mmu04726  Serotonergic synapse
mmu04727  GABAergic synapse
mmu04728  Dopaminergic synapse
mmu04740  Olfactory transduction
mmu04742  Taste transduction
mmu04750  Inflammatory mediator regulation of TRP channels
mmu04910  Insulin signaling pathway
mmu04911  Insulin secretion
mmu04912  GnRH signaling pathway
mmu04913  Ovarian steroidogenesis
mmu04914  Progesterone-mediated oocyte maturation
mmu04915  Estrogen signaling pathway
mmu04916  Melanogenesis
mmu04918  Thyroid hormone synthesis
mmu04919  Thyroid hormone signaling pathway
mmu04921  Oxytocin signaling pathway
mmu04922  Glucagon signaling pathway
mmu04923  Regulation of lipolysis in adipocytes
mmu04924  Renin secretion
mmu04925  Aldosterone synthesis and secretion
mmu04926  Relaxin signaling pathway
mmu04927  Cortisol synthesis and secretion
mmu04928  Parathyroid hormone synthesis, secretion and action
mmu04934  Cushing's syndrome
mmu04961  Endocrine and other factor-regulated calcium reabsorption
mmu04962  Vasopressin-regulated water reabsorption
mmu04970  Salivary secretion
mmu04971  Gastric acid secretion
mmu04976  Bile secretion
mmu05012  Parkinson's disease
mmu05020  Prion diseases
mmu05030  Cocaine addiction
mmu05031  Amphetamine addiction
mmu05032  Morphine addiction
mmu05034  Alcoholism
mmu05146  Amoebiasis
mmu05163  Human cytomegalovirus infection
mmu05165  Human papillomavirus infection
mmu05166  HTLV-I infection
mmu05169  Epstein-Barr virus infection
mmu05200  Pathways in cancer
mmu05203  Viral carcinogenesis
mmu05205  Proteoglycans in cancer
mmu05414  Dilated cardiomyopathy (DCM)
Module
mmu_M00695  cAMP signaling
Brite
KEGG Orthology (KO) [BR:mmu00001]
 Environmental Information Processing
  Signal transduction
   04014 Ras signaling pathway
    18747 (Prkaca)
   04010 MAPK signaling pathway
    18747 (Prkaca)
   04310 Wnt signaling pathway
    18747 (Prkaca)
   04340 Hedgehog signaling pathway
    18747 (Prkaca)
   04371 Apelin signaling pathway
    18747 (Prkaca)
   04020 Calcium signaling pathway
    18747 (Prkaca)
   04024 cAMP signaling pathway
    18747 (Prkaca)
 Cellular Processes
  Transport and catabolism
   04140 Autophagy - animal
    18747 (Prkaca)
  Cell growth and death
   04114 Oocyte meiosis
    18747 (Prkaca)
  Cellular community - eukaryotes
   04530 Tight junction
    18747 (Prkaca)
   04540 Gap junction
    18747 (Prkaca)
 Organismal Systems
  Immune system
   04611 Platelet activation
    18747 (Prkaca)
   04062 Chemokine signaling pathway
    18747 (Prkaca)
  Endocrine system
   04911 Insulin secretion
    18747 (Prkaca)
   04910 Insulin signaling pathway
    18747 (Prkaca)
   04922 Glucagon signaling pathway
    18747 (Prkaca)
   04923 Regulation of lipolysis in adipocyte
    18747 (Prkaca)
   04912 GnRH signaling pathway
    18747 (Prkaca)
   04913 Ovarian Steroidogenesis
    18747 (Prkaca)
   04915 Estrogen signaling pathway
    18747 (Prkaca)
   04914 Progesterone-mediated oocyte maturation
    18747 (Prkaca)
   04921 Oxytocin signaling pathway
    18747 (Prkaca)
   04926 Relaxin signaling pathway
    18747 (Prkaca)
   04918 Thyroid hormone synthesis
    18747 (Prkaca)
   04919 Thyroid hormone signaling pathway
    18747 (Prkaca)
   04928 Parathyroid hormone synthesis, secretion and action
    18747 (Prkaca)
   04916 Melanogenesis
    18747 (Prkaca)
   04924 Renin secretion
    18747 (Prkaca)
   04925 Aldosterone synthesis and secretion
    18747 (Prkaca)
   04927 Cortisol synthesis and secretion
    18747 (Prkaca)
  Circulatory system
   04261 Adrenergic signaling in cardiomyocytes
    18747 (Prkaca)
   04270 Vascular smooth muscle contraction
    18747 (Prkaca)
  Digestive system
   04970 Salivary secretion
    18747 (Prkaca)
   04971 Gastric acid secretion
    18747 (Prkaca)
   04976 Bile secretion
    18747 (Prkaca)
  Excretory system
   04962 Vasopressin-regulated water reabsorption
    18747 (Prkaca)
   04961 Endocrine and other factor-regulated calcium reabsorption
    18747 (Prkaca)
  Nervous system
   04724 Glutamatergic synapse
    18747 (Prkaca)
   04727 GABAergic synapse
    18747 (Prkaca)
   04725 Cholinergic synapse
    18747 (Prkaca)
   04728 Dopaminergic synapse
    18747 (Prkaca)
   04726 Serotonergic synapse
    18747 (Prkaca)
   04720 Long-term potentiation
    18747 (Prkaca)
   04723 Retrograde endocannabinoid signaling
    18747 (Prkaca)
  Sensory system
   04740 Olfactory transduction
    18747 (Prkaca)
   04742 Taste transduction
    18747 (Prkaca)
   04750 Inflammatory mediator regulation of TRP channels
    18747 (Prkaca)
  Aging
   04211 Longevity regulating pathway - mammal
    18747 (Prkaca)
   04213 Longevity regulating pathway - multiple species
    18747 (Prkaca)
  Environmental adaptation
   04713 Circadian entrainment
    18747 (Prkaca)
   04714 Thermogenesis
    18747 (Prkaca)
 Human Diseases
  Cancers
   05200 Pathways in cancer
    18747 (Prkaca)
   05205 Proteoglycans in cancer
    18747 (Prkaca)
   05203 Viral carcinogenesis
    18747 (Prkaca)
  Neurodegenerative diseases
   05012 Parkinson's disease
    18747 (Prkaca)
   05020 Prion diseases
    18747 (Prkaca)
  Substance dependence
   05030 Cocaine addiction
    18747 (Prkaca)
   05031 Amphetamine addiction
    18747 (Prkaca)
   05032 Morphine addiction
    18747 (Prkaca)
   05034 Alcoholism
    18747 (Prkaca)
  Cardiovascular diseases
   05414 Dilated cardiomyopathy (DCM)
    18747 (Prkaca)
  Endocrine and metabolic diseases
   04934 Cushing's syndrome
    18747 (Prkaca)
  Infectious diseases
   05166 HTLV-I infection
    18747 (Prkaca)
   05163 Human cytomegalovirus infection
    18747 (Prkaca)
   05169 Epstein-Barr virus infection
    18747 (Prkaca)
   05165 Human papillomavirus infection
    18747 (Prkaca)
   05146 Amoebiasis
    18747 (Prkaca)
  Drug resistance
   01522 Endocrine resistance
    18747 (Prkaca)
Enzymes [BR:mmu01000]
 2. Transferases
  2.7  Transferring phosphorus-containing groups
   2.7.11  Protein-serine/threonine kinases
    2.7.11.11  cAMP-dependent protein kinase
     18747 (Prkaca)
Protein kinases [BR:mmu01001]
 Serine/threonine kinases: AGC group
  PKA family
   18747 (Prkaca)
Messenger RNA biogenesis [BR:mmu03019]
 Eukaryotic Type
  mRNA surveillance and transport factors
   mRNA cycle factors
    Common to processing body (P body) and stress granule
     18747 (Prkaca)
Chromosome and associated proteins [BR:mmu03036]
 Eukaryotic Type
  Centrosome formation and ciliogenesis proteins
   Kinases and associated factors
    18747 (Prkaca)
BRITE hierarchy
SSDB OrthologParalogGFIT
Motif
Pfam: Pkinase Pkinase_Tyr Kinase-like Haspin_kinase
Motif
Other DBs
NCBI-GeneID: 18747
NCBI-ProteinID: NP_032880
MGI: 97592
Ensembl: ENSMUSG00000005469
Vega: OTTMUSG00000061189
UniProt: P05132
Structure
PDB: 

Position
8; 8 C2
AA seq 351 aa AA seqDB search
MGNAAAAKKGSEQESVKEFLAKAKEDFLKKWETPSQNTAQLDQFDRIKTLGTGSFGRVML
VKHKESGNHYAMKILDKQKVVKLKQIEHTLNEKRILQAVNFPFLVKLEFSFKDNSNLYMV
MEYVAGGEMFSHLRRIGRFSEPHARFYAAQIVLTFEYLHSLDLIYRDLKPENLLIDQQGY
IQVTDFGFAKRVKGRTWTLCGTPEYLAPEIILSKGYNKAVDWWALGVLIYEMAAGYPPFF
ADQPIQIYEKIVSGKVRFPSHFSSDLKDLLRNLLQVDLTKRFGNLKNGVNDIKNHKWFAT
TDWIAIYQRKVEAPFIPKFKGPGDTSNFDDYEEEEIRVSINEKCGKEFTEF
NT seq 1056 nt NT seq  +upstreamnt  +downstreamnt
atgggcaacgccgccgccgccaagaagggcagcgagcaggagagcgtgaaagagttccta
gccaaagccaaggaagatttcctgaaaaaatgggagaccccttctcagaatacagcccag
ttggatcagtttgatagaatcaagacccttggcaccggctcctttgggcgagtgatgctg
gtgaagcacaaggagagtgggaaccactacgccatgaagatcttagacaagcagaaggtg
gtgaagctaaagcagatcgagcacactctgaatgagaagcgcatcctgcaggccgtcaac
ttcccgttcctggtcaaacttgaattctccttcaaggacaactcaaacctgtacatggtc
atggagtatgtagctggtggcgagatgttctcccacctacggcggattggaaggttcagc
gagccccatgcccgtttctacgcggcgcagatcgtcctgacctttgagtatctgcactcc
ctggacctcatctaccgggacctgaagcccgagaatcttctcatcgaccagcagggctat
attcaggtgacagacttcggttttgccaagcgtgtgaaaggccgtacttggaccttgtgt
gggacccctgagtacttggcccccgagattatcctgagcaaaggctacaacaaggctgtg
gactggtgggctctcggagtcctcatctacgagatggctgctggttacccacccttcttc
gctgaccagcctatccagatctatgagaaaatcgtctctgggaaggtgcggttcccatcc
cacttcagctctgacttgaaggacctgctgcggaaccttctgcaggtggatctcaccaag
cgctttgggaacctcaagaacggggtcaatgacatcaagaaccacaagtggtttgccacg
actgactggattgccatctatcagagaaaggtggaagctcccttcataccaaagtttaaa
ggccctggggacacgagtaactttgacgactatgaggaggaagagatccgggtctccatc
aatgagaagtgtggcaaggagtttactgagttttag

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